Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: A link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?

Journal of Biological Chemistry

Volumn 288, Issue 35, 2013, Pages 25219-25228

  Leal, Sónia S ^a   Cardoso, Isabel ^b   Valentine, Joan S ^c   Gomes, Cláudio M ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; CALCIUM IONS; CALCIUM OVERLOAD; CELLULAR MODEL; CONFORMATIONAL CHANGE; MOTOR NEURONS; NON-FIBRILLAR; SUPER OXIDE DISMUTASE;

NEURONS; OXYGEN;

CALCIUM;

8 ANILINO 1 NAPHTHALENESULFONIC ACID; AMYLOID; CALCIUM ION; COPPER ZINC SUPEROXIDE DISMUTASE; NONFIBRILLAR AMYLOID; OLIGOMER; THIOFLAVINE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; BETA SHEET; BIOLOGICAL ACTIVITY; CALCIUM CELL LEVEL; CALCIUM OVERLOAD; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTOXICATION; LIGHT SCATTERING; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID; AMYOTROPHIC LATERAL SCLEROSIS (LOU GEHRIG'S DISEASE); BIOPHYSICS; CALCIUM; CIRCULAR DICHROISM (CD); ELECTRON MICROSCOPY (EM); INFRARED SPECTROSCOPY; NEURODEGENERATIVE DISEASES; PROTEIN AGGREGATION; SUPEROXIDE DISMUTASE (SOD);

AMYOTROPHIC LATERAL SCLEROSIS; CALCIUM; CIRCULAR DICHROISM; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MULTIPROTEIN COMPLEXES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SUPEROXIDE DISMUTASE;

EID: 84883434936     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.470740     Document Type: Article

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