Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

Arthritis and Rheumatism

Volumn 60, Issue 7, 2009, Pages 2142-2155

  Ponticos, Markella ^a,b   Holmes, Alan M ^a,b   Shi wen, Xu ^b   Leoni, Patricia ^b   Khan, Korsa ^b   Rajkumar, Vineeth S ^b   Hoyles, Rachel K ^b   Bou Gharios, George ^c   Black, Carol M ^b   Denton, Christopher P ^b   Abraham, David J ^b   Leask, Andrew ^d   Lindahl, Gisela E ^b  

^a NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BLEOMYCIN; CCAAT BINDING FACTOR; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUTRALIZING ANTIBODY; PROTEIN C JUN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROGENESIS; IMMUNOHISTOCHEMISTRY; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SYSTEMIC SCLEROSIS; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BLEOMYCIN; CELLS, CULTURED; COLLAGEN; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; HUMANS; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-JUN; PULMONARY FIBROSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSCRIPTION, GENETIC;

EID: 67650069660     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24620     Document Type: Article

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