Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase

Journal of Medicinal Chemistry

Volumn 44, Issue 19, 2001, Pages 3195-3198

  Bruhlmann C ^a   Ooms, F ^a   Carrupt, P A ^a   Testa, B ^a   Catto, M ^b   Leonetti, F ^b   Altomare, C ^b   Carotti, A ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANSECULIN; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; DONEPEZIL; GALANTAMINE; HYDROXYL RADICAL; MONOAMINE OXIDASE INHIBITOR; RIVASTIGMINE; TACRINE;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC NERVE CELL; COMPETITIVE INHIBITION; DERIVATIZATION; DRUG INHIBITION; ENZYME INHIBITION; FRONTAL CORTEX; HUMAN; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROTRANSMITTER RELEASE;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; COUMARINS; EELS; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035855832     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010894d     Document Type: Article

References (16)

1. Regional differences in the incidence of dementia in Europe in Europe-EURODEM Collaborative analysis
2. Cholinergic activity and amyloid precursor protein metabolism
3. The cholinergic hypothesis of geriatric memory dysfunction
4. Role of forebrain cholinergic systems in learning and memory: Relevance to the cognitive deficits of aging and Alzheimer's dementia
5. Possible role of the cholinergic system and disease models
6. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
7. Ongoing progress in the Alzheimer's disease arena
8. Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
9. Amyloid β-protein and the genetics of Alzheimer's disease
10. Amyloid, the presenilins and Alzheimer's disease
11. Inhibition of monoamine oxidases by functionalized coumarin derivatives: Biological activities, QSARs, and 3D-QSARs
12. KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo
13. Imino 1,2,3,4-tetrahydrocylcopent[B]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase
14. A new and rapid colorimetric determination of acetylcholinesterase activity
15. Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresofurin O-dealkylase by naturally occurring coumarins
16. Reversible inhibition of acetylcholinesterase by 4,4′-bipyridine and by a coumarin derivative