MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Cell Death and Differentiation

Volumn 13, Issue 4, 2006, Pages 551-563

  Yamaguchi, H ^a   Kajitani, K ^a   Dan, Y ^a   Furuichi, M ^a   Ohno, M ^a   Sakumi, K ^a   Kang, D ^b   Nakabeppu, Yusaku ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

8 oxoguanine; Mitochondria; MPTP; Parkinson's disease; Striatum

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 8 HYDROXYGUANINE; CELL NUCLEUS DNA; DOPAMINE TRANSPORTER; MESSENGER RNA; MITOCHONDRIAL DNA; MUTT HOMOLOG 1 PROTEIN; NUCLEIC ACID; NUCLEOSIDE TRIPHOSPHATASE; PURINE NUCLEOTIDE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; CORPUS STRIATUM; CYTOPLASM; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOREACTIVITY; MALE; MASS SPECTROMETRY; MOUSE; NERVE ENDING; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; WESTERN BLOTTING; WILD TYPE;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DNA REPAIR ENZYMES; DNA, MITOCHONDRIAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GUANINE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; OXIDATIVE STRESS; PARKINSONIAN DISORDERS; PHOSPHORIC MONOESTER HYDROLASES; RNA; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

ANIMALIA;

EID: 33644953588     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401788     Document Type: Article

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