Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 386-394

  Pezdirc, Marko ^a   Žegura, Bojana ^a   Filipič, Metka ^a  

^a NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

Author keywords

Cell cycle; Gene expression; Genotoxicity; HepG2 cells; Heterocyclic aromatic amines; Metabolic transformation

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,4,8 TRIMETHYL 3H IMIDAZO[4,5 F]QUINOXALIN; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; AROMATIC AMINE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; GLUCURONOSYLTRANSFERASE 1A1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 ALPHA; HETEROCYCLIC AMINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BAX GENE; CDKN1A GENE; CELL CYCLE ARREST; CELL SURVIVAL; CONTROLLED STUDY; CYP1A1 GENE; CYP1A2 GENE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GADD45A GENE; GENE ACTIVITY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC ANALYSIS; GENETIC REGULATION; GENOTOXICITY; GSTA1 GENE; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NAT2 GENE; ONCOGENE; SULT1A1 GENE; TP53 GENE; UGT1A GENE;

CELL-CYCLE; GENE EXPRESSION; GENOTOXICITY; HEPG2 CELLS; HETEROCYCLIC AROMATIC AMINES; METABOLIC TRANSFORMATION;

BIOTRANSFORMATION; CARCINOGENS; CELL CYCLE; CELL SURVIVAL; DNA BREAKS; DNA DAMAGE; FOOD CONTAMINATION; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HOT TEMPERATURE; HUMANS; IMIDAZOLES; MUTAGENS; QUINOLINES; QUINOXALINES;

EID: 84880336657     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.06.030     Document Type: Article

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