A scalable, extrusion-free method for efficient liposomal encapsulation of plasmid DNA

Pharmaceutical Research

Volumn 22, Issue 3, 2005, Pages 362-372

  Jeffs, Lloyd B ^a   Palmer, Lorne R ^a   Ambegia, Ellen G ^a   Giesbrecht, Cory ^a   Ewanick, Shannon ^a   MacLachlan, Ian ^a  

^a Protiva Biotherapeutics   (Canada)

Author keywords

DNA; Liposome; Plasmid; Systemic gene delivery

Indexed keywords

1 O [2' (OMEGA METHOXYPOLYETHYLENEGLYCOL) 2000] 2 N ARACHIDOYLSPHINGOSINE; 1,2 DIOLEYLOXY N,N DIMETHYLAMINOPROPANE; 3 O [2' (OMEGA METHOXYPOLYETHYLENEGLYCOL) 2000] 1,2 DISTEAROYLGLYCEROL; ALCOHOL; BUFFER; CATION; CHOLESTEROL; DETERGENT; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DIOLEYLDIMETHYLAMMONIUM CHLORIDE; LIPID; LIPOSOME; OCTYL GLUCOSIDE; PHOSPHATIDYLCHOLINE; PLASMID DNA; SAFRANIN O; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APPARATUS; AQUEOUS SOLUTION; ARTICLE; CIRCULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSIS; DILUTION; DISPERSION; DISSOLUTION; DNA VECTOR; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON MICROSCOPY; ENCAPSULATION; GENE EXPRESSION PROFILING; IN VIVO STUDY; LIPID COMPOSITION; LIPID SOLUBILITY; LIPID VESICLE; LIPOPHILICITY; MALE; MORPHOLOGY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PARTICLE SIZE; PH; PLASMID; PRIORITY JOURNAL; REPRODUCIBILITY; STRUCTURE ANALYSIS; TECHNIQUE; TIME; TUMOR;

ANIMALS; DNA; LIPOSOMES; MICE; PLASMIDS; TECHNOLOGY, PHARMACEUTICAL;

EID: 17644390607     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-1873-z     Document Type: Article

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