Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat

Gene Therapy

Volumn 12, Issue 1, 2005, Pages 59-66

  Tan, P H ^a,b   Yang, L C ^b   Shih, H C ^c   Lan, K C ^d   Cheng, J T ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c CHIA YI CHRISTIAN HOSPITAL   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Antinociception; Formalin pain; Gene knockdown; Intrathecal; N methyl D aspartate receptor; Small interfering RNA

Indexed keywords

DOUBLE STRANDED RNA; FORMALDEHYDE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POLYETHYLENEIMINE; SMALL INTERFERING RNA;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG TARGETING; FEASIBILITY STUDY; GENE EXPRESSION; KNOCKOUT GENE; MALE; NOCICEPTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

ANIMALS; FORMALDEHYDE; GENE SILENCING; GENE THERAPY; GREEN FLUORESCENT PROTEINS; MALE; NOCICEPTORS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SPINAL CORD;

ANIMALIA;

EID: 11844283922     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302376     Document Type: Article

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