Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxication pathway catalyzed by cytochrome P450 1A2

Chemical Research in Toxicology

Volumn 14, Issue 2, 2001, Pages 211-221

  Langouet S ^a   Welti, D H ^b   Kerriguy, N ^a   Fay, L B ^b   Huynh Ba, T ^b   Markovic, J ^b   Guengerich, F P ^c   Guillouzo, A ^a   Turesky, R J ^b,d  

^a INSERM   (France)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; CARBOXYLIC ACID; CARCINOGEN; CYTOCHROME P450 1A2; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CONTROLLED STUDY; DETOXIFICATION; EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; METABOLISM; MUTAGEN TESTING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SALMONELLA TYPHIMURIUM;

ANIMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0035102180     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000176e     Document Type: Article

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