AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability

Journal of Neuroscience

Volumn 20, Issue 1, 2000, Pages 123-132

  Vandenberghe, Wim ^a,b   Robberecht, Wim ^b   Brorson, James R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Amyotrophic lateral sclerosis; Culture; Dorsal horn; Excitotoxicity; Kainate; Rat

Indexed keywords

AMPA RECEPTOR; AMPA RECEPTOR AGONIST; GLUTAMATE RECEPTOR; KAINIC ACID;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; MOTONEURON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; TOXICITY;

EID: 0033993642     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-01-00123.2000     Document Type: Article

References (52)

1. 2+-permeable AMPA receptors. Eur J Neurosci 11:2758-2766.
2. Bar-Peled O, O'Brien RJ, Morrison JH, Rothstein JD (1999) Cultured motoncurons possess calcium-permeable AMPA receptors. NeuroReport 10:855-859.
3. Bleakman D, Ballyk BA, Schoepp DD, Palmer AJ, Bath CP, Sharpe EF, Woolley ML, Bufton HR, Kamboj RK, Tarnawa I, Lodge D (1996) Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology 35:1689-1702.
4. Bochet P, Audinat E, Lambolez B, Crépel F, Rossier J, Iino M, Tsuzuki K, Ozawa S (1994) Subunit composition at the single-cell level explains functional properties of a glutamate-gated channel. Neuron 12:383-388.
5. 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J Neurosci 14:187-197.
6. Brorson JR, Manzolillo PA, Gibbons SJ, Miller RJ (1995) AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity. J Neurosci 15:4515-4524.
7. 2+ permeation of AMPA receptors in cerebellar neurons expressing GluR2. J Neurosci 19:9149-9159.
8. Burnashev N, Monyer H, Sceburg PH, Sakmann B (1992) Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8:189-198.
9. Carriedo SG, Yin HZ, Weiss JH (1996) Motor neurons are selectively vulnerable to AMPA/KA receptor-mediated injury in vitro. J Neurosci 16:4069-4079.
10. Dean JA (1992) In: Lange's handbook of chemistry, Ed 14. New York: McGraw-Hill.
11. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor subunit GluR6. Proc Natl Acad Sci USA 90:755-759.
12. Escurat M, Djabali K, Gumpel M, Gros F, Portier MM (1990) Differential expression of two neuronal intermediate-filament proteins, peripherin and the low-molecular-mass neurofilament protein (NF-L), during the development of the rat. J Neurosci 10:764-784.
13. Feldmeyer D, Kask K, Brusa R, Kornau HC, Kolhekar R, Rozov A, Burnashev N, Jensen V. Hvalby O, Sprengel R, Sceburg PH (1999) Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci 1:57-64.
14. Furuyama T, Kiyama H, Sato K, Park HT, Maeno H, Takagi H, Tohyama M (1993) Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Brain Res Mol Brain Res 18:141-151.
15. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15:193-204.
16. +-impermeable AMPA receptors on embryonic rat dorsal horn neurons. J Neurophysiol 73:2522-2534.
17. Grossman SD, Wolfe BB, Yasuda RP, Wrathall JR (1999) Alterations in AMPA receptor subunit expression after experimental spinal cord contusion injury. J Neurosci 19:5711-5720.
18. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
19. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252:851-853.
20. Hugon J, Vallat JM, Spencer PS, Leboutet MJ, Barthe D (1989) Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord. Ncurosci Lett 104:258-262.
21. Hume RI, Dingledine R, Heinemann SF (1991) Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253:1028-1031.
22. Iino M, Ozawa S, Tsuzuki K (1990) Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J Physiol (Lond) 424:151-165.
23. Iino M, Mochizuki S, Ozawa S (1994) Relationship between calcium permeability and rectification properties of AMPA receptors in cultured rat hippocampal neurons. Neurosci Lett 173:14-16.
24. Ikonomidou C, Qin Qin Y, Labruyere J, Olney JW (1996) Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 55:211-224.
25. Jakowec MW, Yen L, Kalb RG (1995) In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience 67:909-920.
26. Jonas P, Burnashev N (1995) Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels. Neuron 15:987-990.
27. 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron 12:1281-1289.
28. Kolhekar R, Kornau HC, Seeburg PH, Bresink I, Müller G, Taylor J, Turski L (1998) Late-onset neurological symptoms in transgenic mice expressing a calcium-permeable GluR-B subunit. Soc Neurosci Abstr 24:1517.
29. Lambolez B, Audinat E, Buchet P, Crépel F, Rossier J (1992) AMPA receptor subunits expressed by single Purkinje cells. Neuron 9:247-258.
30. 2+ permeability of glutamate receptor channels in hippocampal cells. Eur J Neurosci 6:1080-1088.
31. Mayer ML, Westbrook GL (1987) Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons. J Physiol (Lond) 394:501-527.
32. Morrison BM, Janssen WG, Gordon JW, Morrison JH (1998) Light and electron microscopic distribution of the AMPA receptor subunit. GluR2, in the spinal cord of control and G68R mutant superoxide dismutase transgenic mice. J Comp Neurol 395:523-534.
33. Partin KM, Patneau DK, Winters CA, Mayer ML, Buonanno A (1993) Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazidc and concanavalin A. Neuron 11:1069-1082.
34. Pellegrini-Giampietro DE, Fan S, Ault B, Miller BE, Zukin RS (1994) Glutamate receptor gene expression in spinal cord of arthritic rats. J Neurosci 14:1576-1583.
35. 2+ permeable AMPA receptors in neurological disorders. Trends Neurosci 20:464-470.
36. Petralia RS, Wang YX, Mayat E, Wenthold RJ (1997) Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neurons. J Comp Neurol 385:456-476.
37. Pruss R, Akeson RL, Racke MM, Wilburn JL (1991) Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells. Neuron 7:509-518.
38. Rosenmund C, Stern-Bach Y, Stevens CF (1998) The tetrameric structure of a glutamate receptor channel. Science 280:1596-1599.
39. Rothstein JD (1996) Excitotoxicity hypothesis. Neurology 47 [Suppl 2]:S19-S25.
40. Rothstein JD, Jin L, Dykes-Hoberg M, Kunel RW (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 90:6591-6595.
41. Seeburg PH (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci 16:359-365.
42. Shaw PJ, Ince PG (1997) Glutamate, excitotoxicity and amyotrophic lateral sclerosis. J Neurol 244 [Suppl 2]:S3-S14.
43. Sommer B, Köhler M, Sprengel R, Seeburg PH (1991) RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67:11-19.
44. Temkin R, Lowe D, Jensen P, Hatt H, Smith DO (1997) Expression of glutamate receptor subunits in alpha-motoneurons. Brain Res Mol Brain Res 52:38-45.
45. Tölle TR, Berthele A, Zieglgänsberger W, Seeburg PH, Wisden W (1993) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci 13:5009-5028.
46. Tomiyama M, Rodriguez-Puertas R, Cortes R, Christnacher A, Sommer B, Pazos A, Palacios JM, Mengod G (1996) Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization. Neuroscience 75:901-915.
47. Vandenberghe W, Van Den Bosch L, Robberecht W (1998a) Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system. Brain Res 807:1-10.
48. Vandenberghe W, Van Den Bosch L, Robberecht W (1998b) Tissue-type plasminogen activator is not required for kainate-induced motoneuron death in vitro. NeuroReport 9:2791-2796.
49. Virgo L, Samarasinghe S, de Belleroche J (1996) Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord. NeuroReport 7:2507-2511.
50. Washburn MS, Numberger M, Zhang S, Dingledine R (1997) Differential dependence on GluR2 expression of three characteristic features of AMPA receptors. J Neurosci 17:9393-9406.
51. Williams TL, Day NC, Ince PG, Kamboj RK, Shaw PJ (1997) Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. Ann Neurol 42:200-207.
52. Yin HZ, Park DD, Lindsay AD, Weiss JH (1995) Spinal cord neurons are vulnerable to rapidly triggered kainate neurotoxicity in vitro. Brain Res 689:265-270.