Fibrocytes in chronic lung disease - Facts and controversies

Pulmonary Pharmacology and Therapeutics

Volumn 25, Issue 4, 2012, Pages 263-267

  Maharaj, Shyam S ^a,b   Baroke, Eva ^a,b,c   Gauldie, Jack ^a   Kolb, Martin R J ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Asthma; Fibrocytes; Lung fibrosis; Wound repair

Indexed keywords

CD19 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ENDOTHELIN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VIMENTIN;

ARTICLE; ASTHMA; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CHRONIC KIDNEY DISEASE; CHRONIC LUNG DISEASE; FIBROCYTE; HUMAN; INFLAMMATION; LUNG FIBROSIS; MESENCHYME CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCLERODERMA; TISSUE REPAIR;

ASTHMA; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CHRONIC DISEASE; FIBROBLASTS; HUMANS; HYPERTENSION, PULMONARY; LUNG; LUNG DISEASES; MESENCHYMAL STROMAL CELLS; MONOCYTES;

EID: 84864065934     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2011.09.002     Document Type: Article

References (58)

1. Bucala R., Spiegel L.A., Chesney J., Hogan M., Cerami A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994, 1:71-81.
2. Mori L., Bellini A., Stacey M.A., Schmidt M., Mattoli S. Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Exp Cell Res 2005, 304:81-90.
3. Ebihara Y., Masuya M., Larue A.C., Fleming P.A., Visconti R.P., Minamiguchi H., et al. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol 2006, 34:219-229.
4. Kisseleva T., Uchinami H., Feirt N., Quintana-Bustamante O., Segovia J.C., Schwabe R.F., et al. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 2006, 45:429-438.
5. Haudek S.B., Xia Y., Huebener P., Lee J.M., Carlson S., Crawford J.R., et al. Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc Natl Acad Sci U S A 2006, 103:18284-18289.
6. Pilling D., Tucker N.M., Gomer R.H. Aggregated IgG inhibits the differentiation of human fibrocytes. J Leukoc Biol 2006, 79:1242-1251.
7. Schmidt M., Sun G., Stacey M.A., Mori L., Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003, 171:380-389.
8. Chesney J., Bacher M., Bender A., Bucala R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proc Natl Acad Sci U S A 1997, 94:6307-6312.
9. Gordon S., Taylor P.R. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005, 5:953-964.
10. Tacke F., Randolph G.J. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 2006, 211:609-618.
11. Mattoli S. Tissue repair in asthma: the origin of airway subepithelial fibroblasts and myofibroblasts. Tissue repair, contraction and the myofibroblast 2006, 40-46. Landes Bioscience and Springer Science, Business Media, Georgetown, TX, Chapter 4. C. Chaponnier, A. Desmoulière, G. Gabbiani (Eds.).
12. Abe R., Donnelly S.C., Peng T., Bucala R., Metz C.N. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 2001, 166:7556-7562.
13. Gomperts B.N., Strieter R.M. Fibrocytes in lung disease. J Leukoc Biol 2007, 82:449-456.
14. Bellini A., Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007, 87:858-870.
15. Pilling D., Buckley C.D., Salmon M., Gomer R.H. Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol 2003, 171:5537-5546.
16. Moore B.B., Kolodsick J.E., Thannickal V.J., Cooke K., Moore T.A., Hogaboam C., et al. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 2005, 166:675-684.
17. Pilling D., Fan T., Huang D., Kaul B., Gomer R.H. Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS One 2009, 4:e7475.
18. Phillips R.J., Burdick M.D., Hong K., Lutz M.A., Murray L.A., Xue Y.Y., et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004, 114:438-446.
19. Moeller A., Gilpin S.E., Ask K., Cox G., Cook D., Gauldie J., et al. Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009, 179:588-594.
20. Andersson-Sjoland A., de Alba C.G., Nihlberg K., Becerril C., Ramirez R., Pardo A., et al. Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 2008, 40:2129-2140.
21. Keeley E.C., Mehrad B., Strieter R.M. The role of fibrocytes in fibrotic diseases of the lungs and heart. Fibrogenesis Tissue Repair 2011, 4:2.
22. Barnes J.L., Glass W.F. Renal interstitial fibrosis: a critical evaluation of the origin of myofibroblasts. Contrib Nephrol 2011, 169(22):73-93.
23. Peng X., Mathai S.K., Murray L.A., Russell T., Reilkoff R., Chen Q., et al. Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor beta1-induced lung fibrosis. Fibrogenesis & Tissue Repair 2011, 4(1):12. 10.1186/1755-1536-4-12.
24. Okon K., Szumera A., Kuzniewski M. Are CD34+ cells found in renal interstitial fibrosis?. Am J Nephrol 2003, 23:409-414.
25. Moore B.B., Murray L., Das A., Wilke C.A., Herrygers A.B., Toews G.B. The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am J Respir Cell Mol Biol 2006, 35:175-181.
26. Chauhan H., Abraham A., Phillips J.R., Pringle J.H., Walker R.A., Jones J.L. There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions. J Clin Pathol 2003, 56:271-276.
27. Balmelli C., Ruggli N., McCullough K., Summerfield A. Fibrocytes are potent stimulators of anti-virus cytotoxic T cells. J Leukoc Biol 2005, 77:923-933.
28. Pilling D., Vakil V., Gomer R.H. Improved serum-free culture conditions for the differentiation of human and murine fibrocytes. J Immunol Methods 2009, 351:62-70.
29. Frid M.G., Brunetti J.A., Burke D.L., Carpenter T.C., Davie N.J., Reeves J.T., et al. Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol 2006, 168:659-669.
30. Postlethwaite A.E., Shigemitsu H., Kanangat S. Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis. Curr Opin Rheumatol 2004, 16:733-738.
31. Strieter R.M., Gomperts B.N., Keane M.P. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 2007, 117:549-556.
32. Galan A., Cowper S.E., Bucala R. Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy). Curr Opin Rheumatol 2006, 18:614-617.
33. Nihlberg K., Larsen K., Hultgardh-Nilsson A., Malmstrom A., Bjermer L., Westergren-Thorsson G. Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?. Respir Res 2006, 7:50.
34. Iwano M., Plieth D., Danoff T.M., Xue C., Okada H., Neilson E.G. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002, 110:341-350.
35. Strieter R.M., Keeley E.C., Hughes M.A., Burdick M.D., Mehrad B. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol 2009, 86:1111-1118.
36. Zhang K., Rekhter M.D., Gordon D., Phan S.H. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol 1994, 145:114-125.
37. Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993, 122:103-111.
38. Mattey D.L., Dawes P.T., Nixon N.B., Slater H. Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor. Ann Rheum Dis 1997, 56:426-431.
39. Metz C.N. Fibrocytes: a unique cell population implicated in wound healing. Cell Mol Life Sci 2003, 60:1342-1350.
40. Kalluri R., Neilson E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003, 112:1776-1784.
41. Mehrad B., Burdick M.D., Zisman D.A., Keane M.P., Belperio J.A., Strieter R.M. Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun 2007, 353:104-108.
42. Yang L., Scott P.G., Dodd C., Medina A., Jiao H., Shankowsky H.A., et al. Identification of fibrocytes in postburn hypertrophic scar. Wound Repair Regen 2005, 13:398-404.
43. Chesney J., Metz C., Stavitsky A.B., Bacher M., Bucala R. Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J Immunol 1998, 160:419-425.
44. Hartlapp I., Abe R., Saeed R.W., Peng T., Voelter W., Bucala R., et al. Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. FASEB J 2001, 15:2215-2224.
45. Quan T.E., Cowper S., Wu S.P., Bockenstedt L.K., Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 2004, 36:598-606.
46. Quan T.E., Cowper S.E., Bucala R. The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep 2006, 8:145-150.
47. Wang J.F., Jiao H., Stewart T.L., Shankowsky H.A., Scott P.G., Tredget E.E. Fibrocytes from burn patients regulate the activities of fibroblasts. Wound Repair Regen 2007, 15:113-121.
48. Hashimoto N., Jin H., Liu T., Chensue S.W., Phan S.H. Bone marrow- derived progenitor cells in pulmonary fibrosis. J Clin Invest 2004, 113(2):243-252. 10.1172/JCI18847.
49. Lama V.N., Phan S.H. The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond. Proc Am Thorac Soc 2006, 3(4):373-376. 10.1513/pats.200512-133TK.
50. Durieu I., Peyrol S., Gindre D., Bellon G., Durand D.V., Pacheco Y. Subepithelial fibrosis and degradation of the bronchial extracellular matrix in cystic fibrosis. Am J Respir Crit Care Med 1998, 158:580-588.
51. Selman M., Pardo A., Richeldi L., Cerri S. Emerging drugs for idiopathic pulmonary fibrosis. Expert Opin Emerg Drugs 2011.
52. Saunders R., Siddiqui S., Kaur D., Doe C., Sutcliffe A., Hollins F., et al. Fibrocyte localization to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol 2009, 123:376-384.
53. Burke D.L., Frid M.G., Kunrath C.L., Karoor V., Anwar A., Wagner B.D., et al. Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Am J Physiol Lung Cell Mol Physiol 2009, 297:L238-L250.
54. Stenmark K.R., Frid M.G., Yeager M.E. Fibrocytes: potential new therapeutic targets for pulmonary hypertension?. Eur Respir J 2010, 36:1232-1235.
55. Nikam V.S., Schermuly R.T., Dumitrascu R., Weissmann N., Kwapiszewska G., Morrell N., et al. Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension. Eur Respir J 2010, 36:1302-1314.
56. Mathai S.K., Gulati M., Peng X., Russell T.R., Shaw A.C., Rubinowitz A.N., et al. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Lab Invest 2010, 90:812-823.
57. Quesnel C., Nardelli L., Piednoir P., Lecon V., Marchal-Somme J., Lasocki S., et al. Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance. Eur Respir J 2010, 35(6):1312-1321. 10.1183/09031936.00074709.
58. Aiba S., Tabata N., Ohtani H., Tagami H. CD34+ spindle-shaped cells selectively disappear from the skin lesion of scleroderma. Arch Dermatol 1994 May, 130(5):593-597.