Progesterone increases susceptibility and decreases immune responses to genital herpes infection

Journal of Virology

Volumn 77, Issue 8, 2003, Pages 4558-4565

  Kaushic, Charu ^a,b   Ashkar, Ali A ^a   Reid, Lesley A ^a   Rosenthal, Kenneth L ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MEDROXYPROGESTERONE ACETATE; PROGESTERONE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIESTRUS; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; IMMUNE RESPONSE; IMMUNIZATION; INFECTION SENSITIVITY; MOUSE; NONHUMAN; OVARY CYCLE; PRIORITY JOURNAL; VIRUS ATTENUATION; WILD TYPE;

ANIMALS; ANTIBODIES, VIRAL; DISEASE SUSCEPTIBILITY; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HERPESVIRUS VACCINES; IMMUNITY; MEDROXYPROGESTERONE 17-ACETATE; MICE; MICE, INBRED C57BL; PROGESTERONE; REPRODUCTION; VACCINES, ATTENUATED; VAGINA; VAGINAL DISEASES; VIRAL ENVELOPE PROTEINS;

EID: 0037384980     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.8.4558-4565.2003     Document Type: Article

References (23)

1. Gallichan, W. S., T. Gurasachi, and K. L. Rosenthal. 2001. Intranasal immunization with CpG oligonucleotides as an adjuvant dramatically increases IgA and protection against HSV-2 in the genital tract. J. Immunol. 166:3451-3457.
2. Gallichan, W. S., and K. L. Rosenthal. 1996. Effects of the estrous cycle on local humoral immune responses and protection of intranasally immunized female mice against herpes simplex virus type 2 infection in the genital tract. Virology 224:487-497.
3. Gallichan, W. S., and K. L. Rosenthal. 1996. Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization. J. Exp. Med. 184:1879-1890.
4. Gallichan, W. S., and K. L. Rosenthal. 1998. Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization. J. Infect. Dis. 177:1155-1161.
5. Kaushic, C., E. Frauendorf, R. M. Rossoll, J. M. Richardson, and C. R. Wira. 1998. Influence of estrous cycle on the presence and distribution of immune cells in the rat reproductive tract. Am. J. Reprod. Immunol. 39: 209-216.
6. Kaushic, C., E. Frauendorf, and C. R. Wira. 1997. Polymeric immunoglobulin A receptor in the rodent reproductive tract: influence of estradiol in the vagina and differential expression of messenger ribonucleic acid expression in rodent uteri. Biol. Reprod. 57:958-966.
7. Kaushic, C., J. M. Richardson, and C. R. Wira. 1995. Regulation of polymeric immunoglobulin A receptor messenger ribonucleic acid expression in rodent uteri: effect of sex hormones. Endocrinology 136:2836-2844.
8. Kaushic, C., F. Zhou, A. D. Murdin, and C. R. Wira. 2000. Effect of estradiol and progesterone on susceptibility and immune responses to Chlamydia trachomatis infection in the female reproductive tract. Infec. Immun. 68: 4207-4216.
9. Kuklin, N. A., M. Daheshia, S. Chun, and B. T. Rouse. 1998. Role of mucosal immunity in herpes simplex virus infection. J. Immunol. 160:5998-6003.
10. Lamm, M. E., J. G. Nedrud, C. S. Kaetzel, and M. B. Mazanec. 1995. IgA and mucosal defense. APMIS 103:241-246.
11. Martin, H. L., Jr., P. M. Nyange, B. A. Richardson, L. Lavreys, K. Mandaliya, D. J. Jackson, J. O. Ndinya-Achola, and J. Kreiss. 1998. Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1. J. Infect. Dis. 178:1053-1059.
12. Marx, P. A., A. I. Spira, A. Gettie, et al. 1996. Progesterone implants enhance SIV vaginal transmission and early virus load. Nat. Med. 2:1084-1089.
13. McDermott, M. R., B. J. Smiley, L. J. Brias, et al. 1984. Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated stain of herpes simplex virus. J. Virol. 51:247-253.
14. Milligan, G. N., and D. I. Bernstein. 1995. Analysis of herpes specific T-cells in the murine female genital tract following genital infection with herpes virus type 2. Virology 212:481-489.
15. Parr, M. B., L. Kepple, M. R. McDermott, M. D. Drew, J. J. Bozzola, and E. L. Parr. 1994. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab. Investig. 70:369-380.
16. Smith, S. M., G. B. Baskin, and P. A. Marx. 2000. Estrogen protects against vaginal transmission of simian immunodeficiency virus. J. Infect. Dis. 182: 708-715.
17. Teepe, A. G., L. B. Allen, R. J. Wordinger, and E. F. Harris. 1990. Effect of the estrous cycle on susceptibility of female mice to intravaginal inoculation of herpes simplex virus type 2 (HSV-2). Antivir. Res. 14:227-235.
18. White, H. D., K. M. Crassi, A. L. Givan, J. E. Stern, J. L. Gonzales, V. A. Memoli, W. R. Green, and C. R. Wira. 1997. CD3+ CD8+ CTL activity within the human female reproductive tract: influence of stage and menstrual cycle and menopause. J. Immunol. 158:3017-3027.
19. Wira, C. R., and C. Kaushic. 1996. Mucosal immunity in the female reproductive tract: effect of sex hormones on immune recognition and responses, p. 375-386. In H. Kiyono, P. L. Ogra, and J. R. McGhee (ed.), Mucosal vaccines: New trends in immunization. Academic Press, New York, N.Y.
20. Wira, C. R., C. Kaushic, and J. Richardson. 1999. Role of sex hormones and cytokines in regulating mucosal immune system in the female reproductive tract, p. 1449-1461. In by P. L. Ogra, M. E. Lamm, J. Bienenstock, J. Mestecky, W. Strober, and J. R. McGhee (ed.), Mucosal immunology. Academic Press, New York, N.Y.
21. Wira, C. R., and R. M. Rossoll. 1995. Antigen presenting cells in the female reproductive tract: influence of estrous cycle on antigen presentation by uterine epithelial and stromal cells. Endocrinology 136:4526-4534.
22. Wira, C. R., and C. P. Sandoe. 1977. Sex steroid hormone regulation of immunoglobulin G (IgG) and A (IgA) in rat uterine secretions. Nature 268:534-536.
23. Yeaman, G. R., P. M. Guyre, M. W. Fanger, J. E. Collins, et al. 1997. Unique CD8+ T cell rich lymphoid aggregate in human uterine endometrium. J. Leukoc. Biol. 61:427-435.