메뉴 건너뛰기




Volumn 24, Issue 1, 2013, Pages 204-212

Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways

Author keywords

Docosahexaenoic acid (DHA); Heme oxygenase 1 (HO 1); Intercellular adhesion molecule 1 (ICAM 1); Nuclear factor erythroid 2 related factor 2 (Nrf2); Tumor necrosis factor alpha (TNF )

Indexed keywords

DNA BINDING PROTEIN; DOCOSAHEXAENOIC ACID; HEME OXYGENASE 1; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEASOME; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84870445676     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.05.003     Document Type: Article
Times cited : (131)

References (48)
  • 1
    • 0035955760 scopus 로고    scopus 로고
    • Novel clinical markers of vascular wall inflammation
    • Blake G.J., Ridker P.M. Novel clinical markers of vascular wall inflammation. Circ Res 2001, 89:763-771.
    • (2001) Circ Res , vol.89 , pp. 763-771
    • Blake, G.J.1    Ridker, P.M.2
  • 2
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis A.J. Atherosclerosis. Nature 2000, 407:233-241.
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 3
    • 77950516532 scopus 로고    scopus 로고
    • A novel cyclin-dependent kinase inhibitor down-regulates tumor necrosis factor-alpha (TNF-alpha)-induced expression of cell adhesion molecules by inhibition of NF-kappaB activation in human pulmonary epithelial cells
    • Oh J.H., Park E.J., Park J.W., Lee J., Lee S.H., Kwon T.K. A novel cyclin-dependent kinase inhibitor down-regulates tumor necrosis factor-alpha (TNF-alpha)-induced expression of cell adhesion molecules by inhibition of NF-kappaB activation in human pulmonary epithelial cells. Int Immunopharmacol 2010, 10:572-579.
    • (2010) Int Immunopharmacol , vol.10 , pp. 572-579
    • Oh, J.H.1    Park, E.J.2    Park, J.W.3    Lee, J.4    Lee, S.H.5    Kwon, T.K.6
  • 4
    • 0033996762 scopus 로고    scopus 로고
    • The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling
    • Karin M., Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 2000, 12:85-98.
    • (2000) Semin Immunol , vol.12 , pp. 85-98
    • Karin, M.1    Delhase, M.2
  • 5
    • 33750838526 scopus 로고    scopus 로고
    • Heme oxygenase-1 as a potential therapeutic target for hepatoprotection
    • Farombi E.O., Surh Y.J. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 2006, 39:479-491.
    • (2006) J Biochem Mol Biol , vol.39 , pp. 479-491
    • Farombi, E.O.1    Surh, Y.J.2
  • 6
  • 7
    • 78049442406 scopus 로고    scopus 로고
    • Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential
    • Paine A., Eiz-Vesper B., Blasczyk R., Immenschuh S. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol 2010, 80:1895-1903.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1895-1903
    • Paine, A.1    Eiz-Vesper, B.2    Blasczyk, R.3    Immenschuh, S.4
  • 8
    • 0035834084 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits
    • Ishikawa K., Sugawara D., Goto J., Watanabe Y., Kawamura K., Shiomi M., et al. Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits. Circulation 2001, 104:1831-1836.
    • (2001) Circulation , vol.104 , pp. 1831-1836
    • Ishikawa, K.1    Sugawara, D.2    Goto, J.3    Watanabe, Y.4    Kawamura, K.5    Shiomi, M.6
  • 9
    • 0035896220 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice
    • Ishikawa K., Sugawara D., Wang X., Suzuki K., Itabe H., Maruyama Y., et al. Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice. Circ Res 2001, 88:506-512.
    • (2001) Circ Res , vol.88 , pp. 506-512
    • Ishikawa, K.1    Sugawara, D.2    Wang, X.3    Suzuki, K.4    Itabe, H.5    Maruyama, Y.6
  • 10
    • 0141706806 scopus 로고    scopus 로고
    • Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling
    • Yet S.F., Layne M.D., Liu X., Chen Y.H., Ith B., Sibinga N.E., et al. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J 2003, 17:1759-1761.
    • (2003) FASEB J , vol.17 , pp. 1759-1761
    • Yet, S.F.1    Layne, M.D.2    Liu, X.3    Chen, Y.H.4    Ith, B.5    Sibinga, N.E.6
  • 11
    • 0141885079 scopus 로고    scopus 로고
    • Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway
    • Alam J., Cook J.L. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr Pharm Des 2003, 9:2499-2511.
    • (2003) Curr Pharm Des , vol.9 , pp. 2499-2511
    • Alam, J.1    Cook, J.L.2
  • 12
  • 13
    • 77951497987 scopus 로고    scopus 로고
    • Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages
    • Mullen A., Loscher C.E., Roche H.M. Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages. J Nutr Biochem 2010, 21:444-450.
    • (2010) J Nutr Biochem , vol.21 , pp. 444-450
    • Mullen, A.1    Loscher, C.E.2    Roche, H.M.3
  • 14
    • 0036931477 scopus 로고    scopus 로고
    • Omega-3 fatty acids in inflammation and autoimmune diseases
    • Simopoulos A.P. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002, 21:495-505.
    • (2002) J Am Coll Nutr , vol.21 , pp. 495-505
    • Simopoulos, A.P.1
  • 16
    • 55949097384 scopus 로고    scopus 로고
    • Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects
    • Paulo M.C., Andrade A.M., Andrade M.L., Morais M.G., Kiely M., Parra D., et al. Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects. Nutr Metab Cardiovasc Dis 2008, 18:664-670.
    • (2008) Nutr Metab Cardiovasc Dis , vol.18 , pp. 664-670
    • Paulo, M.C.1    Andrade, A.M.2    Andrade, M.L.3    Morais, M.G.4    Kiely, M.5    Parra, D.6
  • 17
    • 0035083871 scopus 로고    scopus 로고
    • Dietary modulation of endothelial function: implications for cardiovascular disease
    • Brown A.A., Hu F.B. Dietary modulation of endothelial function: implications for cardiovascular disease. Am J Clin Nutr 2001, 73:673-686.
    • (2001) Am J Clin Nutr , vol.73 , pp. 673-686
    • Brown, A.A.1    Hu, F.B.2
  • 18
    • 0037785357 scopus 로고    scopus 로고
    • EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway
    • Chen H., Li D., Chen J., Roberts G.J., Saldeen T., Mehta J.L. EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. J Mol Cell Cardiol 2003, 35:769-775.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 769-775
    • Chen, H.1    Li, D.2    Chen, J.3    Roberts, G.J.4    Saldeen, T.5    Mehta, J.L.6
  • 20
    • 34247597766 scopus 로고    scopus 로고
    • N-3 PUFA in CVD: influence of cytokine polymorphism
    • von Schacky C. n-3 PUFA in CVD: influence of cytokine polymorphism. Proc Nutr Soc 2007, 66:166-170.
    • (2007) Proc Nutr Soc , vol.66 , pp. 166-170
    • von Schacky, C.1
  • 21
    • 0022556085 scopus 로고
    • Structure and lipid binding properties of serum albumin
    • Spector A.A. Structure and lipid binding properties of serum albumin. Methods Enzymol 1986, 128:320-329.
    • (1986) Methods Enzymol , vol.128 , pp. 320-329
    • Spector, A.A.1
  • 22
    • 43649105393 scopus 로고    scopus 로고
    • Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2
    • Liao B.C., Hsieh C.W., Liu Y.C., Tzeng T.T., Sun Y.W., Wung B.S. Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2. Toxicol Appl Pharmacol 2008, 229:161-171.
    • (2008) Toxicol Appl Pharmacol , vol.229 , pp. 161-171
    • Liao, B.C.1    Hsieh, C.W.2    Liu, Y.C.3    Tzeng, T.T.4    Sun, Y.W.5    Wung, B.S.6
  • 23
    • 77954551049 scopus 로고    scopus 로고
    • Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells
    • Yu A.L., Lu C.Y., Wang T.S., Tsai C.W., Liu K.L., Cheng Y.P., et al. Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells. J Agric Food Chem 2010, 58:7641-7648.
    • (2010) J Agric Food Chem , vol.58 , pp. 7641-7648
    • Yu, A.L.1    Lu, C.Y.2    Wang, T.S.3    Tsai, C.W.4    Liu, K.L.5    Cheng, Y.P.6
  • 24
    • 0347355025 scopus 로고    scopus 로고
    • Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway
    • Cheng W.L., Lii C.K., Chen H.W., Lin T.H., Liu K.L. Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway. J Agric Food Chem 2004, 52:71-78.
    • (2004) J Agric Food Chem , vol.52 , pp. 71-78
    • Cheng, W.L.1    Lii, C.K.2    Chen, H.W.3    Lin, T.H.4    Liu, K.L.5
  • 25
    • 0027992051 scopus 로고
    • 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter
    • van de Stolpe A., Caldenhoven E., Stade B.G., Koenderman L., Raaijmakers J.A., Johnson J.P., et al. 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J Biol Chem 1994, 269:6185-6192.
    • (1994) J Biol Chem , vol.269 , pp. 6185-6192
    • van de Stolpe, A.1    Caldenhoven, E.2    Stade, B.G.3    Koenderman, L.4    Raaijmakers, J.A.5    Johnson, J.P.6
  • 26
    • 10744223540 scopus 로고    scopus 로고
    • Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway
    • Stangl V., Lorenz M., Meiners S., Ludwig A., Bartsch C., Moobed M., et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J 2004, 18:272-279.
    • (2004) FASEB J , vol.18 , pp. 272-279
    • Stangl, V.1    Lorenz, M.2    Meiners, S.3    Ludwig, A.4    Bartsch, C.5    Moobed, M.6
  • 27
    • 0034644753 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade
    • Woo C.H., Eom Y.W., Yoo M.H., You H.J., Han H.J., Song W.K., et al. Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade. J Biol Chem 2000, 275:32357-32362.
    • (2000) J Biol Chem , vol.275 , pp. 32357-32362
    • Woo, C.H.1    Eom, Y.W.2    Yoo, M.H.3    You, H.J.4    Han, H.J.5    Song, W.K.6
  • 28
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: from research tools to drug candidates
    • Kisselev A.F., Goldberg A.L. Proteasome inhibitors: from research tools to drug candidates. Chem Biol 2001, 8:739-758.
    • (2001) Chem Biol , vol.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 29
    • 19544370917 scopus 로고    scopus 로고
    • Heme oxygenase and the cardiovascular-renal system
    • Abraham N.G., Kappas A. Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med 2005, 39:1-25.
    • (2005) Free Radic Biol Med , vol.39 , pp. 1-25
    • Abraham, N.G.1    Kappas, A.2
  • 30
    • 61449417240 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy
    • Pae H.O., Lee Y.C., Chung H.T. Heme oxygenase-1 and carbon monoxide: emerging therapeutic targets in inflammation and allergy. Recent Pat Inflamm Allergy Drug Discov 2008, 2:159-165.
    • (2008) Recent Pat Inflamm Allergy Drug Discov , vol.2 , pp. 159-165
    • Pae, H.O.1    Lee, Y.C.2    Chung, H.T.3
  • 31
    • 33344469643 scopus 로고    scopus 로고
    • Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
    • Kobayashi A., Kang M.I., Watai Y., Tong K.I., Shibata T., Uchida K., et al. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 2006, 26:221-229.
    • (2006) Mol Cell Biol , vol.26 , pp. 221-229
    • Kobayashi, A.1    Kang, M.I.2    Watai, Y.3    Tong, K.I.4    Shibata, T.5    Uchida, K.6
  • 32
    • 36348946973 scopus 로고    scopus 로고
    • Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells
    • Aires V., Hichami A., Filomenko R., Plé A., Rébé C., Bettaieb A., et al. Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells. Mol Pharmacol 2007, 72:1545-1556.
    • (2007) Mol Pharmacol , vol.72 , pp. 1545-1556
    • Aires, V.1    Hichami, A.2    Filomenko, R.3    Plé, A.4    Rébé, C.5    Bettaieb, A.6
  • 33
    • 78651292670 scopus 로고    scopus 로고
    • Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for ω-3 fatty acids
    • Lu D.Y., Tsao Y.Y., Leung Y.M., Su K.P. Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for ω-3 fatty acids. Neuropsychopharmacology 2010, 35:2238-2248.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 2238-2248
    • Lu, D.Y.1    Tsao, Y.Y.2    Leung, Y.M.3    Su, K.P.4
  • 34
    • 78650274409 scopus 로고    scopus 로고
    • Andrographolide-induced pi class of glutathione S-transferase gene expression via PI3K/Akt pathway in rat primary hepatocytes
    • Lu C.Y., Li C.C., Lii C.K., Yao H.T., Liu K.L., Tsai C.W., et al. Andrographolide-induced pi class of glutathione S-transferase gene expression via PI3K/Akt pathway in rat primary hepatocytes. Food Chem Toxicol 2011, 49:281-289.
    • (2011) Food Chem Toxicol , vol.49 , pp. 281-289
    • Lu, C.Y.1    Li, C.C.2    Lii, C.K.3    Yao, H.T.4    Liu, K.L.5    Tsai, C.W.6
  • 35
    • 77956515291 scopus 로고    scopus 로고
    • Butein up-regulates the expression of the pi class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathway
    • Chang H.C., Chen H.W., Tung H.S., Liu K.L., Tsai C.W., Lii C.K. Butein up-regulates the expression of the pi class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathway. J Agric Food Chem 2010, 58:8994-9000.
    • (2010) J Agric Food Chem , vol.58 , pp. 8994-9000
    • Chang, H.C.1    Chen, H.W.2    Tung, H.S.3    Liu, K.L.4    Tsai, C.W.5    Lii, C.K.6
  • 36
    • 33644691914 scopus 로고    scopus 로고
    • Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells
    • Chen W., Esselman W.J., Jump D.B., Busik J.V. Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci 2005, 46:4342-4347.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 4342-4347
    • Chen, W.1    Esselman, W.J.2    Jump, D.B.3    Busik, J.V.4
  • 37
    • 56649114482 scopus 로고    scopus 로고
    • Atherosclerosis prevention by a fish oil-rich diet in apoE(-/-) mice is associated with a reduction of endothelial adhesion molecules
    • Casos K., Saiz M.P., Ruiz-Sanz J.I., Mitjavila M.T. Atherosclerosis prevention by a fish oil-rich diet in apoE(-/-) mice is associated with a reduction of endothelial adhesion molecules. Atherosclerosis 2008, 201:306-317.
    • (2008) Atherosclerosis , vol.201 , pp. 306-317
    • Casos, K.1    Saiz, M.P.2    Ruiz-Sanz, J.I.3    Mitjavila, M.T.4
  • 38
    • 0033668713 scopus 로고    scopus 로고
    • ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet
    • Bourdillon M.C., Poston R.N., Covacho C., Chignier E., Bricca G., McGregor J.L. ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol 2000, 20:2630-2635.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2630-2635
    • Bourdillon, M.C.1    Poston, R.N.2    Covacho, C.3    Chignier, E.4    Bricca, G.5    McGregor, J.L.6
  • 40
    • 0035958877 scopus 로고    scopus 로고
    • Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells
    • Denk A., Goebeler M., Schmid S., Berberich I., Ritz O., Lindemann D., et al. Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. J Biol Chem 2001, 276:28451-28458.
    • (2001) J Biol Chem , vol.276 , pp. 28451-28458
    • Denk, A.1    Goebeler, M.2    Schmid, S.3    Berberich, I.4    Ritz, O.5    Lindemann, D.6
  • 41
    • 33947530134 scopus 로고    scopus 로고
    • Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
    • Kaileh M., Vanden Berghe W., Heyerick A., Horion J., Piette J., Libert C., et al. Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem 2007, 282:4253-4264.
    • (2007) J Biol Chem , vol.282 , pp. 4253-4264
    • Kaileh, M.1    Vanden Berghe, W.2    Heyerick, A.3    Horion, J.4    Piette, J.5    Libert, C.6
  • 42
    • 2942555358 scopus 로고    scopus 로고
    • Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries
    • Takahashi T., Morita K., Akagi R., Sassa S. Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. Curr Med Chem 2004, 11:1545-1561.
    • (2004) Curr Med Chem , vol.11 , pp. 1545-1561
    • Takahashi, T.1    Morita, K.2    Akagi, R.3    Sassa, S.4
  • 43
    • 1542724430 scopus 로고    scopus 로고
    • Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation
    • Soares M.P., Seldon M.P., Gregoire I.P., Vassilevskaia T., Berberat P.O., Yu J., et al. Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. J Immunol 2004, 172:3553-3563.
    • (2004) J Immunol , vol.172 , pp. 3553-3563
    • Soares, M.P.1    Seldon, M.P.2    Gregoire, I.P.3    Vassilevskaia, T.4    Berberat, P.O.5    Yu, J.6
  • 44
    • 55949120110 scopus 로고    scopus 로고
    • Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis
    • Li W., Khor T.O., Xu C., Shen G., Jeong W.S., Yu S., et al. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 2008, 76:1485-1489.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1485-1489
    • Li, W.1    Khor, T.O.2    Xu, C.3    Shen, G.4    Jeong, W.S.5    Yu, S.6
  • 45
    • 7944220437 scopus 로고    scopus 로고
    • Diallyl sulfide induces heme oxygenase-1 through MAPK pathway
    • Gong P., Hu B., Cederbaum A.I. Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch Biochem Biophys 2004, 432:252-260.
    • (2004) Arch Biochem Biophys , vol.432 , pp. 252-260
    • Gong, P.1    Hu, B.2    Cederbaum, A.I.3
  • 46
    • 0041742490 scopus 로고    scopus 로고
    • Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
    • Numazawa S., Ishikawa M., Yoshida A., Tanaka S., Yoshida T. Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. Am J Physiol Cell Physiol 2003, 285:C334-C342.
    • (2003) Am J Physiol Cell Physiol , vol.285
    • Numazawa, S.1    Ishikawa, M.2    Yoshida, A.3    Tanaka, S.4    Yoshida, T.5
  • 47
    • 56549083649 scopus 로고    scopus 로고
    • Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1
    • Hwang Y.P., Jeong H.G. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Toxicol Appl Pharmacol 2008, 233:371-381.
    • (2008) Toxicol Appl Pharmacol , vol.233 , pp. 371-381
    • Hwang, Y.P.1    Jeong, H.G.2
  • 48
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    • D'Autreaux B., Toledano M.B. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 2007, 8:813-824.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 813-824
    • D'Autreaux, B.1    Toledano, M.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.