Sequence-dependent synergistic inhibition of human glioma cell lines by combined Temozolomide and miR-21 inhibitor gene therapy

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2636-2645

  Qian, Xiaomin ^a   Ren, Yu ^b   Shi, Zhendong ^b,c   Long, Lixia ^a   Pu, Peiyu ^b,c   Sheng, Jing ^a   Yuan, Xubo ^a   Kang, Chunsheng ^b,c  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c Chinese Glioma Cooperative Group   (China)

Author keywords

glioma; microRNA 21 inhibitor; sequence; STAT; Temozolomide

Indexed keywords

MIR 21 INHIBITOR; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN INHIBITOR; STAT3 PROTEIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG POTENTIATION; GENE THERAPY; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; PRIORITY JOURNAL; THERAPY EFFECT; WILD TYPE;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINED MODALITY THERAPY; DACARBAZINE; DENDRIMERS; DRUG SYNERGISM; GENETIC THERAPY; GLIOMA; HUMANS; MICRORNAS; NANOPARTICLES; PTEN PHOSPHOHYDROLASE; STAT3 TRANSCRIPTION FACTOR;

EID: 84865988896     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3002039     Document Type: Article

References (34)

1. Ahmed, A. U.; Tyler, M. A.; Thaci, B.; Alexiades, N. G.; Han, Y.; Ulasov, I. V.; Lesniak, M. S. A comparative study of neural and mesenchymal stem cell-based carriers for oncolytic adenovirus in a model of malignant glioma Mol. Pharmaceutics 2011, 8 (5) 1559-1572
2. Goellner, E. M.; Grimme, B.; Brown, A. R.; Lin, Y. C.; Wang, X. H.; Sugrue, K. F.; Mitchell, L.; Trivedi, R. N.; Tang, J. B.; Sobol, R. W. Overcoming Temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair Cancer Res. 2011, 71 (6) 2308-2317
3. Shah, N.; Lin, B.; Sibenaller, Z.; Ryken, T.; Lee, H.; Yoon, J. G.; Rostad, S.; Foltz, G. Comprehensive analysis of MGMT promoter methylation: Correlation with MGMT expression and clinical response in GBM PLoS One 2011, 6 (1) e16146
4. Sarkaria, J. N.; Kitange, G. J.; James, C. D.; Plummer, R.; Calvert, H.; Weller, M.; Wick, W. Mechanisms of chemoresistance to alkylating agents in malignant glioma Clin. Cancer Res. 2008, 6 (1) 2900-2908
5. Van Kouwenhove, M.; Kedde, M.; Agami, R. MicroRNA regulation by RNA-binding proteins and its implications for cancer Nat. Rev. Cancer 2011, 11 (9) 644-656
6. Hanahan, D.; Weinberg, R. A. The hallmarks of cancer Cell 2000, 100 (1) 57-70 (Pubitemid 30046295)
7. Fennell, D. A. Caspase regulation in non-small cell lung cancer and its potential for therapeutic exploitation Clin. Cancer Res. 2005, 11 (6) 2097-2105 (Pubitemid 40490165)
8. Lynam-Lennon, N.; Maher, S. G.; Reynolds, J. V. The roles of microRNA in cancer and apoptosis Biol. Rev. Camb. Philos. Soc. 2009, 84 (1) 55-71
9. Blower, P. E.; Chung, J. H.; Verducci, J. S.; Lin, S.; Park, J. K.; Dai, Z.; Liu, C. G.; Schmittgen, T. D.; Reinhold, W. C.; Croce, C. M.; Weinstein, J. N.; Sadee, W. MicroRNAs modulate the chemosensitivity of tumor cells Mol. Cancer Ther. 2008, 7 (1) 1-9
10. Tili, E.; Michaille, J. J.; Gandhi, V.; Plunkett, W.; Sampath, D.; Calin, G. A. miRNAs and their potential for use against cancer and other diseases Future Oncol. 2007, 3 (5) 521-537 (Pubitemid 47595862)
11. Yu, A. M. Role of microRNAs in the regulation of drug metabolism and disposition Expert Opin. Drug Metab. Toxicol. 2009, 5 (12) 1513-1528
12. Pan, Y. Z.; Morris, M. E.; Yu, A. M. MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells Mol. Pharmacol. 2009, 75 (6) 1374-1379
13. Lawler, S.; Chiocca, E. A. Emerging functions of microRNAs in glioblastoma J. Neurooncol. 2009, 92 (3) 297-306
14. Silber, J.; James, C. D.; Hodgson, J. G. microRNAs in gliomas: Small regulators of a big problem Neuromol. Med. 2009, 11 (3) 208-222
15. Conti, A.; Aguennouz, M.; La Torre, D.; Tomasello, C.; Cardali, S.; Angileri, F. F.; Maio, F.; Cama, A.; Germano, A.; Vita, G.; Tomasello, F. miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors J. Neurooncol. 2009, 93 (3) 325-332
16. Li, Y.; Li, W.; Yang, Y.; Lu, Y.; He, C.; Hu, G.; Liu, H.; Chen, J.; He, J.; Yu, H. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme Brain Res. 2009, 1286, 13-18
17. Ren, Y.; Zhou, X.; Mei, M.; Yuan, X. B.; Han, L.; Wang, G. X.; Jia, Z. F.; Xu, P.; Pu, P. Y.; Kang, C. S. MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol BMC Cancer 2010, 10, 27
18. Ren, Y.; Kang, C. S.; Yuan, X. B.; Zhou, X.; Xu, P.; Han, L.; Wang, G. X.; Jia, Z.; Zhong, Y.; Yu, S.; Sheng, J.; Pu, P. Y. Co-delivery of as-miR-21 and 5-FU by poly(amidoamine) dendrimer attenuates human glioma cell growth in vitro J. Biomater. Sci., Polym. Ed. 2010, 21 (3) 303-314
19. Wahid, F.; Shehzad, A.; Khan, T.; Kim, Y. Y. MicroRNAs: Synthesis, mechanism, function, and recent clinical trials Biochim. Biophys. Acta 2010, 1803 (11) 1231-1243
20. Zhou, X.; Ren, Y.; Moore, L.; Mei, M.; You, Y.; Xu, P.; Wang, B.; Wang, G.; Jia, Z.; Pu, P.; Zhang, W.; Kang, C. Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status Lab. Invest. 2010, 90 (2) 144-155
21. Gu, L.; Wu, Z. H.; Qi, X.; He, H.; Ma, X.; Chou, X.; Wen, X.; Zhang, M.; Jiao, F. Polyamidomine dendrimers: An excellent drug carrier for improving the solubility and bioavailability of puerarin. Pharm. Dev. Technol. 2012, not supplied.
22. Jin, Z. J. About the evaluation of drug combination Acta Pharmacol. Sin. 2004, 25 (2) 146-147
23. Lo, H. W.; Cao, X.; Zhu, H.; Ali-Osman, F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators Clin. Cancer Res. 2008, 14 (19) 6042-6054
24. Morgillo, F.; Martinelli, E.; Troiani, T.; Laus, G.; Pepe, S.; Gridelli, C.; Ciardiello, F. Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase Cbeta inhibitor, in non-small cell lung cancer cells Mol. Cancer Ther. 2008, 7 (6) 1698-1707
25. Villano, J. L.; Seery, T. E.; Bressler, L. R. Temozolomide in malignant gliomas: Current use and future targets Cancer Chemother. Pharmacol. 2009, 64 (4) 647-655
26. Lee, E. S.; Ko, K. K.; Joe, Y. A.; Kang, S. G.; Hong, Y. K. Inhibition of STAT3 reverses drug resistance acquired in Temozolomide-resistant human glioma cells Oncol. Lett. 2011, 2 (1) 115-121
27. Han, M; Chen, P. Q; Yang, X. Z. Molecular dynamics simulation of PAMAM dendrimer in aqueous solution Polymer 2005, 46 (10) 3481-3488 (Pubitemid 40466083)
28. Najlah, M; Emanuele, A. D. Crossing cellular barriers using dendrimer nanotechnologies Curr. Opin. Pharmacol. 2006, 6 (5) 522-527 (Pubitemid 44340663)
29. Multiple myeloma patients experience high response rate with new three-drug combination. Cancer Biol. Ther. 2009, 8, (24), 2317-2320.
30. Ma, G.; Kawamura, K.; Li, Q.; Okamoto, S.; Suzuki, N.; Kobayashi, H.; Liang, M.; Tada, Y.; Tatsumi, K.; Hiroshima, K.; Shimada, H.; Tagawa, M. Combinatory cytotoxic effects produced by E1B-55 kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma Cancer Gene Ther. 2010, 17 (11) 803-813
31. Meng, F.; Henson, R.; Wehbe-Janek, H.; Ghoshal, K.; Jacob, S. T.; Patel, T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 2007, 133 (2) 647-658 (Pubitemid 47187346)
32. Real, P. J.; Sierra, A.; De Juan, A.; Segovia, J. C.; Lopez-Vega, J. M.; Fernandez-Luna, J. L. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells Oncogene 2002, 21 (50) 7611-7618 (Pubitemid 35398808)
33. Bratton, M. R.; Duong, B. N.; Elliott, S.; Weldon, C. B.; Beckman, B. S.; McLachlan, J. A.; Burow, M. E. Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: Implications for breast cancer cell survival Int. J. Oncol. 2010, 37 (3) 541-550
34. Dong, J.; Zhao, Y. P.; Zhou, L.; Zhang, T. P.; Chen, G. Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells Arch. Med. Res. 2011, 42, 8-14