Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus

Neuropathology and Applied Neurobiology

Volumn 26, Issue 1, 2000, Pages 41-54

  Jeffrey, M ^a   Halliday, W G ^a   Bell, J ^b   Johnston, A R ^c   Macleod, N K ^c   Ingham, C ^c   Sayers, A R ^d   Brown, D A ^b   Fraser, J R ^b  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d VLA Weybridge   (United Kingdom)

Author keywords

Hippocampus; Neurone; PrP; Scrapie; Synapse; Transmissible spongiform encephalopathies

Indexed keywords

PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DEATH; HIPPOCAMPUS; INCUBATION TIME; MOUSE; NERVE DEGENERATION; NERVE ENDING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SCRAPIE; STEREOMETRY; SYNAPSE; THALAMUS;

ANIMALS; ASTROCYTES; CELL COUNT; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; NERVE DEGENERATION; NEURONS; NEUTROPHILS; PRIONS; SCRAPIE; SYNAPSES; VACUOLES;

EID: 0034016049     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2000.00216.x     Document Type: Article

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