Mechanisms of the behavioural effects of cytokines

Advances in Experimental Medicine and Biology

Volumn 461, Issue , 1999, Pages 83-105

  Dantzer, R ^a   Aubert, A ^a   Bluthe R M ^a   Gheusi, G ^a   Cremona, S ^a   Laye S ^a   Konsman, J P ^a   Parnet, P ^a   Kelley, K W ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOCORTICOID; VASOPRESSIN;

BRAIN; CONFERENCE PAPER; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HIPPOCAMPUS; HYPOTHALAMUS; ILLNESS BEHAVIOR; INFLAMMATION; METABOLIC REGULATION; MOTIVATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; THERMOREGULATION;

EID: 0033282369     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-585-37970-8_6     Document Type: Conference Paper

References (77)

1. Differential effects of lipopolysaccharide on pup retrieving and nest building in lactating mice
2. Differential effect of lipopolysaccharide on food hoarding behavior and food consumption in rats
3. Regulation of interleukin-1 receptor expression in mouse brain and pituitary by lipopolysaccharide and glucocorticoids
4. Human interleukin (IL) 1 alpha, murine IL-1 alpha, and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism
5. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
6. Adrenalectomy sensitizes mice to lethal effects of interleukin-1 and tumor necrosis factor
7. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones
8. Corticosteroid regulation of IL-1 receptors in the mouse hippocampus: Effects of glucocorticoid treatment, stress, and adrenalectomy
9. Neuromodulative actions of cytokines
10. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat
11. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism
12. Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes
13. Vagotomy attenuates behavioral effects of interleukin-1 injected peripherally but not centrally
14. Central mediation of the effects of interleukin-1 on social exploration and body weight in mice
15. Species-specific defense reactions and avoidance learning
16. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide
17. Regional induction of tumor necrosis factor α expression in the mouse brain after systemic lipopolysaccharide administration
18. Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism
19. Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F: Sequencing a rat type II interleukin-1 receptor cDNA
20. Interleukin-1β converting enzyme (ICE)-deficient mice are resistant to central but not systemic lipopolysaccharide-induced aphagia
21. Peripheral lipopolysaccharide stimulation induces interleukin-1β messenger RNA in rat brain microglial cells
22. Endothelial cells of the rat-brain vasculature express cyclooxygenase-2 messenger-RNA in response to systemic interleukin-1: A possible site of prostaglandin synthesis responsible for fever
23. Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats
24. Brain type I but not type II interleukin-1 (IL-1) receptors mediate the effects of IL-1β on behavior in mice
25. How do cytokines say hello to the brain? Neural versus humoral mediation
26. Stress and immunity: An integrated view of relationships between the brain and the immune system
27. Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior
28. Biologic basis for interleukin-1 in disease
29. Mechanisms of CNS response to systemic immune challenge: The febrile response
30. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons
31. Type 1 interleukin-1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL-1 induced cellular activation
32. Induction of tumor necrosis factor α mRNA in the brain after peripheral endotoxin treatment: Comparison with interleukin-1 family and interleukin-6
33. Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1β in mice
34. Endogenous glucocorticoids downregulate central effects of interleukin-1β on body temperature and behavior in mice
35. Stress downregulates lipopolysaccharide-induced expression of proinflammatory cytokines in the spleen, pituitary and brain of mice
36. Adrenalectomy enhances proinflammatory cytokine gene expression in the spleen, pituitary and brain of mice in response to lipopolysaccharide
37. Molecular cloning and characterization of a second subunit of the interleukin-1 receptor complex
38. Vagotomy blocks the induction of interleukin-1β (IL-1β) mRNA in the brain of rats in response to systemic IL-1β
39. Brain interleukin-1 receptors. Characterization and modulation after lipopolysaccharide injection
40. Biological basis of the behavior of sick animals
41. Cytokines and the nervous system. I: Expression and recognition
42. Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1
43. Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin-1
44. Sickness behavior as a new target for drug development
45. Effects of lipopolysaccharide on food-motivated behavior are not blocked by an interleukin-1 receptor antagonist
46. Mechanisms of sickness-induced decreases in food-motivated behavior
47. Interleukin-1β causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats
48. Fever: Role of pyrogens and cryogens
49. Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1β and inducible NO synthase in rat brain
50. Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cycloxygenase enzymes (COX-1 and COX-2) in the rat brain
51. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice
52. Subdiaphragmatic vagotomy blocks induction of IL-1β mRNA in mice brain in response to peripheral LPS
53. Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice
54. Glucocorticoids selectively inhibit the transcription of the interleukin-1β gene and decrease the stability of interleukin-1β mRNA
55. The effect of psychological stress on plasma interleukin-6 activity in rats
56. Central effects of glucocorticoid receptor antagonist RU-38486 on lipopolysacharide and stress-induced fever
57. Some psychophysiological studies of motivation and of the behavioral effects of illness
58. Immobilization stress induces interleukin-1 beta mRNA in the hypothalamus
59. Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide
60. Expression of type I and type II interleukin-1 receptors in mouse brain
61. Cytokines and feeding suppression: An integrative view from neurological to molecular levels
62. Anorexia during acute and chronic disease. Relevance of neurotransmitter-peptide-cytokine interactions
63. Tumor necrosis factor and interleukin-1β suppression of food intake by direct action in the central nervous system
64. Induction of inhibitory factor kappaBalpha mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat
65. Neuro-hormonal host defence in endotoxin shock
66. Endotoxin induces interleukin-1β and nitric oxide synthase mRNA in rat hypothalamus and pituitary
67. Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain
68. Interleukin-1 receptors in mouse brain: Characterization and neuronal localization
69. Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: A pathway for the induction of non-specific symptoms of sickness
70. Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain
71. Cytokine-to-brain communication: A review & analysis of alternative mechanisms
72. Interleukin (IL) 1β, IL-1 receptor antagonist. IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications
73. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation
74. Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
75. Exposure to physical and psychological stressors elevates plasma interleukin-6: Relationship to the activation of hypothalamic-pituitary-adrenal axis
76. Differential regulation of lipopolysacharide-induced interleukin-1 and tumor necrosis factor synthesis: Effects of endogenous glucocorticoids and the role of pituitary-adrenal axis