Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Rodrigo, Ramón ^a   Libuy, Matías ^a   Feliú, Felipe ^a   Hasson, Daniel ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; ALPHA TOCOPHEROL; ANTIOXIDANT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ASCORBIC ACID; BETA CAROTENE; CARNITINE; CATALASE; DNA; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; MYELOPEROXIDASE; NORPHENAZONE; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RETINOL; SODIUM ASCORBIC ACID COTRANSPORTER; SUPEROXIDE DISMUTASE; UBIDECARENONE; CARDIOTONIC AGENT; VITAMIN;

ACUTE HEART INFARCTION; ANTIOXIDANT ACTIVITY; APOPTOSIS; AUTOPHAGY; BLOOD CLOT LYSIS; CARDIOVASCULAR MORTALITY; CELL DEATH; CELL FUNCTION; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; DRUG MECHANISM; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; INFLAMMATION; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PH; REPERFUSION INJURY; REVIEW; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TREATMENT DURATION; TREATMENT OUTCOME; DRUG EFFECT; HEART INFARCTION; METABOLISM; PATHOLOGY; DRUG EFFECTS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY;

ANTIOXIDANTS; CARDIOTONIC AGENTS; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; VITAMINS;

EID: 84881526977     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/437613     Document Type: Review

References (145)

1. Fox K. A. A., Steg P. G., Eagle K. A., Goodman S. G., Anderson F. A. Jr., Granger C. B., Flather M. D., Budaj A., Quill A., Gore J. M., Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. Journal of the American Medical Association 2007 297 17 1892 1900 2-s2.0-34247854930 10.1001/jama.297.17.1892 (Pubitemid 46707843)
2. Furman M. I., Dauerman H. L., Goldberg R. J., Yarzebski J., Lessard D., Gore J. M., Twenty-two year (1975 to 1997) trends in the incidence, in-hospital and long-term case fatality rates from initial Q-wave and non-Q-wave myocardial infarction: a multi-hospital, community-wide perspective. Journal of the American College of Cardiology 2001 37 6 1571 1580 2-s2.0-0035042270 10.1016/S0735-1097(01)01203-7 (Pubitemid 32385991)
3. Liew R., Sulfi S., Ranjadayalan K., Cooper J., Timmis A. D., Declining case fatality rates for acute myocardial infarction in South Asian and white patients in the past 15 years. Heart 2006 92 8 1030 1034 2-s2.0-33746386747 10.1136/hrt.2005.078634 (Pubitemid 44125208)
4. Mandelzweig L., Battler A., Boyko V., Bueno H., Danchin N., Filippatos G., Gitt A., Hasdai D., Hasin Y., Marrugat J., Van De Werf F., Wallentin L., Behar S., The second euro heart survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. European Heart Journal 2006 27 19 2285 2293 2-s2.0-33749000304 10.1093/eurheartj/ehl196 (Pubitemid 44453571)
5. Maxwell S. R. J., Anti-oxidant therapy: does it have a role in the treatment of human disease? Expert Opinion on Investigational Drugs 1997 6 3 211 236 2-s2.0-0030985636 10.1517/13543784.6.3.211 (Pubitemid 27141790)
6. Hori M., Nishida K., Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovascular Research 2009 81 3 457 464 2-s2.0-59449092492 10.1093/cvr/cvn335
7. Yellon D. M., Hausenloy D. J., Myocardial reperfusion injury. The New England Journal of Medicine 2007 357 11 1074 1135 2-s2.0-34548746306 10.1056/NEJMra071667 (Pubitemid 47443217)
8. Jackson T. S., Xu A., Vita J. A., Keaney J. F. Jr., Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circulation Research 1998 83 9 916 922 2-s2.0-0032476697 (Pubitemid 28503080)
9. Hausenloy D. J., Yellon D. M., Myocardial ischemia-reperfusion injury: a neglected therapeutic target. The Journal of Clinical Investigation 2013 123 92 100
10. Tsovolas K., Iliodromitis E. K., Andreadou I., Zoga A., Demopoulou M., Iliodromitis K. E., Manolaki T., Markantonis S. L., Kremastinos D. T., Acute administration of vitamin C abrogates protection from ischemic preconditioning in rabbits. Pharmacological Research 2008 57 4 283 289 2-s2.0-43049183577 10.1016/j.phrs.2008.02.003
11. Furman M. I., Dauerman H. L., Goldberg R. J., Yarzebski J., Lessard D., Gore J. M., Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate. Puerto Rico Health Sciences Journal 2008 27 1 7 19 2-s2.0-70349956364
12. Padayatty S. J., Sun A. Y., Chen Q., Espey M. G., Drisko J., Levine M., Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS ONE 2010 5 7 2-s2.0-77955349971 10.1371/journal.pone.0011414 e11414
13. Juránek I., Bezek Š., Controversy of free radical hypothesis: reactive oxygen species-cause or consequence of tissue injury. General Physiology and Biophysics 2005 24 3 263 278 2-s2.0-28444477027 (Pubitemid 41723833)
14. Venardos K. M., Perkins A., Headrick J., Kaye D. M., Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review. Current Medicinal Chemistry 2007 14 1539 1549 (Pubitemid 46902214)
15. Rodrigo R., Prieto J. C., Castillo R., Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications. Clinical Science 2013 124 1 15
16. Perron N. R., Brumaghim J. L., A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochemistry and Biophysics 2009 53 2 75 100 2-s2.0-63149091751 10.1007/s12013-009-9043-x
17. Jaxa-Chamiec T., Bednarz B., Drozdowska D., Gessek J., Gniot J., Janik K., Kawka-Urbanek T., Maciejewski P., Ogórek M., Szpajer M., Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot myocardial infarction and VITamins (MIVIT) trial. Kardiologia Polska 2005 62 4 344 350 2-s2.0-18144415000 (Pubitemid 40613064)
18. Jaxa-Chamiec T., Bednarz B., Herbaczynska-Cedro K., Maciejewski P., Ceremuzynski L., Effects of vitamins C and E on the outcome after acute myocardial infarction in diabetics: a retrospective, hypothesis-generating analysis from the MIVIT Study. Cardiology 2009 112 3 219 223 2-s2.0-49049090000 10.1159/000151239
19. Bednarz B., Chamiec T., Ceremuzyńiski L., Antioxidant vitamins decrease exercise-induced QT dispersion after myocardial infarction. Kardiologia Polska 2003 58 5 375 379 2-s2.0-0038683375 (Pubitemid 36735398)
20. Singh R. B., Niaz M. A., Rastogi S. S., Rastogi S., Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian Experiment of Infarct Survival-3). American Journal of Cardiology 1996 77 4 232 236 2-s2.0-0030052161 10.1016/S0002-9149(97)89384-8 (Pubitemid 26059288)
21. Chamiec T., Herbaczyńska-Cedro K., Ceremuzyński L., Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction. The American Journal of Cardiology 1996 77 237 241 (Pubitemid 26059289)
22. Singh R. B., Wander G. S., Rastogi A., Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovascular Drugs and Therapy 1998 12 347 353 (Pubitemid 28479167)
23. Singh R. B., Niaz M. A., Agarwal P., Beegum R., Rastogi S. S., Sachan D. S., A randomised, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. Postgraduate Medical Journal 1996 72 843 45 50 2-s2.0-0030063942 (Pubitemid 26018009)
24. Thiele H., Hildebrand L., Schirdewahn C., Eitel I., Adams V., Fuernau G., Erbs S., Linke A., Diederich K.-W., Nowak M., Desch S., Gutberlet M., Schuler G., Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial. Journal of the American College of Cardiology 2010 55 20 2201 2209 2-s2.0-77951959884 10.1016/j.jacc.2009.08.091
25. Tsujita K., Shimomura H., Kaikita K., Kawano H., Hokamaki J., Nagayoshi Y., Yamashita T., Fukuda M., Nakamura Y., Sakamoto T., Yoshimura M., Ogawa H., Long-term efficacy of edaravone in patients with acute myocardial infarction. Circulation Journal 2006 70 7 832 837 2-s2.0-33745536062 10.1253/circj.70.832 (Pubitemid 43979118)
26. Flaherty J. T., Pitt B., Gruber J. W., Heuser R. R., Rothbaum D. A., Burwell L. R., George B. S., Kereiakes D. J., Deitchman D., Gustafson N., Brinker J. A., Becker L. C., Mancini G. B. J., Topol E., Werns S. W., Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 1994 89 5 1982 1991 2-s2.0-0028314520 (Pubitemid 24142772)
27. Guan W., Osanai T., Kamada T., Hanada H., Ishizaka H., Onodera H., Iwasa A., Fujita N., Kudo S., Ohkubo T., Okumura K., Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction. Journal of Cardiovascular Pharmacology 2003 41 5 699 705 2-s2.0-12444266765 10.1097/00005344-200305000-00005 (Pubitemid 36523171)
28. Yunoki K., Naruko T., Sugioka K., Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: association with oxidative stress and its impact on myocardial reperfusion. European Heart Journal 2012 33 1480 1490
29. Eaton P., Clements-Jewery H., Peroxynitrite: in vivo cardioprotectant or arrhythmogen? British Journal of Pharmacology 2008 155 7 972 973 2-s2.0-56749154433 10.1038/bjp.2008.372
30. 2-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation. Journal of Molecular and Cellular Cardiology 2008 45 6 787 795 2-s2.0-55649104113 10.1016/j.yjmcc.2008.08.010
31. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. Journal of the American College of Cardiology 2002 39 5 747 753 2-s2.0-0037028890 10.1016/S0735-1097(02)01693-5 (Pubitemid 34185318)
32. 2 radicals during reperfusion after prolonged myocardial ischemia. American Journal of Physiology 2001 280 6 H2649 H2657 2-s2.0-0034979497
33. Frangogiannis N. G., Smith C. W., Entman M. L., The inflammatory response in myocardial infarction. Cardiovascular Research 2002 53 1 31 47 2-s2.0-0036136667 10.1016/S0008-6363(01)00434-5 (Pubitemid 34020764)
34. Ferdinandy P., Danial H., Ambrus I., Rothery R. A., Schulz R., Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circulation Research 2000 87 3 241 247 2-s2.0-0033900011 (Pubitemid 30626433)
35. Suematsu N., Tsutsui H., Wen J., Kang D., Ikeuchi M., Ide T., Hayashidani S., Shiomi T., Kubota T., Hamasaki N., Takeshita A., Oxidative stress mediates tumor necrosis factor- α -induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation 2003 107 10 1418 1423 2-s2.0-0037453028 10.1161/01.CIR.0000055318.09997.1F (Pubitemid 36350742)
36. Siwik D. A., Pagano P. J., Colucci W. S., Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. American Journal of Physiology 2001 280 1 C53 C60 2-s2.0-0034995893
37. Deten A., Hölzl A., Leicht M., Barth W., Zimmer H.-G., Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats. Journal of Molecular and Cellular Cardiology 2001 33 6 1191 1207 2-s2.0-0034956481 10.1006/jmcc.2001.1383 (Pubitemid 32579285)
38. Rohde L. E., Ducharme A., Arroyo L. H., Matrix metalloproteinase inhibition attenuates early left Ventricular injury. Cardiovascular Research 2000 47 446 456
39. Bolli R., Marbán E., Molecular and cellular mechanisms of myocardial stunning. Physiological Reviews 1999 79 609 634 (Pubitemid 29210931)
40. Ferrari R., The role of Mitochondria in ischemic heart disease. Journal of Cardiovascular Pharmacology 1996 28 1 S1 S10 2-s2.0-0029788601 (Pubitemid 26314972)
41. 2+ dynamics and antioxidant status. Free Radical Biology and Medicine 2006 40 9 1592 1602 2-s2.0-33646034006 10.1016/j.freeradbiomed.2005.12.026
42. 2+ channels in the heart by reactive oxygen species: mechanism for mediating pathology. Clinical and Experimental Pharmacology and Physiology 2008 35 2 229 234 2-s2.0-38149077988 10.1111/j.1440-1681.2007.04727.x
43. +-ATPase activity in congestive heart failure due to myocardial infarction. American Journal of Physiology 1992 262 3 C664 C671 2-s2.0-0026549248
44. Sasaki M., Joh T., Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents. Journal of Clinical Biochemistry and Nutrition 2007 40 1 1 12 2-s2.0-33947367807 10.3164/jcbn.40.1 (Pubitemid 46449682)
45. Egan J. R., Butler T. L., Cole A. D., Abraham S., Murala J. S., Baines D., Street N., Thompson L., Biecker O., Dittmer J., Cooper S., Au C. G., North K. N., Winlaw D. S., Myocardial membrane injury in pediatric cardiac surgery: an animal model. Journal of Thoracic and Cardiovascular Surgery 2009 137 5 1154 1162 2-s2.0-64649089689 10.1016/j.jtcvs.2008.10.009
46. Scarabelli T., Stephanou A., Rayment N., Pasini E., Comini L., Curello S., Ferrari R., Knight R., Latchman D., Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury. Circulation 2001 104 3 253 256 2-s2.0-0035902545 (Pubitemid 32666943)
47. Vandervelde S., van Luyn M. J. A., Rozenbaum M. H., Petersen A. H., Tio R. A., Harmsen M. C., Stem cell-related cardiac gene expression early after murine myocardial infarction. Cardiovascular Research 2007 73 4 783 793 2-s2.0-33846925318 10.1016/j.cardiores.2006.11.030 (Pubitemid 46237616)
48. Chandrasekar B., Smith J. B., Freeman G. L., Ischemia-reperfusion of rat myocardium activates nuclear factor- b and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation 2001 103 18 2296 2302 2-s2.0-0035826728 (Pubitemid 32433721)
49. Cooper D., Stokes K. Y., Tailor A., Granger D. N., Oxidative stress promotes blood cell-endothelial cell interactions in the microcirculation. Cardiovascular Toxicology 2002 2 3 165 180 2-s2.0-0037829843 10.1385/CT:2:3:165 (Pubitemid 37013731)
50. Pavelková M., Kubala L., Cíz M., Blood phagocyte activation during open heart surgery with cardiopulmonary bypass. Physiological Research 2006 55 165 173
51. Kohen R., Nyska A., Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicologic Pathology 2002 30 6 620 650 2-s2.0-0036867895 10.1080/ 01926230290166724 (Pubitemid 36018731)
52. Kinoshita T., Asai T., Takashima N., Hosoba S., Suzuki T., Kambara A., Matsubayashi K., Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. European Journal of Cardio-thoracic Surgery 2011 40 6 1298 1303 2-s2.0-82655166728 10.1016/j.ejcts.2011.03.027
53. Valtchanova-Matchouganska A., Gondwe M., Nadar A., The role of C-reactive protein in ischemia/reperfusion injury and preconditioning in a rat model of myocardial infarction. Life Sciences 2004 75 8 901 910 2-s2.0-2942617219 10.1016/j.lfs.2003.12.029 (Pubitemid 38749249)
54. Lemasters J. J., Bond J. M., Chacon E., Harper I. S., Kaplan S. H., Ohata H., Trollinger D. R., Herman B., Cascio W. E., The pH paradox in ischemia-reperfusion injury to cardiac myocytes. EXS 1996 76 99 114 2-s2.0-0029684022
55. Bond J. M., Herman B., Lemasters J. J., Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes. Biochemical and Biophysical Research Communications 1991 179 2 798 803 2-s2.0-0026063083
56. Lemasters J. J., Theruvath T. P., Zhong Z., Nieminen A.-L., Mitochondrial calcium and the permeability transition in cell death. Biochimica et Biophysica Acta 2009 1787 11 1395 1401 2-s2.0-68649095201 10.1016/j.bbabio.2009.06.009
57. 2+](m) overload in rat hearts. American Journal of Physiology 1996 271 5 H2145 H2153 2-s2.0-0029949676
58. 2+ in toxic cell killing. Trends in Pharmacological Sciences 1989 10 7 281 285 2-s2.0-0024473819 (Pubitemid 19189749)
59. Milberg P., Fink M., Pott C., Frommeyer G., Biertz J., Osada N., Stypmann J., Mönnig G., Koopmann M., Breithardt G., Eckardt L., Blockade of ICa suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure. British Journal of Pharmacology 2012 166 2 557 568 2-s2.0-84859425720 10.1111/j.1476-5381.2011. 01721.x
60. Hausenloy D. J., Yellon D. M., The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion. Journal of Molecular and Cellular Cardiology 2003 35 4 339 341 2-s2.0-0037383432 10.1016/S0022-2828(03)00043-9 (Pubitemid 36411694)
61. Heusch G., Boengler K., Schulz R., Inhibition of mitochondrial permeability transition pore opening: the holy grail of cardioprotection. Basic Research in Cardiology 2010 105 2 151 154 2-s2.0-77950348533 10.1007/s00395-009-0080-9
62. Griffiths E. J., Halestrap A. P., Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochemical Journal 1995 307 1 93 98 2-s2.0-0028968606
63. Otani H., Reactive oxygen species as mediators of signal transduction in ischemic preconditioning. Antioxidants and Redox Signaling 2004 6 2 449 469 2-s2.0-1542619245 10.1089/152308604322899521 (Pubitemid 38332603)
64. von Harsdorf R., Li P.-F., Dietz R., Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 1999 99 22 2934 2941 2-s2.0-0033535974 (Pubitemid 29258983)
65. Dun Y., Zhi J.-M., Sun H.-Y., Zhao R.-R., Zhao Z.-Q., Activated polymorphonuclear leukocytes induce cardiomyocyte apoptosis and the protective effects of carvedilol. Methods and Findings in Experimental and Clinical Pharmacology 2002 24 7 403 412 2-s2.0-0036751799 10.1358/mf.2002.24.7.696541 (Pubitemid 35190648)
66. Vendrov A. E., Hakim Z. S., Madamanchi N. R., Rojas M., Madamanchi C., Runge M. S., Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 12 2714 2721 2-s2.0-36349024676 10.1161/ATVBAHA.107. 152629 (Pubitemid 350158927)
67. Jay Forman H., Torres M., Redox signaling in macrophages. Molecular Aspects of Medicine 2001 22 4-5 189 216 2-s2.0-0034782946 10.1016/S0098-2997(01) 00010-3 (Pubitemid 33000522)
68. Zhao Z.-Q., Velez D. A., Wang N.-P., Hewan-Lowe K. O., Nakamura M., Guyton R. A., Vinten-Johansen J., Progressively developed myocardial apoptotic cell death during late phase of reperfusion. Apoptosis 2001 6 4 279 290 2-s2.0-0034895499 10.1023/A:1011335525219 (Pubitemid 32708522)
69. Nakajima H., Mizuta N., Fujiwara I., Sakaguchi K., Ogata H., Magae J., Yagita H., Koji T., Blockade of the Fas/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver. Apoptosis 2008 13 8 1013 1021 2-s2.0-47349122695 10.1007/s10495-008-0234-5
70. Van Dijk A., Krijnen P. A. J., Vermond R. A., Pronk A., Spreeuwenberg M., Visser F. C., Berney R., Paulus W. J., Hack C. E., Van Milligen F. J., Niessen H. W. M., Inhibition of type 2A secretory phospholipase A2 reduces death of cardiomyocytes in acute myocardial infarction. Apoptosis 2009 14 6 753 763 2-s2.0-67349103346 10.1007/s10495-009-0350-x
71. Matsui Y., Takagi H., Qu X., Abdellatif M., Sakoda H., Asano T., Levine B., Sadoshima J., Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and beclin 1 in mediating autophagy. Circulation Research 2007 100 6 914 922 2-s2.0-34147168105 10.1161/01.RES.0000261924.76669.36 (Pubitemid 46555697)
72. Baines C. P., Kaiser R. A., Purcell N. H., Blair N. S., Osinska H., Hambleton M. A., Brunskill E. W., Sayen M. R., Gottlieb R. A., Dorn G. W. II, Bobbins J., Molkentin J. D., Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005 434 7033 658 662 2-s2.0-15844375853 10.1038/nature03434 (Pubitemid 40488559)
73. Gale C. P., Metcalfe E., West R. M., Das R., Kilcullen N., Morrell C., Crook R., Batin P. D., Hall A. S., Barth J. H., An Assessment of the concentration-related prognostic value of cardiac troponin i following acute coronary syndrome. American Journal of Cardiology 2011 108 9 1259 1265 2-s2.0-80054691727 10.1016/j.amjcard.2011.06.041
74. Dallabrida S. M., Ismail N., Oberle J. R., Himes B. E., Rupnick M. A., Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circulation Research 2005 96 4 e8 e24 2-s2.0-23844544130
75. Whelan R. S., Kaplinskiy V., Kitsis R. N., Cell death in the pathogenesis of heart disease: mechanisms and significance. Annual Review of Physiology 2009 72 19 44 2-s2.0-77951901715 10.1146/annurev.physiol.010908.163111
76. Communal C., Sumandea M., De Tombe P., Narula J., Solaro R. J., Hajjar R. J., Functional consequences of caspase activation in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America 2002 99 9 6252 6256 2-s2.0-0037197974 10.1073/pnas.092022999 (Pubitemid 34493298)
77. Singh T., Sharma S. D., Katiyar S. K., Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells In Vitro and In Vivo. PLoS ONE 2011 6 11 2-s2.0-80555129638 10.1371/journal.pone.0027444 e27444
78. Adrain C., Martin S. J., The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends in Biochemical Sciences 2001 26 6 390 397 2-s2.0-0035369143 10.1016/S0968-0004(01)01844-8 (Pubitemid 32530658)
79. Candé C., Cohen I., Daugas E., Ravagnan L., Larochette N., Zamzami N., Kroemer G., Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie 2002 84 2-3 215 222 2-s2.0-0036479012 10.1016/S0300-9084(02)01374-3
80. Lee P., Sata M., Lefer D. J., Factor S. M., Walsh K., Kitsis R. N., Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. American Journal of Physiology 2003 284 2 H456 H463 2-s2.0-0037304773 (Pubitemid 36142871)
81. Nakamura T., Wang L., Wong C. C. L., Scott F. L., Eckelman B. P., Han X., Tzitzilonis C., Meng F., Gu Z., Holland E. A., Clemente A. T., Okamoto S.-I., Salvesen G. S., Riek R., Yates J. R., Lipton S. A., Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Molecular Cell 2010 39 2 184 195 2-s2.0-77955480840 10.1016/j.molcel.2010.07.002
82. Tatsumi T., Shiraishi J., Keira N., Akashi K., Mano A., Yamanaka S., Matoba S., Fushiki S., Fliss H., Nakagawa M., Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes. Cardiovascular Research 2003 59 2 428 440 2-s2.0-10744229047 10.1016/S0008-6363(03)00391-2 (Pubitemid 37272037)
83. Quinsay M. N., Thomas R. L., Lee Y., Gustafsson Å. B., Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy 2010 6 7 855 862 2-s2.0-77957683915 10.4161/auto.6.7.13005
84. Dai D.-F., Rabinovitch P., Mitochondrial oxidative stress mediates induction of autophagy and hypertrophy in angiotensin-II treated mouse hearts. Autophagy 2011 7 8 917 918 2-s2.0-79961117101 10.4161/auto.7.8.15813
85. Hariharan N., Zhai P., Sadoshima J., Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxidants and Redox Signaling 2011 14 11 2179 2190 2-s2.0-79956126271 10.1089/ars.2010.3488
86. Essick E. E., Sam F., Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxidative Medicine and Cellular Longevity 2010 3 3 168 177 2-s2.0-77956455088 10.4161/oxim.3.3.12106
87. Ushio-Fukai M., Compartmentalization of redox signaling through NaDPH oxidase-derived rOS. Antioxidants and Redox Signaling 2009 11 6 1289 1299 2-s2.0-65349157681 10.1089/ars.2008.2333
88. Matsui Y., Kyoi S., Takagi H., Hsu C.-P., Hariharan N., Ago T., Vatner S. F., Sadoshima J., Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy 2008 4 4 409 415 2-s2.0-43949114864 (Pubitemid 351705136)
89. Juhaszova M., Zorov D. B., Kim S.-H., Pepe S., Fu Q., Fishbein K. W., Ziman B. D., Wang S., Ytrehus K., Antos C. L., Olson E. N., Sollott S. J., Glycogen synthase kinase-3 β mediates convergence of protection signalling to inhibit the mitochondrial permeability transition pore. Journal of Clinical Investigation 2004 113 11 1535 1549 2-s2.0-2942720933 10.1172/JCI200419906 (Pubitemid 39071677)
90. Zhu H., Tannous P., Johnstone J. L., Kong Y., Shelton J. M., Richardson J. A., Le V., Levine B., Rothermel B. A., Hill J. A., Cardiac autophagy is a maladaptive response to hemodynamic stress. Journal of Clinical Investigation 2007 117 7 1782 1793 2-s2.0-34447133404 10.1172/JCI27523 (Pubitemid 47036312)
91. Yan L., Sadoshima J., Vatner D. E., Vatner S. F., Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy 2009 5 5 709 712 2-s2.0-67650228581 10.4161/auto.5.5.8510
92. Zhou L., Azfer A., Niu J., Graham S., Choudhury M., Adamski F. M., Younce C., Binkley P. F., Kolattukudy P. E., Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circulation Research 2006 98 9 1177 1185 2-s2.0-33745027735 10.1080/01431160500353825
93. Younce C. W., Kolattukudy P. E., MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP. Biochemical Journal 2010 426 1 43 53 2-s2.0-76549115938 10.1042/BJ20090976
94. Upston J. M., Witting P. K., Brown A. J., Stocker R., Keaney J. F. Jr., Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits. Free Radical Biology and Medicine 2001 31 10 1245 1253 2-s2.0-0035890304 10.1016/S0891-5849(01)00721-3 (Pubitemid 33052500)
95. Terentis A. C., Thomas S. R., Burr J. A., Liebler D. C., Stocker R., Vitamin E oxidation in human atherosclerotic lesions. Circulation Research 2002 90 3 333 339 2-s2.0-0037155055 10.1161/hh0302.104454 (Pubitemid 34633935)
96. Shi H., Noguchi N., Niki E., Comparative study on dynamics of antioxidative action of α -tocopheryl hydroquinone, ubiquinol, and α -tocopherol against lipid peroxidation. Free Radical Biology and Medicine 1999 27 3-4 334 346 2-s2.0-0032818701 10.1016/S0891-5849(99)00053-2 (Pubitemid 29395426)
97. Brigelius-Flohé R., Kelly F. J., Salonen J. T., Neuzil J., Zingg J.-M., Azzi A., The European perspective on vitamin E: current knowledge and future research. American Journal of Clinical Nutrition 2002 76 4 703 716 2-s2.0-0036784399
98. Li R.-K., Cowan D. B., Mickle D. A. G., Weisel R. D., Burton G. W., Effect of vitamin E on human glutathione peroxidase (GSH-Px1) expression in cardiomyocytes. Free Radical Biology and Medicine 1996 21 4 419 426 2-s2.0-0029812644 10.1016/0891-5849(96)00034-2 (Pubitemid 26313937)
99. Ülker S., McKeown P. P., Bayraktutan U., Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 2003 41 3 534 539 2-s2.0-0037337890 10.1161/01.HYP.0000057421.28533.37 (Pubitemid 36314628)
100. Nakamura T., Goto M., Matsumoto A., Tanaka I., Inhibition of NF- B transcriptional activity by α -tocopheryl succinate. BioFactors 1998 7 1-2 21 30 2-s2.0-0031906123 (Pubitemid 28073871)
101. Kaileh M., Sen R., Role of NF-kappaB in the anti-inflammatory effects of tocotrienols. Journal of the American College of Nutrition 2010 29 334 339
102. Jialal I., Traber M., Devaraj S., Is there a vitamin E paradox? Current Opinion in Lipidology 2001 12 49 53 (Pubitemid 32121285)
103. Rabl H., Koschsorur G., Petek W., Antioxidant vitamin treatment: effect on lipid peroxidation and limb swelling after revascularisation operations. World Journal of Surgery 1995 19 738 744
104. Rabl H., Khoschsorur G., Colombo T., Petritsch P., Rauchenwald M., Koltringer P., Tatzber F., Esterbauer H., A multivitamin infusion prevents lipid peroxidation and improves transplantation performance. Kidney International 1993 43 4 912 917 2-s2.0-0027511798 (Pubitemid 23105227)
105. Cerwenka H., Bacher H., Werkgartner G., El-Shabrawi A., Quehenberger F., Hauser H., Mischinger H. J., Antioxidant treatment during liver resection for alleviation of ischemia-reperfusion injury. Hepato-Gastroenterology 1998 45 21 777 782 2-s2.0-0031829479 (Pubitemid 28321057)
106. Wijnen M. H. W. A., Roumen R. M. H., Vader H. L., Goris R. J. A., A multiantioxidant supplementation reduces damage from ischaemia reperfusion in patients after lower torso ischaemia. A randomised trial. European Journal of Vascular and Endovascular Surgery 2002 23 6 486 490 2-s2.0-0036599294 10.1053/ejvs.2002.1614 (Pubitemid 41079397)
107. Bartels M., Biesalski H. K., Engelhart K., Sendlhofer G., Rehak P., Nagel E., Pilot study on the effect of parenteral vitamin E on ischemia and reperfusion induced liver injury: a double blind, randomized, placebo-controlled trial. Clinical Nutrition 2004 23 6 1360 1370 2-s2.0-8744307845 10.1016/j.clnu.2004.05.003 (Pubitemid 39517629)
108. Levine M., Padayatty S., Graham M. E., Vitamin C: a concentration- function approach yields pharmacology and therapeutic discoveries. Advances in Nutrition 2011 2 78 88
109. Corpe C. P., Tu H., Eck P., Wang J., Faulhaber-Walter R., Schnermann J., Margolis S., Padayatty S., Sun H., Wang Y., Nussbaum R. L., Espey M. G., Levine M., Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. Journal of Clinical Investigation 2010 120 4 1069 1083 2-s2.0-77951167788 10.1172/JCI39191
110. Rivas C. I., Zúñiga F. A., Salas-Burgos A., Mardones L., Ormazabal V., Vera J. C., Vitamin C transporters. Journal of Physiology and Biochemistry 2008 64 4 357 376 2-s2.0-63349101898 10.1007/BF03174092
111. Pfeffer M. A., Braunwald E., Moye L. A., Basta L., Brown E. J. Jr., Cuddy T. E., Davis B. R., Geltman E. M., Goldman S., Flaker G. C., Klein M., Lamas G. A., Packer M., Rouleau J., Rouleau J. L., Rutherford J., Wertheimer J. H., Hawkins C. M., Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction-results of the survival and ventricular enlargement trial. The New England Journal of Medicine 1992 327 10 669 677 2-s2.0-0026786643
112. Jensen-Urstad M., Samad B. A., Jensen-Urstad K., Hulting J., Ruiz H., Bouvier F., Höjer J., Risk assessment in patients with acute myocardial infarction treated with thrombolytic therapy. Journal of Internal Medicine 2001 249 6 527 537 2-s2.0-0034857038 10.1046/j.1365-2796.2001.00838.x (Pubitemid 32823861)
113. Takanaga H., Mackenzie B., Hediger M. A., Sodium-dependent ascorbic acid transporter family SLC23. Pflugers Archiv European Journal of Physiology 2004 447 5 677 682 2-s2.0-1242317668 10.1007/s00424-003-1104-1 (Pubitemid 38241453)
114. Grover-McKay M., Walsh S. A., Thompson S. A., Glucose transporter 3 (GLUT3) protein is present in human myocardium. Biochimica et Biophysica Acta 1999 1416 1-2 145 154 2-s2.0-0032898167 10.1016/S0005-2736(98)00216-8 (Pubitemid 29065432)
115. Savini I., Rossi A., Pierro C., Avigliano L., Catani M. V., SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 2008 34 3 347 355 2-s2.0-42449122220 10.1007/s00726-007-0555-7 (Pubitemid 351569766)
116. Rajan D. P., Huang W., Dutta B., Devoe L. D., Leibach F. H., Ganapathy V., Prasad P. D., Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. Biochemical and Biophysical Research Communications 1999 262 3 762 768 2-s2.0-0033533578 10.1006/bbrc.1999.1272 (Pubitemid 29443732)
117. Guaiquil V. H., Golde D. W., Beckles D. L., Mascareno E. J., Siddiqui M. A. Q., Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts. Free Radical Biology and Medicine 2004 37 9 1419 1429 2-s2.0-5344279750 10.1016/j.freeradbiomed.2004.06. 041 (Pubitemid 39349242)
118. Padayatty S. J., Katz A., Wang Y., Eck P., Kwon O., Lee J.-H., Chen S., Corpe C., Dutta A., Dutta S. K., Levine M., Vitamin C as an antioxidant: evaluation of its role in disease prevention. Journal of the American College of Nutrition 2003 22 1 18 35 2-s2.0-12244289625 (Pubitemid 36164454)
119. Gao F., Yao C.-L., Gao E., Mo Q.-Z., Yan W.-L., McLaughlin R., Lopez B. L., Christopher T. A., Ma X. L., Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury. Journal of Pharmacology and Experimental Therapeutics 2002 301 2 543 550 2-s2.0-0036231417 10.1124/jpet.301.2.543 (Pubitemid 34429966)
120. Packer J. E., Slater T. F., Willson R. L., Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979 278 5706 737 738 2-s2.0-0018348794 (Pubitemid 9160276)
121. Niki E., Noguchi N., Tsuchihashi H., Gotoh N., Interaction among vitamin C, vitamin E, and β -carotene. American Journal of Clinical Nutrition 1995 62 6 2-s2.0-0028834677
122. May J. M., Qu Z.-C., Mendiratta S., Protection and recycling of α -tocopherol in human erythrocytes by intracellular ascorbic acid. Archives of
123. Cárcamo J. M., Pedraza A., Bórquez-Ojeda O., Golde D. W., Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry 2002 41 12995 13002 (Pubitemid 35215783)
124. Yang Z., Ming X.-F., Recent advances in understanding endothelial dysfunction in atherosclerosis. Clinical Medicine and Research 2006 4 1 53 65 2-s2.0-33646108583 10.3121/cmr.4.1.53
125. Taddei S., Virdis A., Ghiadoni L., Magagna A., Salvetti A., Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998 97 22 2222 2229 2-s2.0-0032499667 (Pubitemid 28265383)
126. Ting H. H., Timimi F. K., Boles K. S., Creager S. J., Ganz P., Creager M. A., Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 1996 97 1 22 28 2-s2.0-0030034465 (Pubitemid 26021690)
127. Basili S., Tanzilli G., Mangieri E., Raparelli V., Di Santo S., Pignatelli P., Violi F., Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention. Relationship with oxidative stress markers. Cardiovascular Interventions 2010 3 2 221 229 2-s2.0-76449086110 10.1016/j.jcin.2009.10.025
128. Bhakuni P., Chandra M., Misra M. K., Effect of ascorbic acid supplementation on certain oxidative stress parameters in the post reperfusion patients of myocardial infarction. Molecular and Cellular Biochemistry 2006 290 1-2 153 158 2-s2.0-33749168029 10.1007/s11010-006-9182-y (Pubitemid 44473246)
129. Molyneux C. A., Glyn M. C., Ward B. J., Oxidative stress and cardiac microvascular structure in ischemia and reperfusion: the protective effect of antioxidant vitamins. Microvascular Research 2002 64 2 265 277 2-s2.0-0036385493 10.1006/mvre.2002.2419
130. Stephens N. G., Parsons A., Schofield P. M., Kelly F., Cheeseman K., Mitchinson M. J., Brown M. J., Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). The Lancet 1996 347 9004 781 786 2-s2.0-0029925181 10.1016/S0140-6736(96)90866-1 (Pubitemid 26091640)
131. Rapola J. M., Virtamo J., Ripatti S., Huttunen J. K., Albanes D., Taylor P. R., Heinonen O. P., Randomised trial of α -tocopherol and β -carotene supplements on incidence of major coronary events in men with previous myocardial infarction. The Lancet 1997 349 9067 1715 1720 2-s2.0-0030916162 10.1016/S0140-6736(97)01234-8 (Pubitemid 27252669)
132. GISSI-Prevenzione trial, Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. The Lancet 1999 354 9177 447 455
133. Yusuf S., Dagenais G., Pogue J., Bosch J., Sleight P., Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. The New England Journal of Medicine 2000 342 154 160 (Pubitemid 30051646)
134. de Gaetano G., Collaborative Group of the Primary Prevention Project, Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project. The Lancet 2001 357 89 95
135. Collins R., Armitage J., Parish S., Sleight P., Peto R., MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial. The Lancet 2002 360 9326 23 33 2-s2.0-0037031094 10.1016/S0140-6736(02)09328-5 (Pubitemid 34756488)
136. Cook N. R., Albert C. M., Gaziano J. M., Zaharris E., MacFadyen J., Danielson E., Buring J. E., Manson J. E., A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the women's antioxidant cardiovascular study. Archives of Internal Medicine 2007 167 15 1610 1618 2-s2.0-34548040480 10.1001/archinte.167.15.1610 (Pubitemid 47280341)
137. Sesso H. D., Buring J. E., Christen W. G., Kurth T., Belanger C., MacFadyen J., Bubes V., Manson J. E., Glynn R. J., Gaziano J. M., Vitamins E and C in the prevention of cardiovascular disease in men: the physicians' health study II randomized controlled trial. Journal of the American Medical Association 2008 300 18 2123 2133 2-s2.0-56149111693 10.1001/jama.2008.600
138. Evans A. M., Fornasini G., Pharmacokinetics of L-carnitine. Clinical Pharmacokinetics 2003 42 11 941 967 2-s2.0-0012738864 10.2165/00003088- 200342110-00002 (Pubitemid 37056103)
139. Kalenikova E. I., Gorodetskaya E. A., Medvedev O. S., Pharmacokinetics of coenzyme Q10. Bulletin of Experimental Biology and Medicine 2008 146 3 313 316 2-s2.0-58249127890 10.1007/s10517-008-0270-8
140. Rodrigo R., Guichard C., Charles R., Clinical pharmacology and therapeutic use of antioxidant vitamins. Fundamental and Clinical Pharmacology 2007 21 2 111 127 2-s2.0-33947694252 10.1111/j.1472-8206.2006.00466.x (Pubitemid 46495941)
141. Maritim A. C., Sanders R. A., Watkins J. B. III, Diabetes, oxidative stress, and antioxidants: a review. Journal of Biochemical and Molecular Toxicology 2003 17 1 24 38 2-s2.0-0037253073 10.1002/jbt.10058 (Pubitemid 36410972)
142. Cuzzocrea S., Riley D. P., Caputi A. P., Salvemini D., Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacological Reviews 2001 53 1 135 159 2-s2.0-0035101472 (Pubitemid 32173112)
143. Digiesi V., Lenuzza M., Digiesi G., Prospects for the use of antioxidant therapy in hypertension. Annali Italiani di Medicina Interna 2001 16 2 93 100 2-s2.0-0035317895
144. Gardner R., Salvador A., Moradas-Ferreira P., Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation. Free Radical Biology and Medicine 2002 32 12 1351 1357 2-s2.0-0037096203 10.1016/S0891-5849(02)00861-4 (Pubitemid 34607639)
145. Jialal I., Devaraj S., Kaul N., The effect of α -Tocopherol on monocyte proatherogenic activity. Journal of Nutrition 2001 131 2 389 394 2-s2.0-0035150318