Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 24, 2005, Pages 6588-6597

  Alonso, D ^a   Dorronsoro, I ^a   Rubio, L ^a   Munoz P ^a   Garcia Palomero E ^a   Del Monte, M ^a   Bidon Chanal, A ^b   Orozco, M ^b   Luque, F J ^b   Castro, A ^a   Medina, M ^a   Martinez A ^a  

^a NeuroPharma SA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Donepezil; Tacrine

Indexed keywords

2 [6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLAMINO]INDAN 1,3 DIONE; 5,6 DIMETHOXY 2 [[6 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLAMINO]METHYL] INDAN 1 ONE; 5,6 DIMETHOXY 2 [[7 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEPTYLAMINO] METHYL]INDAN 1 ONE; 6 CHLOROTACRINE; ACRIDINE; ACRIDINE DERIVATIVE; CHOLINESTERASE INHIBITOR; DONEPEZIL; INDANONE DERIVATIVE; N [3 [[3 (6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)PROPYL]METHYLAMINO] PROPYL] 2 (1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)ACETAMIDE; N [6 (6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL] 2 (1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)ACETAMIDE; N [7 (6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEPTYL] 2 (1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)ACETAMIDE; PHTHALIMIDE; PROPIDIUM IODIDE; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CHOLINESTERASE INHIBITION; COMPETITIVE INHIBITION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; INHIBITION KINETICS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CATTLE; CHOLINESTERASE INHIBITORS; HUMANS; INDANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 27644561204     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.029     Document Type: Article

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