Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor

Experimental and Molecular Medicine

Volumn 42, Issue 8, 2010, Pages 574-582

  Jin, Xun ^a   Beck, Samuel ^b   Sohn, Young Woo ^a   Kim, Jun Kyum ^a   Kim, Sung Hak ^a   Yin, Jinlong ^b   Pian, Xumin ^a   Kim, Sung Chan ^c   Choi, Yun Jaie ^b   Kim, Hyunggee ^a  

^a Korea University   (South Korea)

^b Seoul National University   (South Korea)

^c Hallym University   (South Korea)

Author keywords

Apoptosis; Cell death; Fibroblast growth factor 2; Telomerase; Tumor suppressor protein p53

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CASPASE 3; CASPASE 9; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; SHORT HAIRPIN RNA; TELOMERASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRUCTURE; CELL TYPE; CHROMOSOME SIZE; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME REPRESSION; FEMALE; FETUS; FIBROBLAST; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TELOMERE; TRANSCRIPTION INITIATION; UPREGULATION; WILD TYPE;

EID: 77957361644     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.8.058     Document Type: Article

References (28)

1. Aylon Y, Oren M. Living with p53, Dying of p53. Cell 2007;130: 597-600
2. Branca M, Giorgi C, Ciotti M, Santini D, Di Bonito L, Costa S, Benedetto A, Bonifacio D, Di Bonito P, Paba P, Accardi L, Mariani L, Ruutu M, Syrjanen S, Favalli C, Syrjanen K. Upregulation of telomerase (TERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus, virus persistence, or disease outcome in cervical cancer. Diag Cytopathol 2007;34:739-48
3. Cayuela ML, Flores JM, Blasco MA. The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. EMBO J 2005;6:268-74
4. Gorbunova V, Seluanov A, Pereira-Smith OM. Expression of human telomerase (TERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem 2002;277:38540-9
5. Greider CW. Telomere length regulation. Annu Rev Biochem 1996;65:337-65
6. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999;5:1164-70
7. Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 1997;11:3109-15
8. Hiyama E, Hiyama K. Clinical utility of telomerase in cancer. Oncogene 2002;21:643-9
9. Kurvinen K, Syrjanen S, Johansson B. Long-term suppression of telomerase expression in HeLa cell clones, transfected with an expression vector carrying siRNA targeting TERT mRNA. Int J Oncol 2006;29:279-88
10. Kurz EU, Lees-Miller SP. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) 2004;3:889-900
11. Laviola L, Natalicchio A, Giorgino F. The IGF-I signaling pathway. Curr Pharm Des 2007;13:663-9
12. Lee MK, Hande MP, Sabapathy K. Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis. J Cell Sci 2005; 118:819-29
13. Li S, Crothers J, Haqq CM, Blackburn EH. Cellular and gene expression responses involved in the rapid growth inhibition of Human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem 2005;280: 23709-17
14. Luiten RM, Pene J, Yssel H, Spits H. Ectopic TERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 2003;101:4512-9
15. Macaulay VM. The IGF receptor as anticancer treatment target. Novartis Found Symp 2004;262:235-43
16. Massard C, Zermati Y, Pauleau AL, Larochette N, Metivier D, Sabatier L, Kroemer G, Soria JC. TERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. Oncogene 2006;25:4505-14
17. Papadopoulou A, Trangas T, Teixeira MR, Heim S, Dimitriadis E, Tsarouha H, Andersen JA. Evangelou E, Ioannidis P. Telomerase activity and genetic alterations in primary breast carcinomas. Neoplasia 2003;5:170-8
18. Perfettini JL, Kroemer RT, Kroemer G. Fatal liaisons of p53 with Bax and Bak. Nat Cell Biol 2004;6:386-8
19. Romanov VV, James CH, Sherrington PD, Pettitt AR. Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia. Oncogene 2005;24:6855-60
20. Rudolph KL, Millard M, Bosenberg MW. DePinho RA. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 2001;28:155-9
21. Shay JW, Bacchetti SA. Survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91
22. Smith LL, Coller HA, Roberts JM. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 2003;5:474-9
23. Tomoda R, Seto M, Tsumuki H, Iida K, Yamazaki T, Sonoda J, Matsumine A, Uchida A. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer 2002;95:1127-33
24. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000;408:307-10
25. Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604
26. Wang R, Lin F, Wang X, Gao P, Dong K, Wei SH, Cheng SY, Zhang HZ. The therapeutic potential of survivin promoter- driven siRNA on suppressing tumor growth and enhancing radiosensitivity of human cervical carcinoma cells via downregulating hTERT gene expression. Cancer Biol Ther 2007;6:1295-301
27. Xu T, Rao Y, Zhu W, Guo F. Inhibition of cell growth and telomerase activity in osteosarcoma cells by DN-TERT. J Huazhong Univ Sci Technolog Med Sci 2006;26:601-3
28. Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shorting and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 1999;13:2388-99