The triple threat of cryptococcosis: It's the body site, the strain, and/or the host

mBio

Volumn 3, Issue 4, 2012, Pages

  Perfect, John R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELLULAR IMMUNITY; CRYPTOCOCCAL MENINGITIS; CRYPTOCOCCOSIS; CRYPTOCOCCUS GATTII; CRYPTOCOCCUS NEOFORMANS; DISEASE PREDISPOSITION; EPIGENETICS; FUNGAL GENETICS; FUNGAL STRAIN; FUNGAL VIABILITY; FUNGAL VIRULENCE; FUNGUS GROWTH; GENETIC VARIABILITY; GENOME; HOST PATHOGEN INTERACTION; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOCOMPETENCE; INFECTION RISK; MOLECULAR EVOLUTION; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON;

CRYPTOCOCCUS GATTII; FILOBASIDIELLA NEOFORMANS;

EID: 84865785006     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00165-12     Document Type: Article

References (21)

1. Ngamskulrungroj P, Chang Y, Sionov E, Kwon-Chung KJ. 2012. The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model. mBio 3(3):e00103-12.
2. Kwon-Chung KJ, Varma A. 2012. Do major species concepts support one, two or more species with Cryptococcus neoformans? FEMS Yeast Res. 6:574-587.
3. D'Souza CA, et al. 2011. Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. mBio 2(1):e00342-10.
4. Loftus BJ, et al. 2005. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science 307:1321-1324.
5. Ngamskulrungroj P, et al. 2009. The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii. Infect. Immun. 77:4584-4596.
6. Ngamskulrungroj P, Price J, Sorrell T, Perfect JR, Meyer W. 2011. Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver Island outbreak strains. PLoS One 6:e16076.
7. Fraser JA, et al. 2005. Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature 437:1360-1364.
8. Hu G, Wang J, Choi J. 2011. Chromosome copy number variation Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients. BMC Genomics 12:526.
9. Morrow CA, Lee RI, Chow EW. 2012. A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. mBio 3(2):e00310-11.
10. Semighini CP, Averett AF, Perfect JR, Heitman J. 2012. Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. PLoS Pathog. 7:e1002364.
11. Sionov E, Lee H, Chang YC, Kwon-Chung KJ. 2010. Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog. 6:e1000848.
12. Chen S, et al. 2000. Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Clin. Infect. Dis. 31:499-508.
13. Perfect JR, et al. 2010. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin. Infect. Dis. 50:291-322.
14. Park BJ, et al. 2009. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23: 525-530.
15. Lee A, et al. 2010. Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. Infect. Immun. 78:4213-4225.
16. Price MS, et al. 2011. Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. mBio 2(3): e00103-11.
17. Galains E, MacDougall L. 2012. Epidemiology of Cryptococcus gattii, British Columbia, Canada 1999-2007. Emerg. Infect. Dis. 16:251-257.
18. Heitman J, Kozel TR, Kwon-Chung KJ, Perfect JR, Casadevall A. 2012. Clinical perspectives on Cryptococcus neoformans and Cryptococcus gattii: implications for diagnosis and management, p 595-606. American Society for Microbiology, Washington, DC.
19. Shoham S, Levitz SM. 2005. The immune response to fungal infections. Br. J. Haematol. 129:569-582.
20. Cheng PY, Sham A, Kronstad JW. 2012. Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans. Infect. Immun. 77:4284-4294.
21. Wright L, et al. 2002. Metabolites released by Cryptococcus neoformans var. neoformans and var. gattii differentially affect human neutrophil function. Microbes Infect. 4:1427-1438.