Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure

Circulation Research

Volumn 87, Issue 3, 2000, Pages 241-247

  Ferdinandy, Péter ^a,b   Danial, Hajira ^a   Ambrus, Ildikó ^a,b   Rothery, Richard A ^a   Schulz, Richard ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cytokines; NADPH oxidase; Nitric oxide synthase; Oxidoreductases; Xanthine

Indexed keywords

3 NITROTYROSINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; IRON DERIVATIVE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER; TIRON; TUMOR NECROSIS FACTOR ALPHA; XANTHINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART PERFUSION; HEART WORK; ISOLATED HEART; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0033900011     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.3.241     Document Type: Article

References (44)

1. Myocardial contractile dysfunction in the systemic inflammatory response syndrome: Role of a cytokine-inducible nitric oxide synthase in cardiac myocytes
2. Cardiac dysfunction in sepsis: New theories and clinical implications
3. 2+-independent nitric oxide synthase in the myocardium
4. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes: Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro
5. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture
6. Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase
7. The role of nitric oxide incardiac depression induced by interleukin-1β and tumor necrosis factor-α
8. Pro-inflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism
9. Nitric oxide, superoxide, and peroxynitrite: The good, the bad and ugly
10. Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency
11. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
12. Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats
13. Measurement of nitric oxide and peroxynitrite generation in the postischemic: Evidence for peroxynitrite-mediated reperfusion injury
14. Peroxynitrite contributes to spontaneous loss of cardiac efficiency in isolated working rat hearts
15. Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
16. Flavoprotein structure and mechanism, 4: Xanthine oxidase and xanthine dehydrogenase
17. 2 modulate superoxide anion production in bovine cardiac myocytes: Potential role of NADH oxidase
18. Nitric oxide regulation of tissue free radical injury
19. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species
20. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts
21. A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues
22. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
23. Validation of lucigenin (bis-N-methylacridinum) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems
24. Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle
25. Lack of correlation between myocardial nitric oxide and cyclic guanosine monophosphate content in both nitrate-tolerant and nontolerant rats
26. Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration: Involvement in response to hypoxia/reoxygenation
27. Tyrosine modification by reactive nitrogen species: A closer look
28. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury
29. Role of free radicals in septic shock
30. Transforming growth factor-βs block cytokine induction of catalase and xanthine oxidase mRNA levels in cultured rat cardiac cells
31. Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle
32. Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia
33. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
34. Lack of tyrosine nitration by peroxynitrite generated at physiological pH
35. - · under physiological conditions
36. Metalloporphyrin class of therapeutic catalytic antioxidants
37. Peroxynitrite-induced cardiac myocyte injury
38. Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats
39. Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo
40. Extensive tyrosine nitration in human myocardial inflammation: Evidence for the presence of peroxynitrite
41. Measurement of superoxide-derived free radicals in the reperfused heart
42. Pulmonary hypertension and reduced cardiac output during inhibition of nitric oxide synthesis in human septic shock
43. Cardiac depression and cellular injury in hemorrhagic shock and reinfusion: Role of free radicals
44. The effects of intravenous antioxidants in patients with septic shock