A mechanistic basis for the role of cycle arrest in the genetic toxicology of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

Toxicological Sciences

Volumn 84, Issue 2, 2005, Pages 335-343

  Creton, S ^a   Zhu, H ^a   Gooderham, N J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

2 amino 1 methyl 6 phenylimidazo 4,5 b pyridine; Breast epithelial cells; Cell cycle; Cytotoxicity; MDM2; p21; p53; PhIP; RB

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; CARCINOGEN; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DNA; HETEROCYCLIC AMINE; PROTEIN MDM2; PROTEIN MSH6; PROTEIN P53; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN;

ABSORPTION; ARTICLE; BREAST CARCINOGENESIS; BREAST CELL; CELL COUNT; CELL CYCLE G1 PHASE; CELL DAMAGE; CELL DIVISION; CELL METABOLISM; CHEMICAL CARCINOGENESIS; COCULTURE; COLON CARCINOGENESIS; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; COOKING; DNA REPAIR; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE MUTATION; GENETIC TOXICOLOGY; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MEAT; METABOLISM; MITOSIS INHIBITION; MUTATIONAL ANALYSIS; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIME; WESTERN BLOTTING;

CARCINOGENS; CELL COUNT; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; COCULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMIDAZOLES; LYMPHOCYTES; MAMMARY GLANDS, HUMAN; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 17444417490     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi075     Document Type: Article

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