메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; SIRTUIN 1;

EID: 84881523549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071576     Document Type: Article
Times cited : (33)

References (57)
  • 1
    • 9444259813 scopus 로고    scopus 로고
    • Metabolic and cardiovascular disorders in highly inbred lines for intensive pig farming: how animal welfare evaluation could improve the basic knowledge of human obesity
    • Gianfranco B, Alfredo C, (2004) Metabolic and cardiovascular disorders in highly inbred lines for intensive pig farming: how animal welfare evaluation could improve the basic knowledge of human obesity. Ann 1st Super Sanita 40: 241-244.
    • (2004) Ann 1st Super Sanita , vol.40 , pp. 241-244
    • Gianfranco, B.1    Alfredo, C.2
  • 2
    • 33745587273 scopus 로고    scopus 로고
    • Swine models of type 2 diabetes mellitus: insulin resistance, glucose tolerance, and cardiovascular complications
    • Belliger DA, Merrichks EP, Nichols TC, (2006) Swine models of type 2 diabetes mellitus: insulin resistance, glucose tolerance, and cardiovascular complications. ILAR J 47: 243-258.
    • (2006) ILAR J , vol.47 , pp. 243-258
    • Belliger, D.A.1    Merrichks, E.P.2    Nichols, T.C.3
  • 3
    • 21644473153 scopus 로고    scopus 로고
    • Use of the Gottingen minipig as a model of diabetes, with special focus on type 1 diabetes research
    • Larsen MO, Rolin B, (2004) Use of the Gottingen minipig as a model of diabetes, with special focus on type 1 diabetes research. ILAR J 45: 303-313.
    • (2004) ILAR J , vol.45 , pp. 303-313
    • Larsen, M.O.1    Rolin, B.2
  • 4
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM, (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444: 847-853.
    • (2006) Nature , vol.444 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 5
    • 0038624395 scopus 로고    scopus 로고
    • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    • Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365.
    • (2003) Genes Dev , vol.17 , pp. 1352-1365
    • Peng, X.D.1    Xu, P.Z.2    Chen, M.L.3    Hahn-Windgassen, A.4    Skeen, J.5
  • 6
    • 0029891232 scopus 로고    scopus 로고
    • Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation
    • Magun R, Burgering BM, Coffer PJ, Pardasani D, Lin Y, et al. (1996) Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137: 3590-3593.
    • (1996) Endocrinology , vol.137 , pp. 3590-3593
    • Magun, R.1    Burgering, B.M.2    Coffer, P.J.3    Pardasani, D.4    Lin, Y.5
  • 7
    • 84859400813 scopus 로고    scopus 로고
    • Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice
    • Xu F, Burk D, Gao Z, Yin J, Zhang X, et al. (2012) Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice. Endocrinology 153: 1706-1716.
    • (2012) Endocrinology , vol.153 , pp. 1706-1716
    • Xu, F.1    Burk, D.2    Gao, Z.3    Yin, J.4    Zhang, X.5
  • 8
    • 15044363028 scopus 로고    scopus 로고
    • Recent advances in the protein kinase B signaling pathway
    • Woodgett JR, (2005) Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 17: 150-157.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 150-157
    • Woodgett, J.R.1
  • 9
    • 34247116441 scopus 로고    scopus 로고
    • Physiological roles of PKB/Akt isoforms in development and disease
    • Dummler B, Hemmings BA, (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 35: 231-235.
    • (2007) Biochem Soc Trans , vol.35 , pp. 231-235
    • Dummler, B.1    Hemmings, B.A.2
  • 10
    • 0032493105 scopus 로고    scopus 로고
    • Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
    • Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR, (1998) Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene 16: 2407-2411.
    • (1998) Oncogene , vol.16 , pp. 2407-2411
    • Altomare, D.A.1    Lyons, G.E.2    Mitsuuchi, Y.3    Cheng, J.Q.4    Testa, J.R.5
  • 11
    • 0032497288 scopus 로고    scopus 로고
    • Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I
    • Holst LS, Mulder H, Manganiello V, Sundler F, Ahrén B, et al. (1998) Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I. Biochem Biophys Res Commun. 250: 181-186.
    • (1998) Biochem Biophys Res Commun , vol.250 , pp. 181-186
    • Holst, L.S.1    Mulder, H.2    Manganiello, V.3    Sundler, F.4    Ahrén, B.5
  • 12
    • 0037352170 scopus 로고    scopus 로고
    • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
    • Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, et al. (2003) Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17: 590-603.
    • (2003) Leukemia , vol.17 , pp. 590-603
    • Chang, F.1    Lee, J.T.2    Navolanic, P.M.3    Steelman, L.S.4    Shelton, J.G.5
  • 13
    • 3242656480 scopus 로고    scopus 로고
    • Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
    • Dickson LM, Rhodes CJ, (2004) Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab 287: E192-E198.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Dickson, L.M.1    Rhodes, C.J.2
  • 14
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    • Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, et al. (2001) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292: 1728-1731.
    • (2001) Science , vol.292 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3    Thorvaldsen, J.L.4    Chu, Q.5
  • 15
    • 85047693348 scopus 로고    scopus 로고
    • Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
    • Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, et al. (2003) Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 112: 197-208.
    • (2003) J Clin Invest , vol.112 , pp. 197-208
    • Garofalo, R.S.1    Orena, S.J.2    Rafidi, K.3    Torchia, A.J.4    Stock, J.L.5
  • 16
    • 0038624395 scopus 로고    scopus 로고
    • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    • Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365.
    • (2003) Genes Dev , vol.17 , pp. 1352-1365
    • Peng, X.D.1    Xu, P.Z.2    Chen, M.L.3    Hahn-Windgassen, A.4    Skeen, J.5
  • 17
    • 85047693348 scopus 로고    scopus 로고
    • Severe diabetes, age-dependent loss of adipose tissue and mild growth deficiency in mice lacking Akt2/PKBβ
    • Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, et al. (2003) Severe diabetes, age-dependent loss of adipose tissue and mild growth deficiency in mice lacking Akt2/PKBβ. J Clin Invest 112: 197-208.
    • (2003) J Clin Invest , vol.112 , pp. 197-208
    • Garofalo, R.S.1    Orena, S.J.2    Rafidi, K.3    Torchia, A.J.4    Stock, J.L.5
  • 18
    • 78650987216 scopus 로고    scopus 로고
    • Sirtuin-1 regulation of mammalian metabolism, Trends Mol Med
    • Gillum MP, Erion DM, Shulman GI, (2011) Sirtuin-1 regulation of mammalian metabolism, Trends Mol Med. 17: 8-13.
    • (2011) , vol.17 , pp. 8-13
    • Gillum, M.P.1    Erion, D.M.2    Shulman, G.I.3
  • 19
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander G, Guarente L, (2004) The Sir2 family of protein deacetylases. Annu Rev Biochem 73: 417-435.
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 20
    • 84859400813 scopus 로고    scopus 로고
    • Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in Sirt1-/- mice
    • Xu F, Burk D, Gao Z, Yin J, Zhang X, et al. (2012) Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in Sirt1-/- mice. Endocrinology 153: 1706-1716.
    • (2012) Endocrinology , vol.153 , pp. 1706-1716
    • Xu, F.1    Burk, D.2    Gao, Z.3    Yin, J.4    Zhang, X.5
  • 21
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    • Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-776.
    • (2004) Nature , vol.429 , pp. 771-776
    • Picard, F.1    Kurtev, M.2    Chung, N.3    Topark-Ngarm, A.4    Senawong, T.5
  • 22
    • 78649852533 scopus 로고    scopus 로고
    • Sirt1 is regulated by a PPARγ-Sirt1 negative feedback loop associated with senescence
    • Han L, Zhou R, Niu J, McNutt MA, Wang P, et al. (2010) Sirt1 is regulated by a PPARγ-Sirt1 negative feedback loop associated with senescence. Nucleic Acids Res 38: 7458-7471.
    • (2010) Nucleic Acids Res , vol.38 , pp. 7458-7471
    • Han, L.1    Zhou, R.2    Niu, J.3    McNutt, M.A.4    Wang, P.5
  • 23
    • 77950538806 scopus 로고    scopus 로고
    • C/EBPalpha regulates Sirt1 expression during adipogenesis
    • Jin Q, Zhang F, Yan T, Liu Z, Wang C, et al. (2010) C/EBPalpha regulates Sirt1 expression during adipogenesis. Cell Res 20: 470-479.
    • (2010) Cell Res , vol.20 , pp. 470-479
    • Jin, Q.1    Zhang, F.2    Yan, T.3    Liu, Z.4    Wang, C.5
  • 24
    • 84873988190 scopus 로고    scopus 로고
    • Sirt1 attenuates camptothecin-induced apoptosis through Caspase-3 pathway in porcine preadipocytes
    • Pang WJ, Xiong Y, Wang Y, Tong Q, Yang GS, (2013) Sirt1 attenuates camptothecin-induced apoptosis through Caspase-3 pathway in porcine preadipocytes. Exp Cell Res 319: 670-683.
    • (2013) Exp Cell Res , vol.319 , pp. 670-683
    • Pang, W.J.1    Xiong, Y.2    Wang, Y.3    Tong, Q.4    Yang, G.S.5
  • 25
    • 36949021068 scopus 로고    scopus 로고
    • Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
    • Bai L, Pang WJ, Yang YJ, Yang GS, (2008) Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes. Mol Cell Biochem 307: 129-140.
    • (2008) Mol Cell Biochem , vol.307 , pp. 129-140
    • Bai, L.1    Pang, W.J.2    Yang, Y.J.3    Yang, G.S.4
  • 26
  • 27
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR, (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103: 931-943.
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 28
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF, (2002) IRS proteins and the common path to diabetes. Am J Physiol 283: E413-E422.
    • (2002) Am J Physiol , vol.283
    • White, M.F.1
  • 29
    • 0032211844 scopus 로고    scopus 로고
    • Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    • Corvera S, Czech MP, (1998) Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol 8: 442-446.
    • (1998) Trends Cell Biol , vol.8 , pp. 442-446
    • Corvera, S.1    Czech, M.P.2
  • 31
    • 39949084497 scopus 로고    scopus 로고
    • Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells
    • Yu W, Chen Z, Zhang J, Zhang L, Ke H, et al. (2008) Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol Cell Biochem 310: 11-18.
    • (2008) Mol Cell Biochem , vol.310 , pp. 11-18
    • Yu, W.1    Chen, Z.2    Zhang, J.3    Zhang, L.4    Ke, H.5
  • 32
    • 0036836781 scopus 로고    scopus 로고
    • Makino Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice
    • Hasegawa M, Tang Y, Osawa H, Onuma H, Nishimiya T, et al. (2002) Makino Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice. Diabetes Res Clin Pract 58: 79-85.
    • (2002) Diabetes Res Clin Pract , vol.58 , pp. 79-85
    • Hasegawa, M.1    Tang, Y.2    Osawa, H.3    Onuma, H.4    Nishimiya, T.5
  • 33
    • 0347624591 scopus 로고    scopus 로고
    • p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
    • Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, et al. (2004) p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol 24: 320-329.
    • (2004) Mol Cell Biol , vol.24 , pp. 320-329
    • Chen, D.1    Mauvais-Jarvis, F.2    Bluher, M.3    Fisher, S.J.4    Jozsi, A.5
  • 34
    • 77955566802 scopus 로고    scopus 로고
    • Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation
    • Kim SP, Ha JM, Yun SJ, Kim EK, Chung SW, et al. (2010) Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun 399: 55-59.
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 55-59
    • Kim, S.P.1    Ha, J.M.2    Yun, S.J.3    Kim, E.K.4    Chung, S.W.5
  • 35
    • 34248157332 scopus 로고    scopus 로고
    • Sirt1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
    • Li H, Rajendran GK, Liu N, Ware C, Rubin BP, et al. (2007) Sirt1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice. Breast Cancer Res 9: R1.
    • (2007) Breast Cancer Res , vol.9
    • Li, H.1    Rajendran, G.K.2    Liu, N.3    Ware, C.4    Rubin, B.P.5
  • 36
    • 45549096918 scopus 로고    scopus 로고
    • Sirt1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
    • Li Y, Xu W, McBurney MW, Longo VD, (2008) Sirt1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8: 38-48.
    • (2008) Cell Metab , vol.8 , pp. 38-48
    • Li, Y.1    Xu, W.2    McBurney, M.W.3    Longo, V.D.4
  • 37
    • 79951726016 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by Sirt1
    • Fröjdö S, Durand C, Molin L, Carey AL, El-Osta A, et al. (2011) Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by Sirt1. Mol Cell Endocrinol 335: 166-176.
    • (2011) Mol Cell Endocrinol , vol.335 , pp. 166-176
    • Fröjdö, S.1    Durand, C.2    Molin, L.3    Carey, A.L.4    El-Osta, A.5
  • 38
    • 84865090762 scopus 로고    scopus 로고
    • Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
    • Chen S, Xiao X, Feng X, Li W, Zhou N, et al. (2012) Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression. J Nutr Biochem 23: 1100-1112.
    • (2012) J Nutr Biochem , vol.23 , pp. 1100-1112
    • Chen, S.1    Xiao, X.2    Feng, X.3    Li, W.4    Zhou, N.5
  • 41
    • 79959951151 scopus 로고    scopus 로고
    • High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression
    • Zhang J, Huang K, Shi Z, Zou J, Wang Y, et al. (2011) High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression. Neuro Oncol 13: 600-609.
    • (2011) Neuro Oncol , vol.13 , pp. 600-609
    • Zhang, J.1    Huang, K.2    Shi, Z.3    Zou, J.4    Wang, Y.5
  • 43
    • 78650843340 scopus 로고    scopus 로고
    • miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
    • Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, et al. (2010) miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging 7: 415-431.
    • (2010) Aging , vol.7 , pp. 415-431
    • Saunders, L.R.1    Sharma, A.D.2    Tawney, J.3    Nakagawa, M.4    Okita, K.5
  • 44
    • 52749092211 scopus 로고    scopus 로고
    • Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation
    • Wang F, Tong Q, (2008) Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation. Am J Physiol Cell Physiol 295: C213-C220.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Wang, F.1    Tong, Q.2
  • 45
    • 25444469546 scopus 로고    scopus 로고
    • A combined proteome and microarray investigation of inorganic phosphate-induced pre-osteoblast cells
    • Conrads KA, Yi M, Simpson KA, Lucas DA, Camalier CE, et al. (2005) A combined proteome and microarray investigation of inorganic phosphate-induced pre-osteoblast cells. Mol Cell Proteomics 4: 1284-1296.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 1284-1296
    • Conrads, K.A.1    Yi, M.2    Simpson, K.A.3    Lucas, D.A.4    Camalier, C.E.5
  • 46
    • 77951030589 scopus 로고    scopus 로고
    • MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
    • Foley NH, Bray IM, Tivnan A, Bryan K, Murphy DM, et al. (2010) MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Mol Cancer 9: 83.
    • (2010) Mol Cancer , vol.9 , pp. 83
    • Foley, N.H.1    Bray, I.M.2    Tivnan, A.3    Bryan, K.4    Murphy, D.M.5
  • 47
    • 79952241662 scopus 로고    scopus 로고
    • miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression
    • Li J, Chen Y, Zhao J, Kong F, Zhang Y, (2011) miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. Cancer Lett 304: 52-59.
    • (2011) Cancer Lett , vol.304 , pp. 52-59
    • Li, J.1    Chen, Y.2    Zhao, J.3    Kong, F.4    Zhang, Y.5
  • 48
    • 84863127179 scopus 로고    scopus 로고
    • Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes
    • Tan SX, Ng Y, Meoli CC, Kumar A, Khoo PS, et al. (2012) Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes. J Biol Chem 287: 6128-6138.
    • (2012) J Biol Chem , vol.287 , pp. 6128-6138
    • Tan, S.X.1    Ng, Y.2    Meoli, C.C.3    Kumar, A.4    Khoo, P.S.5
  • 49
    • 84882268001 scopus 로고    scopus 로고
    • Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation
    • in press
    • Choi Y, Um SJ, Park T (2012) Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation. Int J Obes: in press.
    • (2012) Int J Obes
    • Choi, Y.1    Um, S.J.2    Park, T.3
  • 50
    • 77950538806 scopus 로고    scopus 로고
    • C/EBPalpha regulates SIRT1 expression during adipogenesis
    • Jin Q, Zhang F, Yan T, Liu Z, Wang C, et al. (2010) C/EBPalpha regulates SIRT1 expression during adipogenesis. Cell Res 20: 470-479.
    • (2010) Cell Res , vol.20 , pp. 470-479
    • Jin, Q.1    Zhang, F.2    Yan, T.3    Liu, Z.4    Wang, C.5
  • 51
    • 0032546454 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition
    • Christoffersen CT, Tornqvist H, Vlahos CJ, Bucchini D, Jami J, et al. (1998) Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition. Biochem Biophys Res Commun 246: 426-430.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 426-430
    • Christoffersen, C.T.1    Tornqvist, H.2    Vlahos, C.J.3    Bucchini, D.4    Jami, J.5
  • 52
    • 3743152831 scopus 로고    scopus 로고
    • Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors
    • Xia X, Serrero G, (1999) Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors. J Cell Physiol 178: 9-16.
    • (1999) J Cell Physiol , vol.178 , pp. 9-16
    • Xia, X.1    Serrero, G.2
  • 54
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signaling: AKTion on multiple fronts
    • Brazil DP, Yang ZZ, Hemmings BA, (2004) Advances in protein kinase B signaling: AKTion on multiple fronts. Trends Biochem Sci 29: 233-242.
    • (2004) Trends Biochem Sci , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 56
    • 67650242164 scopus 로고    scopus 로고
    • Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation
    • Isakson P, Hammarstedt A, Gustafson B, Smith U, (2009) Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Dabetes 58: 1550-1557.
    • (2009) Dabetes , vol.58 , pp. 1550-1557
    • Isakson, P.1    Hammarstedt, A.2    Gustafson, B.3    Smith, U.4
  • 57
    • 0041328816 scopus 로고    scopus 로고
    • Growth arrest by octanoate is required for porcine preadipocyte differentiation
    • Nakajima I, Muroya S, Chikuni K, (2003) Growth arrest by octanoate is required for porcine preadipocyte differentiation. Biochem Biophys Res Commun 309: 702-708.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 702-708
    • Nakajima, I.1    Muroya, S.2    Chikuni, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.