In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9

Diabetologia

Volumn 54, Issue 5, 2011, Pages 1075-1086

  Jimenez, V ^a,b   Ayuso, E ^a,b   Mallol, C ^a,b   Agudo, J ^a,b   Casellas, A ^a,b   Obach, M ^a,b   Munoz S ^a,b   Salavert, A ^a   Bosch, F ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Adeno associated vectors; Beta cells; Diabetes; Gene therapy; Gene transfer; Pancreas

Indexed keywords

GLUCOSE; PARVOVIRUS VECTOR; SCATTER FACTOR; SINGLE STRANDED PARVOVIRUS 6 VECTOR; SINGLE STRANDED PARVOVIRUS 8 VECTOR; SINGLE STRANDED PARVOVIRUS 9 VECTOR; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DIABETES; CELL REGENERATION; CELL SPECIFICITY; CELLULAR PARAMETERS; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC ENGINEERING; GENETIC MANIPULATION; GENETIC TRANSDUCTION; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTIC INFILTRATION; MALE; MARKER GENE; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL MASS; PRIORITY JOURNAL; PROMOTER REGION; PROTECTION; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; DEPENDOVIRUS; GENETIC ENGINEERING; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; MALE; MICE; PANCREAS; TRANSDUCTION, GENETIC;

EID: 79954633819     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2070-3     Document Type: Article

References (39)

1. American Diabetes Association 2010 Diagnosis and classification of diabetes mellitus Diabetes Care 33 Suppl 1 S62 S69 10.2337/dc10-S062
2. DJ Wells 2004 Gene therapy progress and prospects: electroporation and other physical methods Gene Ther 11 1363 1369 15295618 10.1038/sj.gt.3302337 1:CAS:528:DC%2BD2cXntFCnsr4%3D (Pubitemid 39263889)
3. MA Kay JC Glorioso L Naldini 2001 Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics Nat Med 7 33 40 11135613 10.1038/83324 1:CAS:528:DC%2BD3MXmvV2nsw%3D%3D (Pubitemid 32095639)
4. Q Liu DA Muruve 2003 Molecular basis of the inflammatory response to adenovirus vectors Gene Ther 10 935 940 12756413 10.1038/sj.gt.3302036 1:CAS:528:DC%2BD3sXjvVagt74%3D (Pubitemid 36722427)
5. H Buning L Perabo O Coutelle S Quadt-Humme M Hallek 2008 Recent developments in adeno-associated virus vector technology J Gene Med 10 717 733 18452237 10.1002/jgm.1205 (Pubitemid 352003915)
6. Z Wang HI Ma J Li L Sun J Zhang X Xiao 2003 Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo Gene Ther 10 2105 2111 14625564 10.1038/sj.gt.3302133 1:CAS:528: DC%2BD3sXptVCktrk%3D (Pubitemid 37536759)
7. S Chen JH Ding R Bekeredjian, et al. 2006 Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology Proc Natl Acad Sci U S A 103 8469 8474 16709667 10.1073/pnas.0602921103 1:CAS:528:DC%2BD28XlvFChtLk%3D (Pubitemid 43838479)
8. E Ayuso M Chillon J Agudo, et al. 2004 In vivo gene transfer to pancreatic beta cells by systemic delivery of adenoviral vectors Hum Gene Ther 15 805 812 15319037 10.1089/1043034041648426 1:CAS:528:DC%2BD2cXmsVKls7o%3D (Pubitemid 39095252)
9. E Ayuso M Chillon F Garcia, et al. 2006 In vivo gene transfer to healthy and diabetic canine pancreas Mol Ther 13 747 755 16330257 10.1016/j.ymthe.2005. 10.017 1:CAS:528:DC%2BD28XjtFOktLc%3D
10. P Collombat X Xu P Ravassard, et al. 2009 The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells Cell 138 449 462 19665969 10.1016/j.cell.2009.05.035 1:CAS:528: DC%2BD1MXhsVChs7nO
11. X Xu J D'Hoker G Stange, et al. 2008 Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas Cell 132 197 207 18243096 10.1016/j.cell.2007.12.015 1:CAS:528:DC%2BD1cXhvVSrtLc%3D (Pubitemid 351181232)
12. H Cheng SH Wolfe V Valencia, et al. 2007 Efficient and persistent transduction of exocrine and endocrine pancreas by adeno-associated virus type 8 J Biomed Sci 14 585 594 17387636 10.1007/s11373-007-9159-1 1:CAS:528: DC%2BD2sXhsVyju7nE (Pubitemid 47414760)
13. AY Wang PD Peng A Ehrhardt TA Storm MA Kay 2004 Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo Hum Gene Ther 15 405 413 15053865 10.1089/104303404322959551 1:CAS:528: DC%2BD2cXisF2ksb0%3D (Pubitemid 38469782)
14. K Inagaki S Fuess TA Storm, et al. 2006 Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8 Mol Ther 14 45 53 16713360 10.1016/j.ymthe.2006.03.014 1:CAS:528:DC%2BD28XmtVKqu7s%3D (Pubitemid 43899488)
15. H Nakai S Fuess TA Storm S Muramatsu Y Nara MA Kay 2005 Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice J Virol 79 214 224 15596817 10.1128/JVI.79.1.214-224.2005 1:CAS:528: DC%2BD2MXhslemuw%3D%3D (Pubitemid 39650967)
16. SA Loiler Q Tang T Clarke, et al. 2005 Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts Mol Ther 12 519 527 15979413 10.1016/j.ymthe.2005.04.017 1:CAS:528: DC%2BD2MXos1agsLw%3D (Pubitemid 41150138)
17. F Maione F Molla C Meda, et al. 2009 Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models J Clin Invest 119 3356 3372 19809158 1:CAS:528:DC%2BD1MXhtlOitrnF
18. Z Wang T Zhu KK Rehman, et al. 2006 Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes Diabetes 55 875 884 16567506 10.2337/diabetes.55.04.06.db05-0927 1:CAS:528:DC%2BD28XjsVGmtrk%3D (Pubitemid 44100159)
19. A Casellas A Salavert J Agudo, et al. 2006 Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes Diabetes 55 3246 3255 17130467 10.2337/db06-0328 1:CAS:528: DC%2BD28XhtlSmsLbL (Pubitemid 44923580)
20. JC Devedjian M George A Casellas, et al. 2000 Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes J Clin Invest 105 731 740 10727441 10.1172/JCI5656 1:CAS:528: DC%2BD3cXhvFehsLY%3D (Pubitemid 30164111)
21. T Matsushita S Elliger C Elliger, et al. 1998 Adeno-associated virus vectors can be efficiently produced without helper virus Gene Ther 5 938 945 9813665 10.1038/sj.gt.3300680 1:CAS:528:DyaK1cXksFWrsLc%3D (Pubitemid 28371911)
22. E Ayuso F Mingozzi J Montane, et al. 2010 High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency Gene Ther 17 503 510 19956269 10.1038/gt.2009.157 1:CAS:528:DC%2BD1MXhsFSgt7rN
23. M Lock S McGorray A Auricchio, et al. 2010 Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material Hum Gene Ther 21 1273 1285 20486768 10.1089/hum.2009.223 1:CAS:528:DC%2BC3cXht12ju7nF
24. F Kruse SD Rose GH Swift RE Hammer RJ MacDonald 1993 An endocrine-specific element is an integral component of an exocrine-specific pancreatic enhancer Genes Dev 7 774 786 7684006 10.1101/gad.7.5.774 1:CAS:528:DyaK3sXlvFOisrY%3D (Pubitemid 23163582)
25. F Kruse SD Rose GH Swift RE Hammer RJ MacDonald 1995 Cooperation between elements of an organ-specific transcriptional enhancer in animals Mol Cell Biol 15 4385 4394 7623833 1:CAS:528:DyaK2MXntVGitbw%3D
26. A Garcia-Ocana KK Takane MA Syed WM Philbrick RC Vasavada AF Stewart 2000 Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia J Biol Chem 275 1226 1232 10625667 10.1074/jbc.275.2.1226 1:CAS:528:DC%2BD3cXntlensQ%3D%3D (Pubitemid 30051175)
27. A Garcia-Ocana RC Vasavada A Cebrian, et al. 2001 Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice Diabetes 50 2752 2762 11723058 10.2337/diabetes.50.12.2752 1:CAS:528:DC%2BD3MXovVOhsrw%3D (Pubitemid 33733126)
28. NM Fiaschi-Taesch DM Berman BM Sicari, et al. 2008 Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets Diabetes 57 2745 2754 18820214 10.2337/db08-1085 1:CAS:528:DC%2BD1MXhs1KntrY%3D
29. A Garcia-Ocana KK Takane VT Reddy JC Lopez-Talavera RC Vasavada AF Stewart 2003 Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death J Biol Chem 278 343 351 12403787 10.1074/jbc.M207848200 1:CAS:528:DC%2BD38XpvVWgtbo%3D (Pubitemid 36043582)
30. JC Lopez-Talavera A Garcia-Ocana I Sipula KK Takane I Cozar-Castellano AF Stewart 2004 Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation Endocrinology 145 467 474 14551233 10.1210/en.2003-1070 1:CAS:528: DC%2BD2cXovFSiuw%3D%3D (Pubitemid 38183786)
31. FX Jiang M Mehta G Morahan 2010 Quantification of insulin gene expression during development of pancreatic islet cells Pancreas 39 201 208 19812524 10.1097/MPA.0b013e3181bab68f 1:CAS:528:DC%2BC3cXitlens7g%3D
32. VM Schwitzgebel 2001 Programming of the pancreas Mol Cell Endocrinol 185 99 108 11738799 10.1016/S0303-7207(01)00628-1 1:CAS:528:DC%2BD3MXovFyqtLo%3D (Pubitemid 33103958)
33. C Dai Y Li J Yang Y Liu 2003 Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice J Biol Chem 278 27080 27087 12746445 10.1074/jbc.M211947200 1:CAS:528: DC%2BD3sXltlKqur0%3D (Pubitemid 36876862)
34. MK Park DK Kim HJ Lee 2003 Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice Exp Mol Med 35 494 500 14749526 1:CAS:528:DC%2BD2cXosVeiug%3D%3D
35. Mellado-Gil JM, Rosa TC, Demirci C et al. (2011) Disruption of HGF/c-met signaling enhances pancreatic beta cell death and accelerates the onset of diabetes. Diabetes 60:525-536
36. + regulatory T cells Proc Natl Acad Sci USA 107 6424 6429 20332205 10.1073/pnas.0912437107 1:CAS:528:DC%2BC3cXkslynurg%3D
37. H Futamatsu J Suzuki S Mizuno, et al. 2005 Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines Circ Res 96 823 830 15774858 10.1161/01.RES.0000163016.52653.2e 1:CAS:528:DC%2BD2MXjsFagsL8%3D (Pubitemid 40604965)
38. K Oh Y Iimuro M Takeuchi, et al. 2005 Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model Am J Physiol Gastrointest Liver Physiol 288 G729 G735 15550554 10.1152/ajpgi.00438.2004 1:CAS:528:DC%2BD2MXjtlyjsbY%3D (Pubitemid 40388184)
39. LM Hendrick GC Harewood SE Patchett FE Murray 2011 Utilization of resource leveling to optimize ERCP efficiency Ir J Med Sci 180 143 148 10.1007/s11845-010-0570-7 20835852 10.1007/s11845-010-0570-7 1:STN:280:DC%2BC3M7isV2rsQ%3D%3D