Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6360-6366

  Nadri, Hamid ^a   Pirali Hamedani, Morteza ^a   Shekarchi, Maryam ^b   Abdollahi, Mohammad ^c   Sheibani, Vahid ^d   Amanlou, Massoud ^a   Shafiee, Abbas ^a   Foroumadi, Alireza ^a,d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Food and Drug Control Laboratory and Research Center   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Benzofuranone; Benzylpyridinium; Cholinesterase inhibitor; Ellman's method

Indexed keywords

1 (2 FLUOROBENZYL) 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (2 FLUOROBENZYL) 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (2 FLUOROBENZYL) 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (2 METHYLBENZYL) 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (2 METHYLBENZYL) 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (2 METHYLBENZYL) 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (3 FLUOROBENZYL) 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (3 FLUOROBENZYL) 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (3 FLUOROBENZYL) 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (3 METHYLBENZYL) 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (3 METHYLBENZYL) 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (3 METHYLBENZYL) 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (4 FLUOROBENZYL) 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM BROMIDE; 1 (4 FLUOROBENZYL) 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM BROMIDE; 1 (4 FLUOROBENZYL) 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM BROMIDE; 1 (4 METHYLBENZYL) 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (4 METHYLBENZYL) 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 (4 METHYLBENZYL) 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM CHLORIDE; 1 BENZYL 4 ((6 ETHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM BROMIDE; 1 BENZYL 4 ((6 METHOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL) PYRIDINIUM BROMIDE; 1 BENZYL 4 ((6 PROPOXY 3 OXOBENZOFURAN 2 (3H) YLIDENE)METHYL)PYRIDINIUM BROMIDE; CHOLINESTERASE INHIBITOR; DONEPEZIL; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; COLORIMETRY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; IC 50;

BENZOFURANS; CHOLINESTERASE INHIBITORS; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955983855     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.012     Document Type: Article

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