GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway

EMBO Journal

Volumn 21, Issue 13, 2002, Pages 3327-3336

  Clavería, Cristina ^a   Caminero, Eva ^a   Martínez A, Carlos ^a   Campuzano, Sonsoles ^a   Torres, Miguel ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Apoptosis; BH3; Cytochrome c; IAP; Mitochondria

Indexed keywords

APOPTOSIS INDUCING FACTOR; CARRIER PROTEIN; CELL PROTEIN; GENE PRODUCT; PROTEIN GH3; REAPER PROTEIN; SICKLE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE DELETION; GENE DISRUPTION; GENE ISOLATION; GENE OVEREXPRESSION; GRIM GENE; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; CASPASES; CELLS, CULTURED; CYTOCHROME C GROUP; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; MALE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ARACHNIDA; HEXAPODA;

EID: 0036645679     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf354     Document Type: Article

References (52)

1. An emerging blueprint for apoptosis in Drosophila
2. The domains of death: Evolution of the apoptosis machinery
3. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
4. The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
5. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
6. Drosophila p53 binds a damage response element at the reaper locus
7. Apoptotic activity of REAPER is distinct from signaling by the tumor necrosis factor receptor 1 death domain
8. Grim, a novel cell death gene in Drosophila
9. Solution structure of BID, an intracellular amplifier of apoptotic signaling
10. The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim and hid
11. Drosophila grim induces apoptosis in mammalian cells
12. Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery
13. The role of cytochrome c in caspase activation in Drosophila melanogaster cells
14. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
15. Reaper-induced apoptosis in a vertebrate system
16. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
17. Apoptotic pathways: Paper wraps stone blunts scissors
18. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
19. BCL-2 family members and the mitochondria in apoptosis
20. The proapoptotic function of Drosophila Hid is conserved in mammalian cells
21. Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death
22. Programmed cell death in animal development
23. Bcl-2-family proteins: The role of the BH3 domain in apoptosis
24. Mitochondrial control of cell death
25. Ras promotes cell survival in Drosophila by downregulating hid expression
26. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila
27. Facing death in the fly; genetic analysis of apoptosis in Drosophila
28. Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs)
29. Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists
30. Genetics of programmed cell death in C. Elegans: Past, present and future
31. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
32. Activation of the reaper gene during ectopic cell killing in Drosophila
33. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
34. PHD: Predicting one-dimensional protein structure by profile based neural networks
35. Sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein
36. Apoptosis in the pathogenesis and treatment of disease
37. Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity
38. Altered cytochrome c display precedes apoptotic cell death in Drosophila
39. Cell death in development
40. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
41. Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs)
42. Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM
43. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
44. Genetic control of programmed cell death in Drosophila
45. Cell killing by the Drosophila gene reaper
46. Distinct cell killing properties of the Drosophila reaper, head involution defective and grim genes
47. The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities
48. Drosophila sickle is a novel grim-reaper cell death activator
49. Cell death: The significance of apoptosis
50. Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms
51. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak