Myocardial membrane injury in pediatric cardiac surgery: An animal model

Journal of Thoracic and Cardiovascular Surgery

Volumn 137, Issue 5, 2009, Pages 1154-1162

  Egan, Jonathan R ^a,b   Butler, Tanya L ^a,b   Cole, Andrew D ^a   Abraham, Smartin ^a   Murala, John S ^a   Baines, David ^a,b   Street, Neil ^a   Thompson, Lance ^a   Biecker, Oliver ^a   Dittmer, John ^a   Cooper, Sandra ^a   Au, Carol G ^a,b   North, Kathryn N ^a,b   Winlaw, David S ^a,b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b University of Sydney   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 1; DYSTROPHIN; LACTIC ACID; POLOXAMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CLAMPING; ARTICLE; BLOOD PRESSURE; CARDIOPULMONARY BYPASS; CONGENITAL HEART DISEASE; CONTROLLED STUDY; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART SURGERY; HEMODYNAMIC PARAMETERS; LACTATE BLOOD LEVEL; LAMB; NONHUMAN; OXYGEN SATURATION; PEDIATRIC SURGERY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; CARDIOPULMONARY BYPASS; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; FEMALE; HEMODYNAMICS; HUMANS; INTRAOPERATIVE COMPLICATIONS; MALE; MEMBRANE PROTEINS; MEMBRANES; MUSCLE PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PEDIATRICS; PROBABILITY; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC;

EID: 64649089689     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2008.10.009     Document Type: Article

References (28)

1. Hoffman T.M., Wernovsky G., Atz A.M., Kulik T.J., Nelson D.P., Chang A.C., et al. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 107 (2003) 996-1002
2. Bolli R., and Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 79 (1999) 609-634
3. Egan J.R., Butler T.L., Cole A.D., Aharonyan A., Baines D., Street N., et al. Myocardial ischemia is more important than the effects of cardiopulmonary bypass on myocardial water handling and postoperative dysfunction: a pediatric animal model. J Thorac Cardiovasc Surg 136 (2008) 1265-73.e2
4. Jonas R.A., Wypij D., Roth S.J., Bellinger D.C., Visconti K.J., du Plessis A.J., et al. The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants. J Thorac Cardiovasc Surg 126 (2003) 1765-1774
5. Stocker C.F., Shekerdemian L.S., Norgaard M.A., Brizard C.P., Mynard J.P., Horton S.B., et al. Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass. Crit Care Med 35 (2007) 252-259
6. Caldarone C.A., Barner E.W., Wang L., Karimi M., Mascio C.E., Hammel J.M., et al. Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart. Ann Thorac Surg 78 (2004) 948-955
7. McNally E.M., and MacLeod H. Therapy insight: cardiovascular complications associated with muscular dystrophies. Nat Clin Pract Cardiovasc Med 2 (2005) 301-308
8. Han R., Bansal D., Miyake K., Muniz V.P., Weiss R.M., McNeil P.L., et al. Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury. J Clin Invest 117 (2007) 1805-1813
9. Au C.G., Cooper S.T., Lo H.P., Compton A.G., Yang N., Wintour E.M., et al. Expression of aquaporin 1 in human cardiac and skeletal muscle. J Mol Cell Cardiol 36 (2004) 655-662
10. Manley G.T., Fujimura M., Ma T., Noshita N., Filiz F., Bollen A.W., et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6 (2000) 159-163
11. Goodwin F.C., and Muntoni F. Cardiac involvement in muscular dystrophies: molecular mechanisms. Muscle Nerve 32 (2005) 577-588
12. Vatta M., Stetson S.J., Perez-Verdia A., Entman M.L., Noon G.P., Torre-Amione G., et al. Molecular remodelling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance-device therapy. Lancet 359 (2002) 936-941
13. Lee Y.T., Sung K., Shin J.O., and Jeon E.S. Images in cardiovascular medicine. Disruption of dystrophin in acute fulminant coxsackieviral B4 infection. Circulation 113 (2006) e76-e77
14. Kido M., Otani H., Kyoi S., Sumida T., Fujiwara H., Okada T., et al. Ischemic preconditioning-mediated restoration of membrane dystrophin during reperfusion correlates with protection against contraction-induced myocardial injury. Am J Physiol Heart Circ Physiol 287 (2004) H81-H90
15. Rodriguez M., Cai W.J., Kostin S., Lucchesi B.R., and Schaper J. Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury. J Mol Cell Cardiol 38 (2005) 723-733
16. Yasuda S., Townsend D., Michele D.E., Favre E.G., Day S.M., and Metzger J.M. Dystrophic heart failure blocked by membrane sealant poloxamer. Nature 436 (2005) 1025-1029
17. Adams-Graves P., Kedar A., Koshy M., Steinberg M., Veith R., Ward D., et al. RheothRx (poloxamer 188) injection for the acute painful episode of sickle cell disease: a pilot study. Blood 90 (1997) 2041-2046
18. Hunter R.L., Papadea C., Gallagher C.J., Finlayson D.C., and Check I.J. Increased whole blood viscosity during coronary artery bypass surgery. Studies to evaluate the effects of soluble fibrin and poloxamer 188. Thromb Haemost 63 (1990) 6-12
19. Lee R.C., Hannig J., Matthews K.L., Myerov A., and Chen C.T. Pharmaceutical therapies for sealing of permeabilized cell membranes in electrical injuries. Ann N Y Acad Sci 888 (1999) 266-273
20. Effects of RheothRx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction. Collaborative Organization for RheothRx Evaluation (CORE). Circulation 96 (1997) 192-201
21. Bansal D., Miyake K., Vogel S.S., Groh S., Chen C.C., Williamson R., et al. Defective membrane repair in dysferlin-deficient muscular dystrophy. Nature 423 (2003) 168-172
22. NHMRC. Australian code of practice for the care and use of animals for scientific purposes. 7th ed; 2004.
23. Zhang S., Wang S., Li Q., Yao S., Zeng B., Ziegelstein R.C., et al. Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass: a double-blind, randomised controlled study. Lancet 366 (2005) 556-562
24. Jia C.X., Rabkin D.G., Hart J.P., Dean D.A., Cabreriza S.A., Weinberg A.D., et al. Regional variation in myocardial water content in the edematous pig heart. J Surg Res 106 (2002) 70-75
25. Butler T.L., Au C.G., Yang B., Egan J.R., Tan Y.M., Hardeman E.C., et al. Cardiac aquaporin expression in humans, rats, and mice. Am J Physiol Heart Circ Physiol 291 (2006) H705-H713
26. Kusuoka H., and Hoffman J.I. Advice on statistical analysis for Circulation Research. Circ Res 91 (2002) 662-671
27. Mezrow C.K., Mazzoni M., Wolfe D., Shiang H.H., Litwak R.S., and Griepp R.B. Poloxamer 188 improves neurologic outcome after hypothermic circulatory arrest. J Thorac Cardiovasc Surg 103 (1992) 1143-1146
28. Farstad M., Heltne J.K., Rynning S.E., Onarheim H., Mongstad A., Eliassen F., et al. Can the use of methylprednisolone, vitamin C, or alpha-trinositol prevent cold-induced fluid extravasation during cardiopulmonary bypass in piglets?. J Thorac Cardiovasc Surg 127 (2004) 525-534