Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 35, 2013, Pages 14284-14289

  Yeh, Ting Chun ^a,b   Bratton, Shawn B ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; LYSINE; PROTEASOME; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2;

APOPTOSIS; ARTICLE; CELL DEATH; DROSOPHILA; KINETICS; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TARGETING; RING FINGER MOTIF;

ANIMALS; APOPTOSIS; CASPASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME ACTIVATION; INHIBITOR OF APOPTOSIS PROTEINS; NEUROPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITINATION;

EID: 84883357834     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306179110     Document Type: Article

References (58)

1. Kornbluth S, White K (2005) Apoptosis in Drosophila: Neither fish nor fowl (nor man, nor worm). J Cell Sci 118(Pt 9):1779-1787.
2. Fuentes-Prior P, Salvesen GS (2004) The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J 384(pt 2):201-232.
3. Kumar S (2007) Caspase function in programmed cell death. Cell Death Differ 14(1): 32-43.
4. Lüthi AU, Martin SJ (2007) The CASBAH: A searchable database of caspase substrates. Cell Death Differ 14(4):641-650.
5. Tikhomirov O, Carpenter G (2001) Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin. J Biol Chem 276(36):33675-33680.
6. Plesca D, Mazumder S, Gama V, Matsuyama S, Almasan A (2008) A C-terminal fragment of cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron. J Biol Chem 283(45):30796-30803.
7. Sears N, Sen GC, Stark GR, Chattopadhyay S (2011) Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J Biol Chem 286(38):33037-33044.
8. Semple JI, Smits VA, Fernaud JR, Mamely I, Freire R (2007) Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome. Cell Death Differ 14(8): 1433-1442.
9. Landais I, Lee H, Lu H (2006) Coupling caspase cleavage and ubiquitin-proteasomedependent degradation of SSRP1 during apoptosis. Cell Death Differ 13(11):1866-1878.
10. Demontis S, et al. (2006) Twist is substrate for caspase cleavage and proteasomemediated degradation. Cell Death Differ 13(2):335-345.
11. Emoto Y, et al. (1995) Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J 14(24):6148-6156.
12. Graves JD, et al. (1998) Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J 17(8):2224-2234.
13. Cheng EH, et al. (1997) Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278(5345):1966-1968.
14. Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388(6639):300-304.
15. Riedl SJ, et al. (2001) Structural basis for the inhibition of caspase-3 by XIAP. Cell 104(5):791-800.
16. Shiozaki EN, et al. (2003) Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell 11(2):519-527.
17. Meier P, Silke J, Leevers SJ, Evan GI (2000) The Drosophila caspase DRONC is regulated by DIAP1. EMBO J 19(4):598-611.
18. Chai J, et al. (2003) Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat Struct Biol 10(11):892-898.
19. Yan N, Wu JW, Chai J, Li W, Shi Y (2004) Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol 11(5): 420-428.
20. Salvesen GS, Duckett CS (2002) IAP proteins: Blocking the road to death's door. Nat Rev Mol Cell Biol 3(6):401-410.
21. Gyrd-Hansen M, Meier P (2010) IAPs: From caspase inhibitors to modulators of NFkappaB, inflammation and cancer. Nat Rev Cancer 10(8):561-574.
22. Broemer M, et al. (2010) Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. Mol Cell 40(5):810-822.
23. Deveraux QL, et al. (1999) Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 18(19):5242-5251.
24. Wilson R, et al. (2002) The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat Cell Biol 4(6):445-450.
25. Ditzel M, et al. (2008) Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell 32(4):540-553.
26. Lee TV, et al. (2011) Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation. PLoS Genet 7(9): e1002261.
27. Tenev T, Zachariou A, Wilson R, Ditzel M, Meier P (2005) IAPs are functionally nonequivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol 7(1):70-77.
28. Wu JW, Cocina AE, Chai J, Hay BA, Shi Y (2001) Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol Cell 8(1):95-104.
29. Goyal L, McCall K, Agapite J, Hartwieg E, Steller H (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J 19(4): 589-597.
30. Holley CL, Olson MR, Colón-Ramos DA, Kornbluth S (2002) Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. Nat Cell Biol 4(6):439-444.
31. Lisi S, Mazzon I, White K (2000) Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics 154(2):669-678.
32. Yokokura T, et al. (2004) Dissection of DIAP1 functional domains via a mutant replacement strategy. J Biol Chem 279(50):52603-52612.
33. Ryoo HD, Bergmann A, Gonen H, Ciechanover A, Steller H (2002) Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol 4(6): 432-438.
34. Wang SL, Hawkins CJ, Yoo SJ, Müller HA, Hay BA (1999) The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98(4):453-463.
35. Wing JP, et al. (2002) Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat Cell Biol 4(6):451-456.
36. Clavería C, Caminero E, Martínez-A C, Campuzano S, Torres M (2002) GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway. EMBO J 21(13):3327-3336.
37. Fraser AG, McCarthy NJ, Evan GI (1997) drICE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J 16(20):6192-6199.
38. MacFarlane M, Merrison W, Bratton SB, Cohen GM (2002) Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem 277(39):36611-36616.
39. Hao Y, et al. (2004) Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol 6(9):849-860.
40. Hu S, Yang X (2003) Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem 278(12):10055-10060.
41. Olson MR, et al. (2003) Reaper is regulated by IAP-mediated ubiquitination. J Biol Chem 278(6):4028-4034.
42. Feltham R, et al. (2011) Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J Biol Chem 286(19):17015-17028.
43. Dueber EC, et al. (2011) Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science 334(6054):376-380.
44. Chai J, et al. (2000) Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406(6798):855-862.
45. Sandu C, Ryoo HD, Steller H (2010) Drosophila IAP antagonists form multimeric complexes to promote cell death. J Cell Biol 190(6):1039-1052.
46. Silke J, et al. (2005) Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci USA 102(45): 16182-16187.
47. Huang Y, Rich RL, Myszka DG, Wu H (2003) Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. J Biol Chem 278(49):49517-49522.
48. Hays R, Wickline L, Cagan R (2002) Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1. Nat Cell Biol 4(6):425-431.
49. Yoo SJ (2005) Grim stimulates Diap1 poly-ubiquitination by binding to UbcD1. Mol Cells 20(3):446-451.
50. Thrower JS, Hoffman L, Rechsteiner M, Pickart CM (2000) Recognition of the polyubiquitin proteolytic signal. EMBO J 19(1):94-102.
51. Shabek N, et al. (2012) The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Mol Cell 48(1):87-97.
52. Wu JN, et al. (2010) grim promotes programmed cell death of Drosophila microchaete glial cells. Mech Dev 127(9-12):407-417.
53. Tan Y, et al. (2011) Coordinated expression of cell death genes regulates neuroblast apoptosis. Development 138(11):2197-2206.
54. Huh JR, et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol 2(1):E15.
55. Arama E, Agapite J, Steller H (2003) Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev Cell 4(5):687-697.
56. Tapadia MG, Gautam NK (2011) Non-apoptotic function of apoptotic proteins in the development of Malpighian tubules of Drosophila melanogaster. J Biosci 36(3):531-544.
57. Shukla A, Tapadia MG (2011) Differential localization and processing of apoptotic proteins in Malpighian tubules of Drosophila during metamorphosis. Eur J Cell Biol 90(1):72-80.
58. Bornstein B, et al. (2012) X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein. Int J Biochem Cell Biol 44(3):489-495.