Development and validation of a sensitive and selective UHPLC-MS/MS method for simultaneous determination of both free and total eicosapentaeonic acid and docosahexenoic acid in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 30, 2010, Pages 3125-3133

  Bowen, Chester L ^a   Kehler, Jonathan ^a   Evans, Christopher A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Conjugate matrix; Docosahexenoic acid (DHA); Eicosapentaeonic acid (EPA); Mass spectrometry; Polyunsaturated fatty acid; Triglyceride

Indexed keywords

DOCOSAHEXENOIC ACID (DHA); EICOSAPENTAEONIC ACID (EPA); MATRIX; POLYUNSATURATED FATTY ACIDS; TRIGLYCERIDE;

COLUMN CHROMATOGRAPHY; ENVIRONMENTAL PROTECTION AGENCY; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PLASMA (HUMAN); SIZE SEPARATION; SOLVENT EXTRACTION;

FATTY ACIDS;

DOCOSAHEXAENOIC ACID; HUMAN SERUM ALBUMIN; ICOSAPENTAENOIC ACID; TRIACYLGLYCEROL;

ARTICLE; BLOOD SAMPLING; HUMAN; LIPID ANALYSIS; LIQUID LIQUID EXTRACTION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 78049479744     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.09.020     Document Type: Article

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