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Volumn 3, Issue 3, 2013, Pages 527-539

Calcineurin governs thermotolerance and virulence of cryptococcus gattii

Author keywords

Capsule; Cation homeostasis; Cyclosporin A; FK506; Fluconazole tolerance; Melanin; Pathogenicity; Temperature sensitivity

Indexed keywords

ANTIFUNGAL AGENT; CALCINEURIN; CYCLOSPORIN A; FLUCONAZOLE; MELANIN; TACROLIMUS;

EID: 84883250066     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.112.004242     Document Type: Article
Times cited : (54)

References (55)
  • 1
  • 2
    • 39749182112 scopus 로고    scopus 로고
    • Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typing
    • Bovers, M., F. Hagen, E. E. Kuramae, and T. Boekhout, 2008 Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typing. Fungal Genet. Biol. 45: 400-421.
    • (2008) Fungal Genet. Biol. , vol.45 , pp. 400-421
    • Bovers, M.1    Hagen, F.2    Kuramae, E.E.3    Boekhout, T.4
  • 3
    • 77954075537 scopus 로고    scopus 로고
    • Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the Northwest United States
    • Byrnes, E. J., W. Li, Y. Lewit, H. Ma, K. Voelz et al., 2010 Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the Northwest United States. PLoS Pathog. 6: e1000850.
    • (2010) PLoS Pathog. , vol.6
    • Byrnes, E.J.1    Li, W.2    Lewit, Y.3    Ma, H.4    Voelz, K.5
  • 4
    • 80053459911 scopus 로고    scopus 로고
    • A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients
    • Byrnes, E. J., W. Li, P. Ren, Y. Lewit, K. Voelz et al., 2011 A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. PLoS Pathog. 7: e1002205.
    • (2011) PLoS Pathog. , vol.7
    • Byrnes, E.J.1    Li, W.2    Ren, P.3    Lewit, Y.4    Voelz, K.5
  • 5
    • 80755163487 scopus 로고    scopus 로고
    • Cryptococcus gattii: a resurgent fungal pathogen
    • Chaturvedi, V., and S. Chaturvedi, 2011 Cryptococcus gattii: a resurgent fungal pathogen. Trends Microbiol. 19: 564-571.
    • (2011) Trends Microbiol. , vol.19 , pp. 564-571
    • Chaturvedi, V.1    Chaturvedi, S.2
  • 7
    • 77349103477 scopus 로고    scopus 로고
    • Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans
    • Chen, Y. L., A. E. Montedonico, S. Kauffman, J. R. Dunlap, F. M. Menn et al., 2010b Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans. Mol. Microbiol. 75: 1112-1132.
    • (2010) Mol. Microbiol. , vol.75 , pp. 1112-1132
    • Chen, Y.L.1    Montedonico, A.E.2    Kauffman, S.3    Dunlap, J.R.4    Menn, F.M.5
  • 8
    • 79957942182 scopus 로고    scopus 로고
    • Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis
    • Chen, Y. L., A. Brand, E. L. Morrison, F. G. Silao, U. G. Bigol et al., 2011 Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryot. Cell 10: 803-819.
    • (2011) Eukaryot. Cell , vol.10 , pp. 803-819
    • Chen, Y.L.1    Brand, A.2    Morrison, E.L.3    Silao, F.G.4    Bigol, U.G.5
  • 9
    • 84883416226 scopus 로고    scopus 로고
    • Convergent evolution of calcineurin pathway roles in thermotolerance and virulence in Candida glabrata
    • G3: Genes, Genomes, Genetics
    • Chen, Y. L., J. H. Konieczka, D. J. Springer, S. E. Bowen, J. Zhang et al., 2012 Convergent evolution of calcineurin pathway roles in thermotolerance and virulence in Candida glabrata. G3: Genes, Genomes, Genetics 2: 675-691.
    • (2012) , vol.2 , pp. 675-691
    • Chen, Y.L.1    Konieczka, J.H.2    Springer, D.J.3    Bowen, S.E.4    Zhang, J.5
  • 10
    • 80052309751 scopus 로고    scopus 로고
    • Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans
    • Cheon, S. A., K. W. Jung, Y. L. Chen, J. Heitman, Y. S. Bahn et al., 2011 Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. PLoS Pathog. 7: e1002177.
    • (2011) PLoS Pathog. , vol.7
    • Cheon, S.A.1    Jung, K.W.2    Chen, Y.L.3    Heitman, J.4    Bahn, Y.S.5
  • 11
    • 60649118958 scopus 로고    scopus 로고
    • Functional analysis of MCNA, a gene encoding a catalytic subunit of calcineurin, in the rice blast fungus Magnaporthe oryzae
    • Choi, J. H., Y. Kim, and Y. H. Lee, 2009 Functional analysis of MCNA, a gene encoding a catalytic subunit of calcineurin, in the rice blast fungus Magnaporthe oryzae. J. Microbiol. Biotechnol. 19: 11-16.
    • (2009) J. Microbiol. Biotechnol. , vol.19 , pp. 11-16
    • Choi, J.H.1    Kim, Y.2    Lee, Y.H.3
  • 12
    • 0033977390 scopus 로고    scopus 로고
    • Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans
    • Cruz, M. C., R. A. Sia, M. Olson, G.M. Cox, and J. Heitman, 2000 Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infect. Immun. 68: 982-985.
    • (2000) Infect. Immun. , vol.68 , pp. 982-985
    • Cruz, M.C.1    Sia, R.A.2    Olson, M.3    Cox, G.M.4    Heitman, J.5
  • 13
    • 0037083792 scopus 로고    scopus 로고
    • Calcineurin is essential for survival during membrane stress in Candida albicans
    • Cruz, M. C., A. L. Goldstein, J. R. Blankenship, M. Del Poeta, D. Davis et al., 2002 Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J. 21: 546-559.
    • (2002) EMBO J. , vol.21 , pp. 546-559
    • Cruz, M.C.1    Goldstein, A.L.2    Blankenship, J.R.3    Del Poeta, M.4    Davis, D.5
  • 14
    • 0025913953 scopus 로고
    • Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase
    • Cyert, M. S., R. Kunisawa, D. Kaim, and J. Thorner, 1991 Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc. Natl. Acad. Sci. USA 88: 7376-7380.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7376-7380
    • Cyert, M.S.1    Kunisawa, R.2    Kaim, D.3    Thorner, J.4
  • 15
    • 68049107386 scopus 로고    scopus 로고
    • Spread of Cryptococcus gattii into Pacific Northwest region of the United States
    • Datta, K., K. H. Bartlett, R. Baer, E. Byrnes, E. Galanis et al., 2009 Spread of Cryptococcus gattii into Pacific Northwest region of the United States. Emerg. Infect. Dis. 15: 1185-1191.
    • (2009) Emerg. Infect. Dis. , vol.15 , pp. 1185-1191
    • Datta, K.1    Bartlett, K.H.2    Baer, R.3    Byrnes, E.4    Galanis, E.5
  • 16
    • 0036667448 scopus 로고    scopus 로고
    • A PCR-based strategy to generate integrative targeting alleles with large regions of homology
    • Davidson, R. C., J. R. Blankenship, P. R. Kraus, M. de Jesus Berrios, C. M. Hull et al., 2002 A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology 148: 2607-2615.
    • (2002) Microbiology , vol.148 , pp. 2607-2615
    • Davidson, R.C.1    Blankenship, J.R.2    Kraus, P.R.3    de Jesus Berrios, M.4    Hull, C.M.5
  • 17
    • 0033998663 scopus 로고    scopus 로고
    • Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans
    • Del Poeta, M., M. C. Cruz, M. E. Cardenas, J. R. Perfect, and J. Heitman, 2000 Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob. Agents Chemother. 44: 739-746.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 739-746
    • Del Poeta, M.1    Cruz, M.C.2    Cardenas, M.E.3    Perfect, J.R.4    Heitman, J.5
  • 18
    • 0035047590 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans
    • D'Souza, C. A., J. A. Alspaugh, C. Yue, T. Harashima, G. M. Cox et al., 2001 Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol. Cell. Biol. 21: 3179-3191.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3179-3191
    • D'Souza, C.A.1    Alspaugh, J.A.2    Yue, C.3    Harashima, T.4    Cox, G.M.5
  • 19
    • 0035114113 scopus 로고    scopus 로고
    • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans
    • Fox, D. S., M. C. Cruz, R. A. Sia, H. Ke, G. M. Cox et al., 2001 Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Mol. Microbiol. 39: 835-849.
    • (2001) Mol. Microbiol. , vol.39 , pp. 835-849
    • Fox, D.S.1    Cruz, M.C.2    Sia, R.A.3    Ke, H.4    Cox, G.M.5
  • 20
    • 27644483074 scopus 로고    scopus 로고
    • Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
    • Fraser, J. A., S. S. Giles, E. C. Wenink, S. G. Geunes-Boyer, J. R. Wright et al., 2005 Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature 437: 1360-1364.
    • (2005) Nature , vol.437 , pp. 1360-1364
    • Fraser, J.A.1    Giles, S.S.2    Wenink, E.C.3    Geunes-Boyer, S.G.4    Wright, J.R.5
  • 21
    • 0037013093 scopus 로고    scopus 로고
    • Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults
    • French, N.,K. Gray, C. Watera, J. Nakiyingi, E. Lugada et al., 2002 Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults. AIDS 16: 1031-1038.
    • (2002) AIDS , vol.16 , pp. 1031-1038
    • French, N.1    Gray, K.2    Watera, C.3    Nakiyingi, J.4    Lugada, E.5
  • 22
    • 33947674612 scopus 로고    scopus 로고
    • Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade
    • Hicks, J. K., and J. Heitman, 2007 Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade. Eukaryot. Cell 6: 413-420.
    • (2007) Eukaryot. Cell , vol.6 , pp. 413-420
    • Hicks, J.K.1    Heitman, J.2
  • 23
    • 10344226208 scopus 로고    scopus 로고
    • A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)
    • Kidd, S. E., F. Hagen, R. L. Tscharke, M. Huynh, K. H. Bartlett et al., 2004 A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc. Natl. Acad. Sci. USA 101: 17258-17263.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17258-17263
    • Kidd, S.E.1    Hagen, F.2    Tscharke, R.L.3    Huynh, M.4    Bartlett, K.H.5
  • 24
    • 26944492175 scopus 로고    scopus 로고
    • Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas
    • Kidd, S. E.,H. Guo, K.H. Bartlett, J. Xu, and J.W. Kronstad, 2005 Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas. Eukaryot. Cell 4: 1629-1638.
    • (2005) Eukaryot. Cell , vol.4 , pp. 1629-1638
    • Kidd, S.E.1    Guo, H.2    Bartlett, K.H.3    Xu, J.4    Kronstad, J.W.5
  • 25
    • 33645106541 scopus 로고    scopus 로고
    • Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans
    • Kojima, K., Y. S. Bahn, and J. Heitman, 2006 Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152: 591-604.
    • (2006) Microbiology , vol.152 , pp. 591-604
    • Kojima, K.1    Bahn, Y.S.2    Heitman, J.3
  • 26
    • 80053439003 scopus 로고    scopus 로고
    • Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics
    • Kozubowski, L., J. W. Thompson, M. E. Cardenas, M. A. Moseley, and J. Heitman, 2011 Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. PLoS ONE 6: e25280.
    • (2011) PLoS ONE , vol.6
    • Kozubowski, L.1    Thompson, J.W.2    Cardenas, M.E.3    Moseley, M.A.4    Heitman, J.5
  • 28
    • 21544465310 scopus 로고    scopus 로고
    • Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis
    • Mylonakis, E., R. Moreno, J. B. El Khoury, A. Idnurm, J. Heitman et al., 2005 Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect. Immun. 73: 3842-3850.
    • (2005) Infect. Immun. , vol.73 , pp. 3842-3850
    • Mylonakis, E.1    Moreno, R.2    El Khoury, J.B.3    Idnurm, A.4    Heitman, J.5
  • 29
    • 79953876732 scopus 로고    scopus 로고
    • Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host
    • Naderer, T., O. Dandash, and M. J. McConville, 2011 Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host. Mol. Microbiol. 80: 471-480.
    • (2011) Mol. Microbiol. , vol.80 , pp. 471-480
    • Naderer, T.1    Dandash, O.2    McConville, M.J.3
  • 30
    • 0345268706 scopus 로고    scopus 로고
    • Characterization of Cu, Zn superoxide dismutase (SOD1) gene knock-out mutant of Cryptococcus neoformans var. gattii: role in biology and virulence
    • Narasipura, S. D., J. G. Ault, M. J. Behr, V. Chaturvedi, and S. Chaturvedi, 2003 Characterization of Cu, Zn superoxide dismutase (SOD1) gene knock-out mutant of Cryptococcus neoformans var. gattii: role in biology and virulence. Mol. Microbiol. 47: 1681-1694.
    • (2003) Mol. Microbiol. , vol.47 , pp. 1681-1694
    • Narasipura, S.D.1    Ault, J.G.2    Behr, M.J.3    Chaturvedi, V.4    Chaturvedi, S.5
  • 31
    • 0037331111 scopus 로고    scopus 로고
    • Sequence length required for homologous recombination in Cryptococcus neoformans
    • Nelson, R. T., B. A. Pryor, and J. K. Lodge, 2003 Sequence length required for homologous recombination in Cryptococcus neoformans. Fungal Genet. Biol. 38: 1-9.
    • (2003) Fungal Genet. Biol. , vol.38 , pp. 1-9
    • Nelson, R.T.1    Pryor, B.A.2    Lodge, J.K.3
  • 32
    • 70349432299 scopus 로고    scopus 로고
    • The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii
    • Ngamskulrungroj, P., U. Himmelreich, J. A. Breger, C. Wilson, M. Chayakulkeeree et al., 2009 The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii. Infect. Immun. 77: 4584-4596.
    • (2009) Infect. Immun. , vol.77 , pp. 4584-4596
    • Ngamskulrungroj, P.1    Himmelreich, U.2    Breger, J.A.3    Wilson, C.4    Chayakulkeeree, M.5
  • 34
    • 84863471593 scopus 로고    scopus 로고
    • The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model
    • Ngamskulrungroj, P., Y. Chang, E. Sionov, and K. J. Kwon-Chung, 2012b The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model. mBio 3: e00103-00112.
    • (2012) mBio , vol.3
    • Ngamskulrungroj, P.1    Chang, Y.2    Sionov, E.3    Kwon-Chung, K.J.4
  • 35
    • 0031028176 scopus 로고    scopus 로고
    • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein
    • Odom, A., M. Del Poeta, J. Perfect, and J. Heitman, 1997a The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob. Agents Chemother. 41: 156-161.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 156-161
    • Odom, A.1    Del Poeta, M.2    Perfect, J.3    Heitman, J.4
  • 36
    • 0031008864 scopus 로고    scopus 로고
    • Calcineurin is required for virulence of Cryptococcus neoformans
    • Odom, A., S. Muir, E. Lim, D. L. Toffaletti, J. Perfect et al., 1997b Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16: 2576-2589.
    • (1997) EMBO J. , vol.16 , pp. 2576-2589
    • Odom, A.1    Muir, S.2    Lim, E.3    Toffaletti, D.L.4    Perfect, J.5
  • 37
    • 62349130224 scopus 로고    scopus 로고
    • Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
    • Park, B. J., K. A. Wannemuehler, B. J. Marston, N. Govender, P. G. Pappas et al., 2009 Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23: 525-530.
    • (2009) AIDS , vol.23 , pp. 525-530
    • Park, B.J.1    Wannemuehler, K.A.2    Marston, B.J.3    Govender, N.4    Pappas, P.G.5
  • 38
    • 84865785006 scopus 로고    scopus 로고
    • The triple threat of Cryptococcosis: it's the body site, the strain, and/or the host
    • Perfect, J.R. 2012 The triple threat of Cryptococcosis: it's the body site, the strain, and/or the host. mBio 3: e00165-00112.
    • (2012) mBio , vol.3
    • Perfect, J.R.1
  • 39
    • 79960030849 scopus 로고    scopus 로고
    • The history of Cryptococcus and Cryptococcosis
    • in Cryptococcus: From Human Pathogen to Model Yeast, edited by J. Heitman, T. R. Kozel, K. J. Kwon-Chung, J. R. Perfect, and A. Casadevall. American Society for Microbiology, Washington, DC
    • Perfect, J. R., and A. Casadevall, 2012 The history of Cryptococcus and Cryptococcosis, pp. 17-26 in Cryptococcus: From Human Pathogen to
    • (2012) , pp. 17-26
    • Perfect, J.R.1    Casadevall, A.2
  • 41
    • 75749092958 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america
    • Perfect, J. R., W. E. Dismukes, F. Dromer, D. L. Goldman, J. R. Graybill et al., 2010 Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin. Infect. Dis. 50: 291-322.
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 291-322
    • Perfect, J.R.1    Dismukes, W.E.2    Dromer, F.3    Goldman, D.L.4    Graybill, J.R.5
  • 42
    • 33749254466 scopus 로고    scopus 로고
    • Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans
    • Petzold, E. W., U. Himmelreich, E. Mylonakis, T. Rude, D. Toffaletti et al., 2006 Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans. Infect. Immun. 74: 5877-5887.
    • (2006) Infect. Immun. , vol.74 , pp. 5877-5887
    • Petzold, E.W.1    Himmelreich, U.2    Mylonakis, E.3    Rude, T.4    Toffaletti, D.5
  • 43
    • 33746268515 scopus 로고    scopus 로고
    • Transcription factor STE12a has distinct roles in morphogenesis, virulence, and ecological fitness of the primary pathogenic yeast Cryptococcus gattii
    • Ren, P., D. J. Springer, M. J. Behr, W. A. Samsonoff, S. Chaturvedi et al., 2006 Transcription factor STE12a has distinct roles in morphogenesis, virulence, and ecological fitness of the primary pathogenic yeast Cryptococcus gattii. Eukaryot. Cell 5: 1065-1080.
    • (2006) Eukaryot. Cell , vol.5 , pp. 1065-1080
    • Ren, P.1    Springer, D.J.2    Behr, M.J.3    Samsonoff, W.A.4    Chaturvedi, S.5
  • 44
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: form and function
    • Rusnak, F., and P. Mertz, 2000 Calcineurin: form and function. Physiol. Rev. 80: 1483-1521.
    • (2000) Physiol. Rev. , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 45
    • 0038016755 scopus 로고    scopus 로고
    • Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
    • Sanglard, D., F. Ischer, O. Marchetti, J. Entenza, and J. Bille, 2003 Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol. Microbiol. 48: 959-976.
    • (2003) Mol. Microbiol. , vol.48 , pp. 959-976
    • Sanglard, D.1    Ischer, F.2    Marchetti, O.3    Entenza, J.4    Bille, J.5
  • 46
    • 0035039544 scopus 로고    scopus 로고
    • Cryptococcus neoformans variety gattii
    • Sorrell, T. C., 2001 Cryptococcus neoformans variety gattii. Med. Mycol. 39: 155-168.
    • (2001) Med. Mycol. , vol.39 , pp. 155-168
    • Sorrell, T.C.1
  • 47
    • 80052401194 scopus 로고    scopus 로고
    • Clinical perspectives on Cryptococcus neoformans and Cryptococcus gattii: implications for diagnosis and management
    • in Cryptococcus: From Human Pathogen to Model Yeast, edited by J. Heitman, T. R. Kozel, K. J. Kwon-Chung, J. R. Perfect, and A. Casadevall. American Society for Microbiology, Washington, DC.
    • Sorrell, T. C., S. C.-A. Chen, P. Phillips, and K. A. Marr, 2012 Clinical perspectives on Cryptococcus neoformans and Cryptococcus gattii: implications for diagnosis and management, pp. 595-606 in Cryptococcus: From Human Pathogen to Model Yeast, edited by J. Heitman, T. R.
    • (2012) , pp. 595-606
    • Sorrell, T.C.1    Chen, S.C.-A.2    Phillips, P.3    Marr, K.A.4
  • 48
    • 33746239608 scopus 로고    scopus 로고
    • Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus
    • Steinbach, W. J., R. A. Cramer Jr, B. Z. Perfect, Y. G. Asfaw, T. C. Sauer et al., 2006 Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot. Cell 5: 1091-1103.
    • (2006) Eukaryot. Cell , vol.5 , pp. 1091-1103
    • Steinbach, W.J.1    Cramer, R.A.2    Perfect, B.Z.3    Asfaw, Y.G.4    Sauer, T.C.5
  • 49
    • 0027467293 scopus 로고
    • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA
    • Toffaletti, D. L., T. H. Rude, S. A. Johnston, D. T. Durack, and J. R. Perfect, 1993 Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J. Bacteriol. 175: 1405-1411.
    • (1993) J. Bacteriol. , vol.175 , pp. 1405-1411
    • Toffaletti, D.L.1    Rude, T.H.2    Johnston, S.A.3    Durack, D.T.4    Perfect, J.R.5
  • 50
    • 34548670266 scopus 로고    scopus 로고
    • First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak
    • Upton, A., J. A. Fraser, S. E. Kidd, C. Bretz, K. H. Bartlett et al., 2007 First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak. J. Clin. Microbiol. 45: 3086-3088.
    • (2007) J. Clin. Microbiol. , vol.45 , pp. 3086-3088
    • Upton, A.1    Fraser, J.A.2    Kidd, S.E.3    Bretz, C.4    Bartlett, K.H.5
  • 52
    • 0031748055 scopus 로고    scopus 로고
    • Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1
    • Withee, J. L., R. Sen, and M. S. Cyert, 1998 Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1. Genetics 149: 865-878.
    • (1998) Genetics , vol.149 , pp. 865-878
    • Withee, J.L.1    Sen, R.2    Cyert, M.S.3
  • 53
    • 0032585880 scopus 로고    scopus 로고
    • The STE12a homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans
    • Yue, C., L. M. Cavallo, J. A. Alspaugh, P. Wang, G. M. Cox et al., 1999 The STE12a homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics 153: 1601-1615.
    • (1999) Genetics , vol.153 , pp. 1601-1615
    • Yue, C.1    Cavallo, L.M.2    Alspaugh, J.A.3    Wang, P.4    Cox, G.M.5
  • 54
    • 84865019052 scopus 로고    scopus 로고
    • Comparative analysis of calcineurin signaling between Candida dubliniensis and Candida albicans
    • Zhang, J., J. Heitman, and Y. L. Chen, 2012a Comparative analysis of calcineurin signaling between Candida dubliniensis and Candida albicans. Commun. Integr. Biol. 5: 122-126.
    • (2012) Commun. Integr. Biol. , vol.5 , pp. 122-126
    • Zhang, J.1    Heitman, J.2    Chen, Y.L.3
  • 55
    • 84865626877 scopus 로고    scopus 로고
    • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae
    • Zhang, J., F. G. Silao, U. G. Bigol, A. A. Bungay, M. G. Nicolas et al., 2012b Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. PLoS ONE 7(8): e44192.
    • (2012) PLoS ONE , vol.7 , Issue.8
    • Zhang, J.1    Silao, F.G.2    Bigol, U.G.3    Bungay, A.A.4    Nicolas, M.G.5


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