Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

Science

Volumn 334, Issue 6054, 2011, Pages 376-380

  Dueber, Erin C ^a   Schoeffler, Allyn J ^a   Lingel, Andreas ^a   Elliott, J Michael ^a   Fedorova, Anna V ^a   Giannetti, Anthony M ^a   Zobel, Kerry ^a   Maurer, Brigitte ^a   Varfolomeev, Eugene ^a   Wu, Ping ^a   Wallweber, Heidi J A ^a   Hymowitz, Sarah G ^a   Deshayes, Kurt ^a   Vucic, Domagoj ^a   Fairbrother, Wayne J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITOR OF APOPTOSIS PROTEIN; MONOMER; PROTEASOME;

ANTAGONISM; APOPTOSIS; BIOCHEMISTRY; CYTOLOGY; DEGRADATION; ENZYME ACTIVITY; PROTEIN;

ARTICLE; AUTOUBIQUITINATION; CHEMICAL ANALYSIS; CRYSTAL STRUCTURE; DIMERIZATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; STRUCTURE ANALYSIS; UBIQUITINATION;

EID: 80054837173     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1207862     Document Type: Article

References (25)

1. G. S. Salvesen, C. S. Duckett, Nat. Rev. Mol. Cell Biol. 3, 401 (2002).
2. D. Vucic, W. J. Fairbrother, Clin. Cancer Res. 13, 5995 (2007).
3. G. S. Salvesen, J. M. Abrams, Oncogene 23, 2774 (2004).
4. J. N. Dynek, D. Vucic, Cancer Lett. (2010).
5. A. M. Hunter, E. C. LaCasse, R. G. Korneluk, Apoptosis 12, 1543 (2007).
6. S. W. Fesik, Nat. Rev. Cancer 5, 876 (2005).
7. C. Du, M. Fang, Y. Li, L. Li, X. Wang, Cell 102, 33 (2000).
8. A. M. Verhagen et al., Cell 102, 43 (2000).
9. J. A. Flygare, W. J. Fairbrother, Expert Opin. Ther. Pat. 20, 251 (2010).
10. Z. Liu et al., Nature 408, 1004 (2000).
11. G. Wu et al., Nature 408, 1008 (2000).
12. A. Gaither et al., Cancer Res. 67, 11493 (2007).
13. E. Varfolomeev et al., Cell 131, 669 (2007).
14. J. E. Vince et al., Cell 131, 682 (2007).
15. C. Ndubaku et al., ACS Chem. Biol. 4, 557 (2009).
16. T. K. Oost et al., J. Med. Chem. 47, 4417 (2004).
17. K. Zobel et al., ACS Chem. Biol. 1, 525 (2006).
18. J. W. Blankenship et al., Biochem. J. 417, 149 (2009).
19. T. Samuel et al., J. Biol. Chem. 281, 1080 (2006).
20. E. Varfolomeev, S. M. Wayson, V. M. Dixit, W. J. Fairbrother, D. Vucic, J. Biol. Chem. 281, 29022 (2006).
21. R. J. Deshaies, C. A. Joazeiro, Annu. Rev. Biochem. 78, 399 (2009).
22. P. D. Mace, S. Shirley, C. L. Day, Cell Death Differ. 17, 46 (2010).
23. P. D. Mace et al., J. Biol. Chem. 283, 31633 (2008).
24. R. Kulathila et al., Acta Crystallogr. D Biol. Crystallogr. 65, 58 (2009).
25. R. Feltham et al., J. Biol. Chem. 286, 17015 (2011).