Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

Aging Cell

Volumn 12, Issue 4, 2013, Pages 695-705

  De Luca, Gabriele ^a   Ventura, Ilenia ^a   Sanghez, Valentina ^a   Russo, Maria Teresa ^a   Ajmone Cat, Maria Antonietta ^a   Cacci, Emanuele ^b   Martire, Alberto ^a   Popoli, Patrizia ^a   Falcone, Germana ^c   Michelini, Flavia ^a   Crescenzi, Marco ^a   Degan, Paolo ^d   Minghetti, Luisa ^a   Bignami, Margherita ^a   Calamandrei, Gemma ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CNR   (Italy)

^d CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

8 oxoG; Aging; Behavior; Oxidative stress; Senescence

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; DNA; HYDROLASE; MITOCHONDRIAL DNA; NUCLEOSIDE TRIPHOSPHATASE; PROTEIN MTH1; RNA; UNCLASSIFIED DRUG; 8-HYDROXYGUANINE; 8-OXODGTPASE; DNA LIGASE; GUANINE; PHOSPHATASE;

AGE DISTRIBUTION; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANXIETY; ARTICLE; ASSOCIATION; BEHAVIOR CHANGE; BODY GROWTH; BODY WEIGHT; BRAIN; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; ENVIRONMENTAL FACTOR; EXPERIMENTAL MODEL; EXPLORATORY BEHAVIOR; FIBROBLAST; HEART; HIPPOCAMPUS; IN VITRO STUDY; LIFESPAN; LIPID OXIDATION; LIVER; LONGEVITY; MALE; MEMORY; MOUSE; MUSCLE; NEURAL STEM CELL; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; PRIORITY JOURNAL; RECOGNITION; SOCIAL BEHAVIOR; SOCIAL LEARNING; STEADY STATE; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; TIME; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; BEHAVIOR, ANIMAL; CELL AGING; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; DNA REPAIR ENZYMES; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GUANINE; HUMANS; LONGEVITY; MALE; MICE; MICE, TRANSGENIC; NEURAL STEM CELLS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORIC MONOESTER HYDROLASES; TIME FACTORS;

EID: 84880849702     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12094     Document Type: Article

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