Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

Nature

Volumn 494, Issue 7435, 2013, Pages 111-115

  Kornfeld, Jan Wilhelm ^a,b,c   Baitzel, Catherina ^a,b,c   Könner, A Christine ^a,b,c   Nicholls, Hayley T ^a,b,c   Vogt, Merly C ^a,b,c   Herrmanns, Karolin ^d   Scheja, Ludger ^e   Haumaitre, Cécile ^f,g   Wolf, Anna M ^h   Knippschild, Uwe ^h   Seibler, Jost ⁱ   Cereghini, Silvia ^f,g   Heeren, Joerg ^e   Stoffel, Markus ^d   Brüning, Jens C ^a,b,c  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d ETH ZURICH   (Switzerland)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f INSERM   (France)

^g SORBONNE UNIVERSITÉ   (France)

^h UNIVERSITY HOSPITAL ULM   (Germany)

ⁱ TaconicArtemis GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1BETA; INSULIN; MICRORNA; MICRORNA 802; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; HNF1B PROTEIN, MOUSE; MIRN802 MICRORNA, HUMAN; MIRN802 MICRORNA, MOUSE;

DIABETES; GENE EXPRESSION; GLUCOSE; METABOLISM; OBESITY; PATHOGENICITY; RNA; RODENT; SENSITIVITY ANALYSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; GLUCONEOGENESIS; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HORMONE ACTION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; INSULIN RESISTANCE; LIVER; METABOLISM;

ANIMALS; GENE EXPRESSION REGULATION; GENE SILENCING; GLUCONEOGENESIS; GLUCOSE; GLUCOSE INTOLERANCE; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; MICE; MICRORNAS; OBESITY; SIGNAL TRANSDUCTION;

MLCS; MLOWN;

EID: 84874715061     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11793     Document Type: Article

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