-
1
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
2
-
-
0029156035
-
Telomere shortening is associated with cell division in vitro and in vivo
-
Allsopp R.C., Chang E., Kashefi-Aazam M., Rogaev E.I., Piatyszek M.A., Shay J.W., Harley C.B. Telomere shortening is associated with cell division in vitro and in vivo. Exp. Cell Res. 220:1995;194-200
-
(1995)
Exp. Cell Res.
, vol.220
, pp. 194-200
-
-
Allsopp, R.C.1
Chang, E.2
Kashefi-Aazam, M.3
Rogaev, E.I.4
Piatyszek, M.A.5
Shay, J.W.6
Harley, C.B.7
-
3
-
-
0026460896
-
Telomere length predicts replicative capacity of human fibroblasts
-
Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89:1992;10114-10118
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 10114-10118
-
-
Allsopp, R.C.1
Vaziri, H.2
Patterson, C.3
Goldstein, S.4
Younglai, E.V.5
Futcher, A.B.6
Greider, C.W.7
Harley, C.B.8
-
4
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:1961;585-621
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
5
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636
-
(1965)
Exp. Cell Res.
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
6
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie N.D., Dempster M., Dunlop M.G., Thompson A.M., Green D.K., Allshire R.C. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:1990;866-868
-
(1990)
Nature
, vol.346
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.G.3
Thompson, A.M.4
Green, D.K.5
Allshire, R.C.6
-
7
-
-
0027486732
-
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
-
Vaziri H., Schachter F., Uchida I., Wei L., Zhu X., Effros R., Cohen D., Harley C.B. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52:1993;661-667
-
(1993)
Am. J. Hum. Genet.
, vol.52
, pp. 661-667
-
-
Vaziri, H.1
Schachter, F.2
Uchida, I.3
Wei, L.4
Zhu, X.5
Effros, R.6
Cohen, D.7
Harley, C.B.8
-
8
-
-
0037308404
-
Association between telomere length in blood and mortality in people aged 60 years or older
-
Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 361:2003;393-395
-
(2003)
Lancet
, vol.361
, pp. 393-395
-
-
Cawthon, R.M.1
Smith, K.R.2
O'Brien, E.3
Sivatchenko, A.4
Kerber, R.A.5
-
9
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
-
Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell. 43:1985;405-413
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
10
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi K., Yu E.Y., Khurts S., Ben-Porath I., Currier J.L., Metz G.B., Brooks M.W., Kaneko S., Murakami S., DeCaprio J.A., Weinberg R.A., Stewart S.A., Hahn W.C. Telomerase maintains telomere structure in normal human cells. Cell. 114:2003;241-253
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
Yu, E.Y.2
Khurts, S.3
Ben-Porath, I.4
Currier, J.L.5
Metz, G.B.6
Brooks, M.W.7
Kaneko, S.8
Murakami, S.9
Decaprio, J.A.10
Weinberg, R.A.11
Stewart, S.A.12
Hahn, W.C.13
-
11
-
-
17344363008
-
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
-
Nakayama J., Tahara H., Tahara E., Saito M., Ito K., Nakamura H., Nakanishi T., Ide T., Ishikawa F. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat. Genet. 18:1998;65-68
-
(1998)
Nat. Genet.
, vol.18
, pp. 65-68
-
-
Nakayama, J.1
Tahara, H.2
Tahara, E.3
Saito, M.4
Ito, K.5
Nakamura, H.6
Nakanishi, T.7
Ide, T.8
Ishikawa, F.9
-
12
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich S.L., Pruzan R., Ma L., Ouellette M., Tesmer V.M., Holt S.E., Bodnar A.G., Lichtsteiner S., Kim N.W., Trager J.B., Taylor R.D., Carlos R., Andrews W.H., Wright W.E., Shay J.W., Harley C.B., Morin G.B. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17:1997;498-502
-
(1997)
Nat. Genet.
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
Ouellette, M.4
Tesmer, V.M.5
Holt, S.E.6
Bodnar, A.G.7
Lichtsteiner, S.8
Kim, N.W.9
Trager, J.B.10
Taylor, R.D.11
Carlos, R.12
Andrews, W.H.13
Wright, W.E.14
Shay, J.W.15
Harley, C.B.16
Morin, G.B.17
-
13
-
-
17844373798
-
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
-
Liu Y., Snow B.E., Hande M.P., Yeung D., Erdmann N.J., Wakeham A., Itie A., Siderovski D.P., Lansdorp P.M., Robinson M.O., Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr. Biol. 10:2000;1459-1462
-
(2000)
Curr. Biol.
, vol.10
, pp. 1459-1462
-
-
Liu, Y.1
Snow, B.E.2
Hande, M.P.3
Yeung, D.4
Erdmann, N.J.5
Wakeham, A.6
Itie, A.7
Siderovski, D.P.8
Lansdorp, P.M.9
Robinson, M.O.10
Harrington, L.11
-
14
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:1998;349-352
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
15
-
-
0032440891
-
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
-
Counter C.M., Hahn W.C., Wei W., Caddle S.D., Beijersbergen R.L., Lansdorp P.M., Sedivy J.M., Weinberg R.A. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl. Acad. Sci. U. S. A. 95:1998;14723-14728
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 14723-14728
-
-
Counter, C.M.1
Hahn, W.C.2
Wei, W.3
Caddle, S.D.4
Beijersbergen, R.L.5
Lansdorp, P.M.6
Sedivy, J.M.7
Weinberg, R.A.8
-
16
-
-
0342561644
-
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
-
Zhu X.D., Kuster B., Mann M., Petrini J.H., Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat. Genet. 25:2000;347-352
-
(2000)
Nat. Genet.
, vol.25
, pp. 347-352
-
-
Zhu, X.D.1
Kuster, B.2
Mann, M.3
Petrini, J.H.4
Lange, T.5
-
17
-
-
0033543760
-
Human endothelial cell life extension by telomerase expression
-
Yang J., Chang E., Cherry A.M., Bangs C.D., Oei Y., Bodnar A., Bronstein A., Chiu C.P., Herron G.S. Human endothelial cell life extension by telomerase expression. J. Biol. Chem. 274:1999;26141-26148
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26141-26148
-
-
Yang, J.1
Chang, E.2
Cherry, A.M.3
Bangs, C.D.4
Oei, Y.5
Bodnar, A.6
Bronstein, A.7
Chiu, C.P.8
Herron, G.S.9
-
18
-
-
0034616215
-
Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
-
Ouellette M.M., Liao M., Herbert B.S., Johnson M., Holt S.E., Liss H.S., Shay J.W., Wright W.E. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J. Biol. Chem. 275:2000;10072-10076
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10072-10076
-
-
Ouellette, M.M.1
Liao, M.2
Herbert, B.S.3
Johnson, M.4
Holt, S.E.5
Liss, H.S.6
Shay, J.W.7
Wright, W.E.8
-
19
-
-
0034925471
-
Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts
-
Yudoh K., Matsuno H., Nakazawa F., Katayama R., Kimura T. Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts. J. Bone Miner. Res. 16:2001;1453-1464
-
(2001)
J. Bone Miner. Res.
, vol.16
, pp. 1453-1464
-
-
Yudoh, K.1
Matsuno, H.2
Nakazawa, F.3
Katayama, R.4
Kimura, T.5
-
20
-
-
0035426107
-
Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT)
-
Franco S., MacKenzie K.L., Dias S., Alvarez S., Rafii S., Moore M.A. Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT). Exp. Cell Res. 268:2001;14-25
-
(2001)
Exp. Cell Res.
, vol.268
, pp. 14-25
-
-
Franco, S.1
MacKenzie, K.L.2
Dias, S.3
Alvarez, S.4
Rafii, S.5
Moore, M.A.6
-
21
-
-
0034666057
-
Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation
-
MacKenzie K.L., Franco S., May C., Sadelain M., Moore M.A. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation. Exp. Cell Res. 259:2000;336-350
-
(2000)
Exp. Cell Res.
, vol.259
, pp. 336-350
-
-
MacKenzie, K.L.1
Franco, S.2
May, C.3
Sadelain, M.4
Moore, M.A.5
-
22
-
-
0037140078
-
Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas
-
Yan P., Benhattar J., Coindre J.M., Guillou L. Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas. Int. J. Cancer. 98:2002;851-856
-
(2002)
Int. J. Cancer
, vol.98
, pp. 851-856
-
-
Yan, P.1
Benhattar, J.2
Coindre, J.M.3
Guillou, L.4
-
23
-
-
0035584117
-
Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
-
Yi X., Shay J.W., Wright W.E. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res. 29:2001;4818-4825
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 4818-4825
-
-
Yi, X.1
Shay, J.W.2
Wright, W.E.3
-
24
-
-
0033198499
-
High telomerase reverse transcriptase (hTERT) messenger RNA level correlates with tumor recurrence in patients with favorable histology Wilms' tumor
-
Dome J.S., Chung S., Bergemann T., Umbricht C.B., Saji M., Carey L.A., Grundy P.E., Perlman E.J., Breslow N.E., Sukumar S. High telomerase reverse transcriptase (hTERT) messenger RNA level correlates with tumor recurrence in patients with favorable histology Wilms' tumor. Cancer Res. 59:1999;4301-4307
-
(1999)
Cancer Res.
, vol.59
, pp. 4301-4307
-
-
Dome, J.S.1
Chung, S.2
Bergemann, T.3
Umbricht, C.B.4
Saji, M.5
Carey, L.A.6
Grundy, P.E.7
Perlman, E.J.8
Breslow, N.E.9
Sukumar, S.10
-
25
-
-
0028883813
-
Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells
-
Baum C., Hegewisch-Becker S., Eckert H.G., Stocking C., Ostertag W. Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells. J. Virol. 69:1995;7541-7547
-
(1995)
J. Virol.
, vol.69
, pp. 7541-7547
-
-
Baum, C.1
Hegewisch-Becker, S.2
Eckert, H.G.3
Stocking, C.4
Ostertag, W.5
-
26
-
-
0025834275
-
Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus
-
Miller A.D., Garcia J.V., von Suhr N., Lynch C.M., Wilson C., Eiden M.V. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J. Virol. 65:1991;2220-2224
-
(1991)
J. Virol.
, vol.65
, pp. 2220-2224
-
-
Miller, A.D.1
Garcia, J.V.2
Von Suhr, N.3
Lynch, C.M.4
Wilson, C.5
Eiden, M.V.6
-
27
-
-
0030780644
-
High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells
-
Limon A., Briones J., Puig T., Carmona M., Fornas O., Cancelas J.A., Nadal M., Garcia J., Rueda F., Barquinero J. High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells. Blood. 90:1997;3316-3321
-
(1997)
Blood
, vol.90
, pp. 3316-3321
-
-
Limon, A.1
Briones, J.2
Puig, T.3
Carmona, M.4
Fornas, O.5
Cancelas, J.A.6
Nadal, M.7
Garcia, J.8
Rueda, F.9
Barquinero, J.10
-
28
-
-
0031879115
-
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
-
Rufer N., Dragowska W., Thornbury G., Roosnek E., Lansdorp P.M. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16:1998;743-747
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 743-747
-
-
Rufer, N.1
Dragowska, W.2
Thornbury, G.3
Roosnek, E.4
Lansdorp, P.M.5
-
29
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter C.M., Avilion A.A., LeFeuvre C.E., Stewart N.G., Greider C.W., Harley C.B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929
-
(1992)
EMBO J.
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
Lefeuvre, C.E.3
Stewart, N.G.4
Greider, C.W.5
Harley, C.B.6
Bacchetti, S.7
-
30
-
-
0032797296
-
Real-time hTERT quantification: A promising telomerase-associated tumor marker
-
de Kok J.B., Zendman A.J., van de Locht L.T., Ruers T.J., van Muijen G.N., Mensink E.J., Swinkels D.W. Real-time hTERT quantification: a promising telomerase-associated tumor marker. Lab. Invest. 79:1999;911-912
-
(1999)
Lab. Invest.
, vol.79
, pp. 911-912
-
-
De Kok, J.B.1
Zendman, A.J.2
Van De Locht, L.T.3
Ruers, T.J.4
Van Muijen, G.N.5
Mensink, E.J.6
Swinkels, D.W.7
-
31
-
-
18244370768
-
Telomerase activity and expression of telomerase RNA component and catalytic subunits in precancerous and cancerous colorectal lesions
-
Naito Y., Takagi T., Handa O., Ishikawa T., Matsumoto N., Yoshida N., Kato H., Ando T., Takemura T., Itani K., Hisatomi H., Tsuchihashi Y., Yoshikawa T. Telomerase activity and expression of telomerase RNA component and catalytic subunits in precancerous and cancerous colorectal lesions. Tumour Biol. 22:2001;374-382
-
(2001)
Tumour Biol.
, vol.22
, pp. 374-382
-
-
Naito, Y.1
Takagi, T.2
Handa, O.3
Ishikawa, T.4
Matsumoto, N.5
Yoshida, N.6
Kato, H.7
Ando, T.8
Takemura, T.9
Itani, K.10
Hisatomi, H.11
Tsuchihashi, Y.12
Yoshikawa, T.13
-
32
-
-
0032923742
-
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
-
Jiang X.R., Jimenez G., Chang E., Frolkis M., Kusler B., Sage M., Beeche M., Bodnar A.G., Wahl G.M., Tlsty T.D., Chiu C.P. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat. Genet. 21:1999;111-114
-
(1999)
Nat. Genet.
, vol.21
, pp. 111-114
-
-
Jiang, X.R.1
Jimenez, G.2
Chang, E.3
Frolkis, M.4
Kusler, B.5
Sage, M.6
Beeche, M.7
Bodnar, A.G.8
Wahl, G.M.9
Tlsty, T.D.10
Chiu, C.P.11
-
33
-
-
0033049185
-
Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels
-
Yi X., Tesmer V.M., Savre-Train I., Shay J.W., Wright W.E. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol. Cell. Biol. 19:1999;3989-3997
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3989-3997
-
-
Yi, X.1
Tesmer, V.M.2
Savre-Train, I.3
Shay, J.W.4
Wright, W.E.5
-
34
-
-
0942290416
-
TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
-
Machwe A., Xiao L., Orren D.K. TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA. Oncogene. 23:2004;149-156
-
(2004)
Oncogene
, vol.23
, pp. 149-156
-
-
MacHwe, A.1
Xiao, L.2
Orren, D.K.3
-
35
-
-
0035806955
-
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
-
Diede S.J., Gottschling D.E. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Curr. Biol. 11:2001;1336-1340
-
(2001)
Curr. Biol.
, vol.11
, pp. 1336-1340
-
-
Diede, S.J.1
Gottschling, D.E.2
-
36
-
-
0037039716
-
HTERT gene dosage correlates with telomerase activity in human lung cancer cell lines
-
Saretzki G., Petersen S., Petersen I., Kolble K., von Zglinicki T. hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines. Cancer Lett. 176:2002;81-91
-
(2002)
Cancer Lett.
, vol.176
, pp. 81-91
-
-
Saretzki, G.1
Petersen, S.2
Petersen, I.3
Kolble, K.4
Von Zglinicki, T.5
-
37
-
-
0037133563
-
Haploinsufficiency of mTR results in defects in telomere elongation
-
Hathcock K.S., Hemann M.T., Opperman K.K., Strong M.A., Greider C.W., Hodes R.J. Haploinsufficiency of mTR results in defects in telomere elongation. Proc. Natl. Acad. Sci. U. S. A. 99:2002;3591-3596
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 3591-3596
-
-
Hathcock, K.S.1
Hemann, M.T.2
Opperman, K.K.3
Strong, M.A.4
Greider, C.W.5
Hodes, R.J.6
-
38
-
-
0030990049
-
Telomere dynamics and telomerase activity in in vitro immortalised human cells
-
Bryan T.M., Reddel R.R. Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur. J. Cancer. 33:1997;767-773
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 767-773
-
-
Bryan, T.M.1
Reddel, R.R.2
|