Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

Journal of Biological Chemistry

Volumn 286, Issue 19, 2011, Pages 17015-17028

  Feltham, Rebecca ^a   Bettjeman, Bodhi ^b   Budhidarmo, Rhesa ^b   Mace, Peter D ^b   Shirley, Sarah ^b   Condon, Stephen M ^c   Chunduru, Srinivas K ^c   McKinlay, Mark A ^c   Vaux, David L ^a   Silke, John ^a   Day, Catherine L ^b  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c TetraLogic Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACULOVIRAL IAP; CELL SURVIVAL; DIMER FORMATION; E3 LIGASE; INHIBITOR OF APOPTOSIS; LIGASES; MIMETICS; N-TERMINALS; ONCOGENESIS; PARALOGS; UBIQUITIN;

CELL DEATH; CHEMICAL ACTIVATION; DIMERS; ENZYME INHIBITION; PROTEINS;

DIMERIZATION;

CELLULAR INHIBITOR OF APOPTOSIS PROTEIN 1; CELLULAR INHIBITOR OF APOPTOSIS PROTEIN 2; INHIBITOR OF APOPTOSIS PROTEIN 1; PROTEIN INHIBITOR; RING FINGER PROTEIN; SMAC MIMETIC AGENT; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; MUTANT; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; UBIQUITINATION;

ANIMALS; APOPTOSIS; BIOMIMETICS; CIRCULAR DICHROISM; DIMERIZATION; ENZYME ACTIVATION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LENTIVIRUS; MICE; MUTAGENESIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

INTRACISTERNAL A-PARTICLES;

EID: 79955759159     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.222919     Document Type: Article

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