Synthesis of some new 3-coumaranone and coumarin derivatives as dual inhibitors of acetyl- and butyrylcholinesterase

Archiv der Pharmazie

Volumn 346, Issue 8, 2013, Pages 577-587

  Alipour, Masoumeh ^a   Khoobi, Mehdi ^b   Nadri, Hamid ^c   Sakhteman, Amirhossein ^c   Moradi, Alireza ^c   Ghandi, Mehdi ^a   Foroumadi, Alireza ^b   Shafiee, Abbas ^b  

^a UNIVERSITY OF TEHRAN   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

3 Coumaranone; Actylcholinesterase; Butyrylcholinesterase; Coumarin; Docking study; Phenacyl pyridinium

Indexed keywords

1 [2 (3,4 DIHYDROXYPHENYL) 2 OXOETHYL] 4 [(6 ETHOXY 3 OXOBENZOFURAN 2(3H) YLIDENE)METHYL]PYRIDINIUM CHLORIDE; 1 [2 (4 BROMOPHENYL) 2 OXOETHYL] 4 [(6 ETHOXY 3 OXOBENZOFURAN 2(3H) YLIDENE)METHYL]PYRIDINIUM BROMIDE; 1 [2 (4 BROMOPHENYL) 2 OXOETHYL] 4 [3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL]PYRIDINIUM BROMIDE; 1 [2 (4 FLUOROPHENYL) 2 OXOETHYL] 4 [3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL]PYRIDINIUM BROMIDE; 3 COUMARANONE; 4 [(6 ETHOXY 3 OXOBENZOFURAN 2(3H) YLIDENE)METHYL] 1 (2 OXO 2 P TOLYLETHYL)PYRIDINIUM CHLORIDE; 4 [(6 ETHOXY 3 OXOBENZOFURAN 2(3H) YLIDENE)METHYL] 1 (2 OXO 2 PHENYLETHYL)PYRIDINIUM CHLORIDE; 4 [(6 ETHOXY 3 OXOBENZOFURAN 2(3H) YLIDENE)METHYL] 1 [2 (4 FLUOROPHENYL) 2 OXOETHYL]PYRIDINIUM CHLORIDE; 4 [3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL] 1 (2 OXO 2 P TOLYLETHYL)PYRIDINIUM BROMIDE; 4 [3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL] 1 (2 OXO 2 PHENYLETHYL)PYRIDINIUM CHLORIDE; 4 [3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL] 1 [2 (4 METHOXYPHENYL) 2 OXOETHYL]PYRIDINIUM BROMIDE; 5,5' DITHIOBIS(2 NITROBENZOIC ACID); ACETYLCHOLINESTERASE; ASCORBIC ACID; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; DONEPEZIL; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ALKYLATION; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CARBON NUCLEAR MAGNETIC RESONANCE; CENTRAL NERVOUS SYSTEM; CHOLINESTERASE INHIBITION; CYCLIZATION; DRUG BINDING SITE; DRUG SYNTHESIS; HYDROGEN BOND; INTESTINE ABSORPTION; MICROWAVE IRRADIATION; MOLECULAR DOCKING; MOLECULAR MODEL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

3-COUMARANONE; ACTYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; COUMARIN; DOCKING STUDY; PHENACYL PYRIDINIUM;

ACETYLCHOLINESTERASE; ANTIOXIDANTS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COUMARINS; DRUG DESIGN; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881374253     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300080     Document Type: Article

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