Search for dual function inhibitors for Alzheimer's disease: Synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Aβ fibril formation inhibition capacity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 2, 2006, Pages 472-478

  Kapková, Petra ^a   Alptüzün, Vildan ^b   Frey, Peter ^c   Erciyas, Ercin ^b   Holzgrabe, Ulrike ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b EGE UNIVERSITY   (Turkey)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

A fibril formation inhibition; Acetylcholinesterase inhibitors

Indexed keywords

3 [[(PHTHALIMIDOMETHOXY)IMINO]METHYL]PYRIDINE; 3 [[[(2,6 DICHLOROPHENYL)METHOXY]IMINO]METHYL]PYRIDINE; 3 [[[(NAPHTHYL 1 YL)METHOXY]IMINO]METHYL]PYRIDINE; AMYLOID BETA PROTEIN; CHOLINESTERASE INHIBITOR; PYRIDINIUM DERIVATIVE; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; DRUG SYNTHESIS; FLUORESCENCE; PATHOGENESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CHOLINESTERASE INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIDINIUM COMPOUNDS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 28844431542     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.08.034     Document Type: Article

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