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Volumn 109, Issue 38, 2012, Pages 15330-15335

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*

Author keywords

Adipocytes; Fatty acid oxidation; Mitochondrial CO2 production

Indexed keywords

CARNITINE ACETYLTRANSFERASE; FATTY ACID; INSULIN; MICRORNA; MICRORNA 378; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; UNCLASSIFIED DRUG;

EID: 84866546187     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207605109     Document Type: Article
Times cited : (248)

References (51)
  • 1
    • 33646862152 scopus 로고    scopus 로고
    • Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome
    • DOI 10.1385/ENDO:29:1:91
    • Kusunoki J, Kanatani A, Moller DE (2006) Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. Endocrine 29:91-100. (Pubitemid 43780350)
    • (2006) Endocrine , vol.29 , Issue.1 , pp. 91-100
    • Kusunoki, J.1    Kanatani, A.2    Moller, D.E.3
  • 2
    • 34548504082 scopus 로고    scopus 로고
    • Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: A new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus
    • DOI 10.1007/s00125-007-0776-z
    • Maassen JA, Romijn JA, Heine RJ (2007) Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: A new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 50:2036-2041. (Pubitemid 47373858)
    • (2007) Diabetologia , vol.50 , Issue.10 , pp. 2036-2041
    • Maassen, J.A.1    Romijn, J.A.2    Heine, R.J.3
  • 3
    • 67650815430 scopus 로고    scopus 로고
    • 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
    • 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 119: 573-581.
    • (2009) J Clin Invest , vol.119 , pp. 573-581
    • Anderson, E.J.1
  • 6
    • 78049407128 scopus 로고    scopus 로고
    • Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity
    • Li J, et al. (2010) Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab 12:154-165.
    • (2010) Cell Metab , vol.12 , pp. 154-165
    • Li, J.1
  • 7
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • DOI 10.1172/JCI27794
    • Finck BN, Kelly DP (2006) PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease. J Clin Invest 116:615-622. (Pubitemid 43326866)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 8
    • 33845596500 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism
    • DOI 10.1210/er.2006-0037
    • Handschin C, Spiegelman BM (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27:728-735. (Pubitemid 44936056)
    • (2006) Endocrine Reviews , vol.27 , Issue.7 , pp. 728-735
    • Handschin, C.1    Spiegelman, B.M.2
  • 9
    • 0032715653 scopus 로고    scopus 로고
    • Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression
    • Esterbauer H, Oberkofler H, Krempler F, Patsch W (1999) Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62: 98-102.
    • (1999) Genomics , vol.62 , pp. 98-102
    • Esterbauer, H.1    Oberkofler, H.2    Krempler, F.3    Patsch, W.4
  • 10
    • 77957656146 scopus 로고    scopus 로고
    • miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1 β/ERRγ transcriptional pathway
    • Eichner LJ, et al. (2010) miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1 β/ERRγ transcriptional pathway. Cell Metab 12:352-361.
    • (2010) Cell Metab , vol.12 , pp. 352-361
    • Eichner, L.J.1
  • 11
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 12
    • 79551627496 scopus 로고    scopus 로고
    • A parsimonious model for gene regulation by miRNAs
    • Djuranovic S, Nahvi A, Green R (2011) A parsimonious model for gene regulation by miRNAs. Science 331:550-553.
    • (2011) Science , vol.331 , pp. 550-553
    • Djuranovic, S.1    Nahvi, A.2    Green, R.3
  • 13
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet 9:102-114.
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 14
    • 84855323194 scopus 로고    scopus 로고
    • Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2
    • Dill H, Linder B, Fehr A, Fischer U (2012) Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev 26:25-30.
    • (2012) Genes Dev , vol.26 , pp. 25-30
    • Dill, H.1    Linder, B.2    Fehr, A.3    Fischer, U.4
  • 15
    • 77953780835 scopus 로고    scopus 로고
    • MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    • Najafi-Shoushtari SH, et al. (2010) MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 328:1566-1569.
    • (2010) Science , vol.328 , pp. 1566-1569
    • Najafi-Shoushtari, S.H.1
  • 16
    • 78751660177 scopus 로고    scopus 로고
    • Pervasive roles of microRNAs in cardiovascular biology
    • Small EM, Olson EN (2011) Pervasive roles of microRNAs in cardiovascular biology. Nature 469:336-342.
    • (2011) Nature , vol.469 , pp. 336-342
    • Small, E.M.1    Olson, E.N.2
  • 17
    • 71549165765 scopus 로고    scopus 로고
    • A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance
    • van Rooij E, et al. (2009) A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell 17:662-673.
    • (2009) Dev Cell , vol.17 , pp. 662-673
    • Van Rooij, E.1
  • 18
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • Wang S, et al. (2008) The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15:261-271.
    • (2008) Dev Cell , vol.15 , pp. 261-271
    • Wang, S.1
  • 19
    • 79960939388 scopus 로고    scopus 로고
    • MiRs with a sweet tooth
    • Näär AM (2011) MiRs with a sweet tooth. Cell Metab 14:149-150.
    • (2011) Cell Metab , vol.14 , pp. 149-150
    • Näär, A.M.1
  • 20
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • Rottiers V, Näär AM (2012) MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 13:239-250.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 239-250
    • Rottiers, V.1    Näär, A.M.2
  • 21
    • 79959845414 scopus 로고    scopus 로고
    • MicroRNAs 103 and 107 regulate insulin sensitivity
    • Trajkovski M, et al. (2011) MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474:649-653.
    • (2011) Nature , vol.474 , pp. 649-653
    • Trajkovski, M.1
  • 22
    • 80053481600 scopus 로고    scopus 로고
    • The Lin28/let-7 axis regulates glucose metabolism
    • DIAGRAM Consortium; MAGIC Investigators
    • Zhu H, et al.; DIAGRAM Consortium; MAGIC Investigators (2011) The Lin28/let-7 axis regulates glucose metabolism. Cell 147:81-94.
    • (2011) Cell , vol.147 , pp. 81-94
    • Zhu, H.1
  • 23
    • 84855518254 scopus 로고    scopus 로고
    • Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs
    • Frost RJ, Olson EN (2011) Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci USA 108:21075-21080.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 21075-21080
    • Frost, R.J.1    Olson, E.N.2
  • 24
    • 84860340270 scopus 로고    scopus 로고
    • A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
    • Grueter CE, et al. (2012) A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 149:671-683.
    • (2012) Cell , vol.149 , pp. 671-683
    • Grueter, C.E.1
  • 25
    • 0035318741 scopus 로고    scopus 로고
    • The TRAP/SMCC/Mediator complex and thyroid hormone receptor function
    • PII S1043276000003556
    • Ito M, Roeder RG (2001) The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Trends Endocrinol Metab 12:127-134. (Pubitemid 33714201)
    • (2001) Trends in Endocrinology and Metabolism , vol.12 , Issue.3 , pp. 127-134
    • Ito, M.1    Roeder, R.G.2
  • 26
    • 77954932826 scopus 로고    scopus 로고
    • Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis
    • Gerin I, et al. (2010) Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab 299:E198-E206.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Gerin, I.1
  • 27
    • 84861553595 scopus 로고    scopus 로고
    • Dataset integration identifies transcriptional regulation of microRNA genes by PPARγ in differentiating mouse 3T3-L1 adipocytes
    • John E, et al. (2012) Dataset integration identifies transcriptional regulation of microRNA genes by PPARγ in differentiating mouse 3T3-L1 adipocytes. Nucleic Acids Res 40:4446-4460.
    • (2012) Nucleic Acids Res , vol.40 , pp. 4446-4460
    • John, E.1
  • 28
    • 84859762591 scopus 로고    scopus 로고
    • A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: Implications in postnatal cardiac remodeling and cell survival
    • Knezevic I, et al. (2012) A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: Implications in postnatal cardiac remodeling and cell survival. J Biol Chem 287:12913-12926.
    • (2012) J Biol Chem , vol.287 , pp. 12913-12926
    • Knezevic, I.1
  • 29
    • 69249113803 scopus 로고    scopus 로고
    • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
    • Noland RC, et al. (2009) Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem 284: 22840-22852.
    • (2009) J Biol Chem , vol.284 , pp. 22840-22852
    • Noland, R.C.1
  • 30
    • 0036216076 scopus 로고    scopus 로고
    • Coupling of mitochondrial fatty acid uptake to oxidative flux in the intact heart
    • O'Donnell JM, Alpert NM, White LT, Lewandowski ED (2002) Coupling of mitochondrial fatty acid uptake to oxidative fl ux in the intact heart. Biophys J 82:11-18. (Pubitemid 34289777)
    • (2002) Biophysical Journal , vol.82 , Issue.1 , pp. 11-18
    • O'Donnell, J.M.1    Alpert, N.M.2    White, L.T.3    Douglas, L.E.4
  • 31
    • 33751022208 scopus 로고    scopus 로고
    • Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance
    • Lelliott CJ, et al. (2006) Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol 4:e369.
    • (2006) PLoS Biol , vol.4
    • Lelliott, C.J.1
  • 34
    • 78649378267 scopus 로고    scopus 로고
    • MicroRNA functions in stress responses
    • Leung AK, Sharp PA (2010) MicroRNA functions in stress responses. Mol Cell 40:205-215.
    • (2010) Mol Cell , vol.40 , pp. 205-215
    • Leung, A.K.1    Sharp, P.A.2
  • 35
    • 84858379476 scopus 로고    scopus 로고
    • MicroRNAs in stress signaling and human disease
    • Mendell JT, Olson EN (2012) MicroRNAs in stress signaling and human disease. Cell 148:1172-1187.
    • (2012) Cell , vol.148 , pp. 1172-1187
    • Mendell, J.T.1    Olson, E.N.2
  • 37
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • DOI 10.1074/jbc.M507621200
    • Koves TR, et al. (2005) Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 280: 33588-33598. (Pubitemid 41397160)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.39 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3    Akimoto, T.4    Slentz, D.5    Ilkayeva, O.6    Dohm, G.L.7    Yan, Z.8    Newgard, C.B.9    Muoio, D.M.10
  • 38
    • 78650965300 scopus 로고    scopus 로고
    • Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance
    • Vergnes L, Chin R, Young SG, Reue K (2011) Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. J Biol Chem 286:380-390.
    • (2011) J Biol Chem , vol.286 , pp. 380-390
    • Vergnes, L.1    Chin, R.2    Young, S.G.3    Reue, K.4
  • 41
    • 4444333428 scopus 로고    scopus 로고
    • Structural and functional organization of TRAP220, the TRAP/Mediator subunit that is targeted by nuclear receptors
    • DOI 10.1128/MCB.24.18.8244-8254.2004
    • Malik S, et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol 24:8244-8254. (Pubitemid 39167472)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 8244-8254
    • Malik, S.1    Guermah, M.2    Yuan, C.-X.3    Wu, W.4    Yamamura, S.5    Roeder, R.G.6
  • 42
    • 77958111633 scopus 로고    scopus 로고
    • The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
    • Malik S, Roeder RG (2010) The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 11:761-772.
    • (2010) Nat Rev Genet , vol.11 , pp. 761-772
    • Malik, S.1    Roeder, R.G.2
  • 43
    • 0037044767 scopus 로고    scopus 로고
    • A coregulatory role for the TRAP-Mediator complex in androgen receptor-mediated gene expression
    • DOI 10.1074/jbc.M206061200
    • Wang Q, Sharma D, Ren Y, Fondell JD (2002) A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem 277:42852-42858. (Pubitemid 35285661)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.45 , pp. 42852-42858
    • Wang, Q.1    Sharma, D.2    Ren, Y.3    Fondell, J.D.4
  • 44
    • 73349130440 scopus 로고    scopus 로고
    • Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
    • Pospisilik JA, et al. (2010) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 140:148-160.
    • (2010) Cell , vol.140 , pp. 148-160
    • Pospisilik, J.A.1
  • 45
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang CV (2012) Links between metabolism and cancer. Genes Dev 26:877-890.
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 46
    • 79957626588 scopus 로고    scopus 로고
    • MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation
    • Gagan J, Dey BK, Layer R, Yan Z, Dutta A (2011) MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation. J Biol Chem 286:19431-19438.
    • (2011) J Biol Chem , vol.286 , pp. 19431-19438
    • Gagan, J.1    Dey, B.K.2    Layer, R.3    Yan, Z.4    Dutta, A.5
  • 48
    • 34347236921 scopus 로고    scopus 로고
    • Organelle isolation: Functional mitochondria from mouse liver, muscle and cultured filroblasts
    • DOI 10.1038/nprot.2006.478, PII NPROT.2006.478
    • Frezza C, Cipolat S, Scorrano L (2007) Organelle isolation: Functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat Protoc 2:287-295. (Pubitemid 47040043)
    • (2007) Nature Protocols , vol.2 , Issue.2 , pp. 287-295
    • Frezza, C.1    Cipolat, S.2    Scorrano, L.3
  • 49
    • 77950840619 scopus 로고    scopus 로고
    • Toll-like receptor 4 modulates skeletal muscle substrate metabolism
    • Frisard MI, et al. (2010) Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab 298:E988-E998.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Frisard, M.I.1
  • 50
    • 33644821916 scopus 로고    scopus 로고
    • Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
    • Hulver MW, et al. (2005) Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab 2:251-261.
    • (2005) Cell Metab , vol.2 , pp. 251-261
    • Hulver, M.W.1
  • 51
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    • van Rooij E, et al. (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 105:13027-13032.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13027-13032
    • Van Rooij, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.