The Interaction between Brain Inflammation and Systemic Infection

Psychoneuroimmunology

Volumn , Issue , 2006, Pages 429-448

  Felton, Leigh M ^a   Perry, V Hugh ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882494057     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088576-3/50025-3     Document Type: Chapter

References (120)

1. Aguzzi A., Weissmann C. Prion research: the next frontiers. Nature 1997, 389:795-798.
2. Aisen P.S. Evaluation of selective COX-2 inhibitors for the treatment of Alzheimer's disease. J. Pain Symptom Manage. 2002, 23:S35-S40.
3. Aisen P.S. The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol. 2002, 1:279-284.
4. Aisen P.S., Schmeidler J., Pasinetti G.M. Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 2002, 58:1050-1054.
5. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G.M., Cooper N.R., Eikelenboom P., Emmerling M., Fiebich B.L., Finch C.E., Frautschy S., Griffin W.S., Hampel H., Hull M., Landreth G., Lue L., Mrak R., Mackenzie I.R., McGeer P.L., O'Banion M.K., Pachter J., Pasinetti G., Plata-Salaman C., Rogers J., Rydel R., Shen Y., Streit W., Strohmeyer R., Tooyoma I., Van Muiswinkel F.L., Veerhuis R., Walker D., Webster S., Wegrzyniak B., Wenk G., Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol. Aging 2000, 21:383-421.
6. Allan S.M., Parker L.C., Collins B., Davies R., Luheshi G.N., Rothwell N.J. Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:5580-5585.
7. Allan S.M., Rothwell N.J. Inflammation in central nervous system injury. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2003, 358:1669-1677.
8. Allan S.M., Tyrrell P.J., Rothwell N.J. Interleukin-1 and neuronal injury. Nat. Rev. Immunol. 2005, 5:629-640.
9. Aloisi F. Immune function of microglia. Glia. 2001, 36:165-179.
10. Andersson P.B., Perry V.H., Gordon S. Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system. J. Exp. Med. 1992, 176:255-259.
11. Anthony D.C., Bolton S.J., Fearn S., Perry V.H. Agerelated effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats. Brain 1997, 120:435-444. (Pt 3).
12. Bajetto A., Bonavia R., Barbero S., Florio T., Schettini G. Chemokines and their receptors in the central nervous system. Front. Neuroendocrinol. 2001, 22:147-184.
13. Banati R.B., Newcombe J., Gunn R.N., Cagnin A., Turkheimer F., Heppner F., Price G., Wegner F., Giovannoni G., Miller D.H., Perkin G.D., Smith T., Hewson A.K., Bydder G., Kreutzberg G.W., Jones T., Cuzner M.L., Myers R. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000, 123:2321-2337. (Pt 11).
14. Beard C.M., Kokmen E., Sigler C., Smith G.E., Petterson T., O'Brien P.C. Cause of death in Alzheimer's disease. Ann. Epidemiol. 1996, 6:195-200.
15. Betmouni S., Perry V.H., Gordon J.L. Evidence for an early inflammatory response in the central nervous system of mice with scrapie. Neuroscience 1996, 74:1-5.
16. Beutler B. TLR4 as the mammalian endotoxin sensor. Curr. Top. Microbiol. Immunol. 2002, 270:109-120.
17. Boutin H., LeFeuvre R.A., Horai R., Asano M., Iwakura Y., Rothwell N.J. Role of IL-1alpha and IL-1beta in ischemic brain damage. J. Neurosci. 2001, 21:5528-5534.
18. Breder C.D., Hazuka C., Ghayur T., Klug C., Huginin M., Yasuda K., Teng M., Saper C.B. Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:11393-11397.
19. Brocke S., Gaur A., Piercy C., Gautam A., Gijbels K., Fathman C.G., Steinman L. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature 1993, 365:642-644.
20. Broom K.A., Anthony D.C., Blamire A.M., Waters S., Styles P., Perry V.H., Sibson N.R. MRI reveals that early changes in cerebral blood volume precede blood-brain barrier breakdown and overt pathology in MS-like lesions in rat brain. J. Cereb. Blood Flow Metab. 2005, 25:204-216.
21. Bruce M.E., McConnell I., Fraser H., Dickinson A.G. The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. J. Gen. Virol. 1991, 72:595-603. (Pt 3).
22. Buljevac D., Flach H.Z., Hop W.C., Hijdra D., Laman J.D., Savelkoul H.F., van Der Meche F.G., van Doorn P.A., Hintzen R.Q. Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain 2002, 125:952-960.
23. Campbell S.J., Hughes P.M., Iredale J.P., Wilcockson D.C., Waters S., Docagne F., Perry V.H., Anthony D.C. CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury. FASEB J. 2003, 17:1168-1170.
24. Campbell S.J., Perry V.H., Pitossi F.J., Butchart A.G., Chertoff M., Waters S., Dempster R., Anthony D.C. Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the cent system and the liver. Am. J. Pathol. 2005, 166:1487-1497.
25. Cho C., Miller R.J. Chemokine receptors and neural function. J. Neurovirol. 2002, 8:573-584.
26. Combrinck M.I., Perry V.H., Cunningham C. Peripheral infection evokes exaggerated sickness behaviour in preclinical murine prion disease. Neuroscience 2002, 112:7-11.
27. Compston A., Coles A. Multiple sclerosis. Lancet 2002, 359:1221-1231.
28. Crisi G.M., Santambrogio L., Hochwald G.M., Smith S.R., Carlino J.A., Thorbecke G.J. Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth fa and interleukin-10. Eur. J. Immunol. 1995, 25:3035-3040.
29. Cunningham C. Mouse behavioural studies and what they can teach us about prion diseases. Neurodegeneration and prion disease 2005, 111-137. Springer, New York. D. R. Brown (Ed.).
30. Cunningham C., Boche D., Perry V.H. Transforming growth factor beta1, the dominant cytokine in murine prion disease: infl uence on inflammatory cytokine synthesis and alteration of vascular extr matrix. Neuropathol. Appl. Neurobiol. 2002, 28:107-119.
31. Cunningham C., Deacon R., Wells H., Boche D., Waters S., Diniz C.P., Scott H., Rawlins J.N., Perry V.H. Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. Eur. J. Neurosci. 2003, 17:2147-2155.
32. Cunningham C., Deacon R.M., Chan K., Boche D., Rawlins J.N., Perry V.H. Neuropathologically distinct prion strains give rise to similar temporal profi les of behavioral defi -cits. Neurobiol. Dis. 2005, 18:258-269.
33. Cunningham C., Wilcockson D.C., Boche D., Perry V.H. Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease. J. Virol. 2005, 79:5174-5184.
34. Cunningham C., Wilcockson D.C., Campion S., Lunnon K., Perry V.H. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 2005, 25:9275-9284.
35. Danton G.H., Dietrich W.D. Inflammatory mechanisms after ischemia and stroke. J. Neuropathol. Exp. Neurol. 2003, 62:127-136.
36. Dantzer R., Aubert A., Bluthe R.M., Gheusi G., Cremona S., Laye S., Konsman J.P., Parnet P., Kelley K.W. Mechanisms of the behavioural effects of cytokines. Adv. Exp. Med. Biol. 1999, 461:83-105.
37. Dantzer R., Bluthe R.M., Gheusi G., Cremona S., Laye S., Parnet P., Kelley K.W. Molecular basis of sickness behavior. Ann. N. Y. Acad. Sci. 1998, 856:132-138.
38. Dantzer R., Konsman J.P., Bluthe R.M., Kelley K.W. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?. Auton. Neurosci. 2000, 85:60-65.
39. Dantzer R., Wollman E. Molecular mechanisms of fever: the missing links. Eur. Cytokine Netw. 1998, 9:27-31.
40. De Simoni M.G., Del Bo R., De Luigi A., Simard S., Forloni G. Central endotoxin induces different patterns of interleukin (IL)-1 beta and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and per. Endocrinology 1995, 136:897-902.
41. De Simoni M.G., Sironi M., De Luigi, A.Manfridi A., Mantovani A., Ghezzi P. Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. J. Exp. Med. 1990, 171:1773-1778.
42. Di Santo E., Benigni F., Agnello D., Sipe J.D., Ghezzi P. Peripheral effects of centrally administered interleukin-1beta in mice in relation to its clearance from the brain into the blood and tissue distribution. Neuroimmunomodulation 1999, 6:300-304.
43. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999, 22:391-397.
44. Dunn N., Mullee M., Perry V.H., Holmes C. Association between dementia and infectious disease: evidence from a case-control study. Alzheimer Dis. Assoc. Disord. 2005, 19:91-94.
45. Edwards S., Zvartau M., Clarke H., Irving W., Blumhardt L.D. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 1998, 64:736-741.
46. Elkayam O., Yaron M., Caspi D. Safety and effi cacy of vaccination against hepatitis B in patients with rheumatoid arthritis. Ann. Rheum. Dis. 2002, 61:623-625.
47. Elmquist J.K., Breder C.D., Sherin J.E., Scammell T.E., Hickey W.F., Dewitt D., Saper C.B. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J. Comp. Neurol. 1997, 381:119-129.
48. Emsley H.C., Smith C.J., Gavin C.M., Georgiou R.F., Vail A., Barberan E.M., Hallenbeck J.M., del Zoppo G.J., Rothwell N.J., Tyrrell P.J., Hopkins S.J. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J. Neuroimmunol. 2003, 139:93-101.
49. Fabriek B.O., Van Haastert E.S., Galea I., Polfl iet M.M., Dopp E.D., Van Den Heuvel M.M., Van Den Berg T.K., De Groot C.J., Van Der Valk P., Dijkstra C.D. CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation. Glia. 2005, 51:297-305.
50. Fadok V.A., Bratton D.L., Konowal A., Freed P.W., Westcott J.Y., Henson P.M. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGFbeta,. J. Clin. Invest. 1998, 101:890-898.
51. Felton L.M., Cunningham C., Rankine E.L., Waters S., Boche D., Perry V.H. MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease. Neurobiol. Dis. 2005, 20:283-295.
52. Felzien L.K., McDonald J.T., Gleason S.M., Berman N.E., Klein R.M. Increased chemokine gene expression during aging in the murine brain. Brain Res. 2001, 890:137-146.
53. Ferguson B., Matyszak M.K., Esiri M.M., Perry V.H. Axonal damage in acute multiple sclerosis lesions. Brain 1997, 120:393-399. (Pt 3).
54. Ferrari C.C., Depino A.M., Prada F., Muraro N., Campbell S., Podhajcer O., Perry V.H., Anthony D.C., Pitossi F.J. Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. Am. J. Pathol. 2004, 165:1827-1837.
55. Garabedian B.V., Lemaigre-Dubreuil Y., Mariani J. Central origin of IL-1beta produced during peripheral inflammation: role of meninges. Brain Res. Mol. Brain Res. 2000, 75:259-263.
56. Gatti S., Bartfai T. Induction of tumor necrosis factoralpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6. Brain Res. 1993, 624:291-294.
57. Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., Johnson R.W. Exaggerated neuroin-fl ammation and sickness behavior in aged mice after activation of the peripheral innate immune system. FASEB J. 2005, 19:1329-1331.
58. Guenther K., Deacon R.M., Perry V.H., Rawlins J.N. Early behavioural changes in scrapie-affected mice and the infl uence of dapsone. Eur. J. Neurosci. 2001, 14:401-409.
59. Hacham M., Argov S., White R.M., Segal S., Apte R.N. Different patterns of interleukin-1alpha and interleukin-1beta expression in organs of normal young and old mice. Eur. Cytokine Netw. 2002, 13:55-65.
60. Hajjar A.M., Ernst R.K., Tsai J.H., Wilson C.B., Miller S.I. Human toll-like receptor 4 recognizes host-specifi c LPS modifi cations. Nat. Immunol. 2002, 3:354-359.
61. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12:123-137.
62. Holmes C., El-Okl M., Williams A.L., Cunningham C., Wilcockson D., Perry V.H. Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 2003, 74:788-789.
63. Hughes P.M., Allegrini P.R., Rudin M., Perry V.H., Mir A.K., Wiessner C. Monocyte chemoattractant protein-1 defi ciency is protective in a murine stroke model. J. Cereb. Blood Flow Metab. 2002, 22:308-317.
64. Hughes P.M., Anthony D.C., Ruddin M., Botham M.S., Rankine E.L., Sablone M., Baumann D., Mir A.K., Perry V.H. Focal lesions in the rat central nervous system induced by endothelin-1. J. Neuropathol. Exp. Neurol. 2003, 62:1276-1286.
65. Jeffery D.R. Relationship between disease activity and doseresponse relationships with beta interferon therapies in the treatment of multiple sclerosis. J. Neurol. Sci. 2000, 178:2-9.
66. Jeffrey M., Halliday W.G., Bell J., Johnston A.R., MacLeod N.K., Ingham C., Sayers A.R., Brown D.A., Fraser J.R. Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus. Neuropathol. Appl. Neurobiol. 2000, 26:41-54.
67. Kalehua A.N., Nagel J.E., Whelchel L.M., Gides J.J., Pyle R.S., Smith R.J., Kusiak J.W., Taub D.D. Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. Exp. Cell Res. 2004, 297:197-211.
68. Kivisakk P., Trebst C., Eckstein D.J., Kerza-Kwiatecki A.P., Ransohoff R.M. Chemokine-based therapies for MS: how do we get there from here?. Trends Immunol. 2001, 22:591-593.
69. Konsman J.P., Parnet P., Dantzer R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci. 2002, 25:154-159.
70. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
71. La M., Tailor A., D'Amico M., Flower R.J., Perretti M. Analysis of the protection afforded by annexin 1 in ischaemiareperfusion injury: focus on neutrophil recruitment. Eur. J. Pharmacol. 2001, 429:263-278.
72. Lacroix S., Rivest S. Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat br. J. Neurochem. 1998, 70:452-466.
73. Laye S., Parnet P., Goujon E., Dantzer R. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Brain Res. Mol. Brain Res. 1994, 27:157-162.
74. Loddick S.A., Turnbull A.V., Rothwell N.J. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 1998, 18:176-179.
75. Mabbott N.A., Williams A., Farquhar C.F., Pasparakis M., Kollias G., Bruce M.E. Tumor necrosis factor alphadefi cient, but not interleukin-6-defi cient, mice resist peripheral infection with scrapie. J. Virol. 2000, 74:3338-3344.
76. Matsuo Y., Kihara T., Ikeda M., Ninomiya M., Onodera H., Kogure K. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: effect of neutrophil depletion on extracellular ascorbyl radical f. J. Cereb. Blood Flow Metab. 1995, 15:941-947.
77. Matsuo Y., Onodera H., Shiga Y., Nakamura M., Ninomiya M., Kihara T., Kogure K. Correlation between myeloperoxidase-quantifi ed neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion. Stroke 1994, 25:1469-1475.
78. Matyszak M.K., Perry V.H. Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guerin. Neuroscience 1995, 64:967-977.
79. McDonald P.P., Fadok V.A., Bratton D., Henson P.M. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J. Immunol. 1999, 163:6164-6172.
80. McGeer P.L., Rogers J. Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 1992, 42:447-449.
81. McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 1996, 47:425-432.
82. Minghetti L., Greco A., Cardone F., Puopolo M., Ladogana A., Almonti S., Cunningham C., Perry V.H., Pocchiari M., Levi G. Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies. J. Neuropathol. Exp. Neurol. 2000, 59:866-871.
83. Moser B., Willimann K. Chemokines: role in inflammation and immune surveillance. Ann Rheum Dis 2004, 63(Suppl 2). ii84-ii89.
84. Muramami N., Fukata J., Tsukada T., Kobayashi H., Ebisui O., Segawa H., Muro S., Imura H., Nakao K. Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen. Endocrinology 1993, 133:2574-2578.
85. Newman T.A., Woolley S.T., Hughes P.M., Sibson N.R., Anthony D.C., Perry V.H. T-cell-and macrophage-mediated axon damage in the absence of a CNSspecifi c immune response: involvement of metalloproteinases. Brain 2001, 124:2203-2214.
86. Nguyen M.D., D'Aigle T., Gowing G., Julien J.P., Rivest S. Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 2004, 24:1340-1349.
87. Panitch H.S. Infl uence of infection on exacerbations of multiple sclerosis. Ann Neurol 1994, 36:S25-S28. (Suppl).
88. Pavlov V.A., Tracey K.J. The cholinergic antiinfl ammatory pathway. Brain Behav. Immun. 2005, 19:493-499.
89. Perry V.H., Anthony D.C., Bolton S.J., Brown H.C. The blood-brain barrier and the inflammatory response. Mol. Med. Today 1997, 3:335-341.
90. Perry V.H., Cunningham C., Boche D. Atypical inflammation in the central nervous system in prion disease. Curr. Opin. Neurol. 2002, 15:349-354.
91. Perry V.H., Matyszak M.K., Fearn S. Altered anti -gen expression of microglia in the aged rodent CNS. Glia. 1993, 7:60-67.
92. Perry V.H., Newman T.A., Cunningham C. The impact of systemic infection on the progression of neurodegenerative disease. Nat. Rev. Neurosci. 2003, 4:103-112.
93. Polfl iet M.M., Zwijnenburg P.J., van Furth A.M., van der Poll T., Dopp E.A., Renardel de Lavalette C., van Kesteren-Hendrikx E.M., van Rooijen N., Dijkstra C.D., van den Berg T.K. Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. J. Immunol. 2001, 167:4644-4650.
94. Prat A., Biernacki K., Lavoie J.F., Poirier J., Duquette P., Antel J.P. Migration of multiple sclerosis lymphocytes through brain endothelium. Arch. Neurol. 2002, 59:391-397.
95. Prusiner S.B. Novel proteinaceous infectious particles cause scrapie. Science 1982, 216:136-144.
96. Relton J.K., Rothwell N.J. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull 1992, 29:243-246.
97. Rivest S. Molecular insights on the cerebral innate immune system. Brain Behav. Immun. 2003, 17:13-19.
98. Rivest S., Lacroix S., Vallieres L., Nadeau S., Zhang J., Lafl amme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc. Soc. Exp. Biol. Med. 2000, 223:22-38.
99. Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 2004, 22:891-928.
100. Rothwell N.J., Luheshi G.N. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 2000, 23:618-625.
101. Schiffenbauer J., Johnson H.M., Butfiloski E.J., Wegrzyn L., Soos J.M. Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8543-8546.
102. Schiltz J.C., Sawchenko P.E. Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults. J. Neurosci. 2002, 22:5606-5618.
103. Schiltz J.C., Sawchenko P.E. Signaling the brain in systemic inflammation: the role of perivascular cells. Front. Biosci. 2003, 8:s1321321-s1321329.
104. Sheng J.G., Mrak R.E., Griffi n W.S. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol. (Berl) 1998, 95:229-234.
105. Sibley W.A., Bamford C.R., Clark K. Clinical viral infections and multiple sclerosis. Lancet 1985, 1:1313-1315.
106. Sly L.M., Krzesicki R.F., Brashler J.R., Buhl A.E., McKinley D.D., Carter D.B., Chin J.E. Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. Bull. 2001, 56:581-588.
107. Smith C.J., Emsley H.C., Gavin C.M., Georgiou R.F., Vail A., Barberan E.M., del Zoppo G.J., Hallenbeck J.M., Rothwell N.J., Hopkins S.J., Tyrrell P.J. Peak plasma interleukin-6 and other peripheral markers of inflammation in the fi rst week of ischaemic stroke correlate with brain infarct volume, stroke seve long-term outcome. BMC Neurol. 2004, 4:2.
108. Streetz K.L., Wustefeld T., Klein C., Manns M.P., Trautwein C. Mediators of inflammation and acute phase response in the liver. Cell. Mol. Biol. (Noisy-le-grand) 2001, 47:661-673.
109. Szatkowski M., Attwell D. Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 1994, 17:359-365.
110. Veld B.A., Ruitenberg A., Hofman A., Launer L.J., van Duijn C.M., Stijnen T., Breteler M.M., Stricker B.H. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N. Engl. J. Med. 2001, 345:1515-1521.
111. Tracey K.J. The inflammatory refl ex. Nature 2002, 420:853-859.
112. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mork S., Bo L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 1998, 338:278-285.
113. van Dam A.M., Brouns M., Louisse S., Berkenbosch F. Appearance of interleukin-1 in macrophages and in ramifi ed microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specifi c sym sickness?. Brain Res. 1992, 588:291-296.
114. van Rooijen N., Sanders A., van den Berg T.K. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J. Immunol. Methods 1996, 193:93-99.
115. Walsh D.T., Betmouni S., Perry V.H. Absence of detectable IL-1beta production in murine prion disease: a model of chronic neurodegeneration. J. Neuropathol. Exp. Neurol. 2001, 60:173-182.
116. Walsh D.T., Perry V.H., Minghetti L. Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease. Glia 2000, 29:392-396.
117. Wilcockson D.C., Campbell S.J., Anthony D.C., Perry V.H. The systemic and local acute phase response following acute brain injury. J. Cereb. Blood Flow Metab. 2002, 22:318-326.
118. Williams A.E., Lawson L.J., Perry V.H., Fraser H. Characterization of the microglial response in murine scrapie. Neuropathol. Appl. Neurobiol. 1994, 20:47-55.
119. Yang Y.X., Lichtenstein G.R. Corticosteroids in Crohn's disease. Am. J. Gastroenterol. 2002, 97:803-823.
120. Zhang J., Rivest S. Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. J. Neurochem. 2001, 76.