Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms

Experimental Eye Research

Volumn 114, Issue , 2013, Pages 35-47

  Stone, Richard A ^a   Pardue, Machelle T ^b   Iuvone, P Michael ^b   Khurana, Tejvir S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine; Ametropia; Circadian rhythms; Clock genes; Dopamine; Emmetropia; Myopia; Retina

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ATROPINE; DOPAMINE; MELANOPSIN; MELATONIN RECEPTOR; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR;

ARTICLE; CHOLINERGIC SYSTEM; CIRCADIAN RHYTHM; EYE REFRACTION; GENE; GROWTH REGULATION; HUMAN; ILLUMINATION; MYOPIA; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RETINA; SIGNAL TRANSDUCTION; SPECTACLES; UPREGULATION;

ACETYLCHOLINE; AMETROPIA; CIRCADIAN RHYTHMS; CLOCK GENES; DOPAMINE; EMMETROPIA; MYOPIA; RETINA;

ANIMALS; CIRCADIAN CLOCKS; CIRCADIAN RHYTHM; DOPAMINE; HUMANS; LIGHT; MYOPIA; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; RETINA;

EID: 84881313032     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.01.001     Document Type: Article

References (222)

1. Abreu-Villaça Y., Filgueiras C.C., Manhães A.C. Developmental aspects of the cholinergic system. Behav. Brain Res. 2011, 221:367-378.
2. Anisimov V.N. Light pollution, reproductive function and cancer risk. Neuro Endocrinol. Lett. 2006, 27:35-52.
3. 1 receptor-based pathways in the inhibition of experimentally-induced axial myopia in the tree shrew. Invest. Ophthalmol. Vis. Sci. 2012, 53:5827-5837.
4. Ashby R., McCarthy C.S., Maleszka R., Megaw P., Morgan I.G. Amuscarinic cholinergic antagonist and a dopamine agonist rapidly increase ZENK mRNA expression in the form-deprived chicken retina. Exp. Eye Res. 2007, 85:15-22.
5. Ashby R., Ohlendorf A., Schaeffel F. The effect of ambient illuminance on the development of deprivation myopia in chicks. Invest. Ophthalmol. Vis. Sci. 2009, 50:5348-5354.
6. Ashby R.S., Feldkaemper M.P. Gene expression within the amacrine cell layer of chicks after myopic and hyperopic defocus. Invest. Ophthalmol. Vis. Sci. 2010, 51:3726-3735.
7. Ashby R.S., Schaeffel F. The effect of bright light on lens compensation in chicks. Invest. Ophthalmol. Vis. Sci. 2010, 51:5247-5253.
8. Bailes H.J., Lucas R.J. Melanopsin and inner retinal photoreception. Cell. Mol. Life Sci. 2010, 67:99-111.
9. Barnard A.R., Hattar S., Hankins Mark W., Lucas R.J. Melanopsin regulates visual processing in the mouse retina. Curr. Biol. 2006, 16:389-395.
10. Bartlett J.D., Niemann K., Houde B., Allred T., Edmondson M.J., Crockett R.S. Atolerability study of pirenzepine ophthalmic gel in myopic children. J.Ocul. Pharmacol. Ther. 2003, 19:271-279.
11. Bartmann M., Schaeffel F., Hagel G., Zrenner E. Constant light affects retinal dopamine levels and blocks deprivation myopia but not lens-induced refractive errors in chickens. Vis. Neurosci. 1994, 11:199-208.
12. Bartness T.J., Demas G.E., Song C.K. Seasonal changes in adiposity: the roles of the photoperiod, melatonin and other hormones, and sympathetic nervous system. Exp. Biol. Med. 2012, 227:363-376.
13. Bellingham J., Chaurasia S.S., Melyan Z., Liu C., Cameron M.A., Tarttelin E.E., Iuvone P.M., Hankins M.W., Tosini G., Lucas R.J. Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. PLoS Biol. 2006, 4:1334-1343.
14. Borchert M.S., Varma R., Cotter S.A., Tarczy-Hornoch K., McKean-Cowdin R., Lin J.H., Wen G., Azen S.P., Torres M., Tielsch J., Friedman D.S., Repka M.X., Katz J., Ibironke J., Giordano L. Risk factors for hyperopia and myopia in preschool children: the Multi-Ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease Studies. Ophthalmology 2011, 118:1966-1973. Joint Writing Committee for the Multi-Ethnic Pediatric Eye Disease Study and the Baltimore Pediatric Eye Disease Study Groups.
15. Bradley D.V., Fernandes A., Lynn M., Tigges M., Boothe R.G. Emmetropization in the Rhesus monkey (Macaca mulatta): birth to young adulthood. Invest. Ophthalmol. Vis. Sci. 1999, 40:214-229.
16. Brodstein R.S., Brodstein D.E., Olson R.J., Hunt S.C., Williams R.R. The treatment of myopia with atropine and bifocals: a long-term prospective study. Ophthalmology 1984, 91:1373-1379.
17. Brown E.B.L., Carris L.H. Sight saving class work from the standpoint of the American Ophthalmological Society and the National Society for the Prevention of Blindness. Trans. Am. Ophthalmol. Soc. 1930, 28:155-168.
18. Brown J.S., Flitcroft D.I., Ying G.-s., Francis E.L., Schmid G.F., Quinn G.E., Stone R.A. Invivo human choroidal thickness measurements: evidence for diurnal fluctuations. Invest. Ophthalmol. Vis. Sci. 2009, 50:5-12.
19. Cameron M.A., Barnard A.R., Hut R.A., Bonnefont X., van der Horst G.T., Hankins M.W., Lucas R.J. Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses. J.Biol. Rhythms 2008, 23:489-501.
20. Campbell M.C.W., Bunghardt K., Kisilak M.L., Irving E.L. Diurnal rhythms of spherical refractive error, optical axial length and power in the chick. Invest. Ophthalmol. Vis. Sci. 2012, 53:6245-6253.
21. Caulfield M.P., Birdsall N.J.M. International union of pharmacology. XVII.Classification of muscarinic acetylcholine receptors. Pharmacol. Rev. 1998, 50:279-290.
22. Chapell M., Sullivan B., Sardakis S., Costello L., Mazgajiewski N., McGinley J., McGlone J., Andris C., Pasquarella A. Myopia and night-time lighting during sleep in children and adults. Percept. Mot. Skills 2001, 92:640-642.
23. C antagonists inhibit myopia development and facilitate learning and memory. JPET 2009, 328:448-457.
24. Chia A., Chua W.-H., Cheung Y.-B., Wong W.-L., Lingham A., Fong A., Tan D. Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01 doses (Atropine for the Treatment of Myopia 2). Ophthalmology 2012, 119:347-354.
25. Chua W.-H., Balakrishnan V., Chan Y.-H., Tong L., Ling Y., Quah B.-L., Tan D. Atropine for the treatment of myopia. Ophthalmology 2006, 113:2285-2291.
26. Cinzano P., Falchi F., Elvidge C.D. The first world Atlas of the artificial night sky brightness. Mon. Not. R. Astron. Soc. 2001, 328:689-707.
27. Cohen Y., Belkin M., Yehezkel O., Avni I., Polat U. Light intensity modulated corneal power and refraction in the chick eye exposed to continuous light. Vision Res. 2008, 48:2329-2335.
28. Cohen Y., Belkin M., Yehezkel O., Solomon A.S., Polat U. Dependency between light intensity and refractive development under light-dark cycles. Exp. Eye Res. 2011, 92:40-46.
29. Cohen Y., Peleg E., Belkin M., Polat U., Solomon A.S. Ambient illuminance, retinal dopamine release and refractive development in chicks. Exp. Eye Res. 2012, 103:33-40.
30. Cottriall C.L., Brew J., Vessey K.A., McBrien N.A. Diisopropylfluorophosphate alters retinal neurotransmitter levels and reduces experimentally-induced myopia. Naunyn-Schmiedeberg's Arch. Pharmacol. 2001, 364:372-382.
31. Cottriall C.L., McBrien N.A. The M1 muscarinic antagonist pirenzepine reduces myopia and eye enlargement in the tree shrew. Invest. Ophthalmol. Vis. Sci. 1996, 37:1368-1379.
32. 4 receptors?. NeuroReport 2001, 12:2453-2456.
33. Cowan A. Myopia. Am. J. Ophthalmol. 1942, 25:844-853.
34. Czepita D., Goslawski W., Mojsa A. Refractive errors among students occupying rooms lighted with incandescent or fluorescent lamps. Ann. Acad. Med. Stetin. 2004, 50:51-54.
35. Czepita D., Goslawski W., Mojsa A. Occurrence of refractive errors among students who before the age of two grew up under the influence of light emitted by incandescent or fluorescent lamps. Ann. Acad. Med. Stetin. 2005, 51:33-36.
36. Daubs J. Environmental factors in the epidemiology of malignant myopia. Am. J. Optom. Physiol. Opt. 1982, 59:271-277.
37. Daubs J.G. Some geographic, environmental and nutritive concomitants of malignant myopia. Ophthalmic Physiol. Opt. 1984, 4:143-149.
38. Dementi B. Ocular effects of organophosphates: a historical perspective of Saku disease. J.Appl. Toxicol. 1994, 14:119-129.
39. Deng L., Gwiazda J. Birth season, photoperiod, and infancy refraction. Optom. Vis. Sci. 2011, 88:383-387.
40. Deng L., Gwiazda J., Thorn F. Children's refractions and visual activities in the school year and summer. Optom. Vis. Sci. 2010, 87:406-413.
41. Dirani M., Tong L., Gazzard G., Zhuang X., Chia A., Young T.L., Rose K.A., Mitchell P., Saw S.-M. Outdoor activity and myopia in Singapore teenage children. Br. J. Ophthalmol. 2009, 93:997-1000.
42. Duffy J.F., Czeisler C.A. Effect of light on human circadian physiology. Sleep Med. Clin. 2009, 4:165-177.
43. El-Shazly A.A. Passive smoke exposure might be associated with hypermetropia. Ophthalmic Physiol. Opt. 2012, 32:304-307.
44. Farbrother J.E., Kirov G., Owen M.J., Guggenheim J.A. Family aggregation of high myopia: estimation of the sibling recurrence risk ratio. Invest. Ophthalmol. Vis. Sci. 2004, 45:2873-2878.
45. Fischer A.J., McKinnon L.A., Nathanson N.M., Stell W.K. Identification and localization of muscarinic acetylcholine receptors in the ocular tissues of the chick. J.Comp. Neurol. 1998, 392:273-284.
46. Fischer A.J., Miethke P., Morgan I.G., Stell W.K. Cholinergic amacrine cells are not required for the progression and atropine-mediated suppression of form-deprivation myopia. Brain Res. 1998, 794:48-60.
47. Foulds W.S., Luu C.D. Physical factors in myopia and potential therapies. Myopia: Animal Models to Clinical Trials 2010, World Scientific, New Jersey. R.W. Beuerman, S.-M. Saw, D.T.H. Tan, T.-Y. Wong (Eds.).
48. French A.N., O'Donoghue L., Morgan I.G., Saunders K.J., Mitchell P., Rose K.A. Comparison of refraction and ocular biometry in European Caucasian children living in Northern Ireland and Sydney, Australia. Invest. Ophthalmol. Vis. Sci. 2012, 53:4021-4031.
49. Fulk G.W., Cyert L.A., Parker D.A. Seasonal variation in myopia progression and ocular elongation. Optom. Vis. Sci. 2002, 79:46-51.
50. Ganesan P., Wildsoet C.F. Pharmaceutical intervention for myopia control. Expert Rev. Ophthalmol. 2010, 5:759-787.
51. Geller A.M., Abdel-Rahman A.A., Peiffer R.L., Abou-Donia M.B., Boyes W.K. The organophosphate pesticide chlorpyrifos affects form deprivation myopia. Invest. Ophthalmol. Vis. Sci. 1998, 39:1290-1294.
52. Gil D.W., Krauss H.A., Bogardus A.M., WoldeMussie E. Muscarinic receptor subtypes in human iris-ciliary body measured by immunoprecipitation. Invest. Ophthalmol. Vis. Sci. 1997, 38:1434-1442.
53. Glasser A., Howland H.C. Ahistory of studies of visual accommodation in birds. Q.Rev. Biol. 1996, 71:475-509.
54. Golombek D.A., Rosenstein R.E. Physiology of circadian entrainment. Physiol. Rev. 2010, 90:1063-1102.
55. Guggenheim J.A., Hill C., Yam T.-F. Myopia, genetics, and ambient lighting at night in a UK sample. Br. J. Ophthalmol. 2003, 87:580-582.
56. Guggenheim J.A., Northstone K., McMahon G., Ness A.R., Deere K., Mattocks C., St.Pourcain B., Williams C. Time outdoors and physical activity as predictors of incident myopia in childhood: a prospective cohort study. Invest. Ophthalmol. Vis. Sci. 2012, 53:2856-2865.
57. Guo S.S., Sivak J.G., Callender M.G., Diehl-Jones B. Retinal dopamine and lens-induced refractive errors in chicks. Curr. Eye Res. 1995, 14:385-389.
58. Guo S.S., Sivak J.G., Callender M.G., Herbert K.L. Effects of continuous light on experimental refractive errors in chicks. Ophthalmic Physiol. Opt. 1996, 16:486-490.
59. Gwiazda J., Ong E., Held R., Thorn F. Myopia and ambient night-time lighting. Nature 2000, 404:144.
60. Hornbeak D.M., Young T.L. Myopia genetics: a review of current research and emerging trends. Curr. Opin. Ophthalmol. 2009, 20:356-362.
61. Hut R.A., Van der Zee E.A. The cholinergic system, circadian rhythmicity, and time memory. Behav. Brain Res. 2011, 221:466-480.
62. Ip J., Robaei D., Kifley A., Wang J.J., Rose K.A., Mitchell P. Prevalence of hyperopia and associations with eye findings in 6- and 12-year-olds. Ophthalmology 2008, 115:678-685.
63. Ishikawa S., Miyata M. Development of myopia following chronic organophosphate pesticide intoxication: an epidemiological and experimental study. Neurotoxicity of the Visual System 1980, 233-254. Raven Press, New York. W.H. Merigan, B. Weiss (Eds.).
64. Iuvone P.M., Tigges M., Fernandes A., Tigges J. Dopamine synthesis and metabolism in rhesus monkey retina: development, aging and the effects of monocular visual deprivation. Vis. Neurosci. 1989, 2:465-471.
65. Iuvone P.M., Tigges M., Stone R.A., Lambert S., Laties A.M. Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia. Invest. Ophthalmol. Vis. Sci. 1991, 32:1674-1677.
66. Iuvone P.M., Tosini G., Pozdeyev N., Haque R., Klein D.C., Chaurasia S.S. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog. Retin. Eye Res. 2005, 24:433-456.
67. 4 receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina. Eur. J. Neurosci. 2011, 34:57-64.
68. Jackson C.R., Ruan G.X., Aseem F., Abey J., Gamble K., Stanwood G., Palmiter R.D., Iuvone P.M., McMahon D.G. Retinal dopamine mediates multiple dimensions of light-adapted vision. J.Neurosci. 2012, 32:9359-9368.
69. Jacobsen N., Jensen H., Goldschmidt E. Does the level of physical activity in university students influence development and progression of myopia? - a 2-year prospective cohort study. Invest. Ophthalmol. Vis. Sci. 2008, 49:1322-1327.
70. Jakubik J., Tuček S. Two populations of muscarinic binding sites in the chick heart distinguished by affinities for ligands and selective inactivation. Br. J. Pharmacol. 1994, 113:1529-1537.
71. Jensen L.S., Matson W.E. Enlargement of avian eye by subjecting chicks to continuous incandescent illumination. Science 1957, 125:741.
72. Johnson C.H., Elliott J.A., Foster R. Entrainment of circadian programs. Chronobiol. Int. 2003, 20:741-774.
73. Jones-Jordan L.A., Mitchell G.L., Cotter S.A., Kleinstein R.N., Manny R.E., Mutti D.O., Twelker J.D., Sims J.R., Zadnik K. Visual activity before and after the onset of juvenile myopia. Invest. Ophthalmol. Vis. Sci. 2011, 52:1841-1850.
74. Jones-Jordan L.A., Sinnott L.T., Cotter S.A., Kleinstein R.N., Manny R.E., Mutti D.O., Twelker J.D., Zadnik K. Time outdoors, visual activity, and myopia progression in juvenile-onset myopes. Invest. Ophthalmol. Vis. Sci. 2012, 53:7169-7175. CLEERE Study Group.
75. Jones L.A., Sinnott L.T., Mutti D.O., Mitchell G.L., Moeschberger M.L., Zadnik K. Parental history of myopia, sports and outdoor activities, and future myopia. Invest. Ophthalmol. Vis. Sci. 2007, 48:3524-3532.
76. Kee C.-s., Hung L.-F., Qiao-Grider Y., Ramamirtham R., Winawer J., Wallman J., Smith E.L. Temporal constraints on experimental emmetropization in infant monkeys. Invest. Ophthalmol. Vis. Sci. 2007, 48:957-962.
77. Kee C.-s., Marzani D., Wallman J. Differences in time course and visual requirements of ocular responses to lenses and diffusers. Invest. Ophthalmol. Vis. Sci. 2001, 42:575-583.
78. Kennedy R.H. Progression of myopia. Trans. Am. Ophthalmol. Soc. 1995, 93:755-800.
79. Klein A.P., Duggal P., Lee K.E., Klein R., Bailey-Wilson J.E., Klein B.E.K. Support for polygenic influences on ocular refractive error. Invest. Ophthalmol. Vis. Sci. 2005, 46:442-446.
80. Leech E.M., Cottriall C.L., McBrien N.A. Pirenzepine prevents form deprivation myopia in a dose dependent manner. Ophthalmic Physiol. Opt. 1995, 15:351-356.
81. Li T., Howland H.C., Troilo D. Diurnal illumination patterns affect the development of the chick eye. Vision Res. 2000, 40:2387-2393.
82. Li T., Troilo D., Glasser A., Howland H.C. Constant light produces severe corneal flattening and hyperopia in chickens. Vision Res. 1995, 35:1203-1209.
83. Lind G.J., Chew S.J., Marzani D., Wallman J. Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes. Invest. Ophthalmol. Vis. Sci. 1998, 39:2217-2231.
84. Liu J., McGlinn A.M., Fernandes A., Milam A.H., Strang C.E., Andison M.E., Lindstrom J.M., Keyser K.T., Stone R.A. Nicotinic acetylcholine receptor subunits in rhesus monkey retina. Invest. Ophthalmol. Vis. Sci. 2009, 50:1408-1415.
85. Liu J., Pendrak K., Capehart C., Sugimoto R., Schmid G.F., Stone R.A. Emmetropization under continuous but non-constant light in chicks. Exp. Eye Res. 2004, 79:719-728.
86. Liu J.H.K., Farid H. Twenty-four-hour change in axial length in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 1998, 39:2796-2799.
87. Loman J., Quinn G.E., Kamoun L., Ying G.-S., Maguire M.G., Hudesman D., Stone R.A. Darkness and near work: myopia and its progression in third-year law students. Ophthalmology 2002, 109:1032-1038.
88. Low W., Dirani M., Gazzard G., Chan Y.-H., Zhou H.-J., Selvaraj P., Au Eong K.-G., Young T.L., Mitchell P., Wong T.-Y., Saw S.-M. Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool children. Br. J. Ophthalmol. 2010, 94:1012-1016.
89. Lu B., Congdon N., Liu X., Choi K., Lam D.S.C., Zhang M., Zheng M., Zhou Z., Li L., Liu X., Sharma A., Song Y. Associations between near work, outdoor activity, and myopia among adolescent students in rural China: the Xichang Pediatric Refractive Error Study Report No. 2. Arch. Ophthalmol. 2009, 127:769-775.
90. Luft W.A., Ming Y., Stell W.K. Variable effects of previously untested muscarinic receptor antagonists on experimental myopia. Invest. Ophthalmol. Vis. Sci. 2003, 44:1330-1338.
91. Lyhne N., Sjølie K.A., Kyvik K.O., Green A. The importance of genes and environment for ocular refraction and its determiners: a population based study among 20-45 year old twins. Br. J. Ophthalmol. 2001, 85:1470-1476.
92. Mallen E.A.H., Kashyap P., Hampson K.M. Transient axial length change during the accommodation response in young adults. Invest. Ophthalmol. Vis. Sci. 2006, 47:1251-1254.
93. Mandel Y., Grotto I., El-Yaniv R., Belkin M., Israeli E., Polat U., Bartov E. Season of birth, natural light, and myopia. Ophthalmology 2008, 115:686-692.
94. Mapstone R., Clarke C.V. Diurnal variation in the dimensions of the anterior chamber. Arch. Ophthalmol. 1985, 103:1485-1486.
95. McBrien N.A., Arumugam G., Gentle A., Chow A., Sahebjada S. The M4 muscarinic antagonist MT-3 inhibitors myopia in chick: evidence for site of action. Ophthalmic Physiol. Opt. 2011, 31:529-539.
96. McBrien N.A., Cottriall C.L., Annies R. Retinal acetylcholine content in normal and myopic eyes: a role in ocular growth control?. Vis. Neurosci. 2001, 18:571-580.
97. McBrien N.A., Moghaddam H.O., Reeder A.P. Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism. Invest. Ophthalmol. Vis. Sci. 1993, 34:205-215.
98. McCarthy C.S., Megaw P., Devadas M., Morgan I.G. Dopaminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia. Exp. Eye Res. 2007, 84:100-107.
99. McGlinn A.M., Baldwin D.A., Tobias J.W., Budak M.T., Khurana T.S., Stone R.A. Form deprivation myopia in chick induces limited changes in retinal gene expression. Invest. Ophthalmol. Vis. Sci. 2007, 48:3430-3436.
100. McKean-Cowdin R., Varma R., Cotter S.A., Tarczy-Hornoch K., Borchert M.S., Lin J.H., Wen G., Azen S.P., Torres M., Tielsch J.M., Friedman D.S., Repka M.X., Katz J., Ibironke J., Giordano L. Risk factors for astigmatism in preschool children: the Multi-Ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease Studies. Ophthalmology 2011, 118:1974-1981. Joint Writing Committee for the Multi-Ethnic Pediatric Eye Disease Study and the Baltimore Pediatric Eye Disease Study Groups.
101. McKenzie C., Megaw P., Morgan I., Boelen M.K. Deprivation of form vision suppresses diurnal cycling of retinal levels of leu-enkephalin. Aust. N. Z. J. Ophthalmol. 1997, 25(Suppl. 1):S79-S81.
102. McMahon G., Zayats T., Chen Y.-P., Prashar A., Williams C., Guggenheim J.A. Season of birth, daylight hours at birth, and high myopia. Ophthalmology 2009, 116:468-473.
103. Megaw P., McKenzie C., Geue A., Morgan I.G., Boelen M.K. The effect of form deprivation on retinal leu-enkephalin levels is mediated by a rod-driven pathway. Aust. N. Z. J. Ophthalmol. 1996, 24:58-60.
104. Meyer C., Mueller M.F., Duncker G.I., Meyer H.J. Experimental animal myopia models are applicable to human juvenile-onset myopia. Surv. Ophthalmol. 1999, 44(Suppl. 1):S93-S102.
105. Miwa J.M., Freedman R., Lester H.A. Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. Neuron 2011, 70:20-33.
106. Mohawk J.A., Tokahashi J.S. Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators. Trends Neurosci. 2011, 34:349-358.
107. Morgan I., Rose K. How genetic is school myopia?. Prog. Retin. Eye Res. 2005, 24:1-38.
108. Morgan I.G., Boelen M.K. Aretinal dark-light switch: a review of the evidence. Vis. Neurosci. 1996, 13:399-409.
109. Morgan I.G., Ohno-Matsui K., Saw S.-M. Myopia. Lancet 2012, 379:1739-1748.
110. Mutti D.O. Hereditary and environmental contributions to emmetropization and myopia. Optom. Vis. Sci. 2010, 87:255-259.
111. Mutti D.O., Cooper M.E., Dragan E., Jones-Jordan L.A., Bailey M.D., Marazita M.L., Murray J.C., Zadnik K. Vitamin D receptor (VDR) and group-specific component (GC, vitamin E-binding protein) polymorphisms in myopia. Invest. Ophthalmol. Vis. Sci. 2012, 52:3818-3824. CLEERE Study Group.
112. Mutti D.O., Mitchell G.L., Moeschberger M.L., Jones L.A., Zadnik K. Parental myopia, near work, school achievement, and children's refractive error. Invest. Ophthalmol. Vis. Sci. 2002, 43:3633-3640.
113. Navara K.J., Nelson R.J. The dark side of light at night: physiological, epidemiological, and ecological consequences. J.Pineal Res. 2007, 43:215-224.
114. Nickla D.L. The phase relationships between the diurnal rhythms in axial length and choroidal thickness and the association with ocular growth rate in chicks. J.Comp. Physiol. A 2006, 192:399-407.
115. Nickla D.L., Wallman J. The multifunctional choroid. Prog. Retin. Eye Res. 2010, 29:144-168.
116. Nickla D.L., Wildsoet C., Troilo D. Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmoset. Invest. Ophthalmol. Vis. Sci. 2002, 43:2519-2528.
117. Nickla D.L., Wildsoet C., Wallman J. The circadian rhythm in intraocular pressure and its relation to diurnal ocular growth changes in chicks. Exp. Eye Res. 1998, 66:183-193.
118. Nickla D.L., Wildsoet C., Wallman J. Visual influences on diurnal rhythms in ocular length and choroidal thickness in chick eyes. Exp. Eye Res. 1998, 66:163-181.
119. Nickla D.L., Wildsoet C.F., Troilo D. Endogenous rhythms in axial length and choroidal thickness in chicks: implications for ocular growth regulation. Invest. Ophthalmol. Vis. Sci. 2001, 42:584-588.
120. Norton T.T. Animal models of myopia: learning how vision controls the size of the eye. Inst. Lab. Anim. Res. J. 1999, 40:59-77.
121. Norton T.T., Wu W.W., Siegwart J.T. Refractive state of tree shrew eyes measured with cortical visual evoked potentials. Optom. Vis. Sci. 2003, 80:623-631.
122. O'Hara B.F., Edgar D.M., Cao V.H., Wiler S.W., Heller H.C., Kilduff T.S., Miller J.D. Nicotine and nicotinic receptors in the circadian system. Psychoneuroendocrinology 1998, 23:161-173.
123. Oishi T., Murakami Y. Effects of duration and intensity of illumination on several parameters of the chick eye. Comp. Biochem. Physiol. 1985, 81A:319-323.
124. Onal S., Toker E., Akingol Z., Arslan G., Ertan S., Turan C., Kaplan O. Refractive errors of medical students in Turkey: one year follow-up of refraction and biometry. Optom. Vis. Sci. 2007, 84:175-180.
125. Padmanabhan V., Shih J., Wildsoet C.F. Constant light rearing disrupts compensation to imposed- but not induced-hyperopia and facilitates compensation to imposed myopia in chicks. Vision Res. 2007, 47:1855-1868.
126. Pan C.-W., Ramamurthy D., Saw S.-M. Worldwide prevalence and risk factors for myopia. Ophthalmic Physiol. Opt. 2012, 32:3-16.
127. Papastergiou G.I., Schmid G.F., Riva C.E., Mendel M.J., Stone R.A., Laties A.M. Ocular axial length and choroidal thickness in newly hatched chicks and one-year-old chickens fluctuate in a diurnal pattern that is influenced by visual experience and intraocular pressure changes. Exp. Eye Res. 1998, 66:195-205.
128. Pardue M.T., Faulkner A.E., Fernandes A., Yin H., Schaeffel F., Williams R.W., Pozdeyev N., Iuvone P.M. High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Invest. Ophthalmol. Vis. Sci. 2008, 49:706-712.
129. Pärssinen O., Lyyra A.-L. Myopia and myopic progression among schoolchildren: a three-year follow-up study. Invest. Ophthalmol. Vis. Sci. 1993, 34:2794-2802.
130. Paul K.N., Saafir T.B., Tosini G. The role of retinal photoreceptors in the regulation of circadian rhythms. Rev. Endocr. Metab. Disord. 2009, 10:271-278.
131. Pauley S.M. Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue. Med. Hypotheses 2004, 63:588-596.
132. Pearce E., Dunbar R. Latitudinal variation in light levels drives human visual system size. Biol. Lett. 2012, 8:90-93.
133. Pendrak K., Lin T., Stone R.A. Ciliary ganglion choline acetyltransferase activity in avian macrophthalmos. Exp. Eye Res. 1995, 60:237-243.
134. Pickett Seltner R.L., Rohrer G., Grant V., Stell W.K. Endogenous opiates in the chick retina and their role in form-deprivation myopia. Vis. Neurosci. 1997, 14:801-809.
135. Pickett Seltner R.L., Stell W.K. The effect of vasoactive intestinal peptide on development of form deprivation myopia in the chick: a pharmacological and immunocytochemical study. Vision Res. 1995, 35:1265-1270.
136. Poyer J.F., Gabelt B.T., Kaufman P.L. The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle. Exp. Eye Res. 1994, 59:729-736.
137. Pozdeyev N., Tosini G., Li L., Ali F., Rozov S., Lee R.H., Iuvone P.M. Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina. Eur. J. Neurosci. 2008, 27:2691-2700.
138. Quinn G.E., Shin C.H., Maguire M.G., Stone R.A. Myopia and ambient lighting at night. Nature 1999, 399:113-114.
139. Rahi J.S., Cumberland P.M., Peckham C.S. Myopia over the lifecourse: prevalence and early life influences in the 1958 British birth cohort. Ophthalmology 2011, 118:797-804.
140. Rau J. The Danish sight-saving school. Sight Sav. Rev. 1951, 21:142-146.
141. Read S.A., Collins M.J., Iskander D.R. Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics. Invest. Ophthalmol. Vis. Sci. 2008, 49:2911-2918.
142. Read S.A., Collins M.J., Sander B.P. Human optical axial length and defocus. Invest. Ophthalmol. Vis. Sci. 2010, 51:6262-6269.
143. Rickers M., Schaeffel F. Dose-dependent effects of intravitreal pirenzepine on deprivation myopia and lens-induced refractive errors in chickens [letter]. Exp. Eye Res. 1995, 61:509-516.
144. Rohrer B., Iuvone P.M., Stell W.K. Stimulation of dopamine amacrine cells by stroboscopic illumination or fibroblast growth factor (bFGF, FGF-2) injections: possible roles in prevention of form-deprivation myopia. Brain Res. 1995, 686:169-181.
145. Rohrer B., Spira A.W., Stell W.K. Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium. Vis. Neurosci. 1993, 10:447-453.
146. Rose K.A., Morgan I.G., Ip J., Kifley A., Huynh S., Smith W., Mitchell P. Outdoor activity reduces the prevalence of myopia in children. Ophthalmology 2008, 115:1279-1285.
147. Rose K.A., Morgan I.G., Smith W., Burlutsky G., Mitchell P., Saw S.-M. Myopia, lifestyle, and schooling in students of Chinese ethnicity in Singapore and Sydney. Arch. Ophthalmol. 2008, 126:527-530.
148. Rose K.A., Morgan I.G., Smith W., Mitchell G. High heritability of myopia does not preclude rapid changes in prevalence. Clin. Exp. Ophthalmol. 2002, 30:168-172.
149. Rosenfield M., Gilmartin B. Myopia and nearwork: causation or merely association?. Myopia and Nearwork 1998, 193-206. (Chapter 10), Butterworth Heinemann, Oxford. M. Rosenfield, B. Gilmartin (Eds.).
150. Ruan G.X., Allen G.C., Yamazaki S., McMahon D.G. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol. 2008, 6:e249.
151. Ruan G.X., Zhang D.Q., Zhou T., Yamazaki S., McMahon D.G. Circadian organization of the mammalian retina. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:9703-9708.
152. Rymer J., Wildsoet C.F. The role of the retinal pigment epithelium in eye growth regulation and myopia: a review. Vis. Neurosci. 2005, 22:251-261.
153. Sakamoto K., Liu C., Kasamatsu M., Pozdeyev N.V., Iuvone P.M., Tosini G. Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells. Eur. J. Neurosci. 2005, 22:3129-3136.
154. Saw S.-M., Chia K.-S., Lindstrom J.M., Tan D.T.H., Stone R.A. Childhood myopia and parental smoking. Br. J. Ophthalmol. 2004, 88:934-937.
155. Saw S.-M., Nieto F.J., Katz J., Schein O.D., Levy B., Chew S.-J. Factors related to the progression of myopia in Singaporean children. Optom. Vis. Sci. 2000, 77:549-554.
156. Saw S.-M., Wu H.-M., Hong C.-Y., Chua W.-H., Chia K.-S., Tan D. Myopia and night lighting in children in Singapore. Br. J. Ophthalmol. 2001, 85:527-528.
157. Saw S.-M., Zhang M.-Z., Hong R.-Z., Fu Z.-F., Pang M.-H., Tan D.T.H. Near-work activity, night-lights, and myopia in the Singapore-China study. Arch. Ophthalmol. 2002, 120:620-627.
158. Schaeffel F. The mouse as a model for myopia, and optics of its eye. Eye, Retina and Visual System of the Mouse 2008, (Chapter 5), The MIT Press, Cambridge, MA. L.M. Chalupa, R.W. Williams (Eds.).
159. Schaeffel F. The mouse model of myopia. Myopia: Animal Models to Clinical Trials 2010, 303-329. (Chapter 4.3), World Scientific, New Jersey. R.W. Beuerman, S.-M. Saw, D.T.H. Tan, T.-Y. Wong (Eds.).
160. Schmid K.L., Wildsoet C.F. Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks. Optom. Vis. Sci. 2004, 81:137-147.
161. Sherwin J.C., Hewitt A.W., Coroneo M.T., Kearns L.S., Griffiths L.R., Mackey D.A. The association between time spent outdoors and myopia using a novel biomarker of outdoor light exposure. Invest. Ophthalmol. Vis. Sci. 2012, 53:4363-4370.
162. Shih Y.-F., Chen C.-H., Chou A.-C., Ho T.-C., Lin L.L.-K., Hung P.-T. Effects of different concentrations of atropine on controlling myopia in myopic children. J.Ocul. Pharmacol. Ther. 1999, 15:85-90.
163. Siatkowski R.M., Cotter S., Miller J.M., Scher C.A., Crockett R.S., Novack G.D. Safety and efficacy of 2% pirenzepine ophthalmic gel in children with myopia. Arch. Ophthalmol. 2004, 122:1667-1674. the US Pirenzepine Study Group.
164. Siatkowski R.M., Cotter S.A., Crockett R.S., Miller J.M., Novack G.D. Two-year multicenter, randomized double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. J.AAPOS 2008, 12:332-339. U.S. Pirenzepine Study Group.
165. Smith E.L., Bradley D.V., Fernandes A., Hung L.-F., Boothe R.G. Continuous ambient lighting and eye growth in primates. Invest. Ophthalmol. Vis. Sci. 2001, 42:1146-1152.
166. Smith E.L., Hung L.-F., Huang J. Protective effects of high ambient lighting on the development of form-deprivation myopia in rhesus monkeys. Invest. Ophthalmol. Vis. Sci. 2012, 53:421-428.
167. Smith E.L., Hung L.-F., Kee C.-S., Qiao-Grider Y., Ramamirtham R. Continuous ambient lighting and lens compensation in infant monkeys. Optom. Vis. Sci. 2003, 80:374-382.
168. Smith E.L., Hung L.-F., Kee C.-s., Qiao Y. Effects of brief periods of unrestricted vision on the development of form-deprivation myopia in monkeys. Invest. Ophthalmol. Vis. Sci. 2002, 43:291-299.
169. Song Y.-y., Wang H., Wang B.-s., Qi H., Rong Z.-x., Chen H.-z. Atropine in ameliorating the progression of myopia in children with mild to moderate myopia: a meta-analysis of controlled clinical trials. J.Ocul. Pharmacol. Ther. 2011, 27:361-366.
170. Steenhard B.M., Besharse J.C. Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine. J.Neurosci. 2000, 20:8572-8577.
171. Stevens R.G., Rea M.S. Light in the built environment: potential role of circadian disruption in endocrine disruption and breast cancer. Cancer Causes Control 2001, 12:279-287.
172. Stone R.A. Neural mechanisms and eye growth control. Myopia Updates: Proceedings of the 6th International Conference on Myopia 1997, 241-254. Springer, Tokyo. T. Tokoro (Ed.).
173. Stone R.A. Myopia pharmacology: etiologic clues, therapeutic potential. Ocular Therapeutics: an Eye on New Discoveries 2008, 167-196. (Chapter 9), Elsevier/Academic Press, New York. T. Yorio, A. Clark, M. Wax (Eds.).
174. Stone R.A., Khurana T.S. Gene profiling in experimental models of eye growth: clues to myopia pathogenesis. Vision Res. 2010, 50:2322-2333.
175. Stone R.A., Laties A.M., Raviola E., Wiesel T.N. Increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:257-260.
176. Stone R.A., Lin T., Desai D., Capehart C. Photoperiod, early post-natal eye growth, and visual deprivation. Vision Res. 1995, 35:1195-1202. [PMID: 7610580].
177. Stone R.A., Lin T., Laties A.M. Muscarinic antagonist effects on experimental chick myopia. Exp. Eye Res. 1991, 52:755-758.
178. Stone R.A., Lin T., Laties A.M., Iuvone P.M. Retinal dopamine and form-deprivation myopia. Proc. Natl. Acad. Sci. U. S. A. 1989, 86:704-706.
179. Stone R.A., Liu J., Sugimoto R., Capehart C., Zhu X., Pendrak K. GABA, experimental myopia and ocular growth in chick. Invest. Ophthalmol. Vis. Sci. 2003, 44:3933-3946.
180. Stone R.A., McGlinn A.M., Baldwin D.A., Tobias J.W., Iuvone P.M., Khurana T.S. Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia. Invest. Ophthalmol. Vis. Sci. 2011, 52:5765-5777.
181. Stone R.A., Quinn G.E., Francis E.L., Ying G.-S., Flitcroft D.I., Parekh P., Brown J., Orlow J., Schmid G. Diurnal axial length fluctuations in human eyes. Invest. Ophthalmol. Vis. Sci. 2004, 45:63-70.
182. Stone R.A., Sugimoto R., Gill A.S., Liu J., Capehart C., Lindstrom J.M. Effects of nicotinic antagonists on ocular growth and experimental myopia. Invest. Ophthalmol. Vis. Sci. 2001, 42:557-565.
183. Stone R.A., Wilson L.B., Ying G.-s., Liu C., Criss J.S., Orlow J., Lindstrom J.M., Quinn G.E. Associations between childhood refraction and parental smoking. Invest. Ophthalmol. Vis. Sci. 2006, 47:4277-4287.
184. Storch K.-F., Paz C., Signorovitch J., Raviola E., Pawlyk B., Li T., Weitz C.J. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell 2007, 130:730-741.
185. Summers Rada J.A., Wiechmann A.F. Ocular expression of avian thymic hormone: changes during the recovery from induced myopia. Mol. Vis. 2009, 15:778-792.
186. Tan D.T.H., Lam D.S., Chua W.H., Shu-Ping D.F., Crockett R.S. One-year multicenter, double-masked, placebo-controlled, parallel safety and efficacy study of 2% pirenzepine ophthalmic gel in children with myopia. Ophthalmology 2005, 112:84-91. the Asian Pirenzepine Study Group.
187. Tietje K.M., Nathanson N.M. Embryonic chick heart expresses multiple muscarinic acetylcholine receptor subtypes. J.Biol. Chem. 1991, 266:17382-17387.
188. Tigges M., Iuvone P.M., Fernandes A., Sugrue M.F., Mallorga P.J., Laties A.M., Stone R.A. Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys. Optom. Vis. Sci. 1999, 76:397-407.
189. Tkatchenko A.V., Walsh P.A., Tkatchenko T.V., Gustincich S., Raviola E. Form deprivation modulates retinal neurogenesis in primate experimental myopia. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:4681-4686.
190. Tkatchenko T.V., Shen Y., Tkatchenko A.V. Mouse experimental myopia as features of primate myopia. Invest. Ophthalmol. Vis. Sci. 2010, 51:1297-1303.
191. Tomonari S., Takagi A., Akamatsu S., Noji S., Ohuchi H. Anon-canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina. Dev. Dyn. 2005, 234:783-790.
192. Tong L., Huang X.L., Koh A.L.T., Zhang X., Tan D.T.H., Chua W.-H. Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine. Ophthalmology 2009, 116:572-579.
193. Tosini G., Pozdeyev N., Sakamoto K., Iuvone P.M. The circadian clock system in the mammalian retina. BioEssays 2008, 30:624-633.
194. Troilo D., Judge S.J. Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus). Vision Res. 1993, 33:1311-1324.
195. Turner P.L., Mainster M.A. Circadian photoreception: ageing and the eye's important role in systemic health. Br. J. Ophthalmol. 2008, 92:1439-1444.
196. Vannas A.E., Ying G.-S., Stone R.A., Maguire M.G., Jormanainen V., Tervo T. Myopia and natural lighting extremes: risk factors in Finnish army conscripts. Acta Ophthalmol. Scand. 2003, 81:588-595.
197. Vessey K.A., Cottriall C.L., McBrien N.A. Muscarinic receptor protein expression in the ocular tissues of the chick during normal and myopic eye development. Brain Res. Dev. Brain Res. 2002, 135:79-86.
198. Viney T.J., Balint K., Hillier D., Siegert S., Boldogkoi Z., Enquist L.W., Meister M., Cepko C.L., Roska B. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Curr. Biol. 2007, 17:981-988.
199. Vitale S., Sperduto R.D., Ferris F.L. Increased prevalence of myopia in the United States between 1971-1972 and 1999-2004. Arch. Ophthalmol. 2009, 127:1632-1639.
200. Vugler A.A., Redgrave P., Semo M., Lawrence J., Greenwood J., Coffey P.J. Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina. Exp. Neurol. 2007, 205:26-35.
201. Wallman J. Retinal control of eye growth and refraction. Prog. Retin. Res. 1993, 12:133-153.
202. Wallman J., Adams J.I., Trachtman J.N. The eyes of young chickens grow toward emmetropia. Invest. Ophthalmol. Vis. Sci. 1981, 20:557-561.
203. Wallman J., Nickla D.L. The relevance of studies in chicks for understanding myopia in humans. Myopia: Animal Models to Clinical Trials 2010, 239-266. (Chapter 4.1), World Scientific, New Jersey. R.W. Beuerman, S.-M. Saw, D.T.H. Tan, T.-Y. Wong (Eds.).
204. Wallman J., Winawer J. Homeostasis of eye growth and the question of myopia. Neuron 2004, 43:447-468.
205. Weiss S., Schaeffel F. Diurnal growth rhythms in the chicken eye: relation to myopia development and retinal dopamine levels. J.Comp. Physiol. A 1993, 172:263-270.
206. Wells W.C. Observations and experiment on vision. Philos. Trans. R Soc. 1811, 101:389-391.
207. Welsh D.K., Takahashi J.S., Kay S.A. Suprachiasmatic nucleus: cell autonomy and network properties. Annu. Rev. Physiol. 2010, 72:551-577.
208. Wilson L.B., Quinn G.E., Ying G.-s., Francis E.L., Schmid G., Lam A., Orlow J., Stone R.A. The relation of axial length and intraocular pressure fluctuations in human eyes. Invest. Ophthalmol. Vis. Sci. 2006, 47:1778-1784.
209. Witkovsky P. Dopamine and retinal function. Doc. Ophthalmol. 2004, 108:17-40.
210. Wojciechowski R. Nature and nurture: the complex genetics of myopia and refractive error. Clin. Genet. 2011, 301-320.
211. Wojciechowski R., Cogdon N., Bowie H., Munoz G., Gilbert D., West S. Familial aggregation of hyperopia in an elderly population of siblings in Salsbury, Maryland. Ophthalmology 2005, 112:78-83.
212. Woodman E.C., Read S.A., Collins M.J., Hegarty K.J., Priddle S.B., Smith J.M., Perro J.V. Axial elongation following prolonged near work in myopes and emmetropes. Br. J. Ophthalmol. 2011, 95:652-656.
213. Wu J., Lukas R.J. Naturally-expressed nicotinic acetylcholine receptor subtypes. Biochem. Pharmacol. 2011, 82:800-807.
214. Wu P.-C., Tsai C.-L., Hu C.-H., Yang Y.-H. Effects of outdoor activities on myopia among rural school children in Taiwan. Ophthalmic Epidemiol. 2010, 17:338-342.
215. Wyse C.A., Selman C., Page M.M., Coogan A.N., Hazlerigg D.G. Circadian desynchrony and metabolic dysfunction: did light pollution make us fat?. Med. Hypotheses 2011, 77:1139-1144.
216. Yujnovsky I., Hirayama J., Doi M., Borrelli E., Paolo Sassone-Corsi P. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK: BMAL1. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:6386-6391.
217. Zadnik K. Myopia development in childhood. Optom. Vis. Sci. 1997, 74:603-608.
218. Zadnik K., Jones L.A., Irvin B., Kleinstein R.N., Manny R.E., Shin J.A., Mutti D.O. Myopia and ambient night-time lighting. CLEERE Study Group. Collaborative longitudinal evaluation of ethnicity and refractive error. Nature 2000, 404:143-144.
219. Zhang D.-Q., Wong K.Y., Sollars P.J., Berson D.M., Pickard G.E., McMahon D.G. Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:14181-14186.
220. Zhang M., Li L., Chen L., Lee J., Wu J., Yang A., Chen C., Xu D., Lam D.S.C., Sharma A., Griffiths S., Gao Y., Congdon N. Population density and refractive error among Chinese children. Invest. Ophthalmol. Vis. Sci. 2010, 51:4969-4976.
221. Zhilov Y.D. Light and myopic refraction in children. J.Hyg. Epidemiol. Microbiol. Immunol. 1977, 21:234-241.
222. Zhou X., An J., Wu X., Lu R., Huang Q., Xie R., Jiang L., Qu J. Relative axial myopia induced by prolonged light exposure in C57BL/6 mice. Photochem. Photobiol. 2010, 86:131-137.