Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells

International Journal of Oncology

Volumn 41, Issue 3, 2012, Pages 1005-1012

  Dong, Chang G ^a   Wu, William K K ^b   Feng, Su Y ^c   Wang, Xiao J ^b   Shao, Jun F ^d   Qiao, Jian ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c SOOCHOW UNIVERSITY   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cell growth; Cell invasion; Gene expression; Human glioma cell; Inhibitor combination; MicroRNA 10b; MicroRNA 21

Indexed keywords

ALPHA TROPOMYOSIN; AMINO ACID DERIVATIVE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; MATRIX METALLOPROTEINASE; MESSENGER RNA; MICRORNA 10B; MICRORNA 10B INHIBITOR; MICRORNA 21; MICRORNA 21 INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGRAMMED CELL DEATH 4; PROTEIN; RHOC PROTEIN; TROPOMYOSIN; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN HOXD10; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; CANCER INHIBITION; CANCER INVASION; CELL PROLIFERATION; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GENE EXPRESSION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; ONCOGENE; PRIORITY JOURNAL; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSCELLULAR CELL MIGRATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; GLIOMA; HOMEODOMAIN PROTEINS; HUMANS; MATRIX METALLOPROTEINASES; MICRORNAS; NEOPLASM INVASIVENESS; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHO GTP-BINDING PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TROPOMYOSIN;

EID: 84865041580     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1542     Document Type: Article

References (28)

1. Stewart LA: Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359: 1011-1018, 2002.
2. Ambros V: The functions of animal microRNAs. Nature 431: 350-355, 2004.
3. Alvarez-Garcia I and Miska EA: MicroRNA functions in animal development and human disease. Development 132: 4653-4662, 2005. (Pubitemid 41685276)
4. Brennecke J, Hipfner DR, Stark A, et al: Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113: 25-36, 2003. (Pubitemid 36411957)
5. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006. (Pubitemid 44629897)
6. Gaur A, Jewell DA, Liang Y, et al: Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res 67: 2456-2468, 2007. (Pubitemid 46548930)
7. Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005. (Pubitemid 40839735)
8. Kumar MS, Lu J, Mercer KL, et al: Impaired micro-RNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39: 673-677, 2007. (Pubitemid 46676103)
9. Mathupala SP, Mittal S, Guthikonda M and Sloan AE: MicroRNA and brain tumors: a cause and a cure? DNA Cell Biol 26: 301-310, 2007. (Pubitemid 46799179)
10. Lu Z, Liu M, Stribinskis V, et al: MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27: 4373-4379, 2008. (Pubitemid 352010003)
11. Frankel LB, Christoffersen NR, Jacobsen A, et al: Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 283: 1026-1033, 2008.
12. Asangani A, Rasheed SAK, Nikolova DA, et al: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136, 2008. (Pubitemid 351485639)
13. Zhu S, Si ML, Wu H and Mo YY: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282: 14328-14336, 2007. (Pubitemid 47100416)
14. Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688, 2007. (Pubitemid 47552092)
15. Ladeiro Y, Couchy G and Balabaud C: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 47: 1807-1809, 2008.
16. Ciafrè SA, Galardi S, Mangiola A, et al: Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334: 1351-1358, 2005. (Pubitemid 41074723)
17. Sasayama T, Nishihara M and Kondoh T: MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int J Cancer 125: 1407-1413, 2009.
18. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
19. Hildeman D, Jorgensen T, Kappler J and Marrack P: Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol 19: 516-521, 2007. (Pubitemid 47464912)
20. Cheng AM, Byrom MW, Shelton J and Ford LP: Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 33: 1290-1297, 2005. (Pubitemid 41439922)
21. Gabriely G, Wurdinger T, Kesari S, et al: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 28: 5369-5380, 2008.
22. Guillamo JS, de Boüard S, Valable S, et al: Molecular mechanisms underlying effects of epidermal growth factor receptor inhibition on invasion, proliferation, and angiogenesis in experimental glioma. Clin Cancer Res 15: 3697-3704, 2009.
23. Chan JA, Krichevsky AM and Kosik KS: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033, 2005. (Pubitemid 40994386)
24. Conti A, Aguennouz M, La Torre D, et al: miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors. J Neurooncol 3: 325-332, 2009.
25. Mahadev K, Raval G, Bharadwaj S, et al: Suppression of the transformed phenotype of breast cancer by tropomyosin-1. Exp Cell Res 279: 40-51, 2002.
26. Yang J, Mani SA and Donaher JL: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939, 2004. (Pubitemid 38798858)
27. Myers C, Charboneau A, Cheung I, Hanks D and Boudreau N: Sustained expression of homeobox D10 inhibits angiogenesis. Am J Pathol 161: 2099-2109, 2002. (Pubitemid 35434856)
28. Chakravarti A, Chakladar A and Delaney MA: The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS dependent manner. Cancer Res 62: 4307-4315, 2002. (Pubitemid 34827287)