Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 24, 2012, Pages 7214-7222

  Alipour, Masoumeh ^a   Khoobi, Mehdi ^b   Foroumadi, Alireza ^b   Nadri, Hamid ^c   Moradi, Alireza ^c   Sakhteman, Amirhossein ^c   Ghandi, Mehdi ^a   Shafiee, Abbas ^b  

^a UNIVERSITY OF TEHRAN   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Actylcholinesterase inhibitor; Benzylpyridinium; Coumarin; Ellman's method

Indexed keywords

1 (2 CHLOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (2 FLUORO 6 NITROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (2 FLUOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM BROMIDE; 1 (2 FLUOROBENZYL) 4 (3 OXO 3 (2 OXO 2H CHROMEN 3 YL)PROP 1 ENYL)PYRIDINIUM; 1 (2,3 DICHLOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (3 CHLOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (3 CYANOBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM BROMIDE; 1 (3 FLUOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (3,4 DICHLOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (4 (CHLOROMETHYL)BENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (4 FLUOROBENZYL) 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 1 (4 FLUOROBENZYL) 4 (3 OXO 3 (2 OXO 2H CHROMEN 3 YL)PROP 1 ENYL)PYRIDINIUM; 1 BENZYL 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL)PYRIDINIUM; 3 (3 (PYRIDIN 4 YL)ACRYLOYL) 2H CHROMEN 2 ONE; 3 (3 (PYRIDIN 4 YL)ACRYLOYL) 2H CHROMEN 2 ONE DERIVATIVE; 3 ACETYL COUMARIN DERIVATIVE; 4 (3 (6 BROMO 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL) 1 (2 FLUOROBENZYL)PYRIDINIUM; 4 (3 (6 BROMO 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL) 1 (4 FLUOROBENZYL)PYRIDINIUM; 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL) 1 (2 METHYLBENZYL)PYRIDINIUM; 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL) 1 (3 METHYLBENZYL)PYRIDINIUM; 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL) 1 (4 METHOXYBENZYL)PYRIDINIUM; 4 (3 (8 METHOXY 2 OXO 2H CHROMEN 3 YL) 3 OXOPROP 1 ENYL) 1 (4 METHYLBENZYL)PYRIDINIUM; 6 BROMO 3 (3 (PYRIDIN 4 YL)ACRYLOYL) 2H CHROMEN 2 ONE; 8 METHOXY 3 (3 (PYRIDIN 4 YL)ACRYLOYL) 2H CHROMEN 2 ONE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; DONEPEZIL; N BENZYL PYRIMIDINIUM; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHORUS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; COUMARINS; ELECTROPHORUS; MODELS, MOLECULAR; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870060216     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.052     Document Type: Article

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