메뉴 건너뛰기




Volumn 13, Issue 6, 2013, Pages 1010-1022

Oxidative stress protection by novel telomerase activators in mesenchymal stem cells derived from healthy and diseased individuals

Author keywords

Human mesenchymal stem cells; Oxidative stress; Telomerase; TERT activators

Indexed keywords

5' NUCLEOTIDASE; AGS 499; AGS 500; DACTINOMYCIN; ENDOGLIN; NEUROPROTECTIVE AGENT; TELOMERASE REVERSE TRANSCRIPTASE; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

EID: 84881354630     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524011313060013     Document Type: Article
Times cited : (26)

References (71)
  • 1
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006; 98: 1076-1084.
    • (2006) J Cell Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 3
    • 67649628226 scopus 로고    scopus 로고
    • Insights into mesenchymal stem cell aging: Involvement of antioxidant defense and actin cytoskeleton
    • Kasper G, Mao L, Geissler S, et al. Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells 2009; 27: 1288-1297.
    • (2009) Stem Cells , vol.27 , pp. 1288-1297
    • Kasper, G.1    Mao, L.2    Geissler, S.3
  • 4
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le, B.K.2    Mueller, I.3
  • 5
    • 17744394087 scopus 로고    scopus 로고
    • Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy
    • Hamada H, Kobune M, Nakamura K, et al. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci 2005; 96: 149-156.
    • (2005) Cancer Sci , vol.96 , pp. 149-156
    • Hamada, H.1    Kobune, M.2    Nakamura, K.3
  • 9
    • 62749084481 scopus 로고    scopus 로고
    • Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction
    • Wang YQ, Wang M, Zhang P, et al. Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction. Chin Med J (Engl) 2008; 121: 2290-2298.
    • (2008) Chin Med J (Engl) , vol.121 , pp. 2290-2298
    • Wang, Y.Q.1    Wang, M.2    Zhang, P.3
  • 10
    • 49549114293 scopus 로고    scopus 로고
    • Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer
    • Boker W, Yin Z, Drosse I, et al. Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J Cell Mol Med 2008; 12: 1347-1359.
    • (2008) J Cell Mol Med , vol.12 , pp. 1347-1359
    • Boker, W.1    Yin, Z.2    Drosse, I.3
  • 11
    • 69449095008 scopus 로고    scopus 로고
    • Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice
    • Nakahara H, Misawa H, Hayashi T, et al. Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice. Transplantation 2009; 88: 346-353.
    • (2009) Transplantation , vol.88 , pp. 346-353
    • Nakahara, H.1    Misawa, H.2    Hayashi, T.3
  • 12
    • 68849092642 scopus 로고    scopus 로고
    • Treatment of injured neurons with bone marrow stem cells cotransfected by hTERT and Ad-BDNF in vitro
    • Wang Z, Deng Q, Zhang X, Zhang J. Treatment of injured neurons with bone marrow stem cells cotransfected by hTERT and Ad-BDNF in vitro. J Mol Neurosci 2009; 38: 265-272.
    • (2009) J Mol Neurosci , vol.38 , pp. 265-272
    • Wang, Z.1    Deng, Q.2    Zhang, X.3    Zhang, J.4
  • 13
    • 0037148271 scopus 로고    scopus 로고
    • Telomerase in the human organism
    • Collins K, Mitchell JR. Telomerase in the human organism. Oncogene 2002; 21: 564-579.
    • (2002) Oncogene , vol.21 , pp. 564-579
    • Collins, K.1    Mitchell, J.R.2
  • 14
    • 2042429168 scopus 로고    scopus 로고
    • Regulation of telomerase by telomeric proteins
    • Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem 2004; 73: 177-208.
    • (2004) Annu Rev Biochem , vol.73 , pp. 177-208
    • Smogorzewska, A.1    de Lange, T.2
  • 15
    • 0034006777 scopus 로고    scopus 로고
    • Role of telomerase in cell senescence and oncogenesis
    • Urquidi V, Tarin D, Goodison S. Role of telomerase in cell senescence and oncogenesis. Annu Rev Med 2000; 51: 65-79.
    • (2000) Annu Rev Med , vol.51 , pp. 65-79
    • Urquidi, V.1    Tarin, D.2    Goodison, S.3
  • 16
    • 10744219690 scopus 로고    scopus 로고
    • Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
    • Kang HJ, Choi YS, Hong SB, et al. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci 2004; 24: 1280-1287.
    • (2004) J Neurosci , vol.24 , pp. 1280-1287
    • Kang, H.J.1    Choi, Y.S.2    Hong, S.B.3
  • 17
    • 33746851957 scopus 로고    scopus 로고
    • hTERT: A novel endogenous inhibitor of the mitochondrial cell death pathway
    • Massard C, Zermati Y, Pauleau AL, et al. hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. Oncogene 2006; 25: 4505-4514.
    • (2006) Oncogene , vol.25 , pp. 4505-4514
    • Massard, C.1    Zermati, Y.2    Pauleau, A.L.3
  • 18
    • 43149087522 scopus 로고    scopus 로고
    • Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
    • Ahmed S, Passos JF, Birket MJ, et al. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci 2008; 121: 1046-1053.
    • (2008) J Cell Sci , vol.121 , pp. 1046-1053
    • Ahmed, S.1    Passos, J.F.2    Birket, M.J.3
  • 19
    • 66349130192 scopus 로고    scopus 로고
    • Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
    • Haendeler J, Drose S, Buchner N, et al. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol 2009; 29: 929-935.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 929-935
    • Haendeler, J.1    Drose, S.2    Buchner, N.3
  • 20
    • 46749152214 scopus 로고    scopus 로고
    • Actions of human telomerase beyond telomeres
    • Cong Y, Shay JW. Actions of human telomerase beyond telomeres. Cell Res 2008; 18: 725-732.
    • (2008) Cell Res , vol.18 , pp. 725-732
    • Cong, Y.1    Shay, J.W.2
  • 21
    • 0141525391 scopus 로고    scopus 로고
    • Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends
    • Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev 2003; 17: 2384-2395.
    • (2003) Genes Dev , vol.17 , pp. 2384-2395
    • Stellwagen, A.E.1    Haimberger, Z.W.2    Veatch, J.R.3    Gottschling, D.E.4
  • 22
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi K, Yu EY, Khurts S, et al. Telomerase maintains telomere structure in normal human cells. Cell 2003; 114: 241-253.
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1    Yu, E.Y.2    Khurts, S.3
  • 23
    • 2942735029 scopus 로고    scopus 로고
    • Telomerase activity level, but not hTERT mRNA and hTR level, regulates telomere length in telomerase-reconstituted primary fibroblasts
    • Swiggers SJ, Nibbeling HA, Zeilemaker A, Kuijpers MA, Mattern KA, Zijlmans JM. Telomerase activity level, but not hTERT mRNA and hTR level, regulates telomere length in telomerase-reconstituted primary fibroblasts. Exp Cell Res 2004; 297: 434-443.
    • (2004) Exp Cell Res , vol.297 , pp. 434-443
    • Swiggers, S.J.1    Nibbeling, H.A.2    Zeilemaker, A.3    Kuijpers, M.A.4    Mattern, K.A.5    Zijlmans, J.M.6
  • 24
    • 33745642427 scopus 로고    scopus 로고
    • The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: The importance of DNase treatment
    • Hosseini-Asl S, Modarressi MH, Atri M, Salhab M, Mokbel K, Mehdipour P. The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: the importance of DNase treatment. J Carcinog 2006; 5: 17.
    • (2006) J Carcinog , vol.5 , pp. 17
    • Hosseini-Asl, S.1    Modarressi, M.H.2    Atri, M.3    Salhab, M.4    Mokbel, K.5    Mehdipour, P.6
  • 25
  • 26
    • 57149087885 scopus 로고    scopus 로고
    • Stretching the limits: Stem cells in regeneration science
    • Stocum DL, Zupanc GK. Stretching the limits: stem cells in regeneration science. Dev Dyn 2008; 237: 3648-3671.
    • (2008) Dev Dyn , vol.237 , pp. 3648-3671
    • Stocum, D.L.1    Zupanc, G.K.2
  • 27
    • 70450169272 scopus 로고    scopus 로고
    • Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals
    • Tichon A, Gowda BK, Slavin S, Gazit A, Priel E. Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals. Cytotherapy 2009; 11: 837-848.
    • (2009) Cytotherapy , vol.11 , pp. 837-848
    • Tichon, A.1    Gowda, B.K.2    Slavin, S.3    Gazit, A.4    Priel, E.5
  • 28
    • 34250017413 scopus 로고    scopus 로고
    • Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
    • Ju Z, Jiang H, Jaworski M, et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med 2007; 13: 742-747.
    • (2007) Nat Med , vol.13 , pp. 742-747
    • Ju, Z.1    Jiang, H.2    Jaworski, M.3
  • 30
    • 79951812916 scopus 로고    scopus 로고
    • Telomere dysfunction induces metabolic and mitochondrial compromise
    • Sahin E, Colla S, Liesa M, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011; 470: 359-365.
    • (2011) Nature , vol.470 , pp. 359-365
    • Sahin, E.1    Colla, S.2    Liesa, M.3
  • 31
    • 79960322707 scopus 로고    scopus 로고
    • The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
    • de Jesus BB, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 2011; 10: 604-621.
    • (2011) Aging Cell , vol.10 , pp. 604-621
    • de Jesus, B.B.1    Schneeberger, K.2    Vera, E.3    Tejera, A.4    Harley, C.B.5    Blasco, M.A.6
  • 32
    • 78650990326 scopus 로고    scopus 로고
    • Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
    • Jaskelioff M, Muller FL, Paik JH, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011; 469: 102-106.
    • (2011) Nature , vol.469 , pp. 102-106
    • Jaskelioff, M.1    Muller, F.L.2    Paik, J.H.3
  • 33
    • 84859383206 scopus 로고    scopus 로고
    • Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis
    • Eitan E, Tichon A, Gazit A, Gitler D, Slavin S, Priel E. Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis. EMBO Mol Med 2012; 4: 313-329.
    • (2012) EMBO Mol Med , vol.4 , pp. 313-329
    • Eitan, E.1    Tichon, A.2    Gazit, A.3    Gitler, D.4    Slavin, S.5    Priel, E.6
  • 34
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 35
    • 23044472161 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells
    • Konnikova L, Simeone MC, Kruger MM, Kotecki M, Cochran BH. Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Res 2005; 65: 6516-6520.
    • (2005) Cancer Res , vol.65 , pp. 6516-6520
    • Konnikova, L.1    Simeone, M.C.2    Kruger, M.M.3    Kotecki, M.4    Cochran, B.H.5
  • 36
    • 84861010003 scopus 로고    scopus 로고
    • Evaluation of the efficacy of radiation-modifying compounds using gammaH2AX as a molecular marker of DNA double-strand breaks
    • Mah LJ, Orlowski C, Ververis K, Vasireddy RS, El-Osta A, Karagiannis TC. Evaluation of the efficacy of radiation-modifying compounds using gammaH2AX as a molecular marker of DNA double-strand breaks. Genome Integr 2011; 2: 3.
    • (2011) Genome Integr , vol.2 , pp. 3
    • Mah, L.J.1    Orlowski, C.2    Ververis, K.3    Vasireddy, R.S.4    El-Osta, A.5    Karagiannis, T.C.6
  • 37
    • 17844373798 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
    • Liu Y, Snow BE, Hande MP, et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol 2000; 10: 1459-1462.
    • (2000) Curr Biol , vol.10 , pp. 1459-1462
    • Liu, Y.1    Snow, B.E.2    Hande, M.P.3
  • 38
    • 27244440007 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation
    • Li CD, Zhang WY, Li HL, et al. Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation. Cell Res 2005; 15: 539-547.
    • (2005) Cell Res , vol.15 , pp. 539-547
    • Li, C.D.1    Zhang, W.Y.2    Li, H.L.3
  • 39
    • 52049087188 scopus 로고    scopus 로고
    • Conditioned media cause increases in select osteogenic and adipogenic differentiation markers in mesenchymal stem cell cultures
    • Maxson S, Burg KJ. Conditioned media cause increases in select osteogenic and adipogenic differentiation markers in mesenchymal stem cell cultures. J Tissue Eng Regen Med 2008; 2: 147-154.
    • (2008) J Tissue Eng Regen Med , vol.2 , pp. 147-154
    • Maxson, S.1    Burg, K.J.2
  • 40
    • 0033537830 scopus 로고    scopus 로고
    • Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation
    • Tirosh A, Potashnik R, Bashan N, Rudich A. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem 1999; 274: 10595-10602.
    • (1999) J Biol Chem , vol.274 , pp. 10595-10602
    • Tirosh, A.1    Potashnik, R.2    Bashan, N.3    Rudich, A.4
  • 41
    • 78049348334 scopus 로고    scopus 로고
    • Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis
    • Gordon D, Pavlovska G, Uney JB, Wraith DC, Scolding NJ. Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis. J Neuropathol Exp Neurol 2010; 69: 1087-1095.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 1087-1095
    • Gordon, D.1    Pavlovska, G.2    Uney, J.B.3    Wraith, D.C.4    Scolding, N.J.5
  • 42
    • 80051780265 scopus 로고    scopus 로고
    • Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy parkinsonism
    • Park HJ, Bang G, Lee BR, Kim HO, Lee PH. Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy parkinsonism. Cell Transplant 2011; 20: 827-835.
    • (2011) Cell Transplant , vol.20 , pp. 827-835
    • Park, H.J.1    Bang, G.2    Lee, B.R.3    Kim, H.O.4    Lee, P.H.5
  • 43
    • 49349085868 scopus 로고    scopus 로고
    • Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis
    • Vercelli A, Mereuta OM, Garbossa D, et al. Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2008; 31: 395-405.
    • (2008) Neurobiol Dis , vol.31 , pp. 395-405
    • Vercelli, A.1    Mereuta, O.M.2    Garbossa, D.3
  • 45
    • 4444273090 scopus 로고    scopus 로고
    • Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion
    • Baxter MA, Wynn RF, Jowitt SN, Wraith JE, Fairbairn LJ, Bellantuono I. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 2004; 22: 675-682.
    • (2004) Stem Cells , vol.22 , pp. 675-682
    • Baxter, M.A.1    Wynn, R.F.2    Jowitt, S.N.3    Wraith, J.E.4    Fairbairn, L.J.5    Bellantuono, I.6
  • 46
    • 3042591085 scopus 로고    scopus 로고
    • Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
    • Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004; 117: 2417-2426.
    • (2004) J Cell Sci , vol.117 , pp. 2417-2426
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Trivier, E.4    Akhmedov, A.5    Erusalimsky, J.D.6
  • 47
    • 36749006617 scopus 로고    scopus 로고
    • Telomere dysfunction and stem cell ageing
    • Ju Z, Lenhard Rudolph K. Telomere dysfunction and stem cell ageing. Biochimie 2008; 90: 24-32.
    • (2008) Biochimie , vol.90 , pp. 24-32
    • Ju, Z.1    Lenhard, R.K.2
  • 48
    • 69249206823 scopus 로고    scopus 로고
    • Telomere length of donors influences granulocyte recovery in children after hematopoietic stem cell transplantation
    • Mangerini R, Lanino E, Terranova P, et al. Telomere length of donors influences granulocyte recovery in children after hematopoietic stem cell transplantation. Ann Hematol 2009; 88: 1029-1031.
    • (2009) Ann Hematol , vol.88 , pp. 1029-1031
    • Mangerini, R.1    Lanino, E.2    Terranova, P.3
  • 49
    • 39149115057 scopus 로고    scopus 로고
    • Cell and gene therapy using mesenchymal stem cells (MSCs)
    • Ozawa K, Sato K, Oh I, et al. Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun 2008; 30: 121-127.
    • (2008) J Autoimmun , vol.30 , pp. 121-127
    • Ozawa, K.1    Sato, K.2    Oh, I.3
  • 50
    • 84859383206 scopus 로고    scopus 로고
    • Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis
    • Eitan E, Tichon A, Gazit A, Gitler D, Slavin S, Priel E. Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis. EMBO Mol Med 2012; 4: 313-329.
    • (2012) EMBO Mol Med , vol.4 , pp. 313-329
    • Eitan, E.1    Tichon, A.2    Gazit, A.3    Gitler, D.4    Slavin, S.5    Priel, E.6
  • 51
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001; 107: 67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 52
    • 3242759226 scopus 로고    scopus 로고
    • In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues
    • Baykal A, Thompson JA, Xu XC, et al. In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues. Oncol Rep 2004; 11: 297-302.
    • (2004) Oncol Rep , vol.11 , pp. 297-302
    • Baykal, A.1    Thompson, J.A.2    Xu, X.C.3
  • 53
    • 33745289998 scopus 로고    scopus 로고
    • Telomerase activity determined by conventional telomeric repeat amplification protocol and reverse transcriptase-polymerase chain reaction assay in ovarian lesions: A comparison of assays
    • Ernst A, Okkels H, Grove A, et al. Telomerase activity determined by conventional telomeric repeat amplification protocol and reverse transcriptase-polymerase chain reaction assay in ovarian lesions: a comparison of assays. Scand J Clin Lab Invest 2006; 66: 287-297.
    • (2006) Scand J Clin Lab Invest , vol.66 , pp. 287-297
    • Ernst, A.1    Okkels, H.2    Grove, A.3
  • 54
    • 1842852635 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase mRNA is highly expressed in normal breast tissues and down-regulated in ductal carcinoma in situ
    • Liu J, Baykal A, Fung KM, et al. Human telomerase reverse transcriptase mRNA is highly expressed in normal breast tissues and down-regulated in ductal carcinoma in situ. Int J Oncol 2004; 24: 879-884.
    • (2004) Int J Oncol , vol.24 , pp. 879-884
    • Liu, J.1    Baykal, A.2    Fung, K.M.3
  • 55
    • 0029808357 scopus 로고    scopus 로고
    • Telomerase activity in normal human epithelial cells
    • Yasumoto S, Kunimura C, Kikuchi K, et al. Telomerase activity in normal human epithelial cells. Oncogene 1996; 13: 433-439.
    • (1996) Oncogene , vol.13 , pp. 433-439
    • Yasumoto, S.1    Kunimura, C.2    Kikuchi, K.3
  • 56
    • 48949085109 scopus 로고    scopus 로고
    • The many faces of telomerase: Emerging extratelomeric effects
    • Bollmann FM. The many faces of telomerase: emerging extratelomeric effects. Bioessays 2008; 30: 728-732.
    • (2008) Bioessays , vol.30 , pp. 728-732
    • Bollmann, F.M.1
  • 57
    • 67650627734 scopus 로고    scopus 로고
    • Telomerase, mitochondria and oxidative stress
    • Saretzki G. Telomerase, mitochondria and oxidative stress. Exp Gerontol 2009; 44: 485-492.
    • (2009) Exp Gerontol , vol.44 , pp. 485-492
    • Saretzki, G.1
  • 58
    • 0038721199 scopus 로고    scopus 로고
    • Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
    • Haendeler J, Hoffmann J, Brandes RP, Zeiher AM, Dimmeler S. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol 2003; 23: 4598-4610.
    • (2003) Mol Cell Biol , vol.23 , pp. 4598-4610
    • Haendeler, J.1    Hoffmann, J.2    Brandes, R.P.3    Zeiher, A.M.4    Dimmeler, S.5
  • 59
    • 27344446189 scopus 로고    scopus 로고
    • Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
    • Del Bufalo D, Rizzo A, Trisciuoglio D, et al. Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function. Cell Death Differ 2005; 12: 1429-1438.
    • (2005) Cell Death Differ , vol.12 , pp. 1429-1438
    • Del, B.D.1    Rizzo, A.2    Trisciuoglio, D.3
  • 60
    • 77957361644 scopus 로고    scopus 로고
    • Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor
    • Jin X, Beck S, Sohn YW, et al. Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor. Exp Mol Med 2010; 42: 574-582.
    • (2010) Exp Mol Med , vol.42 , pp. 574-582
    • Jin, X.1    Beck, S.2    Sohn, Y.W.3
  • 61
    • 0037427086 scopus 로고    scopus 로고
    • hTERT associates with human telomeres and enhances genomic stability and DNA repair
    • Sharma GG, Gupta A, Wang H, et al. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 2003; 22: 131-146.
    • (2003) Oncogene , vol.22 , pp. 131-146
    • Sharma, G.G.1    Gupta, A.2    Wang, H.3
  • 62
    • 33747595991 scopus 로고    scopus 로고
    • Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro
    • Ebert R, Ulmer M, Zeck S, et al. Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells 2006; 24: 1226-1235.
    • (2006) Stem Cells , vol.24 , pp. 1226-1235
    • Ebert, R.1    Ulmer, M.2    Zeck, S.3
  • 63
    • 77950564444 scopus 로고    scopus 로고
    • Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex
    • Song H, Cha MJ, Song BW, et al. Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex. Stem Cells 2010; 28: 555-563.
    • (2010) Stem Cells , vol.28 , pp. 555-563
    • Song, H.1    Cha, M.J.2    Song, B.W.3
  • 64
    • 73849116441 scopus 로고    scopus 로고
    • Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts
    • Yang YJ, Qian HY, Huang J, et al. Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts. Arterioscler Thromb Vasc Biol 2009; 29: 2076-2082.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 2076-2082
    • Yang, Y.J.1    Qian, H.Y.2    Huang, J.3
  • 65
    • 4444380340 scopus 로고    scopus 로고
    • Immunoblot analysis and band depletion assays
    • Kaufmann SH, Svingen PA. Immunoblot analysis and band depletion assays. Methods Mol Biol 1999; 94: 253-268.
    • (1999) Methods Mol Biol , vol.94 , pp. 253-268
    • Kaufmann, S.H.1    Svingen, P.A.2
  • 67
    • 0032493648 scopus 로고    scopus 로고
    • Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase
    • Ishigami M, Swertfeger DK, Granholm NA, Hui DY. Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase. J Biol Chem 1998; 273: 20156-20161.
    • (1998) J Biol Chem , vol.273 , pp. 20156-20161
    • Ishigami, M.1    Swertfeger, D.K.2    Granholm, N.A.3    Hui, D.Y.4
  • 68
    • 33745290201 scopus 로고    scopus 로고
    • Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen
    • Chin RK, Zhu M, Christiansen PA, et al. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol 2006; 177: 290-297.
    • (2006) J Immunol , vol.177 , pp. 290-297
    • Chin, R.K.1    Zhu, M.2    Christiansen, P.A.3
  • 69
    • 34547122719 scopus 로고    scopus 로고
    • Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow
    • Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2007; 25: 1384-1392.
    • (2007) Stem Cells , vol.25 , pp. 1384-1392
    • Baksh, D.1    Yao, R.2    Tuan, R.S.3
  • 70
    • 77950366686 scopus 로고    scopus 로고
    • Identification of ROS using oxidized DCFDA and flow-cytometry
    • Eruslanov E, Kusmartsev S. Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol 2010; 594: 57-72.
    • (2010) Methods Mol Biol , vol.594 , pp. 57-72
    • Eruslanov, E.1    Kusmartsev, S.2
  • 71
    • 79961160124 scopus 로고    scopus 로고
    • Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions
    • Ueyama H, Horibe T, Hinotsu S, et al. Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions. J Cell Mol Med 2011; 16: 72-82.
    • (2011) J Cell Mol Med , vol.16 , pp. 72-82
    • Ueyama, H.1    Horibe, T.2    Hinotsu, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.