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Volumn 17, Issue 9, 2013, Pages 1073-1080

MicroRNA-21: A therapeutic target for reversing drug resistance in cancer

Author keywords

Cancer; Drug resistance; MicroRNA; MiR 21

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; GELATINASE A; GELATINASE B; GEMCITABINE; MESSENGER RNA; MICRORNA 21; PACLITAXEL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN MSH2; STAT3 PROTEIN; SUNITINIB; TEMOZOLOMIDE; TENIPOSIDE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRASTUZUMAB; VASCULOTROPIN;

EID: 84882726021     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.819853     Document Type: Review
Times cited : (89)

References (80)
  • 1
    • 84860687790 scopus 로고    scopus 로고
    • Immunotherapy: A useful strategy to help combat multidrug resistance
    • Curiel TJ. Immunotherapy: a useful strategy to help combat multidrug resistance. Drug Resist Updat 2012;15:106-13
    • (2012) Drug Resist Updat , vol.15 , pp. 106-113
    • Curiel, T.J.1
  • 2
    • 84865471981 scopus 로고    scopus 로고
    • MiRNAs as mediators of drug resistance
    • Haenisch S, Cascorbi I. miRNAs as mediators of drug resistance. Epigenomics 2012;4:369-81
    • (2012) Epigenomics , vol.4 , pp. 369-381
    • Haenisch, S.1    Cascorbi, I.2
  • 3
    • 84857079737 scopus 로고    scopus 로고
    • The microcosmos of cancer
    • Lujambio A, Lowe SW. The microcosmos of cancer. Nature 2012;482:347-55
    • (2012) Nature , vol.482 , pp. 347-355
    • Lujambio, A.1    Lowe, S.W.2
  • 4
    • 34247495591 scopus 로고    scopus 로고
    • MiR-21-mediated tumor growth
    • Si ML, Zhu S, Wu H, et al. miR-21-mediated tumor growth. Oncogene 2007;26:2799-803
    • (2007) Oncogene , vol.26 , pp. 2799-2803
    • Si, M.L.1    Zhu, S.2    Wu, H.3
  • 5
    • 84871318501 scopus 로고    scopus 로고
    • Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway
    • Sheth S, Jajoo S, Kaur T, et al. Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway. PLoS One 2012;7:e51655
    • (2012) PLoS One , vol.7
    • Sheth, S.1    Jajoo, S.2    Kaur, T.3
  • 6
    • 84873621958 scopus 로고    scopus 로고
    • MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells
    • Xiong B, Cheng Y, Ma L, Zhang C. MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol 2013;42:219-28
    • (2013) Int J Oncol , vol.42 , pp. 219-228
    • Xiong, B.1    Cheng, Y.2    Ma, L.3    Zhang, C.4
  • 7
    • 84865988896 scopus 로고    scopus 로고
    • Sequence-dependent synergistic inhibition of human glioma cell lines by combined temozolomide and miR-21 inhibitor gene therapy
    • Qian X, Ren Y, Shi Z, et al. Sequence-dependent synergistic inhibition of human glioma cell lines by combined temozolomide and miR-21 inhibitor gene therapy. Mol Pharm 2012;9:2636-45
    • (2012) Mol Pharm , vol.9 , pp. 2636-2645
    • Qian, X.1    Ren, Y.2    Shi, Z.3
  • 8
    • 84865041580 scopus 로고    scopus 로고
    • Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells
    • Dong CG, Wu WK, Feng SY, et al. Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. Int J Oncol 2012;41:1005-12
    • (2012) Int J Oncol , vol.41 , pp. 1005-1012
    • Dong, C.G.1    Wu, W.K.2    Feng, S.Y.3
  • 9
    • 84864279381 scopus 로고    scopus 로고
    • Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2
    • Wu Z, Lu H, Sheng J, Li L. Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2. FEBS Lett 2012;586:2459-67
    • (2012) FEBS Lett , vol.586 , pp. 2459-2467
    • Wu, Z.1    Lu, H.2    Sheng, J.3    Li, L.4
  • 10
    • 84855389885 scopus 로고    scopus 로고
    • MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbR2) in colon cancer cells
    • Yu Y, Kanwar SS, Patel BB, et al. MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbR2) in colon cancer cells. Carcinogenesis 2012;33:68-76
    • (2012) Carcinogenesis , vol.33 , pp. 68-76
    • Yu, Y.1    Kanwar, S.S.2    Patel, B.B.3
  • 11
    • 78650385772 scopus 로고    scopus 로고
    • MicroRNA-21: A novel therapeutic target in human cancer
    • Pan X, Wang ZX, Wang R. MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther 2010;10:1224-3212.
    • (2010) Cancer Biol Ther , vol.10 , pp. 1224-3212
    • Pan, X.1    Wang, Z.X.2    Wang, R.3
  • 12
    • 78650966289 scopus 로고    scopus 로고
    • Intracellular and extracellular microRNAs in breast cancer
    • Corcoran C, Friel AM, Duffy MJ, et al. Intracellular and extracellular microRNAs in breast cancer. Clin Chem 2011;57:18-32
    • (2011) Clin Chem , vol.57 , pp. 18-32
    • Corcoran, C.1    Friel, A.M.2    Duffy, M.J.3
  • 13
    • 72449142765 scopus 로고    scopus 로고
    • MicroRNAs: Predictors and modifiers of chemo-and radiotherapy in different tumour types
    • Hummel R, Hussey DJ, Haier J. MicroRNAs: predictors and modifiers of chemo-and radiotherapy in different tumour types. Eur J Cancer 2010;46:298-311
    • (2010) Eur J Cancer , vol.46 , pp. 298-311
    • Hummel, R.1    Hussey, D.J.2    Haier, J.3
  • 14
    • 84876312892 scopus 로고    scopus 로고
    • MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN
    • Yang SM, Huang C, Li XF, et al. miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology 2013;306C:162-8
    • (2013) Toxicology , vol.306 C , pp. 162-168
    • Yang, S.M.1    Huang, C.2    Li, X.F.3
  • 15
    • 33947407250 scopus 로고    scopus 로고
    • The roles of copper transporters in cisplatin resistance
    • Kuo MT, Chen HH, Song IS, et al. The roles of copper transporters in cisplatin resistance. Cancer Metastasis Rev 2007;26:71-83
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 71-83
    • Kuo, M.T.1    Chen, H.H.2    Song, I.S.3
  • 16
    • 84866358168 scopus 로고    scopus 로고
    • The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
    • Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer 2012;12:587-98
    • (2012) Nat Rev Cancer , vol.12 , pp. 587-598
    • Bouwman, P.1    Jonkers, J.2
  • 17
    • 84867313655 scopus 로고    scopus 로고
    • Drug resistance-related microRNAs in esophageal cancer
    • Hong L, Han Y, Lu Q, et al. Drug resistance-related microRNAs in esophageal cancer. Expert Opin Biol Ther 2012;12:1487-94
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 1487-1494
    • Hong, L.1    Han, Y.2    Lu, Q.3
  • 18
    • 0030630022 scopus 로고    scopus 로고
    • Avoidance of apoptosis as a mechanism of drug resistance
    • Dive C. Avoidance of apoptosis as a mechanism of drug resistance. J Intern Med Suppl 1997;740:139-45
    • (1997) J Intern Med Suppl , vol.740 , pp. 139-145
    • Dive, C.1
  • 20
    • 78249269171 scopus 로고    scopus 로고
    • The malignant phenotype-associated microRNA in gastroenteric, hepatobiliary and pancreatic carcinomas
    • Hong L, Han Y, Li S, et al. The malignant phenotype-associated microRNA in gastroenteric, hepatobiliary and pancreatic carcinomas. Expert Opin Biol Ther 2010;10:1693-701
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 1693-1701
    • Hong, L.1    Han, Y.2    Li, S.3
  • 22
    • 84882586963 scopus 로고    scopus 로고
    • MiRNAs in Cancer prevention and treatment and as molecular targets for natural product anticancer agents
    • Qian B, Nag SA, Su Y, et al. miRNAs in Cancer prevention and treatment and as molecular targets for natural product anticancer agents. Curr Cancer Drug Targets 2013; Epub ahead of print
    • (2013) Curr Cancer Drug Targets
    • Qian, B.1    Nag, S.A.2    Su, Y.3
  • 23
    • 84934438006 scopus 로고    scopus 로고
    • MicroRNA-regulated networks: The perfect storm for classical molecular biology, the ideal scenario for systems biology
    • Vera J, Lai X, Schmitz U, Wolkenhauer O. MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology. Adv Exp Med Biol 2013;774:55-76
    • (2013) Adv Exp Med Biol , vol.774 , pp. 55-76
    • Vera, J.1    Lai, X.2    Schmitz, U.3    Wolkenhauer, O.4
  • 24
  • 25
    • 36649025655 scopus 로고    scopus 로고
    • OncomiRs: The discovery and progress of microRNAs in cancers
    • Cho WC. OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 2007;6:60
    • (2007) Mol Cancer , vol.6 , pp. 60
    • Cho, W.C.1
  • 27
    • 79959315095 scopus 로고    scopus 로고
    • Apoptosis and the target genes of microRNA-21
    • Buscaglia LE, Li Y. Apoptosis and the target genes of microRNA-21. Chin J Cancer 2011;30:371-80
    • (2011) Chin J Cancer , vol.30 , pp. 371-380
    • Buscaglia, L.E.1    Li, Y.2
  • 28
    • 78651346918 scopus 로고    scopus 로고
    • MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors
    • Tazawa H, Kagawa S, Fujiwara T. MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors. Expert Opin Biol Ther 2011;11:145-55
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 145-155
    • Tazawa, H.1    Kagawa, S.2    Fujiwara, T.3
  • 29
    • 84862776527 scopus 로고    scopus 로고
    • A systematic-Analysis of predicted miR-21 targets identifies a signature for lung cancer
    • Gao W, Xu J, Liu L, et al. A systematic-Analysis of predicted miR-21 targets identifies a signature for lung cancer. Biomed Pharmacother 2012;66:21-8
    • (2012) Biomed Pharmacother , vol.66 , pp. 21-28
    • Gao, W.1    Xu, J.2    Liu, L.3
  • 30
    • 80053923978 scopus 로고    scopus 로고
    • Prognostic role of microRNA-21 in various carcinomas: A systematic review and meta-Analysis
    • Fu X, Han Y, Wu Y, et al. Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-Analysis. Eur J Clin Invest 2011;41:1245-5331.
    • (2011) Eur J Clin Invest , vol.41 , pp. 1245-5331
    • Fu, X.1    Han, Y.2    Wu, Y.3
  • 31
    • 84859480864 scopus 로고    scopus 로고
    • Clinical outcome prediction by microRNAs in human cancer: A systematic review
    • Nair VS, Maeda LS, Ioannidis JP. Clinical outcome prediction by microRNAs in human cancer: a systematic review. J Natl Cancer Inst 2012;104:528-40
    • (2012) J Natl Cancer Inst , vol.104 , pp. 528-540
    • Nair, V.S.1    Maeda, L.S.2    Ioannidis, J.P.3
  • 32
    • 84872674726 scopus 로고    scopus 로고
    • High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer
    • Yang M, Shen H, Qiu C, et al. High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. Eur J Cancer 2013;49:604-15
    • (2013) Eur J Cancer , vol.49 , pp. 604-615
    • Yang, M.1    Shen, H.2    Qiu, C.3
  • 33
    • 84875140612 scopus 로고    scopus 로고
    • Functionalized graphene oxide mmediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro
    • Zhi F, Dong H, Jia X, et al. Functionalized graphene oxide mmediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS One 2013;8:e60034
    • (2013) PLoS One , vol.8
    • Zhi, F.1    Dong, H.2    Jia, X.3
  • 34
    • 76049119727 scopus 로고    scopus 로고
    • Downregulation of miR-21 enhances chemotherapeutic effect of taxol in breast carcinoma cells
    • Mei M, Ren Y, Zhou X, et al. Downregulation of miR-21 enhances chemotherapeutic effect of taxol in breast carcinoma cells. Technol Cancer Res Treat 2010;9:77-86
    • (2010) Technol Cancer Res Treat , vol.9 , pp. 77-86
    • Mei, M.1    Ren, Y.2    Zhou, X.3
  • 35
    • 79956313718 scopus 로고    scopus 로고
    • Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer
    • Gong C, Yao Y, Wang Y, et al. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem 2011;286:19127-37
    • (2011) J Biol Chem , vol.286 , pp. 19127-19137
    • Gong, C.1    Yao, Y.2    Wang, Y.3
  • 36
    • 79961088478 scopus 로고    scopus 로고
    • MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN
    • Wang ZX, Lu BB, Wang H, et al. MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN. Arch Med Res 2011;42:281-90
    • (2011) Arch Med Res , vol.42 , pp. 281-290
    • Wang, Z.X.1    Lu, B.B.2    Wang, H.3
  • 37
    • 84855781227 scopus 로고    scopus 로고
    • Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-Activated head and neck squamous cell carcinoma cells
    • Bourguignon LY, Earle C, Wong G, et al. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene 2012;31:149-6
    • (2012) Oncogene , vol.31 , pp. 149-156
    • Bourguignon, L.Y.1    Earle, C.2    Wong, G.3
  • 38
    • 78651347241 scopus 로고    scopus 로고
    • Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line
    • Bai H, Xu R, Cao Z, et al. Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line. FEBS Lett 2011;585:402-8
    • (2011) FEBS Lett , vol.585 , pp. 402-408
    • Bai, H.1    Xu, R.2    Cao, Z.3
  • 39
    • 84866059004 scopus 로고    scopus 로고
    • Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression
    • Li H, Hui L, Xu W, et al. Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression. Pharm Biol 2012;50:1233-40
    • (2012) Pharm Biol , vol.50 , pp. 1233-1240
    • Li, H.1    Hui, L.2    Xu, W.3
  • 40
    • 77955202734 scopus 로고    scopus 로고
    • Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis
    • Li Y, Zhu X, Gu J, et al. Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis. Hematology (Am Soc Hematol Educ Program) 2010;15:215-21
    • (2010) Hematology (Am Soc Hematol Educ Program) , vol.15 , pp. 215-221
    • Li, Y.1    Zhu, X.2    Gu, J.3
  • 41
    • 77957270582 scopus 로고    scopus 로고
    • Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis
    • Li Y, Zhu X, Gu J, et al. Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis. Cancer Sci 2010;101:948-54
    • (2010) Cancer Sci , vol.101 , pp. 948-954
    • Li, Y.1    Zhu, X.2    Gu, J.3
  • 42
    • 84875673906 scopus 로고    scopus 로고
    • Inhibition of miR-21 induces biological and behavioral alterations in diffuse large B-cell lymphoma
    • Gu L, Song G, Chen L, et al. Inhibition of miR-21 induces biological and behavioral alterations in diffuse large B-cell lymphoma. Acta Haematol 2013;130:87-94
    • (2013) Acta Haematol , vol.130 , pp. 87-94
    • Gu, L.1    Song, G.2    Chen, L.3
  • 43
    • 67849103555 scopus 로고    scopus 로고
    • MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
    • Li Y, Li W, Yang Y, et al. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res 2009;1286:13-18
    • (2009) Brain Res , vol.1286 , pp. 13-18
    • Li, Y.1    Li, W.2    Yang, Y.3
  • 44
    • 77956178738 scopus 로고    scopus 로고
    • MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity
    • Shi L, Chen J, Yang J, et al. MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res 2010;1352:255-64
    • (2010) Brain Res , vol.1352 , pp. 255-264
    • Shi, L.1    Chen, J.2    Yang, J.3
  • 45
    • 84865988896 scopus 로고    scopus 로고
    • Sequence-dependent synergistic inhibition of human glioma cell lines by combined temozolomide and miR-21 inhibitor gene therapy
    • Qian X, Ren Y, Shi Z, et al. Sequence-dependent synergistic inhibition of human glioma cell lines by combined temozolomide and miR-21 inhibitor gene therapy. Mol Pharm 2012;9:2636-45
    • (2012) Mol Pharm , vol.9 , pp. 2636-2645
    • Qian, X.1    Ren, Y.2    Shi, Z.3
  • 46
    • 84873438180 scopus 로고    scopus 로고
    • MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma
    • Costa PM, Cardoso AL, Nobrega C, et al. MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma. Hum Mol Genet 2013;22:904-18
    • (2013) Hum Mol Genet , vol.22 , pp. 904-918
    • Costa, P.M.1    Cardoso, A.L.2    Nobrega, C.3
  • 47
    • 84876312892 scopus 로고    scopus 로고
    • MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN
    • Yang SM, Huang C, Li XF, et al. miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology 2013;306:162-8
    • (2013) Toxicology , vol.306 , pp. 162-168
    • Yang, S.M.1    Huang, C.2    Li, X.F.3
  • 48
    • 78650500590 scopus 로고    scopus 로고
    • MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)
    • Valeri N, Gasparini P, Braconi C, et al. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA 2010;107:21098-103
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21098-21103
    • Valeri, N.1    Gasparini, P.2    Braconi, C.3
  • 49
    • 84855389885 scopus 로고    scopus 로고
    • MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbR2) in colon cancer cells
    • Yu Y, Kanwar SS, Patel BB, et al. MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbR2) in colon cancer cells. Carcinogenesis 2012;33:68-76
    • (2012) Carcinogenesis , vol.33 , pp. 68-76
    • Yu, Y.1    Kanwar, S.S.2    Patel, B.B.3
  • 50
    • 78149469070 scopus 로고    scopus 로고
    • MicroRNA-21 induces resistance to the anti-tumour effect of interferon-A/5-fluorouracil in hepatocellular carcinoma cells
    • Tomimaru Y, Eguchi H, Nagano H, et al. MicroRNA-21 induces resistance to the anti-tumour effect of interferon-a/5-fluorouracil in hepatocellular carcinoma cells. Br J Cancer 2010;103:1617-26
    • (2010) Br J Cancer , vol.103 , pp. 1617-1626
    • Tomimaru, Y.1    Eguchi, H.2    Nagano, H.3
  • 51
    • 77956296766 scopus 로고    scopus 로고
    • Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer
    • Hwang JH, Voortman J, Giovannetti E, et al. Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer. PLoS One 2010;5:e10630
    • (2010) PLoS One , vol.5
    • Hwang, J.H.1    Voortman, J.2    Giovannetti, E.3
  • 52
    • 66849124564 scopus 로고    scopus 로고
    • MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
    • Moriyama T, Ohuchida K, Mizumoto K, et al. MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther 2009;8:1067-74
    • (2009) Mol Cancer Ther , vol.8 , pp. 1067-1074
    • Moriyama, T.1    Ohuchida, K.2    Mizumoto, K.3
  • 53
    • 79952075732 scopus 로고    scopus 로고
    • Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells
    • Dong J, Zhao YP, Zhou L, et al. Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells. Arch Med Res 2011;42:8-14
    • (2011) Arch Med Res , vol.42 , pp. 8-14
    • Dong, J.1    Zhao, Y.P.2    Zhou, L.3
  • 54
    • 84863229381 scopus 로고    scopus 로고
    • MiRNA-21: A biomarker predictive for platinum-based adjuvant chemotherapy response in patients with non-small cell lung cancer
    • Gao W, Lu X, Liu L, et al. MiRNA-21: a biomarker predictive for platinum-based adjuvant chemotherapy response in patients with non-small cell lung cancer. Cancer Biol Ther 2012;13:330-40
    • (2012) Cancer Biol Ther , vol.13 , pp. 330-340
    • Gao, W.1    Lu, X.2    Liu, L.3
  • 55
    • 84875375142 scopus 로고    scopus 로고
    • Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth
    • Zhang YX, Yue Z, Wang PY, et al. Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth. Biomed Pharmacother 2013;67:97-102
    • (2013) Biomed Pharmacother , vol.67 , pp. 97-102
    • Zhang, Y.X.1    Yue, Z.2    Wang, P.Y.3
  • 56
    • 77954509251 scopus 로고    scopus 로고
    • Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells
    • Shi GH, Ye DW, Yao XD, et al. Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells. Acta Pharmacol Sin 2010;31:867-73
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 867-873
    • Shi, G.H.1    Ye, D.W.2    Yao, X.D.3
  • 57
    • 84882565977 scopus 로고    scopus 로고
    • MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen
    • Bai H, Wei J, Deng C, et al. MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen. Int J Hematol 2013;97:223-31
    • (2013) Int J Hematol , vol.97 , pp. 223-231
    • Bai, H.1    Wei, J.2    Deng, C.3
  • 58
    • 84867492349 scopus 로고    scopus 로고
    • Micro-RNA-21 regulates the sensitivity to cisplatin in human neuroblastoma cells
    • Chen Y, Tsai YH, Fang Y, Tseng SH. Micro-RNA-21 regulates the sensitivity to cisplatin in human neuroblastoma cells. J Pediatr Surg 2012;47:1797-805
    • (2012) J Pediatr Surg , vol.47 , pp. 1797-1805
    • Chen, Y.1    Tsai, Y.H.2    Fang, Y.3    Tseng, S.H.4
  • 59
    • 80053214617 scopus 로고    scopus 로고
    • Myeloma cell adhesion to bone marrow stromal cells confers drug resistance by microRNA-21 up-regulation
    • Wang X, Li C, Ju S, et al. Myeloma cell adhesion to bone marrow stromal cells confers drug resistance by microRNA-21 up-regulation. Leuk Lymphoma 2011;52:1991-8
    • (2011) Leuk Lymphoma , vol.52 , pp. 19918
    • Wang, X.1    Li, C.2    Ju, S.3
  • 60
    • 84855781227 scopus 로고    scopus 로고
    • Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells
    • Bourguignon LY, Earle C, Wong G, et al. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene 2012;31:149-60
    • (2012) Oncogene , vol.31 , pp. 149-160
    • Bourguignon, L.Y.1    Earle, C.2    Wong, G.3
  • 61
    • 79954523687 scopus 로고    scopus 로고
    • MicroRNA-21 modulates cellproliferation and sensitivity to doxorubicin in bladder cancer cells
    • Tao J, Lu Q, Wu D, et al. microRNA-21 modulates cellproliferation and sensitivity to doxorubicin in bladder cancer cells. Oncol Rep 2011;25:1721-9
    • (2011) Oncol Rep , vol.25 , pp. 1721-1729
    • Tao, J.1    Lu, Q.2    Wu, D.3
  • 62
    • 78649992541 scopus 로고    scopus 로고
    • MicroRNA-21 as therapeutic target in cancer and cardiovascular disease
    • Bonci D. MicroRNA-21 as therapeutic target in cancer and cardiovascular disease. Recent Pat Cardiovasc Drug Discov 2010;5:156-6163.
    • (2010) Recent Pat Cardiovasc Drug Discov , vol.5 , pp. 156-6163
    • Bonci, D.1
  • 63
    • 77958024321 scopus 로고    scopus 로고
    • Targeting miR-21 in glioma: A small RNA with big potential
    • Moore LM, Zhang W. Targeting miR-21 in glioma: a small RNA with big potential. Expert Opin Ther Targets 2010;14:1247-57
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 1247-1257
    • Moore, L.M.1    Zhang, W.2
  • 64
    • 77956921020 scopus 로고    scopus 로고
    • MicroRNA-21: From cancer to cardiovascular disease
    • Jazbutyte V, Thum T. MicroRNA-21: from cancer to cardiovascular disease. Curr Drug Targets 2010;11:926-35
    • (2010) Curr Drug Targets , vol.11 , pp. 926-935
    • Jazbutyte, V.1    Thum, T.2
  • 65
    • 77953530401 scopus 로고    scopus 로고
    • The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer
    • Ribas J, Lupold SE. The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle 2010;9:923-9
    • (2010) Cell Cycle , vol.9 , pp. 923-929
    • Ribas, J.1    Lupold, S.E.2
  • 66
    • 84878208503 scopus 로고    scopus 로고
    • Targeting CSC-related miRNAs for cancer therapy by natural agents
    • Bao B, Li Y, Ahmad A, et al. Targeting CSC-related miRNAs for cancer therapy by natural agents. Curr Drug Targets 2012;13:1858-68
    • (2012) Curr Drug Targets , vol.13 , pp. 1858-1868
    • Bao, B.1    Li, Y.2    Ahmad, A.3
  • 67
    • 50249173450 scopus 로고    scopus 로고
    • MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    • Gabriely G, Wurdinger T, Kesari S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 2008;28:5369-80
    • (2008) Mol Cell Biol , vol.28 , pp. 5369-5380
    • Gabriely, G.1    Wurdinger, T.2    Kesari, S.3
  • 68
    • 67849103555 scopus 로고    scopus 로고
    • MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
    • Li Y, Li W, Yang Y, et al. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res 2009;1286:13-18
    • (2009) Brain Res , vol.1286 , pp. 13-18
    • Li, Y.1    Li, W.2    Yang, Y.3
  • 69
    • 54249136806 scopus 로고    scopus 로고
    • MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    • Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008;68:8164-72
    • (2008) Cancer Res , vol.68 , pp. 8164-8172
    • Papagiannakopoulos, T.1    Shapiro, A.2    Kosik, K.S.3
  • 70
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SAK, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2007;27:2128-36
    • (2007) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Sak, R.2    Nikolova, D.A.3
  • 71
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647-58
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3
  • 72
    • 34347266556 scopus 로고    scopus 로고
    • MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    • Zhu S, Si M-L, Wu H, Mo Y-Y. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 2007;282:14328-36
    • (2007) J Biol Chem , vol.282 , pp. 14328-14336
    • Zhu, S.1    Si, M.-L.2    Wu, H.3    Mo, Y.-Y.4
  • 73
    • 77952948062 scopus 로고    scopus 로고
    • Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB
    • Connolly EC, Van Doorslaer K, Rogler LE, Rogler CE. Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB. Mol Cancer Res 2010;8:691-700
    • (2010) Mol Cancer Res , vol.8 , pp. 691-700
    • Connolly, E.C.1    Van Doorslaer, K.2    Rogler, L.E.3    Rogler, C.E.4
  • 74
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456:980-4
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3
  • 75
    • 77953782181 scopus 로고    scopus 로고
    • MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand
    • Sayed D, He M, Hong C, et al. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem 2010;285:20281-90
    • (2010) J Biol Chem , vol.285 , pp. 20281-20290
    • Sayed, D.1    He, M.2    Hong, C.3
  • 76
    • 70350214454 scopus 로고    scopus 로고
    • MicroRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells
    • Wang P, Zou F, Zhang X, et al. microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res 2009;69:8157-65
    • (2009) Cancer Res , vol.69 , pp. 8157-8165
    • Wang, P.1    Zou, F.2    Zhang, X.3
  • 77
    • 68149137764 scopus 로고    scopus 로고
    • Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma
    • Liu M, Wu H, Liu T, et al. Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. Cell Res 2009;19:828-37
    • (2009) Cell Res , vol.19 , pp. 828-837
    • Liu, M.1    Wu, H.2    Liu, T.3
  • 79
    • 67349254469 scopus 로고    scopus 로고
    • MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
    • Li T, Li D, Sha J, et al. MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. Biochem Biophys Res Commun 2009;383:280-5
    • (2009) Biochem Biophys Res Commun , vol.383 , pp. 280-285
    • Li, T.1    Li, D.2    Sha, J.3
  • 80
    • 84864003589 scopus 로고    scopus 로고
    • Growth inhibition by miR-519 via multiple p21-inducing pathways
    • Abdelmohsen K, Srikantan S, Tominaga K, et al. Growth inhibition by miR-519 via multiple p21-inducing pathways. Mol Cell Biol 2012;32:2530-48
    • (2012) Mol Cell Biol , vol.32 , pp. 2530-2548
    • Abdelmohsen, K.1    Srikantan, S.2    Tominaga, K.3


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