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Volumn 30, Issue 8, 2008, Pages 728-732

The many faces of telomerase: Emerging extratelomeric effects

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RIBONUCLEOPROTEIN; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

EID: 48949085109     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.20793     Document Type: Review
Times cited : (62)

References (50)
  • 1
    • 35448962513 scopus 로고    scopus 로고
    • A continuous correlation between oxidative stress and telomere shortening in fibroblasts
    • Richter T, Zglinicki T. 2007. A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 42:1039-1042.
    • (2007) Exp Gerontol , vol.42 , pp. 1039-1042
    • Richter, T.1    Zglinicki, T.2
  • 2
    • 0015844590 scopus 로고
    • A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov AM. 1973. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41:181-190.
    • (1973) J Theor Biol , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 3
    • 2442455288 scopus 로고    scopus 로고
    • Telomeres are double-strand DNA breaks hidden from DNA damage responses
    • Shay JW, Wright WE. 2004. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Mol Cell 14:420-421.
    • (2004) Mol Cell , vol.14 , pp. 420-421
    • Shay, J.W.1    Wright, W.E.2
  • 4
    • 0030668722 scopus 로고    scopus 로고
    • Human telomerase contains evolutionary conserved catalytic and structural subunits
    • Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, et al. 1997. Human telomerase contains evolutionary conserved catalytic and structural subunits. Genes Dev 11:3109-3115.
    • (1997) Genes Dev , vol.11 , pp. 3109-3115
    • Harrington, L.1    Zhou, W.2    McPhail, T.3    Oulton, R.4    Yeung, D.S.5
  • 5
    • 0033397317 scopus 로고    scopus 로고
    • Telomerase in cancer diagnosis and therapy: A clinical perspective
    • Burger AM. 1999. Telomerase in cancer diagnosis and therapy: a clinical perspective. BioDrugs 12:413-422.
    • (1999) BioDrugs , vol.12 , pp. 413-422
    • Burger, A.M.1
  • 6
    • 0343750697 scopus 로고    scopus 로고
    • Impaired germinal center reaction in mice with short telomeres
    • Herrera E, Martinez AC, Blasco MA. 2000. Impaired germinal center reaction in mice with short telomeres. EMBO J 19:472-481.
    • (2000) EMBO J , vol.19 , pp. 472-481
    • Herrera, E.1    Martinez, A.C.2    Blasco, M.A.3
  • 10
    • 34250011694 scopus 로고    scopus 로고
    • Telomere maintenance in sarcomas
    • Johnson JE, Broccoli D. 2007. Telomere maintenance in sarcomas. Curr Opin Oncol 19:377-382.
    • (2007) Curr Opin Oncol , vol.19 , pp. 377-382
    • Johnson, J.E.1    Broccoli, D.2
  • 11
    • 34548269900 scopus 로고    scopus 로고
    • Tel1p preferentially associates with short telomeres to stimulate their elongation
    • Hector RE, Shtofman RL, Ray A, Chen BR, Nyun T, et al. 2007. Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol Cell 27:851-858.
    • (2007) Mol Cell , vol.27 , pp. 851-858
    • Hector, R.E.1    Shtofman, R.L.2    Ray, A.3    Chen, B.R.4    Nyun, T.5
  • 12
    • 33846590977 scopus 로고    scopus 로고
    • Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
    • Benetti R, Garcia-Cao M, Blasco MA. 2007. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet 39:243-250.
    • (2007) Nat Genet , vol.39 , pp. 243-250
    • Benetti, R.1    Garcia-Cao, M.2    Blasco, M.A.3
  • 13
    • 0037224923 scopus 로고    scopus 로고
    • Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression
    • Chang S, Khoo CM, Naylor ML, Maser RS, DePinho RA. 2003. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 17:88-100.
    • (2003) Genes Dev , vol.17 , pp. 88-100
    • Chang, S.1    Khoo, C.M.2    Naylor, M.L.3    Maser, R.S.4    DePinho, R.A.5
  • 14
    • 2942538551 scopus 로고    scopus 로고
    • Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice
    • Canela A, Martin-Caballero J, Flores JM, Blasco MA. 2004. Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Mol Cell Biol 24: 4275-4293.
    • (2004) Mol Cell Biol , vol.24 , pp. 4275-4293
    • Canela, A.1    Martin-Caballero, J.2    Flores, J.M.3    Blasco, M.A.4
  • 16
    • 23044498872 scopus 로고    scopus 로고
    • Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation
    • Sun B, Chen M, Hawks CL, Hornsby PJ. 2005. Immortal ALT+ human cells do not require telomerase reverse transcriptase for malignant transformation. Cancer Res 65:6512-6515.
    • (2005) Cancer Res , vol.65 , pp. 6512-6515
    • Sun, B.1    Chen, M.2    Hawks, C.L.3    Hornsby, P.J.4
  • 17
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW, Dang CV. 2006. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66:8927-8930.
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 19
    • 2942709631 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT)
    • Nishi H, Nakada T, Kyo S, Inoue M, Shay JW, et al. 2004. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol 24:6076-6083.
    • (2004) Mol Cell Biol , vol.24 , pp. 6076-6083
    • Nishi, H.1    Nakada, T.2    Kyo, S.3    Inoue, M.4    Shay, J.W.5
  • 20
    • 40449109731 scopus 로고    scopus 로고
    • Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution
    • Nergadze SG, Santagostino M, Salzano A, Mondello C, Giulotto E. 2007. Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution. Genome Biol 8:R260.
    • (2007) Genome Biol , vol.8
    • Nergadze, S.G.1    Santagostino, M.2    Salzano, A.3    Mondello, C.4    Giulotto, E.5
  • 21
    • 20444371017 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
    • Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, et al. 2005. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. ProcNatl Acad Sci USA 102:8222-8227.
    • (2005) ProcNatl Acad Sci USA , vol.102 , pp. 8222-8227
    • Masutomi, K.1    Possemato, R.2    Wong, J.M.3    Currier, J.L.4    Tothova, Z.5
  • 22
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • Smith LL, Coller HA, Roberts JM. 2003. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 5:474-479.
    • (2003) Nat Cell Biol , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 23
    • 33746257301 scopus 로고    scopus 로고
    • Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling
    • Geserick C, Tejera A, Gonzalez-Suarez E, Klatt P, Blasco MA. 2006. Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling. Oncogene 25:4310-4319.
    • (2006) Oncogene , vol.25 , pp. 4310-4319
    • Geserick, C.1    Tejera, A.2    Gonzalez-Suarez, E.3    Klatt, P.4    Blasco, M.A.5
  • 24
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, et al. 2001. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 20:2619-2630.
    • (2001) EMBO J , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3    Flores, J.M.4    Martin-Caballero, J.5
  • 25
    • 0036732390 scopus 로고    scopus 로고
    • Keeping telomerase in its place
    • Maser RS, DePinho RA. 2002. Keeping telomerase in its place. Nat Med 8:934-936.
    • (2002) Nat Med , vol.8 , pp. 934-936
    • Maser, R.S.1    DePinho, R.A.2
  • 27
    • 33744745014 scopus 로고    scopus 로고
    • Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    • Hertzog Santos J, Meyer JN, van Houten B. 2006. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet 15: 1757-1768.
    • (2006) Hum Mol Genet , vol.15 , pp. 1757-1768
    • Hertzog Santos, J.1    Meyer, J.N.2    van Houten, B.3
  • 28
    • 0038721199 scopus 로고    scopus 로고
    • Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
    • Haendeler J, Hoffmann J, Brandes RP, Zeiher AM, Dimmeler S. 2003. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol 23:4598-4610.
    • (2003) Mol Cell Biol , vol.23 , pp. 4598-4610
    • Haendeler, J.1    Hoffmann, J.2    Brandes, R.P.3    Zeiher, A.M.4    Dimmeler, S.5
  • 29
    • 43149087522 scopus 로고    scopus 로고
    • Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
    • Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, et al. 2008. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci 121:1046-1053.
    • (2008) J Cell Sci , vol.121 , pp. 1046-1053
    • Ahmed, S.1    Passos, J.F.2    Birket, M.J.3    Beckmann, T.4    Brings, S.5
  • 30
    • 0034086553 scopus 로고    scopus 로고
    • The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis
    • Zhu H, Fu W, Mattson MP. 2000. The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis. J Neurochem 75:117-124.
    • (2000) J Neurochem , vol.75 , pp. 117-124
    • Zhu, H.1    Fu, W.2    Mattson, M.P.3
  • 31
    • 10744219690 scopus 로고    scopus 로고
    • Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
    • Kang HJ, Choi YS, Hong SB, Kim KW, Woo RS, et al. 2004. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci 24:1280-1287.
    • (2004) J Neurosci , vol.24 , pp. 1280-1287
    • Kang, H.J.1    Choi, Y.S.2    Hong, S.B.3    Kim, K.W.4    Woo, R.S.5
  • 32
    • 0035978922 scopus 로고    scopus 로고
    • Emerging roles for telomerase in regulating cell differentiation and survival: A neuroscientist's perspective
    • Mattson MP, Fu W, Zhang P. 2001. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech Ageing Dev 122:659-671.
    • (2001) Mech Ageing Dev , vol.122 , pp. 659-671
    • Mattson, M.P.1    Fu, W.2    Zhang, P.3
  • 33
    • 36248979715 scopus 로고    scopus 로고
    • Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: Effects on telomere status and proliferative potential of human prostate cancer cells
    • Folini M, Bandiera R, Millo E, Gandellini P, Sozzi G, et al. 2007. Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells. Cell Prolif 40:905-920.
    • (2007) Cell Prolif , vol.40 , pp. 905-920
    • Folini, M.1    Bandiera, R.2    Millo, E.3    Gandellini, P.4    Sozzi, G.5
  • 34
    • 33645749498 scopus 로고    scopus 로고
    • Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: Effect of ectopic hTERT
    • Brachner A, Sasgary S, Pirker C, Rodgarkia C, Mikula M, et al. 2006. Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT. Cancer Res 66:3584-3592.
    • (2006) Cancer Res , vol.66 , pp. 3584-3592
    • Brachner, A.1    Sasgary, S.2    Pirker, C.3    Rodgarkia, C.4    Mikula, M.5
  • 35
    • 33745016300 scopus 로고    scopus 로고
    • Inhibition of telomerase enhances apoptosis induced by sodium butyrate via mitochondrial pathway
    • Xi L, Chen G, Zhou J, Xu G, Wang S, et al. 2006. Inhibition of telomerase enhances apoptosis induced by sodium butyrate via mitochondrial pathway. Apoptosis 11:789-798.
    • (2006) Apoptosis , vol.11 , pp. 789-798
    • Xi, L.1    Chen, G.2    Zhou, J.3    Xu, G.4    Wang, S.5
  • 36
    • 6344247581 scopus 로고    scopus 로고
    • Death receptor signalling regulatory function for telomerase: HTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance
    • Dudognon C, Pendino F, Hillion J, Saumet A, Lanotte M, et al. 2004. Death receptor signalling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. Oncogene 23:7469-7474.
    • (2004) Oncogene , vol.23 , pp. 7469-7474
    • Dudognon, C.1    Pendino, F.2    Hillion, J.3    Saumet, A.4    Lanotte, M.5
  • 37
    • 85047697807 scopus 로고    scopus 로고
    • TERT regulates cell survival independent of telomerase enzymatic activity
    • Cao Y, Li H, Deb S, Liu JP. 2002. TERT regulates cell survival independent of telomerase enzymatic activity. Oncogene 21:3130-3138.
    • (2002) Oncogene , vol.21 , pp. 3130-3138
    • Cao, Y.1    Li, H.2    Deb, S.3    Liu, J.P.4
  • 38
    • 27344446189 scopus 로고    scopus 로고
    • Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
    • Del Bufalo D, Rizzo A, Trisciuoglio D, Cardinali G, Torrisi MR, et al. 2007. Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function. Cell Death Diff 12:1429-1438.
    • (2007) Cell Death Diff , vol.12 , pp. 1429-1438
    • Del Bufalo, D.1    Rizzo, A.2    Trisciuoglio, D.3    Cardinali, G.4    Torrisi, M.R.5
  • 39
    • 14844301658 scopus 로고    scopus 로고
    • hTERT antagonizes p53-induced apoptosis independently of telomerase activity
    • Rahman R, Latonen L, Wiman KG. 2005. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 24:1320-1327.
    • (2005) Oncogene , vol.24 , pp. 1320-1327
    • Rahman, R.1    Latonen, L.2    Wiman, K.G.3
  • 40
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin KY, Cheung P, Gilison D, Lee E, Tennen RI, et al. 2005. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436:1048-1052.
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1    Cheung, P.2    Gilison, D.3    Lee, E.4    Tennen, R.I.5
  • 41
    • 38949156672 scopus 로고    scopus 로고
    • TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
    • Choi J, Southworth LK, Sarin KY, Venteicher AS, Ma W, et al. 2008. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PloS Genet 4:e10.
    • (2008) PloS Genet , vol.4
    • Choi, J.1    Southworth, L.K.2    Sarin, K.Y.3    Venteicher, A.S.4    Ma, W.5
  • 43
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    • Blasco MA, Rizen M, Greider CW, Hanahan D. 1996. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 12:200-204.
    • (1996) Nat Genet , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 44
    • 0032869795 scopus 로고    scopus 로고
    • Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions
    • Bachor C, Bachor OA, Boukamp P. 1999. Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions. J Cancer Res Clin Oncol 125:453-460.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 453-460
    • Bachor, C.1    Bachor, O.A.2    Boukamp, P.3
  • 46
    • 1842852635 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase mRNA is highly expressed in normal breast tissues and down-regulated in ductal carcinoma in situ
    • Liu J, Baykal A, Fung KM, Thompson-Lanza JA, Hoque A, et al. 2004. Human telomerase reverse transcriptase mRNA is highly expressed in normal breast tissues and down-regulated in ductal carcinoma in situ. Int J Oncol 24:879-884.
    • (2004) Int J Oncol , vol.24 , pp. 879-884
    • Liu, J.1    Baykal, A.2    Fung, K.M.3    Thompson-Lanza, J.A.4    Hoque, A.5
  • 47
    • 23044486120 scopus 로고    scopus 로고
    • Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity
    • Nagao K, Ohyashiki JH, Ohyashiki K, Tabata K, Takai K, et al. 2005. Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity. Int J Mol Med 15:683-688.
    • (2005) Int J Mol Med , vol.15 , pp. 683-688
    • Nagao, K.1    Ohyashiki, J.H.2    Ohyashiki, K.3    Tabata, K.4    Takai, K.5
  • 48
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, et al. 2003. Telomerase maintains telomere structure in normal human cells. Cell 114:241-253.
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1    Yu, E.Y.2    Khurts, S.3    Ben-Porath, I.4    Currier, J.L.5
  • 50
    • 26444523061 scopus 로고    scopus 로고
    • Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells
    • Wang JC, Warner JK, Erdmann N, Lansdorp PM, Harrington L, Dick JE. 2005. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. Proc Natl Acad Sci USA 102:14398-14403.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14398-14403
    • Wang, J.C.1    Warner, J.K.2    Erdmann, N.3    Lansdorp, P.M.4    Harrington, L.5    Dick, J.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.