Extracellular matrix microenvironment contributes actively to pulmonary fibrosis

Current Opinion in Pulmonary Medicine

Volumn 19, Issue 5, 2013, Pages 446-452

  Shimbori, Chiko ^a,b   Gauldie, Jack ^a   Kolb, Martin ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b SHIMANE UNIVERSITY   (Japan)

Author keywords

Extracellular matrix; Microenvironment; Pulmonary fibrosis

Indexed keywords

CHRONIC DISEASE; DISEASE COURSE; EXTRACELLULAR MATRIX; FATALITY; FIBROBLAST; FIBROGENESIS; FIBROSING ALVEOLITIS; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MESENCHYME CELL; MYOFIBROBLAST; PATHOGENESIS; REVIEW;

BIOMECHANICAL PHENOMENA; CELLULAR MICROENVIRONMENT; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; HUMANS; PULMONARY FIBROSIS;

EID: 84882237753     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e328363f4de     Document Type: Review

References (79)

1. Noble PW, Barkauskas CE, Jiang D. Pulmonary fibrosis: Patterns and perpetrators. J Clin Invest 2012; 122:2756-2762
2. Ueha S, Shand FH, Matsushima K. Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis. Front Immunol 2012; 3:71
3. Sivakumar P, Ntolios P, Jenkins G, Laurent G. Into the matrix: Targeting fibroblasts in pulmonary fibrosis. Curr Opin Pulm Med 2012; 18:46246-46249
4. Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clin Exp Metastasis 2009; 26:35-49
5. Wipff PJ, Rifkin DB, Meister JJ, Hinz B. Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol 2007; 179:1311-1323
6. Hinz B. Mechanical aspects of lung fibrosis: A spotlight on the myofibroblast. Proc Am Thorac Soc 2012; 9:137-147
7. Huang X, Yang N, Fiore VF, et al. Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am J Respir Cell Mol Biol 2012; 47:340-348
8. Brown AC, Fiore VF, Sulchek TA, Barker TH. Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosisassociated epithelial-To-mesenchymal transitions. J Pathol 2013; 229:25-35
9. Bonniaud P, Martin G, Margetts PJ, et al. Connective tissue growth factor is crucial to inducing a profibrotic environment in 'fibrosis-resistant' BALB/c mouse lungs. Am J Respir Cell Mol Biol 2004; 31:510-516
10. Wells RG, Discher DE. Matrix elasticity, cytoskeletal tension, and TGF-beta; the insoluble and soluble meet. Sci Signal 2008; 1:e13
11. Vancheri C, Failla M, Crimi N, Raghu G. Idiopathic pulmonary fibrosis: A disease with similarities and links to cancer biology. Eur Respir J 2010; 35:496-504
12. Allen M, Louise Jones J. Jekyll and Hyde: The role of the microenvironment on the progression of cancer. J Pathol 2011; 223:162-176
13. Cox TR, Erler JT. Remodeling and homeostasis of the extracellular matrix; implications for fibrotic diseases and cancer. Dis Model Mech 2011; 4:165-178
14. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3:349-363
15. Kis K, Liu X, Hagood JS. Myofibroblast differentiation and survival in fibrotic disease. Expert Rev Mol Med 2011; 13:e27
16. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 2003; 200:500-503
17. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-890
18. Maharaj SS, Baroke E, Gauldie J, KolbMR. Fibrocytes in chronic lung disease; facts and controversies. Pulm Pharmacol Ther 2012; 25:263-267
19. Tanjore H, Xu XC, Polosukhin VV, et al. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 2009; 180:657-665
20. Rock JR, Barkauskas CE, Cronce MJ, et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A 2011; 108:E1475-E1483
21. Baum CL, Arpey CJ. Normal cutaneous wound healing: Clinical correlation with cellular and molecular events. Dermatol Surg 2005; 31:674-686
22. Tatler AL, Jenkins G. TGF-b activation and lung fibrosis. Proc Am Thorac Soc 2012; 9:130-136
23. Coker RK, Laurent GJ, Shahzeidi S, et al. Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 1997; 150:981-991
24. Coker RK, Laurent GJ, Jeffery PK, et al. Localisation of transforming growth factor beta1 and beta3 mRNA transcripts in normal and fibrotic human lung. Thorax 2001; 56:549-556
25. Sime PJ, Xing Z, Graham FL, et al. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997; 100:768-776
26. Leask A, Abraham DJ. The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 2003; 81:355-363
27. Ponticos M, Holmes AM, Shi-wen X, et al. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum 2009; 60:2142-2155
28. Lee CH, Shah B, Moioli EK, Mao JJ. CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model. J Clin Invest 2010; 120:3340-3349
29. Leitinger B, Hohenester E. Mammalian collagen receptors. Matrix Biol 2007; 26:146-155
30. Yeh YC, Lin HH, Tang MJ. A tale of two collagen receptors, integrin b1 and discoidin domain receptor 1, in epithelial cell differentiation. Am J Physiol Cell Physiol 2012; 303:C1207-C1217
31. Kim KK, Wei Y, Szekeres C, et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 2009; 119:213-224
32. Yeh YC, Wei WC, Wang YK, et al. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelialto- mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol 2010; 177:1743-1754
33. Li Y, Yang J, Dai C, et al. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 2003; 112:503-516
34. Li Y, Tan X, Dai C, et al. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol 2009; 20:1907-1918
35. Ruiz PA, Jarai G. Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices. Fibrogenesis Tissue Repair 2012; 5:3
36. Manni ML, Czajka CA, Oury TD, Gilbert TW. Extracellular matrix powder protects against bleomycin-induced pulmonary fibrosis. Tissue Eng Part A 2011; 17:2795-2804
37. Shi M, Zhu J, Wang R, et al. Latent TGF-b structure and activation. Nature 2011; 474:343-349
38. Klingberg F, Hinz B, White ES. The myofibroblast matrix: Implications for tissue repair and fibrosis. J Pathol 2013; 229:298-309
39. Munger JS, Huang X, Kawakatsu H, et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999; 96:319-328
40. Tatler AL, John AE, Jolly L, et al. Integrin avb5-mediated TGF-b activation by airway smooth muscle cells in asthma. J Immunol 2011; 187:6094-6107
41. Kadler KE, Hill A, Canty-Laird EG. Collagen fibrillogenesis: Fibronectin, integrins, and minor collagens as organizers and nucleators. Curr Opin Cell Biol 2008; 20:495-501
42. Kagan HM, Li W. Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 2003; 88:660-672
43. Barry-Hamilton V, Spangler R, Marshall D, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med 2010; 16:1009-1017
44. Olsen KC, Sapinoro RE, Kottmann RM, et al. Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med 2011; 184:699-707
45. Paszek MJ, Zahir N, Johnson KR, et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 2005; 8:241-254
46. Barker TH, Grenett HE, MacEwen MW, et al. Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. Exp Cell Res 2004; 295:488-496
47. Zhou Y, Huang X, Hecker L, et al. Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest 2013; 123:1096-1108
48. Jiang C, Huang H, Liu J, et al. Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice. Int J Mol Sci 2012; 13:8293-8307
49. Georges PC, Hui JJ, Gombos Z, et al. Increased stiffness of the rat liver precedes matrix deposition: Implications for fibrosis. Am J Physiol Gastrointest Liver Physiol 2007; 293:G1147-G1154
50. Booth AJ, Hadley R, Cornett AM, et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med 2012; 186:866-876
51. Jordana M, Schulman J, McSharry C, et al. Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis 1988; 137:579-584
52. Ramos C, Montanö M, García-Alvarez J, et al. Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression. Am J Respir Cell Mol Biol 2001; 24:591-598
53. Pierce EM, Carpenter K, Jakubzick C, et al. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol 2007; 170:1152-1164
54. Raghu G, Masta S, Meyers D, Narayanan AS. Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-beta. Am Rev Respir Dis 1989; 140:95-100
55. Pierce EM, Carpenter K, Jakubzick C, et al. Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21. Eur Respir J 2007; 29:1082-1093
56. Strieter RM, Gomperts BN, Keane MP. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 2007; 117:549-556
57. Li Y, Jiang D, Liang J, et al. Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44. J Exp Med 2011; 208:1459-1471
58. Thannickal VJ, Horowitz JC. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006; 3:350-356
59. Garrison G, Huang SK, Okunishi K, et al. Reversal of myofibroblast differentiation by prostaglandin E2. Am J Respir Cell Mol Biol 2013; 48:550-558
60. McAnulty RJ, Herná ndez-Rodriguez NA, Mutsaers SE, et al. Indomethacin suppresses the antiproliferative effects of transforming growth factor-beta isoforms on fibroblast cell cultures. Biochem J 1997; 321:639-643
61. Liu F, Mih JD, Shea BS, et al. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol 2010; 190:693-706
62. Selman M, Pardo A, Kaminski N. Idiopathic pulmonary fibrosis: Aberrant recapitulation of developmental programs? PLoS Med 2008; 5:e62
63. Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 2006; 103:13180-13185
64. Humphreys BD, Lin SL, Kobayashi A, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176:85-97
65. Masszi A, Fan L, Rosivall L, et al. Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-To-myofibroblast transition: Role for beta-catenin. Am J Pathol 2004; 165:1955-1967
66. Farkas L, Farkas D, Gauldie J, et al. Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. Am J Respir Cell Mol Biol 2011; 44:870-878
67. Heise RL, Stober V, Cheluvaraju C, et al. Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem 2011; 286:17435-17444
68. Leight JL, Wozniak MA, Chen S, et al. Matrix rigidity regulates a switch between TGF-b1-induced apoptosis and epithelial-mesenchymal transition. Mol Biol Cell 2012; 23:781-791
69. Shukla S, Nair R, Rolle MW, et al. Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation. J Histochem Cytochem 2010; 58:345-358
70. Ramos C, Becerril C, MontanöM, et al. FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway. Am J Physiol Lung Cell Mol Physiol 2010; 299:L222-L231
71. Andersson-Sjö land A, de Alba CG, Nihlberg K, et al. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 2008; 40:2129-2140
72. Ding L, Dolgachev V, Wu Z, et al. Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis. J Pathol 2013; 230:205-214
73. Lama VN, Phan SH. The extrapulmonary origin of fibroblasts: Stem/progenitor cells and beyond. Proc Am Thorac Soc 2006; 3:373-376
74. Elkabets M, Gifford AM, Scheel C, et al. Human tumors instigate granulinexpressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest 2011; 121:784-799
75. Mackinnon A, Forbes S. Bone marrow contributions to fibrosis. Biochim Biophys Acta 2013; 1832:955-961
76. Maron-Gutierrez T, Castiglione RC, Xisto DG, et al. Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis. Eur Respir J 2011; 37:1217-1225
77. Tzouvelekis A, Antoniadis A, Bouros D. Stem cell therapy in pulmonary fibrosis. Curr Opin Pulm Med 2011; 17:368-373
78. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006; 126:677-689
79. Wozniak MA, Desai R, Solski PA, et al. ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol 2003; 163:583-595