Eicosapentaenoic acid increases cytochrome P-450 2J2 gene expression and epoxyeicosatrienoic acid production via peroxisome proliferator-activated receptor γ in endothelial cells

Journal of Cardiology

Volumn 54, Issue 3, 2009, Pages 368-374

  Wang, Dahai ^a   Hirase, Tetsuaki ^a   Nitto, Takeaki ^a   Soma, Masaaki ^b   Node, Koichi ^a  

^a SAGA UNIVERSITY   (Japan)

^b MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

Cytochrome P 450; Eicosapentaenoic acid; Endothelial cells; Peroxisome proliferator activated receptor

Indexed keywords

11,12 DIHYDROXYEICOSATRIENOIC ACID; 2 CHLORO 5 NITROBENZANILIDE; CYTOCHROME P450 2J2; EPOXYICOSATRIENOIC ACID; FATTY ACID DERIVATIVE; ICOSAPENTAENOIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; ENZYME SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN;

8,11,14-EICOSATRIENOIC ACID; ANILIDES; ARACHIDONIC ACIDS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; PPAR GAMMA; RNA, MESSENGER; STIMULATION, CHEMICAL; TIME FACTORS; UMBILICAL VEINS;

EID: 70450224477     PISSN: 09145087     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jjcc.2009.06.004     Document Type: Article

References (24)

1. Kris-Etherton P.M., Harris W.S., and Appel L.J. American Heart Association Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106 (2002) 2747-2757
2. Yokoyama M., Origasa H., Matsuzaki M., Matsuzawa Y., Saito Y., Ishikawa Y., Oikawa S., Sasaki J., Hishida H., Itakura H., Kita T., Kitabatake A., Nakaya N., Sakata T., Shimada K., et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369 (2007) 1090-1098
3. Li H., Ruan X.Z., Powis S.H., Fernando R., Mon W.Y., Wheeler D.C., Moorhead J.F., and Varghese Z. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. Kidney Int 67 (2005) 867-874
4. Brown J.D., and Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 115 (2007) 518-533
5. Marx N., Sukhova G.K., Collins T., Libby P., and Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 99 (1999) 3125-3131
6. Goetze S., Kim S., Xi X.P., Graf K., Yang D.C., Fleck E., Meehan W.P., Hsueh W.A., and Law R.E. Troglitazone inhibits mitogenic signaling by insulin in vascular smooth muscle cells. J Cardiovasc Pharmacol 35 (2000) 749-757
7. Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
8. Node K., Huo Y., Ruan X., Yang B., Spiecker M., Ley K., Zeldin D.C., and Liao J.K. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285 (1999) 1276-1279
9. Node K., Ruan X.L., Dai J., Yang S.X., Graham L., Zeldin D.C., and Liao J.K. Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem 276 (2001) 15983-15989
10. Spiecker M., Darius H., Hankeln T., Soufi M., Sattler A.M., Schaefer J.R., Node K., Börgel J., Mügge A., Lindpaintner K., Huesing A., Maisch B., Zeldin D.C., and Liao J.K. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation 110 (2004) 2132-2136
11. Fisslthaler B., Popp R., Kiss L., Potente M., Harder D.R., Fleming I., and Busse R. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401 (1999) 493-497
12. Rosolowsky M., and Campbell W.B. Synthesis of hydroxyeicosatetraenoic (HETEs) and epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. Biochim Biophys Acta 1299 (1996) 267-277
13. Potente M., Fisslthaler B., Busse R., and Fleming R. 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. J Biol Chem 278 (2003) 29619-29625
14. Michaelis U.R., Fisslthaler B., Barbosa-Sicard E., Falck J.R., Fleming I., and Busse R. Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci 118 (2005) 5489-5498
15. Omura M., Kobayashi S., Mizukami Y., Mogami K., Todoroki-Ikeda N., Miyake T., and Matsuzaki M. Eicosapentaenoic acid (EPA) induces Ca(2+)-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent vasorelaxation. FEBS Lett 487 (2001) 361-366
16. Spector A.A., and Norris A.W. Action of epoxyeicosatrienoic acids on cellular function. Am J Physiol Cell Physiol 292 (2007) C996-1012
17. Liu Y., Zhang Y., Schmelzer K., Lee T.S., Fang X., Zhu Y., Spector A.A., Gill S., Morisseau C., Hammock B.D., and Shyy J.Y. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci USA 102 (2005) 16747-16752
18. Huang A., Sun D., Jacobson A., Carroll M.A., Falck J.R., and Kaley G. Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle. Circ Res 96 (2005) 376-383
19. Blaschke F., Takata Y., Caglayan E., Law R.E., and Hsueh W.A. Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol 26 (2006) 28-40
20. 2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism 50 (2001) 3-11
21. Hwang J., Kleinhenz D.J., Lassègue B., Griendling K.K., Dikalov S., and Hart C.M. Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. Am J Physiol Cell Physiol 288 (2005) C899-905
22. Xu H.E., Lambert M.H., Montana V.G., Parks D.J., Blanchard S.G., Brown P.J., Sternbach D.D., Lehmann J.M., Wisely G.B., Willson T.M., Kliewer S.A., and Milburn M.V. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 3 (1999) 397-403
23. Nolte R.T., Wisely G.B., Westin S., Cobb J.E., Lambert M.H., Kurokawa R., Rosenfeld M.G., Willson T.M., Glass C.K., and Milburn M.V. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395 (1998) 137-143
24. Coyne G.S., Kenny D.A., Childs S., Sreenan J.M., and Waters S.M. Dietary n-3 polyunsaturated fatty acids alter the expression of genes involved in prostaglandin biosynthesis in the bovine uterus. Theriogenology 70 (2008) 772-782