Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1682-1688

  Khode, Suresh ^a   Maddi, Veeresh ^a   Aragade, Prashant ^a   Palkar, Mahesh ^a   Ronad, Pradeep Kumar ^a   Mamledesai, Shivalingarao ^a   Thippeswamy, A H M ^a   Satyanarayana, D ^b  

^a KLES s College of Pharmacy   (India)

^b NITTE DEEMED TO BE UNIVERSITY   (India)

Author keywords

Analgesic; Anti inflammatory; Coumarin; NSAIDs; Pyrazoline

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; COUMARIN DERIVATIVE; DICLOFENAC; PARACETAMOL; PHENYLHYDRAZINE; PYRAZOLINE DERIVATIVE; PYRIDINE;

ADJUVANT ARTHRITIS; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE MODEL; DRUG DETERMINATION; DRUG DOSE INCREASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; FEMALE; FEVER; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MOUSE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; ULCEROGENESIS; WRITHING TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DRUG DESIGN; EDEMA; FEMALE; MALE; MICE; PYRAZOLES; RATS; STOMACH ULCER;

EID: 61349181828     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.020     Document Type: Article

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