Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis

Journal of Pathology

Volumn 230, Issue 2, 2013, Pages 205-214

  Ding, Lin ^a   Dolgachev, Vladilsav ^a   Wu, Zhuang ^a,b   Liu, Tianju ^a   Nakashima, Taku ^a   Wu, Zhe ^a   Ullenbruch, Matthew ^a   Lukacs, Nicholas W ^a   Chen, Zidi ^a   Phan, Sem H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

bone marrow cells; c kit; pulmonary fibrosis; stem cell factor

Indexed keywords

BLEOMYCIN; COLLAGEN TYPE 1; STEM CELL FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; FEMALE; FIBROBLAST; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BLEOMYCIN; BONE MARROW CELLS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CELL MOVEMENT; CELLS, CULTURED; FEMALE; FIBROBLASTS; HEMATOPOIETIC STEM CELLS; HUMANS; LUNG; LUNG INJURY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-KIT; PULMONARY FIBROSIS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STEM CELL FACTOR; TISSUE EXTRACTS;

EID: 84877729882     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4177     Document Type: Article

References (38)

1. Lama VN, Phan SH,. The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond. Proc Am Thorac Soc 2006; 3: 373-376.
2. Fleming WH, Alpern EJ, Uchida N, et al,. Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo. Proc Natl Acad Sci USA 1993; 90: 3760-3764.
3. Lukacs NW, Kunkel SL, Strieter RM, et al,. The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation. Blood 1996; 87: 2262-2268.
4. Domen J, Weissman IL,. Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. J Exp Med 2000; 192: 1707-1718.
5. Erlandsson A, Larsson J, Forsberg-Nilsson K,. Stem cell factor is a chemoattractant and a survival factor for CNS stem cells. Exp Cell Res 2004; 301: 201-210.
6. Nakamura Y, Tajima F, Ishiga K, et al,. Soluble c-kit receptor mobilizes hematopoietic stem cells to peripheral blood in mice. Exp Hematol 2004; 32: 390-396.
7. Tajima F, Tsuchiya H, Nishikawa K, et al,. Hepatocyte growth factor mobilizes and recruits hematopoietic progenitor cells into liver through a stem cell factor-mediated mechanism. Hepatol Res 2010; 40: 711-719.
8. El Kossi MM, Haylor JL, et al,. Stem cell factor in a rat model of serum nephrotoxic nephritis. Nephron Exp Nephrol 2008; 108: e1-10.
9. Meloni M, Caporali A, Graiani G, et al,. Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res 2010; 106: 1275-1284.
10. Sun L, Lee J, Fine HA,. Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. J Clin Invest 2004; 113: 1364-1374.
11. Matsumoto T, Ii M, Nishimura H, et al,. Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing. J Exp Med 2010; 207: 2207-2223.
12. Wang CH, Anderson N, Li SH, et al,. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circ Res 2006; 99: 617-625.
13. Fireman E, Kivity S, Shahar I, et al,. Secretion of stem cell factor by alveolar fibroblasts in interstitial lung diseases. Immunol Lett 1999; 67: 229-236.
14. Dolgachev VA, Ullenbruch MR, Lukacs NW, et al,. Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling. Am J Pathol 2009; 174: 390-400.
15. Cheng M, Zhou J, Wu M, et al,. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 2010; 107: 1083-1093.
16. Zheng B, Zhang Z, Black CM, et al,. Ligand-dependent genetic recombination in fibroblasts: a potentially powerful technique for investigating gene function in fibrosis. Am J Pathol 2002; 160: 1609-1617.
17. Thrall RS, Phan SH, McCormick JR, et al,. The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats. Am J Pathol 1981; 105: 76-81.
18. Abkowitz JL, Robinson AE, Kale S, et al,. Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Blood 2003; 102: 1249-1253.
19. Corbel M, Caulet-Maugendre S, Germain N, et al,. Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat. J Pathol 2005; 193: 538-545.
20. Heissig B, Hattori K, Dias S, et al,. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 2002; 109: 625-637.
21. Lama VN, Phan SH,. The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond. Proc Am Thorac Soc 2006; 3: 373-376.
22. Ogawa M, Matsuzaki Y, Nishikawa S, et al,. Expression and function of c-kit in hemopoietic progenitor cells. J Exp Med 1991; 174: 63-71.
23. Montani D, Perros F, Gambaryan N, et al,. C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2011; 184: 116-123.
24. Ray P, Krishnamoorthy N, Ray A,. Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiation. Cell Cycle 2008; 7: 2826-2832.
25. Hashimoto N, Jin H, Liu T, et al,. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 2004; 113: 243-252.
26. Phillips RJ, Burdick MD, Hong K, et al,. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004; 114: 438-446.
27. Rojas M, Xu J, Woods CR, et al,. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33: 145-152.
28. Ortiz LA, Gambelli F, McBride C, et al,. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003; 100: 8407-8411.
29. Andersson-Sjöland A, de Alba CG, Nihlberg K, et al,. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 2008; 40: 2129-2140.
30. Xu J, Mora A, Shim H, et al,. Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Am J Respir Cell Mol Biol 2007; 37: 291-299.
31. Cheng M, Zhou J, Wu M, et al,. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-Kit activity. Circ Res 2010; 107: 1083-1093.
32. Emblom-Callahan MC, Chhina MK, Shlobin OA, et al,. Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis. Genomics 2010; 96: 134-145.
33. Ducy P, Schinke T, Karsenty G,. The osteoblast: a sophisticated fibroblast under central surveillance. Science 2000; 289: 1501-1504.
34. Aono Y, Nishioka Y, Inayama M, et al,. Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 2005; 171: 1279-1285.
35. Vuorinen K, Gao F, Oury TD, et al,. Imatinib mesylate inhibits fibrogenesis in asbestos-induced interstitial pneumonia. Exp Lung Res 2007; 33: 357-373.
36. Huaux F, Liu T, McGarry B, et al. Dual roles of IL-4 in lung injury and fibrosis. J Immunol 2003; 170: 2083-2092.
37. Liu T, Chung MJ, Ullenbruch M, et al. Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice. J Clin Invest 2007; 117: 3800-3809.
38. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC t) method. Methods 2001; 25: 402-408.