메뉴 건너뛰기




Volumn , Issue , 2013, Pages 193-216

Lowering the sirna delivery barrier: Alginate scaffolds and immune stimulation

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84881685682     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.4032/9789814411059     Document Type: Chapter
Times cited : (2)

References (78)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A., et al., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 1998. 391(6669): pp. 806-811.
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1
  • 2
    • 67649865399 scopus 로고    scopus 로고
    • The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
    • Gao, S., et al., The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. Mol Ther, 2009. 17(7): pp. 1225-1233.
    • (2009) Mol Ther , vol.17 , Issue.7 , pp. 1225-1233
    • Gao, S.1
  • 3
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek, J., et al., Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature, 2004. 432 (7014): pp. 173-178.
    • (2004) Nature , vol.432 , Issue.7014 , pp. 173-178
    • Soutschek, J.1
  • 4
    • 52049090811 scopus 로고    scopus 로고
    • Chemically modified siRNA: tools and applications
    • Watts, J.K., G.F. Deleavey, and M.J. Damha, Chemically modified siRNA: tools and applications. Drug Discov Today, 2008. 13(19-20): pp. 842-855.
    • (2008) Drug Discov Today , vol.13 , Issue.19-20 , pp. 842-855
    • Watts, J.K.1    Deleavey, G.F.2    Damha, M.J.3
  • 5
    • 52449107112 scopus 로고    scopus 로고
    • Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
    • Yuan, H., et al., Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes. Am J Physiol Renal Physiol, 2008. 295(2): pp. F605-617.
    • (2008) Am J Physiol Renal Physiol , vol.295 , Issue.2
    • Yuan, H.1
  • 6
    • 33747031960 scopus 로고    scopus 로고
    • Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
    • McNamara, J.O., 2nd, et al., Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol, 2006. 24(8): pp. 1005-1015.
    • (2006) Nat Biotechnol , vol.24 , Issue.8 , pp. 1005-1015
    • McNamara, J.O.1
  • 7
    • 70449089802 scopus 로고    scopus 로고
    • Strategies for targeted nonviral delivery of siRNAs in vivo
    • Kim, S.S., et al., Strategies for targeted nonviral delivery of siRNAs in vivo. Trends Mol Med, 2009. 15(11): pp. 491-500.
    • (2009) Trends Mol Med , vol.15 , Issue.11 , pp. 491-500
    • Kim, S.S.1
  • 8
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: delivery of a biologically active protein into the mouse
    • Schwarze, S.R., et al., In vivo protein transduction: delivery of a biologically active protein into the mouse. Science, 1999. 285(5433): pp. 1569-1572.
    • (1999) Science , vol.285 , Issue.5433 , pp. 1569-1572
    • Schwarze, S.R.1
  • 9
    • 0035902477 scopus 로고    scopus 로고
    • TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
    • Torchilin, V.P., et al., TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci USA, 2001. 98(15): pp. 8786-8791.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.15 , pp. 8786-8791
    • Torchilin, V.P.1
  • 10
    • 34447114618 scopus 로고    scopus 로고
    • Transvascular delivery of small interfering RNA to the central nervous system
    • Kumar, P., et al., Transvascular delivery of small interfering RNA to the central nervous system. Nature, 2007. 448(7149): pp. 39-43.
    • (2007) Nature , vol.448 , Issue.7149 , pp. 39-43
    • Kumar, P.1
  • 11
    • 34648834877 scopus 로고    scopus 로고
    • Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity
    • Moschos, S.A., et al., Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. Bioconjug Chem, 2007. 18(5): pp. 1450-1459.
    • (2007) Bioconjug Chem , vol.18 , Issue.5 , pp. 1450-1459
    • Moschos, S.A.1
  • 12
    • 77952742068 scopus 로고    scopus 로고
    • Enhanced siRNA delivery using cationic liposomes with new polyarginine-conjugated PEG-lipid
    • Kim, H.K., et al., Enhanced siRNA delivery using cationic liposomes with new polyarginine-conjugated PEG-lipid. Int J Pharm, 2010. 392(1-2): pp. 141-147.
    • (2010) Int J Pharm , vol.392 , Issue.1-2 , pp. 141-147
    • Kim, H.K.1
  • 13
    • 24644489197 scopus 로고    scopus 로고
    • Lipid-protamine-DNA-mediated antigen delivery
    • Vangasseri, D.P., S.J. Han, and L. Huang, Lipid-protamine-DNA-mediated antigen delivery. Curr Drug Deliv, 2005. 2(4): pp. 401-406.
    • (2005) Curr Drug Deliv , vol.2 , Issue.4 , pp. 401-406
    • Vangasseri, D.P.1    Han, S.J.2    Huang, L.3
  • 14
    • 67249096677 scopus 로고    scopus 로고
    • Nonviral methods for siRNA delivery
    • Gao, K., and L. Huang, Nonviral methods for siRNA delivery. Mol Pharm, 2009. 6(3): pp. 651-658.
    • (2009) Mol Pharm , vol.6 , Issue.3 , pp. 651-658
    • Gao, K.1    Huang, L.2
  • 15
    • 42549142820 scopus 로고    scopus 로고
    • Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA
    • Li, S.D., S. Chono, and L. Huang, Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol Ther, 2008. 16(5): pp. 942-946.
    • (2008) Mol Ther , vol.16 , Issue.5 , pp. 942-946
    • Li, S.D.1    Chono, S.2    Huang, L.3
  • 16
    • 34248228071 scopus 로고    scopus 로고
    • Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system
    • Pirollo, K.F., et al., Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. Cancer Res, 2007. 67(7): pp. 2938-2943.
    • (2007) Cancer Res , vol.67 , Issue.7 , pp. 2938-2943
    • Pirollo, K.F.1
  • 17
    • 39749099838 scopus 로고    scopus 로고
    • Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine
    • Shim, M.S., and Y.J. Kwon, Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules, 2008. 9(2): pp. 444-455.
    • (2008) Biomacromolecules , vol.9 , Issue.2 , pp. 444-455
    • Shim, M.S.1    Kwon, Y.J.2
  • 18
    • 17644418754 scopus 로고    scopus 로고
    • Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
    • Thomas, M., et al., Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci USA, 2005. 102(16): pp. 5679-5684.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.16 , pp. 5679-5684
    • Thomas, M.1
  • 19
    • 11844283922 scopus 로고    scopus 로고
    • Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat
    • Tan, P.H., et al., Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat. Gene Ther, 2005. 12(1): pp. 59-66.
    • (2005) Gene Ther , vol.12 , Issue.1 , pp. 59-66
    • Tan, P.H.1
  • 20
    • 33646356236 scopus 로고    scopus 로고
    • Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells
    • Guo, S., F. Huang, and P. Guo, Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells. Gene Ther, 2006. 13(10): pp. 814-820.
    • (2006) Gene Ther , vol.13 , Issue.10 , pp. 814-820
    • Guo, S.1    Huang, F.2    Guo, P.3
  • 21
    • 62649108009 scopus 로고    scopus 로고
    • Formulation and delivery of siRNA by oleic acid and stearic acid modified polyethylenimine
    • Alshamsan, A., et al., Formulation and delivery of siRNA by oleic acid and stearic acid modified polyethylenimine. Mol Pharm, 2009. 6(1): pp. 121-133.
    • (2009) Mol Pharm , vol.6 , Issue.1 , pp. 121-133
    • Alshamsan, A.1
  • 22
    • 47749100430 scopus 로고    scopus 로고
    • Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity
    • Zintchenko, A., et al., Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjug Chem, 2008. 19(7): pp. 1448-1455.
    • (2008) Bioconjug Chem , vol.19 , Issue.7 , pp. 1448-1455
    • Zintchenko, A.1
  • 23
    • 58149215702 scopus 로고    scopus 로고
    • Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    • Howard, K.A., et al., Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther, 2009. 17(1): pp. 162-168.
    • (2009) Mol Ther , vol.17 , Issue.1 , pp. 162-168
    • Howard, K.A.1
  • 24
    • 77957858210 scopus 로고    scopus 로고
    • Intraperitoneal administration of chitosan/dsiRNA nanoparticles targeting TNFalpha prevents radiation-induced fibrosis
    • Nawroth, I., et al., Intraperitoneal administration of chitosan/dsiRNA nanoparticles targeting TNFalpha prevents radiation-induced fibrosis. Radiother Oncol, 2010. 97(1): pp. 143-148.
    • (2010) Radiother Oncol , vol.97 , Issue.1 , pp. 143-148
    • Nawroth, I.1
  • 25
    • 33748054817 scopus 로고    scopus 로고
    • RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system
    • Howard, K.A., et al., RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol Ther, 2006. 14(4): pp. 476-484.
    • (2006) Mol Ther , vol.14 , Issue.4 , pp. 476-484
    • Howard, K.A.1
  • 26
    • 13444252624 scopus 로고    scopus 로고
    • Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene
    • Zhang, W., et al., Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat Med, 2005. 11(1): pp. 56-62.
    • (2005) Nat Med , vol.11 , Issue.1 , pp. 56-62
    • Zhang, W.1
  • 27
    • 77952043572 scopus 로고    scopus 로고
    • RNAi-based therapeutics-current status, challenges and prospects
    • Tiemann, K., and J.J. Rossi, RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med, 2009. 1(3): pp. 142-151.
    • (2009) EMBO Mol Med , vol.1 , Issue.3 , pp. 142-151
    • Tiemann, K.1    Rossi, J.J.2
  • 28
    • 60049089373 scopus 로고    scopus 로고
    • Development of a novel method for formulating stable siRNA-loaded lipid particles for in vivo use
    • Wu, S.Y., et al., Development of a novel method for formulating stable siRNA-loaded lipid particles for in vivo use. Pharm Res, 2009. 26(3): pp. 512-522.
    • (2009) Pharm Res , vol.26 , Issue.3 , pp. 512-522
    • Wu, S.Y.1
  • 29
    • 33746913567 scopus 로고    scopus 로고
    • Engineering mucosal RNA interference in vivo
    • Zhang, Y., et al., Engineering mucosal RNA interference in vivo. Mol Ther, 2006. 14(3): pp. 336-342.
    • (2006) Mol Ther , vol.14 , Issue.3 , pp. 336-342
    • Zhang, Y.1
  • 30
    • 0032938324 scopus 로고    scopus 로고
    • PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
    • Ogris, M., et al., PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther, 1999. 6(4): pp. 595-605.
    • (1999) Gene Ther , vol.6 , Issue.4 , pp. 595-605
    • Ogris, M.1
  • 31
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • Akinc, A., et al., A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol, 2008. 26(5): pp. 561-569.
    • (2008) Nat Biotechnol , vol.26 , Issue.5 , pp. 561-569
    • Akinc, A.1
  • 32
    • 65649085603 scopus 로고    scopus 로고
    • Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
    • Judge, A.D., et al., Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest, 2009. 119(3): pp. 661-673.
    • (2009) J Clin Invest , vol.119 , Issue.3 , pp. 661-673
    • Judge, A.D.1
  • 33
    • 33750417183 scopus 로고    scopus 로고
    • Targeted delivery of antisense oligodeoxynuc-leotide and small interference RNA into lung cancer cells
    • Li, S.D., and L. Huang, Targeted delivery of antisense oligodeoxynuc-leotide and small interference RNA into lung cancer cells. Mol Pharm, 2006. 3(5): pp. 579-588.
    • (2006) Mol Pharm , vol.3 , Issue.5 , pp. 579-588
    • Li, S.D.1    Huang, L.2
  • 34
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura, Y., and H. Maeda, A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res, 1986. 46(12 Pt 1): pp. 6387-6392.
    • (1986) Cancer Res , vol.46 , Issue.12 PT 1 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 35
    • 17644390607 scopus 로고    scopus 로고
    • A scalable, extrusion-free method for efficient liposomal encapsulation of plasmid DNA
    • Jeffs, L.B., et al., A scalable, extrusion-free method for efficient liposomal encapsulation of plasmid DNA. Pharm Res, 2005. 22(3): pp. 362-372.
    • (2005) Pharm Res , vol.22 , Issue.3 , pp. 362-372
    • Jeffs, L.B.1
  • 36
    • 5444231272 scopus 로고    scopus 로고
    • A sterically stabilized immunolipoplex for systemic administration of a therapeutic gene
    • Yu, W., et al., A sterically stabilized immunolipoplex for systemic administration of a therapeutic gene. Gene Ther, 2004. 11(19): pp. 1434-1440.
    • (2004) Gene Ther , vol.11 , Issue.19 , pp. 1434-1440
    • Yu, W.1
  • 37
    • 23444445660 scopus 로고    scopus 로고
    • Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
    • Morrissey, D.V., et al., Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol, 2005. 23(8): pp. 1002-1007.
    • (2005) Nat Biotechnol , vol.23 , Issue.8 , pp. 1002-1007
    • Morrissey, D.V.1
  • 38
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann, T.S., et al., RNAi-mediated gene silencing in non-human primates. Nature, 2006. 441(7089): pp. 111-114.
    • (2006) Nature , vol.441 , Issue.7089 , pp. 111-114
    • Zimmermann, T.S.1
  • 39
    • 77952680862 scopus 로고    scopus 로고
    • Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study
    • Geisbert, T.W., et al., Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study. Lancet, 2010. 375(9729): pp. 1896-1905.
    • (2010) Lancet , vol.375 , Issue.9729 , pp. 1896-1905
    • Geisbert, T.W.1
  • 40
    • 71549144082 scopus 로고    scopus 로고
    • Chapter 17 - Engineering cationic liposome siRNA complexes for in vitro and in vivo delivery
    • Podesta, J.E., and K. Kostarelos, Chapter 17 - Engineering cationic liposome siRNA complexes for in vitro and in vivo delivery. Methods Enzymol, 2009. 464: pp. 343-354.
    • (2009) Methods Enzymol , vol.464 , pp. 343-354
    • Podesta, J.E.1    Kostarelos, K.2
  • 41
    • 66149145277 scopus 로고    scopus 로고
    • Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes
    • Buyens, K., et al., Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes. Langmuir, 2009. 25(9): pp. 4886-4891.
    • (2009) Langmuir , vol.25 , Issue.9 , pp. 4886-4891
    • Buyens, K.1
  • 42
    • 0034815482 scopus 로고    scopus 로고
    • Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes
    • Shi, N., R.J. Boado, and W.M. Pardridge, Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes. Pharm Res, 2001. 18(8): pp. 1091-1095.
    • (2001) Pharm Res , vol.18 , Issue.8 , pp. 1091-1095
    • Shi, N.1    Boado, R.J.2    Pardridge, W.M.3
  • 43
    • 0035039280 scopus 로고    scopus 로고
    • Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes
    • Maurer, N., et al., Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes. Biophys J, 2001. 80(5): pp. 2310-2326.
    • (2001) Biophys J , vol.80 , Issue.5 , pp. 2310-2326
    • Maurer, N.1
  • 44
    • 0033977066 scopus 로고    scopus 로고
    • A new liposomal formulation for antisense oligodeoxynucleotides with small size, high incorporation efficiency and good stability
    • Stuart, D.D., and T.M. Allen, A new liposomal formulation for antisense oligodeoxynucleotides with small size, high incorporation efficiency and good stability. Biochim Biophys Acta, 2000. 1463(2): pp. 219-229.
    • (2000) Biochim Biophys Acta , vol.1463 , Issue.2 , pp. 219-229
    • Stuart, D.D.1    Allen, T.M.2
  • 45
    • 78650997059 scopus 로고    scopus 로고
    • Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models
    • Wu, S.Y., et al., Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models. Gene Ther, 2011. 18(1): pp. 14-22.
    • (2011) Gene Ther , vol.18 , Issue.1 , pp. 14-22
    • Wu, S.Y.1
  • 46
    • 30644464212 scopus 로고    scopus 로고
    • RNAi tackles a sexually transmitted disease
    • Cristofaro, P., and B. Ramratnam, RNAi tackles a sexually transmitted disease. Nat Biotechnol, 2006. 24(1): pp. 48-49.
    • (2006) Nat Biotechnol , vol.24 , Issue.1 , pp. 48-49
    • Cristofaro, P.1    Ramratnam, B.2
  • 47
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone, R.A., Barrier properties of mucus. Adv Drug Deliv Rev, 2009. 61(2): pp. 75-85.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.2 , pp. 75-85
    • Cone, R.A.1
  • 48
    • 47049118557 scopus 로고    scopus 로고
    • Effects of menstrual cycle on gene transfection through mouse vagina for DNA vaccine
    • Kanazawa, T., et al., Effects of menstrual cycle on gene transfection through mouse vagina for DNA vaccine. Int J Pharm, 2008. 360(1-2): pp. 164-170.
    • (2008) Int J Pharm , vol.360 , Issue.1-2 , pp. 164-170
    • Kanazawa, T.1
  • 49
    • 30144434185 scopus 로고    scopus 로고
    • An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
    • Palliser, D., et al., An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature, 2006. 439(7072): pp. 89-94.
    • (2006) Nature , vol.439 , Issue.7072 , pp. 89-94
    • Palliser, D.1
  • 50
    • 58249094519 scopus 로고    scopus 로고
    • Durable protection from herpes simplex virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene
    • Wu, Y., et al., Durable protection from herpes simplex virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe, 2009. 5(1): pp. 84-94.
    • (2009) Cell Host Microbe , vol.5 , Issue.1 , pp. 84-94
    • Wu, Y.1
  • 51
    • 66249083866 scopus 로고    scopus 로고
    • Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
    • Woodrow, K.A., et al., Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater, 2009. 8(6): pp. 526-533.
    • (2009) Nat Mater , vol.8 , Issue.6 , pp. 526-533
    • Woodrow, K.A.1
  • 52
    • 80054692841 scopus 로고    scopus 로고
    • Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system
    • Wu, S.Y., et al., Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system. J Control Release, 2011. 155(3): pp. 418-426.
    • (2011) J Control Release , vol.155 , Issue.3 , pp. 418-426
    • Wu, S.Y.1
  • 53
    • 0036150902 scopus 로고    scopus 로고
    • Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
    • Khanna, K.V., et al., Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest, 2002. 109(2): pp. 205-211.
    • (2002) J Clin Invest , vol.109 , Issue.2 , pp. 205-211
    • Khanna, K.V.1
  • 54
    • 0141682084 scopus 로고    scopus 로고
    • Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2
    • Gillgrass, A.E., et al., Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J Virol, 2003. 77(18): pp. 9845-9851.
    • (2003) J Virol , vol.77 , Issue.18 , pp. 9845-9851
    • Gillgrass, A.E.1
  • 55
    • 0037384980 scopus 로고    scopus 로고
    • Progesterone increases susceptibility and decreases immune responses to genital herpes infection
    • Kaushic, C., et al., Progesterone increases susceptibility and decreases immune responses to genital herpes infection. J Virol, 2003. 77(8): pp. 4558-4565.
    • (2003) J Virol , vol.77 , Issue.8 , pp. 4558-4565
    • Kaushic, C.1
  • 56
    • 57149131570 scopus 로고    scopus 로고
    • Nanoparticles as protein and gene carriers to mucosal surfaces
    • de la Fuente, M., et al., Nanoparticles as protein and gene carriers to mucosal surfaces. Nanomedicine (Lond), 2008. 3(6): pp. 845-857.
    • (2008) Nanomedicine (Lond) , vol.3 , Issue.6 , pp. 845-857
    • de la Fuente, M.1
  • 57
    • 0034666728 scopus 로고    scopus 로고
    • Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response
    • Mittal, S.K., et al., Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine, 2000. 19(2-3): pp. 253-263.
    • (2000) Vaccine , vol.19 , Issue.2-3 , pp. 253-263
    • Mittal, S.K.1
  • 58
    • 67649948772 scopus 로고    scopus 로고
    • Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels
    • Krebs, M.D., O. Jeon, and E. Alsberg, Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels. J Am Chem Soc, 2009. 131(26): pp. 9204-9206.
    • (2009) J Am Chem Soc , vol.131 , Issue.26 , pp. 9204-9206
    • Krebs, M.D.1    Jeon, O.2    Alsberg, E.3
  • 59
    • 0032788329 scopus 로고    scopus 로고
    • Compressive and shear properties of alginate gel: effects of sodium ions and alginate concentration
    • LeRoux, M.A., F. Guilak, and L.A. Setton, Compressive and shear properties of alginate gel: effects of sodium ions and alginate concentration. J Biomed Mater Res, 1999. 47(1): pp. 46-53.
    • (1999) J Biomed Mater Res , vol.47 , Issue.1 , pp. 46-53
    • LeRoux, M.A.1    Guilak, F.2    Setton, L.A.3
  • 60
    • 33746198092 scopus 로고    scopus 로고
    • Nonviral gene delivery from nonwoven fibrous scaffolds fabricated by interfacial complexation of polyelectrolytes
    • Lim, S.H., I.C. Liao, and K.W. Leong, Nonviral gene delivery from nonwoven fibrous scaffolds fabricated by interfacial complexation of polyelectrolytes. Mol Ther, 2006. 13(6): pp. 1163-1172.
    • (2006) Mol Ther , vol.13 , Issue.6 , pp. 1163-1172
    • Lim, S.H.1    Liao, I.C.2    Leong, K.W.3
  • 61
    • 53449092024 scopus 로고    scopus 로고
    • Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex
    • Hong, H.J., et al., Accelerated wound healing by smad3 antisense oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex. Biomaterials, 2008. 29(36): pp. 4831-4837.
    • (2008) Biomaterials , vol.29 , Issue.36 , pp. 4831-4837
    • Hong, H.J.1
  • 62
    • 33748208710 scopus 로고    scopus 로고
    • PEI-alginate nanocomposites as efficient in vitro gene transfection agents
    • Patnaik, S., et al., PEI-alginate nanocomposites as efficient in vitro gene transfection agents. J Control Release, 2006. 114(3): pp. 398-409.
    • (2006) J Control Release , vol.114 , Issue.3 , pp. 398-409
    • Patnaik, S.1
  • 63
    • 0347626104 scopus 로고    scopus 로고
    • Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer
    • Brake, T., et al., Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res, 2003. 63(23): pp. 8173-8180.
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 8173-8180
    • Brake, T.1
  • 64
    • 58049202272 scopus 로고    scopus 로고
    • Innate immunity to virus infection
    • Takeuchi, O., and S. Akira, Innate immunity to virus infection. Immunol Rev, 2009. 227(1): pp. 75-86.
    • (2009) Immunol Rev , vol.227 , Issue.1 , pp. 75-86
    • Takeuchi, O.1    Akira, S.2
  • 65
    • 27944459341 scopus 로고    scopus 로고
    • Activation of the mammalian immune system by siRNAs
    • Marques, J.T., and B.R. Williams, Activation of the mammalian immune system by siRNAs. Nat Biotechnol, 2005. 23(11): pp. 1399-1405.
    • (2005) Nat Biotechnol , vol.23 , Issue.11 , pp. 1399-1405
    • Marques, J.T.1    Williams, B.R.2
  • 66
    • 0030664277 scopus 로고    scopus 로고
    • PKR-a protein kinase regulated by double-stranded RNA
    • Clemens, M.J., PKR-a protein kinase regulated by double-stranded RNA. Int J Biochem Cell Biol, 1997. 29(7): pp. 945-949.
    • (1997) Int J Biochem Cell Biol , vol.29 , Issue.7 , pp. 945-949
    • Clemens, M.J.1
  • 67
    • 33750976374 scopus 로고    scopus 로고
    • 5'-Triphosphate RNA is the ligand for RIG-I
    • Hornung, V., et al., 5'-Triphosphate RNA is the ligand for RIG-I. Science, 2006. 314(5801): pp. 994-997.
    • (2006) Science , vol.314 , Issue.5801 , pp. 994-997
    • Hornung, V.1
  • 68
    • 54949095836 scopus 로고    scopus 로고
    • Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
    • Robbins, M., et al., Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Human Gene Ther, 2008. 19(10): pp. 991-999.
    • (2008) Human Gene Ther , vol.19 , Issue.10 , pp. 991-999
    • Robbins, M.1
  • 69
    • 15444376742 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo
    • Flynn, M.A., et al., Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. J Inflamm (Lond), 2004. 1(1): p. 4.
    • (2004) J Inflamm (Lond) , vol.1 , Issue.1 , pp. 4
    • Flynn, M.A.1
  • 70
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • Ge, Q., et al., Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci USA, 2004. 101(23): pp. 8676-8681.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.23 , pp. 8676-8681
    • Ge, Q.1
  • 71
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song, E., et al., Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol, 2005. 23(6): pp. 709-717.
    • (2005) Nat Biotechnol , vol.23 , Issue.6 , pp. 709-717
    • Song, E.1
  • 72
    • 2942620143 scopus 로고    scopus 로고
    • Protection against lethal influenza virus challenge by RNA interference in vivo
    • Tompkins, S.M., et al., Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci USA, 2004. 101(23): pp. 8682-8686.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.23 , pp. 8682-8686
    • Tompkins, S.M.1
  • 73
    • 33845298010 scopus 로고    scopus 로고
    • Design of bifunctional siRNAs: combining immunostimulation and gene-silencing in one single siRNA molecule
    • Furset, G., and M. Sioud, Design of bifunctional siRNAs: combining immunostimulation and gene-silencing in one single siRNA molecule. Biochem Biophys Res Commun, 2007. 352(3): pp. 642-649.
    • (2007) Biochem Biophys Res Commun , vol.352 , Issue.3 , pp. 642-649
    • Furset, G.1    Sioud, M.2
  • 74
    • 69949168026 scopus 로고    scopus 로고
    • Drug delivery-mediated control of RNA immunostimulation
    • Nguyen, D.N., et al., Drug delivery-mediated control of RNA immunostimulation. Mol Ther, 2009. 17(9): pp. 1555-1562.
    • (2009) Mol Ther , vol.17 , Issue.9 , pp. 1555-1562
    • Nguyen, D.N.1
  • 75
    • 76249117467 scopus 로고    scopus 로고
    • Immunostimulatory RNA blocks suppression by regulatory T cells
    • Anz, D., et al., Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol, 2010. 184(2): pp. 939-946.
    • (2010) J Immunol , vol.184 , Issue.2 , pp. 939-946
    • Anz, D.1
  • 76
    • 55549114663 scopus 로고    scopus 로고
    • 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
    • Poeck, H., et al., 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med, 2008. 14(11): pp. 1256-1263.
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1256-1263
    • Poeck, H.1
  • 77
    • 70349971417 scopus 로고    scopus 로고
    • In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
    • Kortylewski, M., et al., In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol, 2009. 27(10): pp. 925-932.
    • (2009) Nat Biotechnol , vol.27 , Issue.10 , pp. 925-932
    • Kortylewski, M.1
  • 78
    • 84857033446 scopus 로고    scopus 로고
    • siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo
    • Khairuddin, N., et al., siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunol Cell Biol, 2012. 90(2): pp. 187-196.
    • (2012) Immunol Cell Biol , vol.90 , Issue.2 , pp. 187-196
    • Khairuddin, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.