The STE12α homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans

Genetics

Volumn 153, Issue 4, 1999, Pages 1601-1615

  Yue, Changli ^a   Cavallo, Lora M ^a   Andrew Alspaugh, J ^a   Wang, Ping ^a   Cox, Gary M ^a   Perfect, John R ^a   Heitman, Joseph ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITROGEN; TRANSCRIPTION FACTOR; PEPTIDE; PRIMER DNA; SACCHAROMYCES CEREVISIAE PROTEIN; STE12 PROTEIN, FUNGUS; STE12 PROTEIN, S CEREVISIAE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CELL CYCLE; CELL GROWTH; CRYPTOCOCCUS NEOFORMANS; EPISTASIS; FEMALE; FUNGAL MENINGITIS; GENE DISRUPTION; GENE LOCUS; GENE OVEREXPRESSION; HAPLOIDY; IMMUNE DEFICIENCY; MATING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SPOROGENESIS; VIRULENCE; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; CRYPTOCOCCAL MENINGITIS; GENETICS; MATING FACTOR; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CRYPTOCOCCUS NEOFORMANS; DNA PRIMERS; FEMALE; FUNGAL PROTEINS; HAPLOIDY; MENINGITIS, CRYPTOCOCCAL; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; VIRULENCE;

EID: 0032585880     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. ALSPAUGH, J. A., J. R. PERFECT and J. HEITMAN, 1997 Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP. Genes Dev. 11: 3206-3217.
2. ALSPAUGH, J. A., J. R. PERFECT and J. HEITMAN, 1998 Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genet. Biol. 25: 1-14.
3. ALSPAUGH, J. A., R. C. DAVIDSON and J. HEITMAN, 1999 Morphogenesis of Cryptococcus neoformans, in Dimorphism in Human Pathogenic and Apathogenic Yeasts, edited by J. F. ERNST and A. SCHMIDT. Karger, Basel, Switzerland (in press).
4. BANUETT, F., 1998 Signalling in the yeasts: an informational cascade with links to the filamentous fungi. Microbiol. Mol. Biol. Rev. 62: 249-274.
5. CASADEVALL, A., and J. R. PERFECT, 1998 Cryptococcus neoformans. American Society for Microbiology, Washington, DC.
6. CHEN, S. C. A., M. MULLER, J. Z. ZHOU, L. C. WRIGHT and T. C. SORRELL, 1997 Phospholipase activity in Cryptococcus neoformans: a new virulence factor? J. Infect. Dis. 175: 414-420.
7. COX, G. M., D. L. TOFFALETTI and J. R. PERFECT, 1996 Dominant selection system for use in Cryptococcus neoformans. J. Med. Vet. Mycol. 34: 385-391.
8. DEL POETA, M., D. L. TOFFALETTI, T. H. RUDE, C. C. DYKSTRA, J. HEITMAN et al., 1999 Topoisomerase 1 is essential in Cryptococcus neoformans: role in pathobiology and as an antifungal target. Genetics 152: 167-178.
9. DÜRRENBERGER, F., K. WONG and J. W. KRONSTAD, 1998 Identification of a cAMP-dependent protein kinase catalytic subunit required for virulence and morphogenesis in Ustilago maydis. Proc. Natl. Acad. Sci. USA 95: 5684-5689.
10. DYKSTRA, M. A., L. FRIEDMAN and J. W. MURPHY, 1977 Capsule size of Cryptococcus neoformans: control and relationship to virulence. Infect. Immun. 16: 129-135.
11. GAVRIAS, V., A. ANDRIANOPOULOS, C. J. GIMENO and W. W. TIMBERLAKE, 1996 Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth. Mol. Microbiol. 19: 1255-1263.
12. GIMENO, C. J., P. O. LJUNGDAHL, C. A. STYLES and G. R. FINK, 1992 Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68: 1077-1090.
13. GOLD, S., G. DUNCAN, K. BARRETT and J. KRONSTAD, 1994 cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis. Genes Dev. 8: 2805-2816.
14. GRANGER, D. L., J. R. PERFECT and D. T. DURACK, 1985 Virulence of Cryptococcus neoformans: regulation of capsule synthesis by carbon dioxide. J. Clin. Invest. 76: 508-516.
15. HARTMANN, H. A., R. KAHMANN and M. BOLKER, 1996 The pheromone response factor coordinates filamentous growth and pathogenicity in Ustilago maydis. EMBO J. 15: 1632-1641.
16. HARTWELL, L. H., 1980 Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J. Cell Biol. 85: 811-822.
17. KIRKMAN-CORREIA, C., I. L. STROKE and S. FIELDS, 1993 Functional domains of the yeast STE12 protein, a pheromone-responsive transcriptional activator. Mol. Cell. Biol. 13: 3765-3772.
18. KRONSTAD, J., A. D. MARIA, D. FUNNELL, R. D. LAIDLAW, N. LEE et al., 1998 Signaling via cAMP in fungi: interconnections with mitogen-activated protein kinase pathways. Arch. Microbiol. 170: 395-404.
19. KRÜGER, J., G. LOUBRADOU, E. REGENFELDER, A. HARTMANN and R. KAHMANN, 1998 Crosstalk between cAMP and pheromone signaling pathways in Ustilago maydis. Mol. Gen. Genet. 260: 193-198.
20. KWON-CHUNG, K. J., 1975 A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia 67: 1197-1200.
21. KWON-CHUNG, K. J., 1976 Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68: 942-946.
22. KWON-CHUNG, K. J., and J. E. BENNETT, 1978 Distribution of a and α mating types of Cryptococcus neoformans among natural and clinical isolates. Am. J. Epidemiol. 108: 337-340.
23. KWON-CHUNG, K. J., J. C. EDMAN and B. L. WICKES, 1992a Genetic association of mating types and virulence in Crytococcus neoformans. Infect. Immun. 60: 602-605.
24. KWON-CHUNG, K. J., A. VARMA, J. C. EDMAN and J. E. BENNETT, 1992b Selection of ura5 and ura3 mutants from the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium. J. Med. Vet. Mycol. 30: 61-69.
25. LIU, H., C. A. STYLES and G. R. FINK, 1993 Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262: 1741-1744.
26. LIU, H., J. KÖHLER and G. R. FINK, 1994 Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726.
27. LO, H.-J., J. R. KOHLER, B. DIDOMENICO, D. LOEBENBERG, A. CACCIAPUOTI et al., 1997 Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
28. LODGE, J. K., E. JACKSON-MACHELSKI, D. L. TOFFALETTI, J. R. PERFECT and J. I. GORDON, 1994 Targeted gene replacement demonstrates that myristoyl-CoA:protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. Proc. Natl. Acad. Sci. USA 91: 12008-12012.
29. LORENZ, M. C., and J. HEITMAN, 1997 Yeast pseudohyphal growth is regulated by GPA2, a G protein a homolog. EMBO J. 16: 7008-7018.
30. MADHANI, H. D., and G. R. FINK, 1997 Combinatorial control required for the specificity of yeast MAPK signaling. Science 275: 1314-1317.
31. MOORE, T. D. E., and J. C. EDMAN, 1993 The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol. Cell. Biol. 13: 1962-1970.
32. NEILSON, J. B., R. A. FROMTLING and G. S. BULMER, 1977 Cryptococcus neoformans: size range of infectious particles from aerosolized soil. Infect. Immun. 17: 634-638.
33. ODOM, A., S. MUIR, E. LIM, D. L. TOFFALETTI, J. PERFECT et al., 1997 Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16: 2576-2589.
34. PAN, X., and J. HEITMAN, 1999 Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyes cerevisiae. Mol. Cell. Biol. 19: 4874-4887.
35. PERFECT, J. R., S. D. R. LANG and D. T. DURACK, 1980 Chronic cryptococcal meningitis: a new experimental model in rabbits. Am. J. Pathol. 101: 177-194.
36. PERFECT, J. R., D. L. TOFFALETTI and T. H. RUDE, 1993 The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect. Immun. 61: 4446-4451.
37. PI, H., C.-T. CHIEN and S. FIELDS, 1997 Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Mol. Cell. Biol. 17: 6410-6418.
38. PITKIN, J. W., D. G. PANACCIONE and J. D. WALTON, 1996 A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology 142: 1557-1565.
39. ROBERTSON, L. S., and G. R. FINK, 1998 The three yeast A kinases have specific signaling functions in pseudohyphal growth. Proc. Natl. Acad. Sci. USA 95: 13783-13787.
40. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
41. SHERMAN, F., 1991 Getting started with yeast, pp. 3-21 in Methods in Enzymology, edited by C. GUTHRIE and G. R. FINK. Academic Press, San Diego, CA.
42. + encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev. 5: 1990-1999.
43. TOFFALETTI, D. L., T. H. RUDE, S. A. JOHNSTON, D. T. DURACK and J. R. PERFECT, 1993 Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J. Bacteriol. 175: 1405-1411.
44. VARTIVARIAN, S. E., E. J. ANAISSIE, R. E. COWART, H. A. SPRIGG, M. J. TINGLER et al., 1993 Regulation of cryptococcal capsular polysaccharide by iron. J. Infect. Dis. 167: 186-190.
45. WICKES, B. L., M. E. MAYORGA, U. EDMAN and J. C. EDMAN, 1996 Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the α-mating type. Proc. Natl. Acad. Sci. USA 93: 7327-7331.
46. WICKES, B. L., U. EDMAN and J. C. EDMAN, 1997 The Cryptococcus neoformans STE12α gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific. Mol. Microbiol. 26: 951-960.
47. WILLIAMSON, P. R., 1994 Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J. Bacteriol. 176: 656-664.
48. YUAN, Y. L., and S. FIELDS, 1991 Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Mol. Cell. Biol. 11: 5910-5918.